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  1. AU="Sovel, Mindy"
  2. AU="Lukyanov, Sergey"
  3. AU="Baptistella, Amanda"
  4. AU="Dichter, Gabriel S"
  5. AU="D Urbano, Vanessa"
  6. AU="Farhad Shirini"
  7. AU="Wu, Wenming"
  8. AU="Wiedermann, Christian J"
  9. AU="Corradin, Giampietro"
  10. AU="Guan, Xiaodong"
  11. AU=Burmester Gerd R.
  12. AU="Mańczak, Rafał"
  13. AU="Cristina Ceron"
  14. AU=Scardapane Arnaldo
  15. AU="Taylor, Daniel J"
  16. AU="Sabanadzovic, Sead"
  17. AU=Lee Yangsoon AU=Lee Yangsoon
  18. AU="Sahoo, Aditi"
  19. AU="Reyes, Peter Andrew C"
  20. AU="Collobert, Géromine"
  21. AU="Guevara, Katterine"
  22. AU=Ahmadivand Arash

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  1. Artikel ; Online: Comparing surgical infections in National Surgical Quality Improvement Project and an Institutional Database.

    Selby, Luke V / Sjoberg, Daniel D / Cassella, Danielle / Sovel, Mindy / Weiser, Martin R / Sepkowitz, Kent / Jones, David R / Strong, Vivian E

    The Journal of surgical research

    2015  Band 196, Heft 2, Seite(n) 416–420

    Abstract: Background: Surgical quality improvement requires accurate tracking and benchmarking of postoperative adverse events. We track surgical site infections (SSIs) with two systems; our in-house surgical secondary events (SSE) database and the National ... ...

    Abstract Background: Surgical quality improvement requires accurate tracking and benchmarking of postoperative adverse events. We track surgical site infections (SSIs) with two systems; our in-house surgical secondary events (SSE) database and the National Surgical Quality Improvement Project (NSQIP). The SSE database, a modification of the Clavien-Dindo classification, categorizes SSIs by their anatomic site, whereas NSQIP categorizes by their level. Our aim was to directly compare these different definitions.
    Materials and methods: NSQIP and the SSE database entries for all surgeries performed in 2011 and 2012 were compared. To match NSQIP definitions, and while blinded to NSQIP results, entries in the SSE database were categorized as either incisional (superficial or deep) or organ space infections. These categorizations were compared with NSQIP records; agreement was assessed with Cohen kappa.
    Results: The 5028 patients in our cohort had a 6.5% SSI in the SSE database and a 4% rate in NSQIP, with an overall agreement of 95% (kappa = 0.48, P < 0.0001). The rates of categorized infections were similarly well matched; incisional rates of 4.1% and 2.7% for the SSE database and NSQIP and organ space rates of 2.6% and 1.5%. Overall agreements were 96% (kappa = 0.36, P < 0.0001) and 98% (kappa = 0.55, P < 0.0001), respectively. Over 80% of cases recorded by the SSE database but not NSQIP did not meet NSQIP criteria.
    Conclusions: The SSE database is an accurate, real-time record of postoperative SSIs. Institutional databases that capture all surgical cases can be used in conjunction with NSQIP with excellent concordance.
    Mesh-Begriff(e) Databases, Factual ; General Surgery/organization & administration ; General Surgery/standards ; General Surgery/statistics & numerical data ; Humans ; New York/epidemiology ; Quality Improvement ; Retrospective Studies ; Surgical Wound Infection/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2015-06-15
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2015.02.072
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Development and assessment of Memorial Sloan Kettering Cancer Center's Surgical Secondary Events grading system.

    Strong, Vivian E / Selby, Luke V / Sovel, Mindy / Disa, Joseph J / Hoskins, William / Dematteo, Ronald / Scardino, Peter / Jaques, David P

    Annals of surgical oncology

    2014  Band 22, Heft 4, Seite(n) 1061–1067

    Abstract: Background: Studying surgical secondary events is an evolving effort with no current established system for database design, standard reporting, or definitions. Using the Clavien-Dindo classification as a guide, in 2001 we developed a Surgical Secondary ...

    Abstract Background: Studying surgical secondary events is an evolving effort with no current established system for database design, standard reporting, or definitions. Using the Clavien-Dindo classification as a guide, in 2001 we developed a Surgical Secondary Events database based on grade of event and required intervention to begin prospectively recording and analyzing all surgical secondary events (SSE).
    Methods: Events are prospectively entered into the database by attending surgeons, house staff, and research staff. In 2008 we performed a blinded external audit of 1,498 operations that were randomly selected to examine the quality and reliability of the data.
    Results: Of 4,284 operations, 1,498 were audited during the third quarter of 2008. Of these operations, 79 % (N = 1,180) did not have a secondary event while 21 % (N = 318) had an identified event; 91 % of operations (1,365) were correctly entered into the SSE database. Also 97 % (129 of 133) of missed secondary events were grades I and II. There were 3 grade III (2 %) and 1 grade IV (1 %) secondary event that were missed. There were no missed grade 5 secondary events.
    Conclusions: Grade III-IV events are more accurately collected than grade I-II events. Robust and accurate secondary events data can be collected by clinicians and research staff, and these data can safely be used for quality improvement projects and research.
    Mesh-Begriff(e) Databases, Factual ; Follow-Up Studies ; Humans ; Neoplasms/surgery ; Outcome Assessment, Health Care ; Postoperative Complications ; Prognosis ; Prospective Studies ; Quality Improvement ; Secondary Prevention
    Sprache Englisch
    Erscheinungsdatum 2014-10-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-014-4141-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Preoperative Chemoprophylaxis is Safe in Major Oncology Operations and Effective at Preventing Venous Thromboembolism.

    Selby, Luke V / Sovel, Mindy / Sjoberg, Daniel D / McSweeney, Margaret / Douglas, Damon / Jones, David R / Scardino, Peter T / Soff, Gerald A / Fabbri, Nicola / Sepkowitz, Kent / Strong, Vivian E / Sarkaria, Inderpal S

    Journal of the American College of Surgeons

    2016  Band 222, Heft 2, Seite(n) 129–137

    Abstract: Background: We prospectively evaluated the safety and efficacy of adding preoperative chemoprophylaxis to our institution's operative venous thromboembolism (VTE) prophylaxis policy as part of a physician-led quality improvement initiative.: Study ... ...

    Abstract Background: We prospectively evaluated the safety and efficacy of adding preoperative chemoprophylaxis to our institution's operative venous thromboembolism (VTE) prophylaxis policy as part of a physician-led quality improvement initiative.
    Study design: Patients undergoing major cancer surgery between August 2013 and January 2014 were screened according to service-specific eligibility criteria and targeted to receive preoperative VTE chemoprophylaxis. Bleeding, transfusion, and VTE rates were compared with rates of historical controls who had not received preoperative chemoprophylaxis.
    Results: The 2,058 eligible patients who underwent operation between August 2013 and January 2014 (post-intervention) were compared with a cohort of 4,960 patients operated on between January 2012 and June 2013, who did not receive preoperative VTE chemoprophylaxis (pre-intervention). In total, 71% of patients in the post-intervention group were screened for eligibility; 82% received preoperative anticoagulation. When compared with the pre-intervention group, the post-intervention group had significantly lower transfusion rates (pre- vs post-intervention, 17% vs 14%; difference 3.5%, 95% CI 1.7% to 5%, p = 0.0003) without significant difference in major bleeding (difference 0.3%, 95% CI -0.1% to 0.7%, p = 0.2). Rates of deep venous thrombosis (1.3% vs 0.2%; difference 1.1%, 95% CI 0.7% to 1.4%, p < 0.0001) and pulmonary embolus (1.0% vs 0.4%; difference 0.6%, 95% CI 0.2% to 1%, p = 0.017) were significantly lower in the post-intervention group.
    Conclusions: In patients undergoing major cancer surgery, institution of a single dose of preoperative chemoprophylaxis, as part of a physician-led quality improvement initiative, did not increase bleeding or blood transfusions and was associated with a significant decrease in VTE rates.
    Mesh-Begriff(e) Aged ; Chemoprevention ; Female ; Fibrinolytic Agents/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Historically Controlled Study ; Humans ; Male ; Middle Aged ; Neoplasms/surgery ; Postoperative Complications ; Prospective Studies ; Quality Improvement ; Venous Thromboembolism/prevention & control
    Chemische Substanzen Fibrinolytic Agents ; Heparin, Low-Molecular-Weight
    Sprache Englisch
    Erscheinungsdatum 2016-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2015.11.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Risk of Surgical Site Infection (SSI) following Colorectal Resection Is Higher in Patients With Disseminated Cancer: An NCCN Member Cohort Study.

    Kamboj, Mini / Childers, Teresa / Sugalski, Jessica / Antonelli, Donna / Bingener-Casey, Juliane / Cannon, Jamie / Cluff, Karie / Davis, Kimberly A / Dellinger, E Patchen / Dowdy, Sean C / Duncan, Kim / Fedderson, Julie / Glasgow, Robert / Hall, Bruce / Hirsch, Marilyn / Hutter, Matthew / Kimbro, Lisa / Kuvshinoff, Boris / Makary, Martin /
    Morris, Melanie / Nehring, Sharon / Ramamoorthy, Sonia / Scott, Rebekah / Sovel, Mindy / Strong, Vivian / Webster, Ashley / Wick, Elizabeth / Aguilar, Julio Garcia / Carlson, Robert / Sepkowitz, Kent

    Infection control and hospital epidemiology

    2018  Band 39, Heft 5, Seite(n) 555–562

    Abstract: BACKGROUNDSurgical site infections (SSIs) following colorectal surgery (CRS) are among the most common healthcare-associated infections (HAIs). Reduction in colorectal SSI rates is an important goal for surgical quality improvement.OBJECTIVETo examine ... ...

    Abstract BACKGROUNDSurgical site infections (SSIs) following colorectal surgery (CRS) are among the most common healthcare-associated infections (HAIs). Reduction in colorectal SSI rates is an important goal for surgical quality improvement.OBJECTIVETo examine rates of SSI in patients with and without cancer and to identify potential predictors of SSI risk following CRSDESIGNAmerican College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data files for 2011-2013 from a sample of 12 National Comprehensive Cancer Network (NCCN) member institutions were combined. Pooled SSI rates for colorectal procedures were calculated and risk was evaluated. The independent importance of potential risk factors was assessed using logistic regression.SETTINGMulticenter studyPARTICIPANTSOf 22 invited NCCN centers, 11 participated (50%). Colorectal procedures were selected by principal procedure current procedural technology (CPT) code. Cancer was defined by International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) codes.MAIN OUTCOMEThe primary outcome of interest was 30-day SSI rate.RESULTSA total of 652 SSIs (11.06%) were reported among 5,893 CRSs. Risk of SSI was similar for patients with and without cancer. Among CRS patients with underlying cancer, disseminated cancer (SSI rate, 17.5%; odds ratio [OR], 1.66; 95% confidence interval [CI], 1.23-2.26; P=.001), ASA score ≥3 (OR, 1.41; 95% CI, 1.09-1.83; P=.001), chronic obstructive pulmonary disease (COPD; OR, 1.6; 95% CI, 1.06-2.53; P=.02), and longer duration of procedure were associated with development of SSI.CONCLUSIONSPatients with disseminated cancer are at a higher risk for developing SSI. ASA score >3, COPD, and longer duration of surgery predict SSI risk. Disseminated cancer should be further evaluated by the Centers for Disease Control and Prevention (CDC) in generating risk-adjusted outcomes.Infect Control Hosp Epidemiol 2018;39:555-562.
    Mesh-Begriff(e) Adult ; Aged ; Cohort Studies ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/surgery ; Databases, Factual ; Digestive System Surgical Procedures/adverse effects ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Rectum/surgery ; Risk Factors ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; United States/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2018-03-19
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2018.40
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial.

    Keefe, Richard S E / Malhotra, Anil K / Meltzer, Herbert Y / Kane, John M / Buchanan, Robert W / Murthy, Anita / Sovel, Mindy / Li, Chunming / Goldman, Robert

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2008  Band 33, Heft 6, Seite(n) 1217–1228

    Abstract: Altered expression of central muscarinic and nicotinic acetylcholine receptors in hippocampal and cortical regions may contribute to the cognitive impairment exhibited in patients with schizophrenia. Increasing cholinergic activity through the use of a ... ...

    Abstract Altered expression of central muscarinic and nicotinic acetylcholine receptors in hippocampal and cortical regions may contribute to the cognitive impairment exhibited in patients with schizophrenia. Increasing cholinergic activity through the use of a cholinesterase inhibitor (ChEI) therefore represents a possible strategy for cognitive augmentation in schizophrenia. We examined the efficacy and safety of the ChEI donepezil as cotreatment for mild to moderate cognitive impairment in schizophrenia or schizoaffective disorder in a prospective, 12-week, placebo-controlled, double-blind, parallel-group study. In total, 250 patients (18-55 years) with schizophrenia or schizoaffective disorder who were clinically stabilized on risperidone, olanzapine, quetiapine, ziprasidone, or aripiprazole, alone or in combination, were enrolled at 38 outpatient psychiatric clinics in the United States. Patients were randomized to donepezil 5 mg q.d. for 6 weeks then 10 mg q.d. for 6 weeks, or placebo administered as oral tablets. The primary outcome measure was the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) neurocognitive battery composite score. In the intent-to-treat sample (donepezil, n=121; placebo, n=124), both treatments showed improvement in the composite score from baseline to week 12. At week 12, cognitive improvement with donepezil was similar to that with placebo (last-observation-carried-forward effect size, 0.277 vs 0.411; p=0.1182) and statistically significantly inferior for the observed-cases analysis (0.257 vs 0.450; p=0.044). There was statistically significant improvement in the Positive and Negative Syndrome Assessment Scale negative symptoms score for placebo compared with donepezil, while total and positive symptom scores were similar between both treatments. Statistically significant improvements in positive symptoms score and Clinical Global Impression-Improvement for donepezil compared with placebo were noted at Week 6. Treatment-emergent adverse events (AEs) were observed for 54.5% of donepezil- and 61.3% of placebo-treated patients; most AEs were rated as mild to moderate in severity. Donepezil was safe and well-tolerated but was not effective compared with placebo as a cotreatment for the improvement of cognitive impairment in this patient population. A significant and surprisingly large placebo/practice effect was observed among placebo-treated patients, and is a serious consideration in future clinical trial study designs for potential cognitive enhancing compounds in schizophrenia.
    Mesh-Begriff(e) Adult ; Cholinesterase Inhibitors/therapeutic use ; Clinical Trials as Topic ; Cognition Disorders/etiology ; Cognition Disorders/therapy ; Double-Blind Method ; Female ; Humans ; Indans/therapeutic use ; Male ; Middle Aged ; Neuropsychological Tests ; Piperidines/therapeutic use ; Placebo Effect ; Practice (Psychology) ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychotic Disorders/complications ; Psychotic Disorders/drug therapy ; Schizophrenia/complications ; Schizophrenia/drug therapy ; Time Factors
    Chemische Substanzen Cholinesterase Inhibitors ; Indans ; Piperidines ; donepezil (8SSC91326P)
    Sprache Englisch
    Erscheinungsdatum 2008-05
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/sj.npp.1301499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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