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  1. Article ; Online: Das EDEC-Curriculum – der Weg zur fortgeschrittenen Echokardiographie auf der Intensivstation.

    Spacek, M / Verner, M

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2024  

    Abstract: Good knowledge of echocardiography is essential for modern intensive care medicine. A standardized curriculum for acquiring the expertise to perform TTE and TEE is a good way to strengthen one's own diagnostic skills.The EDEC curriculum from ESICM, which ...

    Title translation The EDEC curriculum-the path to advanced echocardiography in the intensive care unit.
    Abstract Good knowledge of echocardiography is essential for modern intensive care medicine. A standardized curriculum for acquiring the expertise to perform TTE and TEE is a good way to strengthen one's own diagnostic skills.The EDEC curriculum from ESICM, which has been established for years, offers a good opportunity for structural further training at the advanced level in combination with gaining a high level of professional competence.
    Language German
    Publishing date 2024-01-02
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-023-01101-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Thesis: Verlauf und Prädiktoren von chronisch kritisch kranken Patienten nach akuter Nierenschädigung mit prolongierter Dialysepflichtigkeit

    Spacek, Michal

    2015  

    Author's details von Michal Spacek
    Language German
    Size 76 Blätter, Illustrationen
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, 2016
    HBZ-ID HT018982859
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 E 926 order for loan Magazin

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  3. Article: Malé molekuly v léčbě chronické lymfocytární leukemie v roce 2015 a v blízké budoucnosti.

    Špaček, M

    Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

    2015  Volume 28 Suppl 3, Page(s) 3S45–9

    Abstract: Chronic lymphocytic leukemia is one of the most common lymphoid malignancies and is characterized by a highly heterogeneous clinical course. Combined regimens, such as fludarabine, cyclophosphamide, and rituximab have led to improvements in survival in ... ...

    Title translation Small Molecules in the Treatment of Chronic Lymphocytic Leukemia in 2015 and in the Near Future.
    Abstract Chronic lymphocytic leukemia is one of the most common lymphoid malignancies and is characterized by a highly heterogeneous clinical course. Combined regimens, such as fludarabine, cyclophosphamide, and rituximab have led to improvements in survival in younger patients with chronic lymphocytic leukemia and have become the standard of care in fit patients. However, the majority of chronic lymphocytic leukemia patients are elderly and not all patients are eligible for aggressive chemoimmunotherapy. In addition, patients with poor- risk cytogenetics have inferior responses to standard treatments with often shorter durations of response. Furthermore, the treatment outcomes of refractory disease are dismal. Nevertheless, there has been a dramatic change in therapeutic paradigms in the past year. Several new drugs have been approved for the treatment of chronic lymphocytic leukemia, including ibrutinib and idelalisib. These new molecules are orally active agents and both target the B -cell receptor associated kinases. Ibrutinib is a selective, irreversible inhibitor of Bruton tyrosine kinase, whereas idelalisib selectively targets phosphatidylinositol 3- kinase (PI3K) δ isoform. These agents have demonstrated remarkable activity in patients with relapsed/ refractory chronic lymphocytic leukemia, as well as patients with high-risk deletion of the 17p chromosome and/ or TP53 mutation. This review focuses on some of the novel small molecules that are currently approved or in advanced clinical development.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/mortality
    Language Czech
    Publishing date 2015-10-20
    Publishing country Czech Republic
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1217739-8
    ISSN 0862-495X
    ISSN 0862-495X
    DOI 10.14735/amko20153s45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Positive Effekte eines Einarbeitungs- und Weiterbildungscurriculums am Beispiel der interdisziplinären Intensivstation.

    Spacek, M / Prautzsch, C / Mehrholz, J / Eberlein-Gonska, M

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2022  Volume 118, Issue 4, Page(s) 277–282

    Abstract: The training of new medical colleagues in hospitals is due to various aspects such as for instance staff shortages and time pressure often very challenging for everyone involved. Using the example of the interdisciplinary intensive care unit, the ... ...

    Title translation Positive effects of training curriculum using the example of the interdisciplinary intensive care unit.
    Abstract The training of new medical colleagues in hospitals is due to various aspects such as for instance staff shortages and time pressure often very challenging for everyone involved. Using the example of the interdisciplinary intensive care unit, the positive effects of a structured training curriculum have been scientifically proven in regular employee surveys. There was a statistically significant increase in satisfaction in the quality of induction (p < 0.0001), quality of training (p < 0.0001),  preparation for night shifts in the intensive care unit (p < 0.0001) and an improvement in general satisfaction in the clinic (p < 0.003) can also be shown. For these reasons, such curriculum contributes to increasing the quality of care and patient safety as well as the safety of medical staff in the medical work.
    MeSH term(s) Humans ; Curriculum ; Intensive Care Units ; Surveys and Questionnaires
    Language German
    Publishing date 2022-07-09
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-022-00938-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Neoadjuvantní užití izolované perfuze končetiny u objemného myxoidního liposarkomu stehna: kazuistika.

    Lesenský, J / Vočka, M / Špaček, M / Hósová, M

    Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

    2021  Volume 88, Issue 4, Page(s) 321–324

    Abstract: Large unresectable STS presents a therapeutic challenge. Several options are being explored to avoid amputation without compromising the oncological outcome. Neoadjuvant chemotherapy delivers inconsistent and rather unsatisfactory results, preoperative ... ...

    Title translation Neoadjuvant Use of Isolated Limb Perfusion in Large Myxoid Liposarcoma of the Thigh: a Case Report.
    Abstract Large unresectable STS presents a therapeutic challenge. Several options are being explored to avoid amputation without compromising the oncological outcome. Neoadjuvant chemotherapy delivers inconsistent and rather unsatisfactory results, preoperative radiotherapy compromises healing, hence it can impede adjuvant systemic treatment. We present a case report of neoadjuvant use of isolated limb perfusion with TNF-alfa and Alkeran (Melphalan) in a patient with initially unresectable large myxoid liposarcoma of the thigh. We achieved 55% reduction in size of the tumor that allowed for wide resection with a safe margin. Pathology confirmed 99% tumor necrosis. The patient has a full function of his extremity and is disease-free at one year follow-up. ILP should be considered as a treatment option which, in selected cases, can contribute to limb sparing surgery. Key words: sarcoma, soft tissue, regional perfusion, chemotherapy, surgery, orthopedic, limb salvage.
    Language Czech
    Publishing date 2021-09-17
    Publishing country Czech Republic
    Document type English Abstract ; Journal Article
    ZDB-ID 418889-5
    ISSN 0001-5415
    ISSN 0001-5415
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  6. Article: Partial resection of native and prosthetic arteriovenous fistula as a treatment of late infections complications - series of case reports.

    Svobodová, A / Slavíková, M / Lainková, R / Špaček, M / Grus, T / Lindner, J

    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti

    2022  Volume 101, Issue 9, Page(s) 460–464

    Abstract: Introduction: Infection of arteriovenous fistula (AV) used for hemodialysis (HD) is associated with massive bleeding, sepsis development, formation of metastatic infectious foci, and a high risk of AV loss. Urgent management of an infected AV is crucial ...

    Title translation Parciální resekce jako možnost řešení pozdní infekce nativního i protetického arteriovenózního zkratu - kazuistiky.
    Abstract Introduction: Infection of arteriovenous fistula (AV) used for hemodialysis (HD) is associated with massive bleeding, sepsis development, formation of metastatic infectious foci, and a high risk of AV loss. Urgent management of an infected AV is crucial for successful treatment and AV salvage.
    Case reports: We present the use of partial resection as a successful method of dealing with late AV infection in two cases. In case 1, the resection was performed due to an infection of the native arteriovenous fistula (AVF) with two defects above the drainage vein aneurysms. In case 2, partial resection and replacement of the prosthetic arteriovenous fistula (AVG) were done due to an infection of HD puncture site. The AVs remained patent in both cases, with no further signs of infection postoperatively and, most importantly, without the need to use a temporary HD catheter.
    Conclusion: The establishment of a new AV is limited by the quality of the venous and arterial systems. All surgical, interventional and non-surgical means should be used to safely maintain the created AV patent. Provided that the requirements of an early indication are met, partial resection of the AV is the method of choice for AV infections and allows us to avoid using a permanent dialysis catheter in our patients.
    MeSH term(s) Humans ; Arteriovenous Shunt, Surgical/adverse effects ; Arteriovenous Shunt, Surgical/methods ; Treatment Outcome ; Renal Dialysis/adverse effects ; Arteriovenous Fistula/etiology ; Arteriovenous Fistula/surgery ; Aneurysm/surgery
    Language English
    Publishing date 2022-10-18
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 414059-x
    ISSN 1805-4579 ; 0035-9351
    ISSN (online) 1805-4579
    ISSN 0035-9351
    DOI 10.33699/PIS.2022.101.9.460-464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: And again.

    Spacek, M

    Canadian family physician Medecin de famille canadien

    2010  Volume 25, Page(s) 1434

    Language English
    Publishing date 2010-05-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 603565-6
    ISSN 0008-350X
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Langzeitverlauf von beatmeten Patienten nach SARS-COV-2 (Post-COVID-Studie)

    Oehmichen, F. / Bauer, A. / Spacek, M. / Rückriem, S. / Mehnert, K. / Mehrholz, J.

    Neurologie & Rehabilitation

    2023  Volume 29, Issue 2, Page(s) 107

    Language German
    Document type Article
    ZDB-ID 1314800-X
    ISSN 0947-2177
    Database Current Contents Medicine

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  9. Article: Langzeitverlauf von beatmeten Patienten nach SARS-COV-2 (Post-COVID-Studie)

    Oehmichen, F. / Bauer, A. / Spacek, M. / Rückriem, S. / Mehnert, K. / Mehrholz, J.

    Neurologie & Rehabilitation

    2023  Volume 29, Issue 2, Page(s) 107

    Language German
    Document type Article
    ZDB-ID 1314800-X
    ISSN 0947-2177
    Database Current Contents Medicine

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  10. Article: Langzeitverlauf von beatmeten Patienten nach SARS-COV-2 (Post-COVID-Studie)

    Oehmichen, F. / Bauer, A. / Spacek, M. / Rückriem, S. / Mehnert, K. / Mehrholz, J.

    Neurologie & Rehabilitation

    2023  Volume 29, Issue 2, Page(s) 107

    Language German
    Document type Article
    ZDB-ID 1314800-X
    ISSN 0947-2177
    Database Current Contents Medicine

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