Article ; Online: Relationships of Hematocrit With Chronic Covert and Acute Symptomatic Lacunar Ischemic Lesions.
2023 Volume 102, Issue 2, Page(s) e207961
Abstract: Background and objectives: Red blood cell (RBC) concentrations are known to associate with ischemic stroke. It is unclear whether RBC concentrations associate specifically with small vessel disease lacunar infarcts. We investigated the hypothesis that ... ...
| Abstract | Background and objectives: Red blood cell (RBC) concentrations are known to associate with ischemic stroke. It is unclear whether RBC concentrations associate specifically with small vessel disease lacunar infarcts. We investigated the hypothesis that RBC concentrations associate with both chronic covert and acute symptomatic brain MRI lacunar infarcts. Methods: A cross-sectional observational analysis was performed across 2 cohorts with available hematocrit (as the assessment of RBC concentration exposure) and MRI outcome data. The primary setting was a population-based cohort of stroke-free, older adult (>50 years) participants from the Northern Manhattan Study (NOMAS) enrolled between 2003 and 2009. A second replication sample consisted of patients admitted with acute stroke and enrolled into the Columbia Stroke Registry (CSR) between 2005 and 2020. Associations of hematocrit with (1) chronic, covert lacunar infarcts and (2) symptomatic (i.e., acute) lacunar strokes were separately assessed from the NOMAS and CSR cohorts, respectively, using general additive models after adjusting for relevant covariates. Results: Of 1,218 NOMAS participants analyzed, 6% had chronic, covert lacunar infarcts. The association between hematocrit and these covert lacunar infarcts was U-shaped (χ Discussion: We identified relationships of hematocrit with MRI lacunar infarcts in both stroke-free and ischemic stroke cohorts, respectively. The relationship between increased hematocrit concentrations with lacunar infarcts was replicated in both cohorts. Further studies are required to clarify the mechanisms behind the relationships of hematocrit with ischemic cerebral small vessel disease. |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH term(s) | Aged ; Humans ; Cross-Sectional Studies ; Hematocrit ; Ischemic Stroke ; Noma ; Stroke ; Stroke, Lacunar/diagnostic imaging ; Middle Aged | |||||||||||||||
| Language | English | |||||||||||||||
| Publishing date | 2023-12-19 | |||||||||||||||
| Publishing country | United States | |||||||||||||||
| Document type | Journal Article ; Observational Study | |||||||||||||||
| ZDB-ID | 207147-2 | |||||||||||||||
| ISSN | 1526-632X ; 0028-3878 | |||||||||||||||
| ISSN (online) | 1526-632X | |||||||||||||||
| ISSN | 0028-3878 | |||||||||||||||
| DOI | 10.1212/WNL.0000000000207961 | |||||||||||||||
| Shelf mark |
|
|||||||||||||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Ui II Zs.153: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MG 18: Show issues | ||||
| Zs.MO 374: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.