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  1. Book ; Online ; E-Book: Nutraceuticals and human health

    Spagnuolo, Paul A.

    the food-to-supplement paradigm

    (Food chemistry, function and analysis ; 23)

    2020  

    Author's details edited by Paul A. Spagnuolo
    Series title Food chemistry, function and analysis ; 23
    Collection
    Keywords Functional foods
    Language English
    Size 1 Online-Ressource (xiii, 237 Seiten), Illustrationen
    Publisher Royal Society of Chemistry
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020419763
    ISBN 978-1-83916-057-8 ; 978-1-83916-058-5 ; 9781788014168 ; 1-83916-057-8 ; 1-83916-058-6 ; 1788014162
    DOI 10.1039/9781839160578
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Reductive carboxylation of glutamine as a potential target in acute myeloid leukemia.

    Roma, Alessia / Goodridge, Lawrence D / Spagnuolo, Paul A

    Oncotarget

    2023  Volume 14, Page(s) 947–948

    MeSH term(s) Humans ; Glutamine/metabolism ; Citric Acid Cycle ; Cell Line, Tumor ; Leukemia, Myeloid, Acute/drug therapy ; Oxidation-Reduction
    Chemical Substances Glutamine (0RH81L854J)
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Avocado‐derived avocadyne is a potent inhibitor of fatty acid oxidation

    Tcheng, Matthew / Minden, Mark D. / Spagnuolo, Paul A.

    Journal of food biochemistry. 2022 Mar., v. 46, no. 3

    2022  

    Abstract: Avocatin‐B (Avo‐B), an avocado‐derived 1:1 mixture of the polyhydroxylated alcohols avocadyne (AYNE) and avocadene, eliminated leukemia cells by suppressing fatty acid oxidation (FAO) in vivo and in vitro while sparing healthy blood cells. In this study, ...

    Abstract Avocatin‐B (Avo‐B), an avocado‐derived 1:1 mixture of the polyhydroxylated alcohols avocadyne (AYNE) and avocadene, eliminated leukemia cells by suppressing fatty acid oxidation (FAO) in vivo and in vitro while sparing healthy blood cells. In this study, we identified AYNE as the most potent FAO inhibitor within the Avo‐B mixture capable of inducing cell death in leukemia cells lines (IC₅₀: 3.10 ± 0.14 µM in TEX cells; 11.53 ± 3.32 µM in OCI‐AML2) and patient‐derived acute myeloid leukemia cells. When added individually, the two Avo‐B constituents demonstrated antagonism (Combination Index values >1), highlighting the need for future studies to assess AYNE alone. Together, this work highlighted AYNE as the most potent FAO inhibitor within the Avo‐B mixture. PRACTICAL APPLICATIONS: This work identifies which of the two molecules in avocatin B (Avo‐B), an avocado‐derived mixture of two molecules with demonstrated human safety, utility against leukemia, insulin resistance and diabetes, is most useful. Therefore, it provides the basis for future clinical studies that will focus on testing and developing the most active Avo‐B constituent.
    Keywords antagonism ; beta oxidation ; cell death ; diabetes ; humans ; insulin resistance ; myeloid leukemia
    Language English
    Dates of publication 2022-03
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13895
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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  4. Article: Estrogen Receptors Alpha and Beta in Acute Myeloid Leukemia.

    Roma, Alessia / Spagnuolo, Paul A

    Cancers

    2020  Volume 12, Issue 4

    Abstract: Estrogen receptor (ER) signaling has been widely studied in a variety of solid tumors, where the differential expression of ERα and ERβ subtypes can impact prognosis. ER signaling has only recently emerged as a target of interest in acute myeloid ... ...

    Abstract Estrogen receptor (ER) signaling has been widely studied in a variety of solid tumors, where the differential expression of ERα and ERβ subtypes can impact prognosis. ER signaling has only recently emerged as a target of interest in acute myeloid leukemia (AML), an aggressive hematological malignancy with sub-optimal therapeutic options and poor clinical outcomes. In a variety of tumors, ERα activation has proliferative effects, while ERβ targeting results in cell senescence or death. Aberrant ER expression and hypermethylation have been characterized in AML, making ER targeting in this disease of great interest. This review describes the expression patterns of ERα and ERβ in AML and discusses the differing signaling pathways associated with each of these receptors. Furthermore, we assess how these signaling pathways can be targeted by various selective estrogen receptor modulators to induce AML cell death. We also provide insight into ER targeting in AML and discuss pending questions that require further study.
    Language English
    Publishing date 2020-04-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12040907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Avocado-derived avocadyne is a potent inhibitor of fatty acid oxidation.

    Tcheng, Matthew / Minden, Mark D / Spagnuolo, Paul A

    Journal of food biochemistry

    2021  Volume 46, Issue 3, Page(s) e13895

    Abstract: Avocatin-B (Avo-B), an avocado-derived 1:1 mixture of the polyhydroxylated alcohols avocadyne (AYNE) and avocadene, eliminated leukemia cells by suppressing fatty acid oxidation (FAO) in vivo and in vitro while sparing healthy blood cells. In this study, ...

    Abstract Avocatin-B (Avo-B), an avocado-derived 1:1 mixture of the polyhydroxylated alcohols avocadyne (AYNE) and avocadene, eliminated leukemia cells by suppressing fatty acid oxidation (FAO) in vivo and in vitro while sparing healthy blood cells. In this study, we identified AYNE as the most potent FAO inhibitor within the Avo-B mixture capable of inducing cell death in leukemia cells lines (IC
    MeSH term(s) Fatty Acids/metabolism ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Lipid Metabolism ; Persea/metabolism ; Polyketides
    Chemical Substances Fatty Acids ; Polyketides ; avocadyne
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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  6. Article ; Online: Inhibitors of fatty acid oxidation enhance death of acute myeloid leukemia cells lacking NIX or SQSTM1.

    Tcheng, Matthew / Samudio, Ishmael / Spagnuolo, Paul A

    Leukemia & lymphoma

    2019  Volume 61, Issue 3, Page(s) 741–744

    MeSH term(s) Fatty Acids ; Humans ; Leukemia, Myeloid, Acute/genetics ; Membrane Proteins ; Oxidation-Reduction ; Proto-Oncogene Proteins ; Sequestosome-1 Protein/genetics ; Tumor Suppressor Proteins
    Chemical Substances BNIP3L protein, human ; Fatty Acids ; Membrane Proteins ; Proto-Oncogene Proteins ; SQSTM1 protein, human ; Sequestosome-1 Protein ; Tumor Suppressor Proteins
    Language English
    Publishing date 2019-11-11
    Publishing country United States
    Document type Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2019.1682570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Diosmetin Induces Apoptosis of Acute Myeloid Leukemia Cells.

    Roma, Alessia / Rota, Sarah G / Spagnuolo, Paul A

    Molecular pharmaceutics

    2018  Volume 15, Issue 3, Page(s) 1353–1360

    Abstract: Acute myeloid leukemia is an aggressive disease with limited and nonselective therapeutic options. This study explored the bioactivity and cell death inducing mechanism of diosmetin, a novel compound identified in a nutraceutical screen to impart ... ...

    Abstract Acute myeloid leukemia is an aggressive disease with limited and nonselective therapeutic options. This study explored the bioactivity and cell death inducing mechanism of diosmetin, a novel compound identified in a nutraceutical screen to impart selective anti-AML activity. Diosmetin, a citrus flavone, induced apoptosis characterized by increases in caspases 8 and 3/7 and the death inducing cytokine TNFα. In fact, through protein and mRNA expression analysis, activity was shown to be dependent on expression of estrogen receptor (ER) β. Treatment with diosmetin also delayed tumor growth in AML mouse xenografts. In summary, these studies highlight diosmetin as a novel therapeutic that induces apoptosis through estrogen receptor β.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 7/metabolism ; Caspase 8/metabolism ; Cell Line, Tumor ; Estrogen Receptor beta/metabolism ; Flavonoids/pharmacology ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Tumor Necrosis Factor-alpha/metabolism ; Xenograft Model Antitumor Assays
    Chemical Substances ESR2 protein, human ; Estrogen Receptor beta ; Flavonoids ; TNF protein, human ; Tumor Necrosis Factor-alpha ; CASP3 protein, human (EC 3.4.22.-) ; CASP7 protein, human (EC 3.4.22.-) ; CASP8 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; diosmetin (TWZ37241OT)
    Language English
    Publishing date 2018-02-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.7b01151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Food as a drug.

    Spagnuolo, Paul A / Rogers, Michael A

    Oncoscience

    2015  Volume 2, Issue 10, Page(s) 801–802

    Language English
    Publishing date 2015-09-23
    Publishing country United States
    Document type Journal Article
    ISSN 2331-4737
    ISSN 2331-4737
    DOI 10.18632/oncoscience.250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Novel Mango Ginger Bioactive (2,4,6-Trihydroxy-3,5-diprenyldihydrochalcone) Inhibits Mitochondrial Metabolism in Combination with Avocatin B.

    Jayasankar, Varsha / Vrdoljak, Nikolina / Roma, Alessia / Ahmed, Nawaz / Tcheng, Matthew / Minden, Mark D / Spagnuolo, Paul A

    ACS omega

    2022  Volume 7, Issue 2, Page(s) 1682–1693

    Abstract: Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel ... ...

    Abstract Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel therapeutics. The roots of the
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c04053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Shikonin impairs mitochondrial activity to selectively target leukemia cells

    Roma, Alessia / Tcheng, Matthew / Ahmed, Nawaz / Walker, Sarah / Jayanth, Preethi / Minden, Mark D. / Reisz, Julie A. / D'Alessandro, Angelo / Rohlena, Jakub / Spagnuolo, Paul A.

    Phytomedicine plus. 2022,

    2022  

    Abstract: Acute myeloid leukemia (AML) is a hematopoietic malignancy that results from the accumulation of undifferentiated myeloid cells in the peripheral blood and bone marrow. Limited therapeutics contribute to unfavourable patient outcomes, highlighting the ... ...

    Abstract Acute myeloid leukemia (AML) is a hematopoietic malignancy that results from the accumulation of undifferentiated myeloid cells in the peripheral blood and bone marrow. Limited therapeutics contribute to unfavourable patient outcomes, highlighting the need for novel therapeutics to improve prognosis. We previously demonstrated that shikonin, a constituent of Lithospermum erythrorhizon, preferentially targets bulk AML cells through inhibition of electron transport chain complex II. In this study, we aim to further characterize the anti-leukemia effects of shikonin in vitro and in vivo. AML cell lines and patient-derived cells were used to assess the cytotoxic effect of shikonin in vitro and in vivo. Respirometry, stable-isotope tracing, flow cytometry and immunoblotting were used to assess the metabolic changes which precede shikonin-mediated cell death. Shikonin induced cytotoxicity in AML cell lines and patient-derived cells while sparing normal hematopoietic cells through a reactive-oxygen species (ROS) dependent mechanism. Shikonin (2.5 mg/kg) reduced patient-derived AML cell engraftment in mouse bone marrow without toxicity. Mechanistically, it increased mitochondrial ROS, impaired oxidative tricarboxylic acid cycling, and reprogrammed metabolism towards glycolysis. Chronic cellular exposure to shikonin resulted in a unique phenotype characterized by decreased mitochondrial activity and increased glycolysis. Consistent with this, cells with increased glycolytic and antioxidant capacity were less sensitive to shikonin. Together, these results highlight shikonin as a mitochondria-targeting agent and provide further insight into its anti-AML activity.
    Keywords Lithospermum erythrorhizon ; antioxidant activity ; blood ; bone marrow ; cell death ; cytotoxicity ; electron transport chain ; flow cytometry ; glycolysis ; immunoblotting ; mice ; mitochondria ; myeloid leukemia ; patients ; phenotype ; prognosis ; shikonin ; stable isotopes ; therapeutics
    Language English
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 2667-0313
    DOI 10.1016/j.phyplu.2022.100300
    Database NAL-Catalogue (AGRICOLA)

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