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  1. Book ; Online ; E-Book: Childhood Trauma in Mental Disorders

    Spalletta, Gianfranco / Janiri, Delfina / Piras, Federica / Sani, Gabriele

    A Comprehensive Approach

    2020  

    Abstract: This volume presents a comprehensive overview of childhood trauma, considering the psychopathological definition and its neurobiological implications as well as its impact on different psychiatric disorders. The focus on childhood trauma rather than that ...

    Author's details edited by Gianfranco Spalletta, Delfina Janiri, Federica Piras, Gabriele Sani
    Abstract This volume presents a comprehensive overview of childhood trauma, considering the psychopathological definition and its neurobiological implications as well as its impact on different psychiatric disorders. The focus on childhood trauma rather than that occurring in adulthood is important due to its general “neuro-psyco-socio” and its specific biological implications, since trauma during childhood impacts directly on neurodevelopment. It has been suggested that early life stress increases vulnerability to psychiatric disorders; however, the exact mechanisms of this association are not yet completely understood. Although childhood trauma could be considered too unspecific to be an important risk factor for individual psychiatric disorders since it seems to occur across the board, it impacts differently on different psychiatric disorders, and it can modulate their clinical expression. Therefore, the assessment of early trauma needs to be included in the clinical evaluation of patients with psychiatric disorders. The volume will be an invaluable tool for psychiatrists, helping them to select suitable pharmacological, psychotherapeutic and rehabilitative treatments.
    Keywords Psychiatry ; Neurology  ; Neurosciences ; Neurology ; Traumes psíquics ; Psicologia infantil ; Psiquiatria infantil ; Psicoteràpia infantil ; Atenció a la infància i a l'adolescència ; Farmacologia pediàtrica
    Subject code 616.8582239
    Language English
    Size 1 online resource (456 pages)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-49414-4 ; 3-030-49413-6 ; 978-3-030-49414-8 ; 978-3-030-49413-1
    DOI 10.1007/978-3-030-49414-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The Role of the Anterior Thalamic Nuclei in the Genesis of Memory Disorders in Alzheimer's Disease: An Exploratory Study.

    De Simone, Maria Stefania / Spalletta, Gianfranco / Vecchio, Daniela / Bassi, Andrea / Carlesimo, Giovanni Augusto / Piras, Fabrizio

    Journal of Alzheimer's disease : JAD

    2024  Volume 97, Issue 1, Page(s) 507–519

    Abstract: Background: Increasing evidence is demonstrating that degeneration of specific thalamic nuclei, in addition to the hippocampus, may occur in Alzheimer's disease (AD) from the prodromal stage (mild cognitive impairment - MCI) and contribute to memory ... ...

    Abstract Background: Increasing evidence is demonstrating that degeneration of specific thalamic nuclei, in addition to the hippocampus, may occur in Alzheimer's disease (AD) from the prodromal stage (mild cognitive impairment - MCI) and contribute to memory impairment.
    Objective: Here, we evaluated the presence of macro and micro structural alterations at the level of the anterior thalamic nuclei (ATN) and medio-dorsal thalamic nuclei (MDTN) in AD and amnestic MCI (aMCI) and the possible relationship between such changes and the severity of memory impairment.
    Methods: For this purpose, a sample of 50 patients with aMCI, 50 with AD, and 50 age- and education-matched healthy controls (HC) were submitted to a 3-T MRI protocol with whole-brain T1-weighted and diffusion tensor imaging and a comprehensive neuropsychological assessment.
    Results: At macro-structural level, both the ATN and MDTN were found significantly smaller in patients with aMCI and AD when compared to HC subjects. At micro-structural level, instead, diffusion alterations that significantly differentiated aMCI and AD patients from HC subjects were found only in the ATN, but not in the MDTN. Moreover, diffusion values of the ATN were significantly associated with poor episodic memory in the overall patients' group.
    Conclusions: These findings represent the first in vivo evidence of a relevant involvement of ATN in the AD-related neurodegeneration and memory profile and strengthen the importance to look beyond the hippocampus when considering neurological conditions characterized by memory decline.
    MeSH term(s) Humans ; Anterior Thalamic Nuclei/diagnostic imaging ; Alzheimer Disease/complications ; Alzheimer Disease/diagnostic imaging ; Diffusion Tensor Imaging ; Memory Disorders/diagnostic imaging ; Memory Disorders/etiology ; Thalamic Nuclei
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Editorial: Rising stars in aging psychiatry: 2022.

    Spalletta, Gianfranco / Pipino, Vanessa / Piras, Federica

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 974099

    Language English
    Publishing date 2022-07-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.974099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Insights in Aging Psychiatry: 2021.

    Spalletta, Gianfranco / Banaj, Nerisa / Piras, Federica

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 901931

    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.901931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: I disturbi della consapevolezza nelle malattie neuropsichiatriche

    Orfei, Maria Donata / Caltagirone, Carlo / Spalletta, Gianfranco

    2007  

    Author's details by Maria Donata Orfei, Carlo Caltagirone, Gianfranco Spalletta
    Keywords Geriatrics ; Neurology ; Neuropsychological tests ; Psychiatry ; Rehabilitation
    Publisher Springer-Verlag Italia
    Publishing place Milano
    Document type Book ; Online
    HBZ-ID TT050387976
    ISBN 978-88-470-0656-0 ; 978-88-470-0657-7 ; 88-470-0656-2 ; 88-470-0657-0
    DOI 10.1007/978-88-470-0657-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article: Preoperative Navigated Transcranial Magnetic Stimulation: New Insight for Brain Tumor-Related Language Mapping.

    Natalizi, Federica / Piras, Federica / Vecchio, Daniela / Spalletta, Gianfranco / Piras, Fabrizio

    Journal of personalized medicine

    2022  Volume 12, Issue 10

    Abstract: Preoperative brain mapping methods are particularly important in modern neuro-oncology when a tumor affects eloquent language areas since damage to parts of the language circuits can cause significant impairments in daily life. This narrative review ... ...

    Abstract Preoperative brain mapping methods are particularly important in modern neuro-oncology when a tumor affects eloquent language areas since damage to parts of the language circuits can cause significant impairments in daily life. This narrative review examines the literature regarding preoperative and intraoperative language mapping using repetitive navigated transcranial magnetic stimulation (rnTMS) with or without direct electrical stimulation (DES) in adult patients with tumors in eloquent language areas. The literature shows that rnTMS is accurate in detecting preexisting language disorders and positive intraoperative mapping regions. In terms of the region extent and clinical outcomes, rnTMS has been shown to be accurate in identifying positive sites to guide resection, reducing surgery duration and craniotomy size and thus improving clinical outcomes. Before incorporating rnTMS into the neurosurgical workflow, the refinement of protocols and a consensus within the neuro-oncology community are required.
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12101589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Implication of Aging Related Chronic Neuroinflammation on COVID-19 Pandemic.

    Bossù, Paola / Toppi, Elisa / Sterbini, Valentina / Spalletta, Gianfranco

    Journal of personalized medicine

    2020  Volume 10, Issue 3

    Abstract: SARS-CoV-2, the virus responsible for the COVID-19 pandemic, leads to a respiratory syndrome and other manifestations. Most affected people show no or mild symptoms, but the risk of severe disease and death increases in older people. Here, we report a ... ...

    Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, leads to a respiratory syndrome and other manifestations. Most affected people show no or mild symptoms, but the risk of severe disease and death increases in older people. Here, we report a narrative review on selected studies targeting aging-related chronic neuroinflammation in the COVID-19 pandemic. A hyperactivation of the innate immune system with elevated levels of pro-inflammatory cytokines occurs during severe COVID-19, pointing to an important role of the innate immune dysregulation in the disease outcome. Aging is characterized by a general condition of low-grade inflammation, also connected to chronic inflammation of the brain (neuroinflammation), which is involved in frailty syndrome and contributes to several age-associated diseases, including neurodegenerative and neuropsychiatric disorders. Since neuroinflammation can be induced or worsened by the virus infection itself, as well as by stressful conditions like those linked to the recent pandemic, the role of neuroinflammatory mechanisms could be central in a vicious circle leading to an increase in the mortality risk in aged COVID-19 patients. Furthermore, triggered neuroinflammatory pathways and consequent neurodegenerative and neuropsychiatric conditions might be potential long-term complications of COVID-19. In order to provide insights to help clinicians in identifying patients who progress to a more severe case of the disease, this review underlines the potential implications of aging-related neuroinflammation in COVID-19 pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm10030102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Cognitive, Psychological, and Psychiatric Consequences of the Coronavirus (COVID-19) Pandemic in the Population of Older Persons With Cognitive Impairment, Dementia, and/or Neuropsychiatric Disorders.

    Palmer, Katie / Kivipelto, Miia / Gianni, Walter / Banaj, Nerisa / Spalletta, Gianfranco

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 748963

    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.748963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Narrative discourse production in Parkinson's disease: Decoupling the role of cognitive-linguistic and motor speech changes.

    D'Ascanio, Sara / Piras, Fabrizio / Banaj, Nerisa / Assogna, Francesca / Pellicano, Clelia / Bassi, Andrea / Spalletta, Gianfranco / Piras, Federica

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e18633

    Abstract: Introduction: the interplay between neuropsychological and communicative abilities in Parkinson's disease (PD) has been relatively overlooked, and it is not entirely understood which difficulties are consequent to impaired motor control, and which have ... ...

    Abstract Introduction: the interplay between neuropsychological and communicative abilities in Parkinson's disease (PD) has been relatively overlooked, and it is not entirely understood which difficulties are consequent to impaired motor control, and which have a linguistic/cognitive basis. Here, we examined narrative discourse in PD using a multi-level analysis procedure considering sentence-level (productivity, lexical-grammatical processing) and discourse-level processes (narrative organization, informativeness), and partialling out patients' motor speech impairments. The interaction between cognitive (i.e. linguistic and executive) and communication abilities was also investigated.
    Methods: Twenty-nine PD subjects in the mild stage of the disease were compared to 29 matched healthy comparators (HC) on quantitative measures of narrative discourse derived from two picture description tasks. Multivariate (considering articulation rate and educational attainment as covariates) and univariate (with group membership as independent variable) analyses of variance were conducted on separate linguistic domains. The contribution of executive/linguistic abilities to PD's narrative performance was explored by multiple regression analyses on narrative measures significantly differentiating patients from HC.
    Results: significant reductions in patients were observed on measures of productivity (less well-formed words, shorter sentences) and informativeness (fewer conceptual units, less informative elements, lower number of details) and these alterations were explained by variations in linguistic abilities (action and object naming) rather than executive abilities. Articulation rate and educational attainment did not impact the observed reduced productivity and under-informativeness.
    Conclusion: referential narrative discourse is altered in PD, regardless of motor impairments in speech production. The observed reductions in productivity/informativeness aspects of narratives were related to naming abilities and in particular to verbs processing, consistently with the neurocognitive model of motor language coupling. Since narratives are amenable to recurrent and automated analysis for the identification of linguistic patterns potentially anticipating the development of PD and the onset of cognitive deterioration, discourse abilities should be quantitatively and repeatedly profiled in the disorder.
    Language English
    Publishing date 2023-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Italian Validation of the Beck Cognitive Insight Scale: Underlying Factor Structure in Psychotic Patients and the General Population.

    Orfei, Maria Donata / Porcari, Desirée Estela / Spalletta, Gianfranco / Assogna, Francesca / Piras, Fabrizio / Banaj, Nerisa / Ricciardi, Emiliano

    International journal of environmental research and public health

    2023  Volume 20, Issue 17

    Abstract: Cognitive insight refers to the ability to question one's judgments and cognitive biases and is underpinned by specific metacognitive processes. The Beck Cognitive Insight Scale was developed to assess cognitive insight and includes two subscales, Self- ... ...

    Abstract Cognitive insight refers to the ability to question one's judgments and cognitive biases and is underpinned by specific metacognitive processes. The Beck Cognitive Insight Scale was developed to assess cognitive insight and includes two subscales, Self-Reflectiveness and Self-Certainty (SC). The present study aimed to investigate the underlying factor structure of the Italian version of the BCIS in patients with schizophrenia (SZ) and in the general population (GP) for the first time. A cross-sectional design was adopted and a GP sample of 624 subjects and an SZ sample of 130 patients were enrolled. In the SZ group, a two-factor solution was supported. The internal reliability of each factor was satisfactory. Two items were eliminated and one item moved from the SC to the SR subscale. In the GP group, a two-factor solution was highlighted. The internal reliability of each factor was satisfactory. However, four items of the SR subscale were deleted. The Italian-validated version of the BCIS shows different structures for the SZ and the GP and is characterized by different features concerning previous studies. This evidence suggests new interpretations of metacognitive processes in the two populations and implies specific therapeutic approaches.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Reproducibility of Results ; Mental Disorders ; Judgment ; Metacognition
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20176634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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