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  1. Article: [No title information]

    Spanaus, Katharina

    Praxis

    2016  Volume 105, Issue 23, Page(s) 1361–1362

    Title translation CME-Labor 48: Zink – ein wichtiges Spurenelement.
    Language German
    Publishing date 2016-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a002542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [No title information]

    Spanaus, Katharina

    Praxis

    2016  Volume 105, Issue 24, Page(s) 1446–1447

    Title translation CME-Labor 48/Auflösung: Zink – ein wichtiges Spurenelement.
    Language German
    Publishing date 2016-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a002543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effects of enhanced adsorption haemofiltration versus haemoadsorption in severe, refractory septic shock with high levels of endotoxemia: the ENDoX bicentric, randomized, controlled trial.

    Wendel-Garcia, Pedro David / Eberle, Barbara / Kleinert, Eva-Maria / Hilty, Matthias Peter / Blumenthal, Stephan / Spanaus, Katharina / Fodor, Patricia / Maggiorini, Marco

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 127

    Abstract: Background: Endotoxin adsorption is a promising but controversial therapy in severe, refractory septic shock and conflicting results exist on the effective capacity of available devices to reduce circulating endotoxin and inflammatory cytokine levels.!## ...

    Abstract Background: Endotoxin adsorption is a promising but controversial therapy in severe, refractory septic shock and conflicting results exist on the effective capacity of available devices to reduce circulating endotoxin and inflammatory cytokine levels.
    Methods: Multiarm, randomized, controlled trial in two Swiss intensive care units, with a 1:1:1 randomization of patients suffering severe, refractory septic shock with high levels of endotoxemia, defined as an endotoxin activity ≥ 0.6, a vasopressor dependency index ≥ 3, volume resuscitation of at least 30 ml/kg/24 h and at least single organ failure, to a haemoadsorption (Toraymyxin), an enhanced adsorption haemofiltration (oXiris) or a control intervention. Primary endpoint was the difference in endotoxin activity at 72-h post-intervention to baseline. In addition, inflammatory cytokine, vasopressor dependency index and SOFA-Score dynamics over the initial 72 h were assessed inter alia.
    Results: In the 30, out of 437 screened, randomized patients (10 Standard of care, 10 oXiris, 10 Toraymyxin), endotoxin reduction at 72-h post-intervention-start did not differ among interventions (Standard of Care: 12 [1-42]%, oXiris: 21 [10-51]%, Toraymyxin: 23 [10-36]%, p = 0.82). Furthermore, no difference between groups could be observed neither for reduction of inflammatory cytokine levels (p = 0.58), nor for vasopressor weaning (p = 0.95) or reversal of organ injury (p = 0.22).
    Conclusions: In a highly endotoxemic, severe, refractory septic shock population neither the Toraymyxin adsorber nor the oXiris membrane could show a reduction in circulating endotoxin or cytokine levels over standard of care. Trial registration ClinicalTrials.gov. NCT01948778. Registered August 30, 2013. https://clinicaltrials.gov/study/NCT01948778.
    Language English
    Publishing date 2023-12-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01224-8
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  4. Article ; Online: Evaluation of two fully automated immunoassay based tests for the measurement of 1α,25-dihydroxyvitamin D in human serum and comparison with LC-MS/MS.

    Spanaus, Katharina / von Eckardstein, Arnold

    Clinical chemistry and laboratory medicine

    2017  Volume 55, Issue 9, Page(s) 1305–1314

    Abstract: Background: 1α,25-Dihydroxyvitamin D [1,25(OH)2 vitD] is the bioactive form of vitamin D. Due to the very low concentrations of 1,25(OH)2 vitD in the blood and its lipophilic character, measurement of this parameter is analytically challenging. ... ...

    Abstract Background: 1α,25-Dihydroxyvitamin D [1,25(OH)2 vitD] is the bioactive form of vitamin D. Due to the very low concentrations of 1,25(OH)2 vitD in the blood and its lipophilic character, measurement of this parameter is analytically challenging. Requiring preceding manual extraction steps before analysis, previous assays have been laborious.
    Methods: In the presented study, we evaluated the performance of two immunoassays from DiaSorin and from Immunodiagnostic Systems (IDS) which combine fully automated extraction and measurement of 1,25(OH)2 vitD. Imprecision and linearity were verified according to Clinical and Laboratory Standards Institute EP15-A3 and EP6-A guidelines, respectively. Ninety-three patient serum samples sent to our institute for determination of 1,25(OH)2 vitD, as well as 20 Vitamin D External Quality Assessment Scheme (DEQAS) samples, were used to evaluate correlation and agreement of 1,25(OH)2 vitD measurements between the two immunoassays and with liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
    Results: Total imprecision was 5.2% or less for the DiaSorin test but reached 20.1% for the IDS iSYS test. 1,25(OH)2 vitD concentrations measured with the DiaSorin assay showed a strong correlation with 1,25(OH)2 vitD levels measured by LC-MS/MS and a good agreement with method specific means of DEQAS samples. By contrast, the IDS iSYS test overestimated 1,25(OH)2 vitD concentrations in human serum, particularly at higher concentrations.
    Conclusions: Due to its high sensitivity, low imprecision, broad measurement range, and good agreement with 1,25(OH)2 vitD concentrations measured by LC-MS/MS, the DiaSorin test is a valuable analytical option for the determination of 1,25(OH)2 vitD.
    MeSH term(s) Automation ; Calcitriol/blood ; Chromatography, Liquid ; Humans ; Immunoassay ; Tandem Mass Spectrometry
    Chemical Substances Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2017-08-28
    Publishing country Germany
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2016-1074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interassay Variability and Clinical Implications of Five Different Prostate-specific Antigen Assays.

    Kaufmann, Basil / Pellegrino, Paloma / Zuluaga, Laura / Ben-David, Reuben / Müntener, Michael / Keller, Etienne X / Spanaus, Katharina / von Eckardstein, Arnold / Gorin, Michael A / Poyet, Cédric

    European urology open science

    2024  Volume 63, Page(s) 4–12

    Abstract: Background and objective: Prostate-specific antigen (PSA) remains a critical marker for prostate cancer (PCa) detection and monitoring. Recognising historical variability in PSA assays and the evolution of assay technology and calibration, this study ... ...

    Abstract Background and objective: Prostate-specific antigen (PSA) remains a critical marker for prostate cancer (PCa) detection and monitoring. Recognising historical variability in PSA assays and the evolution of assay technology and calibration, this study aims to reassess interassay variability using the latest generation of five assays in a contemporary cohort of men undergoing prostate biopsy.
    Methods: Five different commercially available PSA assays were tested in a blood sample of 76 men before undergoing a prostate biopsy. Total PSA (tPSA) and free-to-total PSA ratio (%fPSA) were compared across assays, using Roche (Basel, Switzerland) as the benchmark, and correlated with biopsy outcome to analyse the impact on PCa diagnosis. The statistical analysis included Passing-Bablok regression and Bland-Altman plots, with a
    Key findings and limitations: Among the 76 men, 28 (36.8%) were diagnosed with significant PCa (defined as International Society of Urological Pathology grade ≥2). A high correlation was observed between tPSA and %fPSA values among the different PSA assays tested (
    Conclusions and clinical implications: Despite the use of the latest PSA assays, relevant variability of tPSA and %fPSA results can be observed among different assays. There is an urgent need for standardised calibration methods and greater awareness among practitioners concerning interassay variability. Clinicians should acknowledge that clinically relevant thresholds may depend on the specific PSA assay and that ideally the same assay is applied over time for better clinical decision-making.
    Patient summary: Prostate-specific antigen (PSA) is a critical marker for prostate cancer (PCa) detection and monitoring. However, significant variations were observed in the results of the latest PSA assays. Thus, standardised calibration methods and greater awareness among practitioners concerning interassay variability are needed.
    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2024.03.008
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  6. Article: Pro-angiogenic and antibacterial copper containing nanoparticles in PLGA/amorphous calcium phosphate bone nanocomposites.

    Näf, Lukas / Miescher, Iris / Pfuderer, Lara / Schweizer, Tiziano A / Brunner, David / Dürig, Johannes / Gröninger, Olivier / Rieber, Julia / Meier-Buergisser, Gabriella / Spanaus, Katharina / Calcagni, Maurizio / Bosshard, Philipp P / Achermann, Yvonne / Stark, Wendelin J / Buschmann, Johanna

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e27267

    Abstract: Large bone defects after trauma demand for adequate bone substitutes. Bone void fillers should be antibacterial and pro-angiogenic. One viable option is the use of composite materials like the combination of PLGA and amorphous calcium phosphate (aCaP). ... ...

    Abstract Large bone defects after trauma demand for adequate bone substitutes. Bone void fillers should be antibacterial and pro-angiogenic. One viable option is the use of composite materials like the combination of PLGA and amorphous calcium phosphate (aCaP). Copper stimulates angiogenesis and has antibacterial qualities. Either copper oxide (CuO) nanoparticles (NPs) were therefore added to PLGA/aCaP/CuO in different concentrations (1, 5 and 10 w/w %) or copper-doped tricalcium phosphate NPs (TCP with 2% of copper) were electrospun into PLGA/CuTCP nanocomposites. Bi-layered nanocomposites of PLGA/aCaP with different copper NPs (CuO or TCP) and a second layer of pristine PLGA were fabricated. Two clinical bacterial isolates (
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27267
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  7. Article: Suizide weiblicher Inhaftierter in Justizvollzugsanstalten: Ergebnisse der deutschen Totalerhebung von 2000 bis 2019

    Meischner-Al-Mousawi, Maja / Spanaus, Katharina / Hartenstein, Sven / Hinz, Sylvette

    Suizidprophylaxe

    2021  Volume 48, Issue 2 = 185, Page(s) 67

    Language German
    Document type Article
    ZDB-ID 526735-3
    ISSN 0173-458X
    Database Current Contents Medicine

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  8. Article: The Role of Electrocardiographic Markers for Predicting Atrial Fibrillation in Patients with Acute Ischemic Stroke: Data from the BIOSIGNAL Cohort Study.

    Schütz, Valerie / Dougoud, Svetlana / Bracher, Katja / Arnold, Markus / Schweizer, Juliane / Nakas, Christos / Westphal, Laura P / Inauen, Corinne / Pokorny, Thomas / Duru, Firat / Steffel, Jan / Luft, Andreas / Spanaus, Katharina / Saguner, Ardan Muammer / Katan, Mira

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: Background and aims: P-wave abnormalities in the 12-lead electrocardiogram (ECG) have been associated with a higher risk of acute ischemic stroke (AIS) as well as atrial fibrillation (AF). This study aimed to assess pre-determined ECG criteria during ... ...

    Abstract Background and aims: P-wave abnormalities in the 12-lead electrocardiogram (ECG) have been associated with a higher risk of acute ischemic stroke (AIS) as well as atrial fibrillation (AF). This study aimed to assess pre-determined ECG criteria during sinus rhythm in unselected AIS patients and their value for predicting newly diagnosed atrial fibrillation (NDAF) after hospital admission.
    Methods: P-wave alterations were measured on 12-lead ECG on admission in all consecutively enrolled patients without known AF between October 2014 and 2017. The outcome of interest was NDAF, identified by prolonged electrocardiographic monitoring within one year after the index AIS. Univariable and multivariable logistic regression was applied to assess the magnitude and independence of the association between pre-selected ECG markers and NDAF. The discriminatory accuracy was evaluated with the area under the receiver operating characteristic curve (AUC), and the incremental prognostic value was estimated with the net reclassification index.
    Results: NDAF was detected in 87 (10%) of 856 patients during a follow-up of 365 days. Out of the pre-selected ECG parameters, advanced interatrial block (aIAB) and PR interval in lead II were independently associated with NDAF in univariable regression analysis. Only aIAB remained a significant predictor in multivariable analysis. Adding aIAB to the best-performing multivariable regression model improved the discriminatory accuracy to predict NDAF from an AUC of 0.78 (95%-CI 0.77-0.80) to 0.81 (95%-CI 0.80-0.83,
    Conclusion: aIAB is independently and highly associated with NDAF in patients with AIS, has high inter-rater reliability, and therefore may be helpful to refine diagnostic work-up to search for AF in AIS.
    Language English
    Publishing date 2023-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216830
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  9. Article ; Online: Heritability and association with distinct genetic loci of erythropoietin levels in the general population.

    Corre, Tanguy / Ponte, Belen / Pivin, Edward / Pruijm, Menno / Ackermann, Daniel / Ehret, Georg / Spanaus, Katharina / Bochud, Murielle / Wenger, Roland H

    Haematologica

    2021  Volume 106, Issue 9, Page(s) 2499–2501

    MeSH term(s) Erythropoietin/genetics ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2021-09-01
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.278389
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  10. Article: High-Affinity Cu(I)-Chelator with Potential Anti-Tumorigenic Action-A Proof-of-Principle Experimental Study of Human H460 Tumors in the CAM Assay.

    Heuberger, Dorothea M / Wolint, Petra / Jang, Jae-Hwi / Itani, Saria / Jungraithmayr, Wolfgang / Waschkies, Conny F / Meier-Bürgisser, Gabriella / Andreoli, Stefano / Spanaus, Katharina / Schuepbach, Reto A / Calcagni, Maurizio / Fahrni, Christoph J / Buschmann, Johanna

    Cancers

    2022  Volume 14, Issue 20

    Abstract: Human lung cancer ranks among the most frequently treated cancers worldwide. As copper appears critical to angiogenesis and tumor growth, selective removal of copper represents a promising strategy to restrict tumor growth. To this end, we explored the ... ...

    Abstract Human lung cancer ranks among the most frequently treated cancers worldwide. As copper appears critical to angiogenesis and tumor growth, selective removal of copper represents a promising strategy to restrict tumor growth. To this end, we explored the activity of the novel high-affinity membrane-permeant Cu(I) chelator PSP-2 featuring a low-zeptomolar dissociation constant. Using H460 human lung cancer cells, we generated small tumors on the chorioallantoic membrane of the chicken embryo (CAM assay) and studied the effects of topical PSP-2 application on their weight and vessel density after one week. We observed a significant angiosuppression along with a marked decrease in tumor weight under PSP-2 application compared to controls. Moreover, PSP-2 exposure resulted in lower ki67
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14205122
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