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  1. Article ; Online: Giant extraluminal leiomyoma of the colon: rare cause of symptomatic pelvic mass.

    Sagnotta, Andrea / Sparagna, Alessandra / Uccini, Stefania / Mercantini, Paolo

    International surgery

    2015  Volume 100, Issue 5, Page(s) 805–808

    Abstract: Leiomyomas (LMs) may appear throughout the entire gastrointestinal tract but are rarely seen in the colon-rectum and only 5 of those measured greater than 15 cm in diameter. Pain and palpable abdominal mass are the most common symptoms. Surgical ... ...

    Abstract Leiomyomas (LMs) may appear throughout the entire gastrointestinal tract but are rarely seen in the colon-rectum and only 5 of those measured greater than 15 cm in diameter. Pain and palpable abdominal mass are the most common symptoms. Surgical resection is the treatment of choice for most LMs. We here describe a case of a 46-year-old woman who presented with a 3-month history of abdominal pain associated with worsening constipation and abdominal distension. A pelvic solid, polylobulate, left-sided mass was noted on examination. Preoperative findings revealed a dishomogeneous sigmoid mass with calcified spots compressing small intestine and bladder. At laparotomy, a large polylobulate and well-circumscribed mass arising from the descending colon mesentery and displacing small intestine, uterus, and ovaries. A segmental colon resection was performed. An extraluminal 18- × 12- × 5-cm paucicellular sigmoid colon leiomyoma was histologically diagnosed. Our case is one of the few giant (>15 cm) sigmoid colon LMs reported in the literature. Although rare and benign in nature, LMs of the colon can cause life-threatening complications that could require emergency treatment and they should be included in the differential diagnosis of large abdominopelvic masses. Follow-up after surgery is necessary for tumors with any atypia or mitotic activity.
    MeSH term(s) Colectomy ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/surgery ; Diagnosis, Differential ; Female ; Humans ; Leiomyoma/diagnosis ; Leiomyoma/surgery ; Middle Aged
    Language English
    Publishing date 2015-05
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 80343-1
    ISSN 2520-2456 ; 0020-8868
    ISSN (online) 2520-2456
    ISSN 0020-8868
    DOI 10.9738/INTSURG-D-14-00054.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extragastrointestinal stromal tumor localized in the retroperitoneum.

    Provenza, Giuseppe / Cunsolo, Gaetano / Giaccaglia, Valentina / Sparagna, Alessandra / Serafini, Francesco Maria

    The American surgeon

    2014  Volume 80, Issue 5, Page(s) E129–31

    MeSH term(s) Aged ; Fatal Outcome ; Humans ; Male ; Neoplasms, Connective Tissue/diagnosis ; Retroperitoneal Neoplasms/diagnosis
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Value of diagnostic and therapeutic laparoscopy for abdominal impalement injuries.

    Mercantini, Paolo / Virgilio, Edoardo / Sparagna, Alessandra / Salaj, Adelona / Cunsolo, Gaetano / Cavallini, Marco

    World journal of surgery

    2013  Volume 37, Issue 11, Page(s) 2719–2720

    MeSH term(s) Abdominal Injuries/diagnosis ; Abdominal Injuries/surgery ; Female ; Humans ; Laparoscopy ; Male ; Wounds, Stab/diagnosis ; Wounds, Stab/surgery
    Language English
    Publishing date 2013-05-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-013-2119-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ischemic pseudotumor of the colon: an insidious form of ischemic colitis.

    Virgilio, Edoardo / Mercantini, Paolo / Ferri, Mario / Corleto, Vito Domenico / Sparagna, Alessandra / Ziparo, Vincenzo

    World journal of surgery

    2012  Volume 36, Issue 12, Page(s) 2949–50; author reply 2951

    MeSH term(s) Colitis, Ischemic/diagnosis ; Female ; Humans ; Male
    Language English
    Publishing date 2012-07-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-012-1739-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute abdomen: rare and unusual presentation of right colic xanthogranulomatosis.

    Addario Chieco, Paola / Antolino, Laura / Giaccaglia, Valentina / Centanini, Francesca / Cunsolo, Gaetano Vincenzo / Sparagna, Alessandra / Uccini, Stefania / Ziparo, Vincenzo

    World journal of gastroenterology

    2014  Volume 20, Issue 26, Page(s) 8717–8721

    Abstract: Xanthogranulomatous inflammation (XGI) is a disease of unknown origin, most frequently described in the kidney and gallbladder; its localization in the colorectal tract is extremely rare. The extension of the typical inflammatory process to the ... ...

    Abstract Xanthogranulomatous inflammation (XGI) is a disease of unknown origin, most frequently described in the kidney and gallbladder; its localization in the colorectal tract is extremely rare. The extension of the typical inflammatory process to the surrounding tissues may lead to misdiagnosis as cancer. We report the case of a 56-year-old woman presenting to the Emergency Department with pain, increased levels of α1 and α2 proteins and C-reactive protein (17.5 mg/dL; normal value 0-0.5), and a palpable mass, localized in the right lower quadrant of the abdomen. A computed tomography scan showed a large right cecal mass with necrotic areas, local inflammation of retroperitoneal fat, and enlargement of local lymph nodes. Because of the high suspicion of colic abscess as well as malignancy and worsening of the clinical condition, the patient underwent right colectomy after 4 d of antibiotic treatment. Pathology revealed xanthogranulomatous inflammation involving the ileocecal valve. We review the reports of large bowel tract XGI in the international literature.
    MeSH term(s) Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; Abdomen, Acute/surgery ; Biopsy ; Colectomy ; Colic/diagnosis ; Colic/etiology ; Colic/surgery ; Colonic Neoplasms/diagnosis ; Diagnosis, Differential ; Female ; Granuloma/complications ; Granuloma/diagnosis ; Granuloma/surgery ; Humans ; Ileal Diseases/complications ; Ileal Diseases/diagnosis ; Ileal Diseases/surgery ; Ileocecal Valve/diagnostic imaging ; Ileocecal Valve/pathology ; Ileocecal Valve/surgery ; Middle Aged ; Predictive Value of Tests ; Tomography, X-Ray Computed ; Xanthomatosis/complications ; Xanthomatosis/diagnosis ; Xanthomatosis/surgery
    Language English
    Publishing date 2014-06-15
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v20.i26.8717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lymph-node ratio classification strongly correlates with cancer survivals of patients who underwent r0 resection for gastric cancer with more than 15 nodes harvested.

    Lorenzon, Laura / Mercantini, Paolo / Ferri, Mario / La Torre, Marco / Sparagna, Alessandra / Balducci, Genoveffa / Cavallini, Marco / Ziparo, Vincenzo

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

    2014  Volume 53, Issue 1-4, Page(s) 1–10

    Abstract: Background: During the last few years, the gastric cancer nodal staging has been extensively revised. Lately, a new system emerged in this field with the purpose of implementing the prognostic stratification: the lymph-node ratio (LNR). The aim of this ... ...

    Abstract Background: During the last few years, the gastric cancer nodal staging has been extensively revised. Lately, a new system emerged in this field with the purpose of implementing the prognostic stratification: the lymph-node ratio (LNR). The aim of this study was to investigate the prognostic value of the LNR in relation to cancer survivors undergoing resection for gastric adenocarcinoma.
    Methods: Off 227 patients undergoing surgical resection for gastric cancer at our Department, 129 curative gastric resections with more than 15 nodes harvested were selected. The LNR was calculated and patients were stratified into 6 subgroups based on the ratio values. The subgroups were compared for data analysis. Survivals were calculated by the Kaplan-Meier method, and the mean follow-up period was 40 months. ROC curves were calculated in order to analyze the performance of the LNR system.
    Results: LNR stratification correlated with the stage of the disease, with the rate of patients undergoing chemotherapy and patients presenting with a relapse of disease at follow-up. Moreover, an increased ratio correlated with a worse overall, a disease-free and a disease-specific survival of the patients. The ROC curves documented a significant performance of the stratification system with the endpoints of disease-free and disease-specific survivals.
    Conclusion: LNR stratification correlated with cancer-related survivals in our case series. It is a reliable system that might improve current nodal staging and thereby the identification of patients with a higher risk of recurrence or cancer-related mortality.
    MeSH term(s) Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Italy/epidemiology ; Lymph Nodes/pathology ; Male ; Middle Aged ; Retrospective Studies ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Survival Analysis
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000360937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Lymph-Node Ratio Classification Strongly Correlates with Cancer Survivals of Patients Who Underwent R0 Resection for Gastric Cancer with More than 15 Nodes Harvested

    Lorenzon, Laura / Mercantini, Paolo / Ferri, Mario / La Torre, Marco / Sparagna, Alessandra / Balducci, Genoveffa / Cavallini, Marco / Ziparo, Vincenzo

    European Surgical Research

    2014  Volume 53, Issue 1-4, Page(s) 1–10

    Abstract: Background: During the last few years, the gastric cancer nodal staging has been extensively revised. Lately, a new system emerged in this field with the purpose of implementing the prognostic stratification: the lymph-node ratio (LNR). The aim of this ... ...

    Institution Surgical and Medical Department of Translational Medicine, Sant'Andrea Hospital, Faculty of Medicine and Psychology, University of Rome ‘La Sapienza', Rome, Italy
    Abstract Background: During the last few years, the gastric cancer nodal staging has been extensively revised. Lately, a new system emerged in this field with the purpose of implementing the prognostic stratification: the lymph-node ratio (LNR). The aim of this study was to investigate the prognostic value of the LNR in relation to cancer survivors undergoing resection for gastric adenocarcinoma. Methods: Off 227 patients undergoing surgical resection for gastric cancer at our Department, 129 curative gastric resections with more than 15 nodes harvested were selected. The LNR was calculated and patients were stratified into 6 subgroups based on the ratio values. The subgroups were compared for data analysis. Survivals were calculated by the Kaplan-Meier method, and the mean follow-up period was 40 months. ROC curves were calculated in order to analyze the performance of the LNR system. Results: LNR stratification correlated with the stage of the disease, with the rate of patients undergoing chemotherapy and patients presenting with a relapse of disease at follow-up. Moreover, an increased ratio correlated with a worse overall, a disease-free and a disease-specific survival of the patients. The ROC curves documented a significant performance of the stratification system with the endpoints of disease-free and disease-specific survivals. Conclusion: LNR stratification correlated with cancer-related survivals in our case series. It is a reliable system that might improve current nodal staging and thereby the identification of patients with a higher risk of recurrence or cancer-related mortality.
    Keywords Gastric cancer ; Lymph-node ratio ; Nodal staging system ; Cancer-specific survival ; Nodal dissection ; Gastrectomy
    Language English
    Publishing date 2014-05-13
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000360937
    Database Karger publisher's database

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  8. Article ; Online: Lymph-Node Ratio Classification Strongly Correlates with Cancer Survivals of Patients Who Underwent R0 Resection for Gastric Cancer with More than 15 Nodes Harvested

    Lorenzon, Laura / Mercantini, Paolo / Ferri, Mario / La Torre, Marco / Sparagna, Alessandra / Balducci, Genoveffa / Cavallini, Marco / Ziparo, Vincenzo

    European Surgical Research - Clinical and Experimental Surgery

    2014  Volume 53, Issue 1-4, Page(s) 1–10

    Abstract: Background: During the last few years, the gastric cancer nodal staging has been extensively revised. Lately, a new system emerged in this field with the purpose of implementing the prognostic stratification: the lymph-node ratio (LNR). The aim of this ... ...

    Abstract Background: During the last few years, the gastric cancer nodal staging has been extensively revised. Lately, a new system emerged in this field with the purpose of implementing the prognostic stratification: the lymph-node ratio (LNR). The aim of this study was to investigate the prognostic value of the LNR in relation to cancer survivors undergoing resection for gastric adenocarcinoma. Methods: Off 227 patients undergoing surgical resection for gastric cancer at our Department, 129 curative gastric resections with more than 15 nodes harvested were selected. The LNR was calculated and patients were stratified into 6 subgroups based on the ratio values. The subgroups were compared for data analysis. Survivals were calculated by the Kaplan-Meier method, and the mean follow-up period was 40 months. ROC curves were calculated in order to analyze the performance of the LNR system. Results: LNR stratification correlated with the stage of the disease, with the rate of patients undergoing chemotherapy and patients presenting with a relapse of disease at follow-up. Moreover, an increased ratio correlated with a worse overall, a disease-free and a disease-specific survival of the patients. The ROC curves documented a significant performance of the stratification system with the endpoints of disease-free and disease-specific survivals. Conclusion: LNR stratification correlated with cancer-related survivals in our case series. It is a reliable system that might improve current nodal staging and thereby the identification of patients with a higher risk of recurrence or cancer-related mortality.© 2014 S. Karger AG, Basel
    Keywords Gastric cancer ; Lymph-node ratio ; Nodal staging system ; Cancer-specific survival ; 
Nodal dissection ; Gastrectomy
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000360937
    Database Karger publisher's database

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  9. Article ; Online: Profiling the prognosis of gastric cancer patients: is it worth correlating the survival with the clinical/pathological and molecular features of gastric cancers?

    Lorenzon, Laura / Mercantini, Paolo / Ferri, Mario / La Torre, Marco / Sparagna, Alessandra / Balducci, Genoveffa / Tarantino, Giulia / Romiti, Adriana / Pilozzi, Emanuela / Ziparo, Vincenzo

    TheScientificWorldJournal

    2013  Volume 2013, Page(s) 196541

    Abstract: Background: The prognosis of gastric cancer patients still remains poor. The aim of this study was investigating the prognostic value of several clinical/pathological/molecular features in a consecutive series of gastric cancers.: Methods: 150 R0 ... ...

    Abstract Background: The prognosis of gastric cancer patients still remains poor. The aim of this study was investigating the prognostic value of several clinical/pathological/molecular features in a consecutive series of gastric cancers.
    Methods: 150 R0 gastrectomies plus 77 gastric cancer patients evaluated for the HER2 overexpression were selected. Survival was calculated and patients stratified according to the stage, the T-stage, the LNRs, the LNH, and the HER2 scoring system. ROC curves were calculated in order to compare the performance of the LRN and LNH systems.
    Results: Prognosis correlated with the stage and with the T-stage. We documented a statistical correlation between the LNRs and the survival. Conversely, a LNH > 15 did not correlate with the outcomes. The ROC curves documented a significant performance of the LRN system, whereas a statistical correlation was documented for the LNH exclusively with the endpoint of disease-free survival. We documented a trend of worse prognosis for patients with an HER2 overexpression, even though it was not of statistical value.
    Conclusion: The LNR and the evaluation of the HER2 overexpression might be useful since they correlate with survival, might identify patients with a higher risk of recurrence, and might select patients for a tailored medical treatment.
    MeSH term(s) Adenocarcinoma/metabolism ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Female ; Gastrectomy ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Receptor, ErbB-2/metabolism ; Retrospective Studies ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Survival Analysis
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2013-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075968-X
    ISSN 1537-744X ; 1537-744X
    ISSN (online) 1537-744X
    ISSN 1537-744X
    DOI 10.1155/2013/196541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intestinal endometriosis: a sigmoid mass mimicking a colic neoplasm.

    Petrucciani, Niccolò / Socciarelli, Fabio / Di Cesare, Tatiana / Virgilio, Edoardo / Cavaniglia, Daniele / Novi, Luciano / Grieco, Michele / Kazemi, Andrea / Tierno, Simone / Sparagna, Alessandra / Ferri, Mario / Ziparo, Vincenzo

    The American surgeon

    2012  Volume 78, Issue 9, Page(s) E383–4

    MeSH term(s) Abdominal Pain/diagnosis ; Abdominal Pain/etiology ; Abdominal Pain/surgery ; Adult ; Colonoscopy ; Diagnosis, Differential ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/surgery ; Female ; Humans ; Sigmoid Diseases/complications ; Sigmoid Diseases/diagnosis ; Sigmoid Diseases/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2012-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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