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  1. Article ; Online: A case of a neuropathic diabetic foot ulcer causing rupture of the Achilles tendon.

    Saleem, Hafees Ahmad / Newman, Sheri L / Puckridge, Phillip James / Spark, James Ian

    ANZ journal of surgery

    2010  Volume 80, Issue 7-8, Page(s) 574–575

    MeSH term(s) Achilles Tendon/pathology ; Achilles Tendon/physiopathology ; Angioplasty/methods ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetic Foot/complications ; Diabetic Foot/diagnosis ; Diabetic Neuropathies/complications ; Diabetic Neuropathies/diagnosis ; Female ; Femoral Artery/surgery ; Follow-Up Studies ; Humans ; Middle Aged ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/surgery ; Radiography ; Rupture, Spontaneous/etiology ; Rupture, Spontaneous/therapy ; Splints ; Stents ; Tendon Injuries/etiology ; Tendon Injuries/therapy ; Treatment Outcome
    Language English
    Publishing date 2010-07
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/j.1445-2197.2010.05369.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An elevated neutrophil-lymphocyte ratio independently predicts mortality in chronic critical limb ischemia.

    Spark, James Ian / Sarveswaran, Janahan / Blest, Nadia / Charalabidis, Peter / Asthana, Sonal

    Journal of vascular surgery

    2010  Volume 52, Issue 3, Page(s) 632–636

    Abstract: Background: Atherogenesis represents an active inflammatory process with leucocytes playing a major role. An elevated white blood cell count has been shown to be predictive of death in coronary artery disease patients. The aim of this study was to ... ...

    Abstract Background: Atherogenesis represents an active inflammatory process with leucocytes playing a major role. An elevated white blood cell count has been shown to be predictive of death in coronary artery disease patients. The aim of this study was to examine the predictive ability of neutrophil count and neutrophil/lymphocyte ratio for predicting survival in patients with critical lower limb ischemia (CLI).
    Methods: All patients admitted to a single vascular unit with CCLI were identified prospectively over a 2-year period starting from January 2005. Patient demographics, clinical history, comorbidity, and risk factors for peripheral vascular disease were documented. The white blood count and differential cell count at admission was recorded. Overall, patient mortality was studied as the primary outcome.
    Results: One hundred forty-nine patients were identified, with a median age of 72 years (Interquartile range [IQR], 65.7-81). A neutrophil-lymphocyte ratio (NLR) of >or=5.25 was taken as the cutoff, based upon the receiver-operating-characteristic.The median follow up was 8.7 months (IQR, 3.1-16). During the follow-up period, there have been 62 deaths (43.4%). An elevated neutrophil/lymphocyte ratio and a high troponin level (>0.1) were found to be the only two factors independently associated with shorter survival on multivariate analysis using the Cox proportional hazards model.
    Conclusions: This study suggests that an elevated NLR can identify a poor-risk subset of patients among those being treated for critical limb ischemia. This simple, inexpensive test may, therefore, add to risk stratification of these high-risk patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/blood ; Chi-Square Distribution ; Chronic Disease ; Critical Illness ; Extremities/blood supply ; Humans ; Ischemia/blood ; Ischemia/mortality ; Kaplan-Meier Estimate ; Leukocyte Count ; Lymphocyte Count ; Lymphocytes ; Neutrophils ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Troponin/blood ; Up-Regulation
    Chemical Substances Biomarkers ; Troponin
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2010.03.067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Massive aneurysmal dilatation of a depopulated ureteric hemodialysis xenograft.

    Smith, Matthew P Welberry / Spark, James Ian / Patel, Jai V / Border, David J / Oswal, Dilip / Lewington, Andrew J P

    Hemodialysis international. International Symposium on Home Hemodialysis

    2009  Volume 13, Issue 1, Page(s) 3–5

    Abstract: Use of depopulated bovine ureteric xenografts for hemodialysis vascular access has recently been described. Cellular components have been removed, giving a connective tissue matrix which can be neocellularized, retaining native biomechanics. A 24-year- ... ...

    Abstract Use of depopulated bovine ureteric xenografts for hemodialysis vascular access has recently been described. Cellular components have been removed, giving a connective tissue matrix which can be neocellularized, retaining native biomechanics. A 24-year-old male with end-stage renal disease from focal segmental glomerulosclerosis presented with particularly difficult vascular access. A depopulated bovine ureteric xenograft was implanted from the left subclavian artery to innominate vein. It became massively aneurysmal, requiring emergency embolization. Biopsy of the graft stained positive for alpha-gal. We believe this is the first reported case of massive aneurysmal dilatation of a depopulated bovine ureteric xenograft.
    MeSH term(s) Adult ; Aneurysm/etiology ; Animals ; Arteriovenous Shunt, Surgical/methods ; Bioprosthesis/adverse effects ; Blood Vessel Prosthesis Implantation/adverse effects ; Brachiocephalic Veins/surgery ; Cattle ; Humans ; Male ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Subclavian Artery/surgery ; Transplantation, Heterologous ; Ureter/transplantation
    Language English
    Publishing date 2009-01
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 2192458-2
    ISSN 1492-7535
    ISSN 1492-7535
    DOI 10.1111/j.1542-4758.2009.00349.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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