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  1. Article: Inherited arrhythmias and gene therapy: Are there any ethical considerations to take into account?

    Spartalis, Michael / Spartalis, Eleftherios / Siasos, Gerasimos

    World journal of cardiology

    2023  Volume 15, Issue 12, Page(s) 623–626

    Abstract: Interventional electrophysiology represents a relatively recent subspecialty within the field of cardiology. In the past half-century, there has been significant advancement in the development and implementation of innovative ablation treatments and ... ...

    Abstract Interventional electrophysiology represents a relatively recent subspecialty within the field of cardiology. In the past half-century, there has been significant advancement in the development and implementation of innovative ablation treatments and approaches. However, the treatment of arrhythmias continues to be inadequate. Several arrhythmias, such as ventricular tachycardia and atrial fibrillation, pose significant challenges in terms of therapeutic efficacy, whether through interventional procedures or the administration of antiarrhythmic drugs. Cardiologists are engaged in ongoing research to explore innovative methodologies, such as genome editing, with the purpose of effectively managing arrhythmias and meeting the growing needs of patients afflicted with rhythm disturbances. The field of genome editing has significant promise and has the potential to serve as a highly effective personalized therapy for rhythm disorders in patients. However, several ethical issues must be considered.
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573665-6
    ISSN 1949-8462
    ISSN 1949-8462
    DOI 10.4330/wjc.v15.i12.623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antiarrhythmic Potential of Epicardial Botulinum Toxin Injection for Suppression of Postoperative Atrial Fibrillation.

    Spartalis, Michael / Spartalis, Eleftherios / Iliopoulos, Dimitrios / Siasos, Gerasimos

    Current molecular pharmacology

    2023  Volume 17, Issue 1, Page(s) e200623218118

    Abstract: Following heart surgery, postoperative atrial fibrillation (AF) is the most prevalent kind of secondary AF and the most frequent adverse event. Postoperative AF is related to a number of unfavorable cardiac outcomes, such as heart failure, stroke, and ... ...

    Abstract Following heart surgery, postoperative atrial fibrillation (AF) is the most prevalent kind of secondary AF and the most frequent adverse event. Postoperative AF is related to a number of unfavorable cardiac outcomes, such as heart failure, stroke, and death. However, the pharmacological treatment for postoperative AF is only relatively efficient and is frequently linked to detrimental complications, including symptomatic bradycardia with atrioventricular block due to rate control drugs and elevated hemorrhage hazard attributable to the administration of anticoagulants. Ablation procedures also result in the irreversible damage of cardiac anatomic structures, which may have long-term negative implications on heart performance. As a result, there is an unmet demand for treatments that can minimize the incidence of postoperative AF in an effective and safe manner. Botulinum toxin is an established neurotoxin that has progressively gained use in every medical science domain. It hinders the propagation of impulses across nerve fibers without causing immediate damage to the cardiac tissue. The transient feature of botulinum toxin action and the eventual restoration of the autonomic nervous system transmission are undeniably advantageous and may render botulinum toxin a potential and feasible treatment approach for postoperative AF.
    MeSH term(s) Humans ; Atrial Fibrillation/drug therapy ; Heart ; Heart Failure ; Botulinum Toxins/therapeutic use
    Chemical Substances Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2023-09-04
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1874-4702
    ISSN (online) 1874-4702
    DOI 10.2174/1874467217666230620114931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The development of Brugada syndrome phenotype is multifactorial, combining genetic and environmental factors.

    Spartalis, M / Athanasiou, A / Spartalis, E / Voudris, V

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 7, Page(s) 3444–3445

    MeSH term(s) Atrial Fibrillation ; Brugada Syndrome ; Electrocardiography ; Humans ; Phenotype
    Language English
    Publishing date 2020-04-23
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202004_20799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Controversy regarding the disease taxonomy of Takotsubo syndrome: pathophysiological, morphological and anatomical considerations.

    Spartalis, M / Tzima, I / Anastasiou, A / Spartalis, E / Iliopoulos, D C / Siasos, G

    European review for medical and pharmacological sciences

    2022  Volume 26, Issue 12, Page(s) 4161–4162

    MeSH term(s) Humans ; Risk Factors ; Takotsubo Cardiomyopathy/diagnosis
    Language English
    Publishing date 2022-07-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202206_29052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Anticoagulation in Patients with Atrial High-rate Episodes Detected by Cardiac Implantable Electronic Devices.

    Spartalis, Michael / Kontogiannis, Christos / Spartalis, Eleftherios / Iliopoulos, Dimitrios C / Siasos, Gerasimos

    Current pharmaceutical design

    2024  

    Abstract: Atrial high-rate episodes (AHRE) are atrial tachyarrhythmias that are identified by the use of continuous rhythm monitoring devices such as pacemakers, defibrillators, or implantable cardiac monitors. Nevertheless, the therapeutic implications of these ... ...

    Abstract Atrial high-rate episodes (AHRE) are atrial tachyarrhythmias that are identified by the use of continuous rhythm monitoring devices such as pacemakers, defibrillators, or implantable cardiac monitors. Nevertheless, the therapeutic implications of these rhythm disturbances remain uncertain. The presence of AHRE is associated with an increased risk of stroke as compared to patients who do not exhibit AHRE. The utilisation of oral anticoagulation has the ability to mitigate the likelihood of stroke occurrence in patients with AHRE. However, it is important to note that this treatment approach is also linked to a severe bleeding rate of approximately 2% per year. The stroke rate among individuals diagnosed with AHRE appears to be comparatively lower when compared to patients diagnosed with atrial fibrillation. The efficacy and safety of anticoagulation in patients with AHRE have yet to be definitively established. Further research is required to provide a comprehensive understanding of the effectiveness and safety of oral anticoagulation in individuals with AHRE.
    Language English
    Publishing date 2024-02-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128291822240131063712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anatomical considerations regarding the oncological safety of platelet-rich fibrin application at the tumor bed after total laryngectomy for advanced carcinoma.

    Spartalis, Eleftherios / Troupis, Theodore

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2020  Volume 278, Issue 2, Page(s) 617–618

    MeSH term(s) Carcinoma ; Humans ; Laryngectomy ; Platelet-Rich Fibrin
    Language English
    Publishing date 2020-11-10
    Publishing country Germany
    Document type Letter
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06469-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CRP in Drain Fluid as a Predictive Marker of Anastomotic Leak in Colorectal Surgery: A Systematic Review of the Literature.

    Kyrochristou, Ilektra / Spartalis, Eleftherios / Anagnostopoulos, Georgios / Tsourouflis, Gerasimos / Dimitroulis, Dimitrios / Nikiteas, Nikolaos I

    In vivo (Athens, Greece)

    2023  Volume 37, Issue 4, Page(s) 1450–1454

    Abstract: Background/aim: Anastomotic leak (AL) remains one of the most troublesome complications in general surgery. The current review aimed to assess the level of C-reactive protein (CRP) in drainage fluid after entero-enteric, colonic, or colorectal ... ...

    Abstract Background/aim: Anastomotic leak (AL) remains one of the most troublesome complications in general surgery. The current review aimed to assess the level of C-reactive protein (CRP) in drainage fluid after entero-enteric, colonic, or colorectal anastomosis as a predictive biomarker for AL.
    Materials and methods: Four medical databases (PUBMED-MEDLINE, Google Scholar, UpToDate, and Cochrane Library) were searched in January 2023 for prospective or retrospective studies on the role of acute-phase proteins in drainage fluid as a predictive biomarker of AL. Two independent researchers gathered and processed the data using MedCalc. The data were pooled and Student's t-test was used to compare the data between the AL and non-AL groups.
    Results: Overall, four studies were included in the current review, containing 753 patients in total, for whom various types of enteric and colonic anastomoses were constructed. Overall 79 (10.49%) of patients demonstrated AL and the mean CRP level (±standard deviation) on postoperative day 3 was 167.7±77.13 mg/l. On the contrary, the non-AL group (674/753) had a statistically significantly lower mean CRP level at 83.76±20.32 mg/l. CRP values were not related to mortality. It was not possible to propose a CRP cut-off indicating an increased risk for AL as the data were insufficient.
    Conclusion: The CRP level in drainage fluid might be a valuable biomarker for predicting the possibility of AL in general surgery. However, further and larger-scale studies are needed to establish a CRP cut-off value and this variable would possibly be different for patients with different pathologies.
    MeSH term(s) Humans ; C-Reactive Protein/metabolism ; Anastomotic Leak/diagnosis ; Anastomotic Leak/etiology ; Prospective Studies ; Retrospective Studies ; Colorectal Surgery/adverse effects ; Biomarkers/metabolism ; Drainage
    Chemical Substances C-Reactive Protein (9007-41-4) ; Biomarkers
    Language English
    Publishing date 2023-06-27
    Publishing country Greece
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hemodynamic support during catheter ablation of ventricular arrhythmias in patients with cardiogenic shock.

    Spartalis, Michael / Zweiker, David / Spartalis, Eleftherios / Iliopoulos, Dimitrios C / Siasos, Gerasimos

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1145123

    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1145123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Hemorrhagic complications after removal of an external ventricular drain: A case report and literature review.

    Plakopitis, Nikolaos / Themistoklis, Konstantinos / Melanis, Konstantinos / Spartalis, Eleftherios / Patrikelis, Panayiotis / Papasilekas, Themistoklis

    Surgical neurology international

    2023  Volume 14, Page(s) 298

    Abstract: Background: External ventricular drainage (EVD) is one of the most common neurosurgical procedures. Complications are rather rare and mostly include hemorrhage and infection. Hematomas may form during placement or even after the removal of an EVD. ... ...

    Abstract Background: External ventricular drainage (EVD) is one of the most common neurosurgical procedures. Complications are rather rare and mostly include hemorrhage and infection. Hematomas may form during placement or even after the removal of an EVD. Regarding the latter, the literature is scarce, with only nine clinically significant cases reported.
    Case description: We present the case of a young woman who suffered an extensive hemorrhage after removal of an EVD, in the setting of a posterior fossa stroke. We discuss the management and possible consequences of such an event and we emphasize the need for alertness to avoid such complications.
    Conclusion: Removal of an EVD is a safe procedure, with rare cases of hemorrhagic complications being reported. A case of a large hematoma that formed after the removal of an EVD is presented. Stricter follow-up protocols should be implemented to better estimate the risk of hemorrhage.
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_415_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Thyroid-cardiac Axis: Thyroid Function, Cardiac Rhythmology, and Sudden Cardiac Death.

    Spartalis, Michael / Spartalis, Eleftherios / Paschou, Stavroula A / Iliopoulos, Dimitrios / Siasos, Gerasimos

    Endocrine, metabolic & immune disorders drug targets

    2023  

    Abstract: It is well known that thyroid dysfunction increases the risk of cardiovascular mortality and morbidity. The pleiotropic effect of thyroid hormones has a profound effect on the cardiovascular system, influencing both the formation of a normal cardiac ... ...

    Abstract It is well known that thyroid dysfunction increases the risk of cardiovascular mortality and morbidity. The pleiotropic effect of thyroid hormones has a profound effect on the cardiovascular system, influencing both the formation of a normal cardiac rhythm and rhythm disturbance. A number of research studies have demonstrated correlations between TSH and FT4 levels and significant cardiovascular events. The pathophysiological mechanisms underlying these complex associations are, however, inadequately defined. A system-based examination of the relationship between thyroid homeostasis and cardiovascular disease could pave the way for novel study areas and a more individualised strategy for the management of individuals at cardiovascular risk.
    Language English
    Publishing date 2023-11-03
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/0118715303243951231024112208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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