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Article ; Online: Short and Long-Term Cardiovascular Sequelae after SARS-CoV-2 Infection: A Narrative Review Focusing on Athletes.

Monosilio, Sara / Prosperi, Silvia / Squeo, Maria Rosaria / Spataro, Stefano / Spataro, Antonio / Maestrini, Viviana

2023 Volume 15, Issue 2

Abstract: Cardiovascular (CV) involvement after severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection was found to be frequent among the general population, especially in the pre-vaccination era, and particularly for hospitalized patients or those ... ...

Abstract	Cardiovascular (CV) involvement after severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection was found to be frequent among the general population, especially in the pre-vaccination era, and particularly for hospitalized patients or those who experienced a more severe course of the disease. The spectrum of CV disease varies; however, acute myocarditis is particularly fearsome for the athletic population due to the possible associated risk of malignant arrhythmias during training. Alarming percentages of CV injuries, even in young and healthy athletes with a benign course of the disease, arose from a few initial studies limited to case series. Subsequent single-center studies and larger observational registries reported a lower prevalence of SARS-CoV2 CV involvement in athletes. Studies showing the occurrence of CV adverse events during follow-up periods are now available. The objective of our narrative review is to provide an updated summary of the literature on CV involvement after coronavirus disease 2019, both in the early post-infection period and over a longer period of time, with a focus on athletic populations.
MeSH term(s)	Humans ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; RNA, Viral ; Athletes ; Disease Progression ; Myocarditis
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15020493
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The university as a safe environment during the SARS-COV-2 pandemic: the experience of Bari Politecnico.

Cupertino, F / Spataro, S / Spinelli, G / Schirinzi, A / Bianchi, F P / Stefanizzi, P / Di Serio, F / Tafuri, S

Annali di igiene : medicina preventiva e di comunita

2021 Volume 33, Issue 2, Page(s) 201–202

Abstract: the SARS-CoV-2 pandemic started in December 2019 and still remains a major global health issue. Every country in the world has adopted drastic measures to contain the virus, although their stringency varies among countries, ranging from increased ... ...

Abstract	the SARS-CoV-2 pandemic started in December 2019 and still remains a major global health issue. Every country in the world has adopted drastic measures to contain the virus, although their stringency varies among countries, ranging from increased surveillance and focused interventions to strict lockdown (1). Italy was the second country where the disease had a major impact early in the pandemic, such that a strict nationwide lockdown was declared from March 9 to May 3, 2020. Nonetheless, between January and May 2020, there were 210,000 COVID-19 cases in Italy and 29,000 deaths were recorded (2). Due to the lockdown, universities (and in general all educational services) shifted to online classes, with students attending lessons and taking their exams from home. On-site activities were reduced to those considered indispensable. Research activities also had to be modified, such as by the adoption of a smart-working model (3). Between May and August 2020, the number of SARS-CoV-2 infections in Italy decreased. In response, the lockdown was loosened and some activities were restarted, albeit with specific safety protocols (social distancing, use of masks, temperature checks at the workplace entry, environmental disinfection, mixed models of smart and in-office work). These actions were accompanied by periodic serological and PCR screening tests (4).
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Communicable Disease Control/methods ; Humans ; Italy/epidemiology ; Masks ; Pandemics ; Physical Distancing ; SARS-CoV-2 ; Universities ; Vaccination
Language	English
Publishing date	2021-02-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1018045-x
ISSN	1120-9135 ; 0029-6287
ISSN	1120-9135 ; 0029-6287
DOI	10.7416/ai.2021.2425
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Article ; Online: Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo.

Spataro, Sofia / Maco, Bohumil / Escrig, Stéphane / Jensen, Louise / Polerecky, Lubos / Knott, Graham / Meibom, Anders / Schneider, Bernard L

Acta neuropathologica communications

2023 Volume 11, Issue 1, Page(s) 157

Abstract: In Parkinson's disease, pathogenic factors such as the intraneuronal accumulation of the protein α-synuclein affect key metabolic processes. New approaches are required to understand how metabolic dysregulations cause degeneration of vulnerable subtypes ... ...

Abstract	In Parkinson's disease, pathogenic factors such as the intraneuronal accumulation of the protein α-synuclein affect key metabolic processes. New approaches are required to understand how metabolic dysregulations cause degeneration of vulnerable subtypes of neurons in the brain. Here, we apply correlative electron microscopy and NanoSIMS isotopic imaging to map and quantify
MeSH term(s)	Rats ; Humans ; Animals ; alpha-Synuclein/metabolism ; Parkinson Disease/pathology ; Isotope Labeling ; Dopaminergic Neurons/metabolism ; Brain/pathology ; Substantia Nigra/metabolism
Chemical Substances	alpha-Synuclein
Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01608-8
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Article ; Online: Poly (1-butene-

Marega, Carla / Malizia, Federica / Spataro, Stefano

Polymers

2019 Volume 11, Issue 7

Abstract: Samples of random poly(butene- ...

Abstract	Samples of random poly(butene-
Language	English
Publishing date	2019-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym11071133
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Article ; Online: CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease

Spataro, Sofia / Guerra, Concetta / Cavalli, Andrea / Sgrignani, Jacopo / Sleeman, Jonathan / Poulain, Lina / Boland, Andreas / Scapozza, Leonardo / Moll, Solange / Prunotto, Marco

The FEBS Journal. 2023 Aug., v. 290, no. 16 p.3946-3962

2023

Abstract: CEMIP (cell migration‐inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients ... ...

Abstract	CEMIP (cell migration‐inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients affected by nonsyndromic hearing loss and has subsequently been shown to play a key role in tumour initiation and progression, as well as arthritis, atherosclerosis and idiopathic pulmonary fibrosis. Despite the vast literature associating CEMIP with these diseases, its biology remains elusive. The present review article summarises all the major scientific evidence regarding its structure, function, role and expression, and attempts to cast light on a protein that modulates EMT, fibrosis and tissue inflammation, an unmet key aspect in several inflammatory disease conditions.
Keywords	arthritis ; atherosclerosis ; depolymerization ; extracellular matrix ; fibrosis ; hyaluronic acid ; inflammation ; neoplasms ; pulmonary fibrosis
Language	English
Dates of publication	2023-08
Size	p. 3946-3962.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16600
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease.

Spataro, Sofia / Guerra, Concetta / Cavalli, Andrea / Sgrignani, Jacopo / Sleeman, Jonathan / Poulain, Lina / Boland, Andreas / Scapozza, Leonardo / Moll, Solange / Prunotto, Marco

The FEBS journal

2022 Volume 290, Issue 16, Page(s) 3946–3962

Abstract: CEMIP (cell migration-inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients ... ...

Abstract	CEMIP (cell migration-inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients affected by nonsyndromic hearing loss and has subsequently been shown to play a key role in tumour initiation and progression, as well as arthritis, atherosclerosis and idiopathic pulmonary fibrosis. Despite the vast literature associating CEMIP with these diseases, its biology remains elusive. The present review article summarises all the major scientific evidence regarding its structure, function, role and expression, and attempts to cast light on a protein that modulates EMT, fibrosis and tissue inflammation, an unmet key aspect in several inflammatory disease conditions.
MeSH term(s)	Humans ; Cell Movement ; Extracellular Matrix/metabolism ; Hyaluronic Acid/metabolism ; Hyaluronoglucosaminidase/genetics ; Hyaluronoglucosaminidase/metabolism
Chemical Substances	Hyaluronic Acid (9004-61-9) ; Hyaluronoglucosaminidase (EC 3.2.1.35) ; CEMIP protein, human (EC 3.2.1.35)
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16600
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Zs.A 260: Show issues

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Article ; Online: Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts.

Schmaus, Anja / Rothley, Melanie / Schreiber, Caroline / Möller, Stephanie / Roßwag, Sven / Franz, Sandra / Garvalov, Boyan K / Thiele, Wilko / Spataro, Sofia / Herskind, Carsten / Prunotto, Marco / Anderegg, Ulf / Schnabelrauch, Matthias / Sleeman, Jonathan

Matrix biology : journal of the International Society for Matrix Biology

2022 Volume 109, Page(s) 173–191

Abstract: Hyaluronan (HA) is an extracellular matrix component that regulates a variety of physiological and pathological processes. The function of HA depends both on its overall amount and on its size, properties that are controlled by HA synthesizing and ... ...

Abstract	Hyaluronan (HA) is an extracellular matrix component that regulates a variety of physiological and pathological processes. The function of HA depends both on its overall amount and on its size, properties that are controlled by HA synthesizing and degrading enzymes. The lack of inhibitors that can specifically block individual HA degrading enzymes has hampered attempts to understand the contribution of individual hyaluronidases to different physiological and pathological processes. CEMIP is a recently discovered hyaluronidase that cleaves HA through mechanisms and under conditions that are distinct from those of other hyaluronidases such as HYAL1 or HYAL2. The role of its hyaluronidase activity in physiology and disease is poorly understood. Here, we characterized a series of sulfated HA derivatives (sHA) with different sizes and degrees of sulfation for their ability to inhibit specific hyaluronidases. We found that highly sulfated sHA derivatives potently inhibited CEMIP hyaluronidase activity. One of these compounds, designated here as sHA3.7, was characterized further and shown to inhibit CEMIP with considerable selectivity over other hyaluronidases. Inhibition of CEMIP with sHA3.7 in fibroblasts, which are the main producers of HA in the interstitial matrix, increased the cellular levels of total and high molecular weight HA, while decreasing the fraction of low molecular weight HA fragments. Genetic deletion of CEMIP in mouse embryonic fibroblasts (MEFs) produced analogous results and confirmed that the effects of sHA3.7 on HA levels were mediated by CEMIP inhibition. Importantly, both CEMIP deletion and its inhibition by sHA3.7 suppressed fibroblast proliferation, while promoting differentiation into myofibroblasts, as reflected in a lack of CEMIP in myofibroblasts within skin wounds in experimental mice. By contrast, adipogenic and osteogenic differentiation were attenuated upon CEMIP loss or inhibition. Our results demonstrate the importance of CEMIP for the HA metabolism, proliferation and differentiation of fibroblasts, and suggest that inhibition of CEMIP with sulfated HA derivatives such as sHA3.7 has potential utility in pathological conditions that are dependent on CEMIP function.
MeSH term(s)	Animals ; Cell Proliferation ; Fibroblasts/metabolism ; Hyaluronic Acid/metabolism ; Hyaluronic Acid/pharmacology ; Hyaluronoglucosaminidase/metabolism ; Mice ; Osteogenesis ; Sulfates/metabolism ; Sulfates/pharmacology
Chemical Substances	Sulfates ; Hyaluronic Acid (9004-61-9) ; Hyaluronoglucosaminidase (EC 3.2.1.35)
Language	English
Publishing date	2022-04-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1183793-7
ISSN	1569-1802 ; 0945-053X
ISSN (online)	1569-1802
ISSN	0945-053X
DOI	10.1016/j.matbio.2022.04.001
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Article ; Online: Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice.

Wu, Jason / Solanes, Paola / Nist-Lund, Carl / Spataro, Sofia / Shubina-Oleinik, Olga / Marcovich, Irina / Goldberg, Hannah / Schneider, Bernard L / Holt, Jeffrey R

Molecular therapy : the journal of the American Society of Gene Therapy

2020 Volume 29, Issue 3, Page(s) 973–988

Abstract: AAV-mediated gene therapy is a promising approach for treating genetic hearing loss. Replacement or editing of the Tmc1 gene, encoding hair cell mechanosensory ion channels, is effective for hearing restoration in mice with some limitations. Efficient ... ...

Abstract	AAV-mediated gene therapy is a promising approach for treating genetic hearing loss. Replacement or editing of the Tmc1 gene, encoding hair cell mechanosensory ion channels, is effective for hearing restoration in mice with some limitations. Efficient rescue of outer hair cell function and lack of hearing recovery with later-stage treatment remain issues to be solved. Exogenous genes delivered with the adeno-associated virus (AAV)9-PHP.B capsid via the utricle transduce both inner and outer hair cells of the mouse cochlea with high efficacy. Here, we demonstrate that AAV9-PHP.B gene therapy can promote hair cell survival and successfully rescues hearing in three distinct mouse models of hearing loss. Tmc1 replacement with AAV9-PHP.B in a Tmc1 knockout mouse rescues hearing and promotes hair cell survival with equal efficacy in inner and outer hair cells. The same treatment in a recessive Tmc1 hearing-loss model, Baringo, partially recovers hearing even with later-stage treatment. Finally, dual delivery of Streptococcus pyogenes Cas9 (SpCas9) and guide RNA (gRNA) in separate AAV9-PHP.B vectors selectively disrupts a dominant Tmc1 allele and preserves hearing in Beethoven mice, a model of dominant, progressive hearing loss. Tmc1-targeted gene therapies using single or dual AAV9-PHP.B vectors offer potent and versatile approaches for treating dominant and recessive deafness.
MeSH term(s)	Animals ; Dependovirus/genetics ; Disease Models, Animal ; Female ; Genetic Therapy/methods ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; Hearing Loss/genetics ; Hearing Loss/pathology ; Hearing Loss/therapy ; Male ; Membrane Proteins/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Chemical Substances	Membrane Proteins ; TMC1 protein, mouse
Language	English
Publishing date	2020-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2020.11.016
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Article ; Online: Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György, Bence / Nist-Lund, Carl / Pan, Bifeng / Asai, Yukako / Karavitaki, K Domenica / Kleinstiver, Benjamin P / Garcia, Sara P / Zaborowski, Mikołaj P / Solanes, Paola / Spataro, Sofia / Schneider, Bernard L / Joung, J Keith / Géléoc, Gwenaëlle S G / Holt, Jeffrey R / Corey, David P

Nature medicine

2019 Volume 25, Issue 7, Page(s) 1123–1130

Abstract: Since most dominant human mutations are single nucleotide ... ...

Abstract	Since most dominant human mutations are single nucleotide substitutions
MeSH term(s)	Alleles ; Animals ; CRISPR-Associated Protein 9/physiology ; Cell Line ; Cells, Cultured ; Dependovirus/genetics ; Disease Models, Animal ; Gene Editing ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/prevention & control ; Humans ; Membrane Proteins/genetics ; Mice ; Mice, Inbred C57BL
Chemical Substances	Membrane Proteins ; TMC1 protein, mouse ; CRISPR-Associated Protein 9 (EC 3.1.-)
Language	English
Publishing date	2019-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-019-0500-9
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Article: Lower schooling, higher hepatitis C virus prevalence in Italy: an association dependent on age.

Picardi, Antonio / Gentilucci, Umberto Vespasiani / Bambacioni, Federica / Galati, Giovanni / Spataro, Sandro / Mazzarelli, Chiara / D'Avola, Delia / Fiori, Enrica / Riva, Elisabetta

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2007 Volume 40, Issue 2, Page(s) 168–170

MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Education ; Female ; Hepacivirus ; Hepatitis C/epidemiology ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Prevalence ; Regression Analysis ; Retrospective Studies ; Socioeconomic Factors
Language	English
Publishing date	2007-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2007.07.010
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