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  1. Article ; Online: Time to First Whole Blood Associated With Survival-First (Whole) Blood?

    Sperry, Jason L / Neal, Matthew D

    JAMA surgery

    2024  Volume 159, Issue 4, Page(s) 381–382

    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.7186
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  2. Article ; Online: Whole-Blood Resuscitation Following Traumatic Injury and Hemorrhagic Shock-Should It Be Standard Care?

    Sperry, Jason L / Brown, Joshua B

    JAMA surgery

    2023  Volume 158, Issue 5, Page(s) 540

    MeSH term(s) Animals ; Humans ; Shock, Hemorrhagic/etiology ; Shock, Hemorrhagic/therapy ; Resuscitation ; Disease Models, Animal
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.6986
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  3. Article ; Online: Invited Commentary: Why Would We Withhold a Beneficial Treatment? Use of Low-Titer Group O-Positive Whole Blood in Women of Childbearing Age.

    Sperry, Jason L / Yazer, Mark H

    Journal of the American College of Surgeons

    2023  Volume 238, Issue 3, Page(s) 357–358

    MeSH term(s) Female ; Humans ; ABO Blood-Group System ; Withholding Treatment
    Chemical Substances ABO Blood-Group System
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1097/XCS.0000000000000909
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  4. Article ; Online: Prehosptial low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial.

    Guyette, Frank X / Sperry, Jason L

    The journal of trauma and acute care surgery

    2022  Volume 93, Issue 5, Page(s) e175–e176

    MeSH term(s) Humans ; Prospective Studies ; Pilot Projects ; ABO Blood-Group System ; Transfusion Reaction
    Chemical Substances ABO Blood-Group System
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Comment
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000003686
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  5. Article ; Online: How do we forecast tomorrow's transfusion? Prehospital transfusion.

    Yazer, Mark H / Jenkins, Donald H / Sperry, Jason L / Spinella, Philip C

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2022  Volume 30, Issue 1, Page(s) 39–42

    MeSH term(s) Humans ; Blood Transfusion ; Emergency Medical Services ; Wounds and Injuries
    Language English
    Publishing date 2022-07-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/j.tracli.2022.07.007
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  6. Article ; Online: Prehospital Tranexamic Acid Administration in Injured Patients-Reply.

    Guyette, Francis X / Brown, Joshua B / Sperry, Jason L

    JAMA surgery

    2021  Volume 156, Issue 7, Page(s) 688–689

    MeSH term(s) Antifibrinolytic Agents ; Emergency Medical Services ; Humans ; Injury Severity Score ; Tranexamic Acid
    Chemical Substances Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1)
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2021.0262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Prehospital Plasma Transfusion: What Does the Literature Show?

    Jackson, Bryon P / Sperry, Jason L / Yazer, Mark H

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2021  Volume 48, Issue 6, Page(s) 358–365

    Abstract: Background: Early initiation of blood products transfusion after injury has been associated with improved patient outcomes following traumatic injury. The ability to transfuse patients' plasma in the prehospital setting provides a prime opportunity to ... ...

    Abstract Background: Early initiation of blood products transfusion after injury has been associated with improved patient outcomes following traumatic injury. The ability to transfuse patients' plasma in the prehospital setting provides a prime opportunity to begin resuscitation with blood products earlier and with a more balanced plasma: RBC ratio than what has traditionally been done. Published studies on the use of prehospital plasma show a complex relationship between its use and improved survival.
    Summary: Examination of the literature shows that there may be a mortality benefit from the use of prehospital plasma, but that it may be limited to certain subgroups of trauma patients. The likelihood of realizing these survival benefits appears to be predicted by several factors including the type of injury, length of transport time, presence of traumatic brain injury, and total number of blood products transfused, whether the patient required only a few products or a massive transfusion. When taken as a whole the evidence appears to show that prehospital plasma may have a mortality benefit that is most clearly demonstrated in patients with blunt injuries, moderate transfusion requirements, traumatic brain injury, and/or transport time greater than 20 min, as well as those who demonstrate a certain cytokine expression profile.
    Key messages: The evidence suggests that a targeted use of prehospital plasma will most likely maximize the benefits from the use of this limited resource. It is also possible that prehospital plasma may best be provided through whole blood as survival benefits were greatest in patients who received both prehospital plasma and RBCs.
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000519627
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    Zs.A 959: Show issues Location:
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  8. Article ; Online: Rate of RhD-alloimmunization after the transfusion of multiple RhD-positive primary red blood cell-containing products.

    Yazer, Mark H / Triulzi, Darrell J / Sperry, Jason L / Seheult, Jansen N

    Transfusion

    2021  Volume 61 Suppl 1, Page(s) S150–S158

    Abstract: Introduction: Early transfusion reduces mortality in bleeding patients. In this setting, RhD-positive blood products might be transfused. This study determined the association between the RhD-alloimmunization rate and the number of RhD-positive products ...

    Abstract Introduction: Early transfusion reduces mortality in bleeding patients. In this setting, RhD-positive blood products might be transfused. This study determined the association between the RhD-alloimmunization rate and the number of RhD-positive products transfused.
    Methods: RhD-negative patients between 13 and 50 years who were transfused with ≥1 RhD-positive red blood cell (RBC) or whole blood units between January 1, 2000 and December 31, 2019 in a healthcare network were identified. Study patients had to have had at least one antibody detection test performed ≥14 days after the index RhD-positive transfusion and not receive RhIg. Patients were stratified into groups that received 1, 2, 3-5, 6-10, 11-20, and >20 RhD-positive transfusions and the RhD-alloimmunization rate was determined for each group.
    Results: There were 335 patients included; 52/335 (15.5%) were females. Overall, there were 117/335 (34.9%, CI: 29.8%-40.3%) recipients who became RhD-alloimmunized. There was no significant dosage effect in the RhD-alloimmunization rates as the exposure to RhD-positive units increased from one RhD-positive unit to more than 20 RhD-positive units (p = .270 for non-parametric trend test). In an exploratory analysis, patients who received 100% of their RhD-positive transfusions within 72 h of the index transfusion had a significantly higher rate of RhD-alloimmunization compared to those who were transfused over a longer period of time (42.3% vs. 21.4%, respectively; p = .001).
    Conclusion: These results suggest that there may not be an increased RhD-alloimmunization risk with transfusing multiple RhD-positive units after one RhD-positive unit has been transfused. These findings need confirmation in larger studies.
    MeSH term(s) Adult ; Erythrocyte Transfusion/adverse effects ; Erythrocytes/immunology ; Female ; Humans ; Isoantibodies/blood ; Isoantibodies/immunology ; Male ; Middle Aged ; Rh-Hr Blood-Group System/blood ; Rh-Hr Blood-Group System/immunology ; Young Adult
    Chemical Substances Isoantibodies ; Rh-Hr Blood-Group System
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16495
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    Zs.A 284: Show issues Location:
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  9. Article ; Online: Administration of blood products in the prehospital setting can decrease trauma patient mortality.

    Dishong, Devin / Sperry, Jason L / Spinella, Philip C / Triulzi, Darrell J / Yazer, Mark H

    Transfusion

    2022  Volume 62, Issue 4, Page(s) 725–727

    MeSH term(s) Emergency Medical Services ; Humans ; Retrospective Studies ; Shock, Hemorrhagic ; Wounds and Injuries/therapy
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16848
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  10. Article ; Online: Funding the war in America: A look in the mirror.

    Hynes, Allyson M / Weaver, Jessica L / Hatchimonji, Justin S / Sperry, Jason L / Sanchez, Sabrina E / Seamon, Mark J / Kheirbek, Tareq / Scantling, Dane R

    The journal of trauma and acute care surgery

    2023  Volume 95, Issue 5, Page(s) 621–627

    Abstract: Background: Health care political action committees (HPACs) historically contribute more to candidates opposing firearm restrictions (FRs), clashing with their affiliated medical societies. These societies have increasingly emphasized the prevention of ... ...

    Abstract Background: Health care political action committees (HPACs) historically contribute more to candidates opposing firearm restrictions (FRs), clashing with their affiliated medical societies. These societies have increasingly emphasized the prevention of firearm violence and it is not known if recent contributions by their HPACs have aligned with their stated goals. We hypothesized that such HPACs still contribute similar amounts toward legislators up for reelection opposing FR.
    Methods: We identified HPACs of medical societies endorsing one or both calls-to-action against firearm violence published in the Annals of Internal Medicine (2015, 2019). House of Representatives (HOR) votes on H.R.8, a background checks bill, were characterized from GovTrack. We compiled HPAC contributions between the H.R.8 vote and election to HOR members up for re-election from the National Institute on Money in Politics. Our primary outcome was total campaign contributions by H.R.8 stance. Secondary outcomes included percentage of politicians funded and total contributions.
    Results: Nineteen societies endorsed one or both call-to-action articles. Three hundred eighty-five of 430 HOR members ran for reelection in 2020. Those endorsing H.R.8 (n = 226, 59%) received $2.8 M for $4,750 (interquartile range [IQR], $1000-$15,500) per candidate. Those opposing (n = 159, 41%) received $1.5 M for $2,500 (IQR, $0-$11,000) per candidate ( p = 0.0057). Health care political action committees donated toward a median of 20% (IQR, 7-28) of candidates endorsing H.R.8 and 9% (IQR, 4-22) of candidates opposing H.R.8 ( p = 0.0014). Those endorsing H.R.8 received 1,585 total contributions for a median of 3 (IQR, 1-10) contributions per candidate, while those opposing received 834 total contributions for a median of 2 (IQR, 0-7) contributions per candidate ( p = 0.0029).
    Conclusion: Politicians voting against background checks received substantial contributions toward reelection from the HPACs of societies advocating for firearm restrictions. However, this is the first study to suggest that HPAC's contributions have become more congruent with their respective societies. Further alignment of medical society goals and their HPAC political contributions could have a profound impact on firearm violence.
    Level of evidence: Prognostic and Epidemiological; Level III.
    MeSH term(s) United States ; Politics ; Societies, Medical ; Firearms ; Violence
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000003982
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