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  1. Article ; Online: Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes.

    Chandrasekar, Akila / Schmidtlein, Paula Marie / Neve, Vanessa / Rivagorda, Manon / Spiecker, Frauke / Gauthier, Karine / Prevot, Vincent / Schwaninger, Markus / Müller-Fielitz, Helge

    Thyroid : official journal of the American Thyroid Association

    2024  Volume 34, Issue 2, Page(s) 261–273

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Thyrotropin/pharmacology ; Thyrotropin/metabolism ; Ependymoglial Cells/metabolism ; Thyroid Hormones/metabolism ; Thyroid Gland/metabolism ; Receptors, Thyrotropin/genetics ; Receptors, Thyrotropin/metabolism ; Pituitary Hormone-Releasing Hormones/metabolism ; Protein Kinase C/metabolism
    Chemical Substances Thyrotropin (9002-71-5) ; Thyroid Hormones ; Receptors, Thyrotropin ; Pituitary Hormone-Releasing Hormones ; Protein Kinase C (EC 2.7.11.13)
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2023.0375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory.

    Hernandez Torres, Luis Daniel / Rezende, Flavia / Peschke, Eva / Will, Olga / Hövener, Jan-Bernd / Spiecker, Frauke / Özorhan, Ümit / Lampe, Josephine / Stölting, Ines / Aherrahrou, Zouhair / Künne, Carsten / Kusche-Vihrog, Kristina / Matschl, Urte / Hille, Susanne / Brandes, Ralf P / Schwaninger, Markus / Müller, Oliver J / Raasch, Walter

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1338458

    Abstract: Introduction: The development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require additional vascular damage, for example, in atherosclerotic mice.: Methods: We ... ...

    Abstract Introduction: The development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require additional vascular damage, for example, in atherosclerotic mice.
    Methods: We induced atherosclerosis in male C57BL/6N mice by injecting AAV-PCSK9
    Results: In AAV-PCSK9
    Discussion: We conclude that the hyperlipidemic PCSK9
    MeSH term(s) Male ; Mice ; Animals ; Proprotein Convertase 9/genetics ; Incidence ; Mice, Inbred C57BL ; Hyperlipidemias/pathology ; Atherosclerosis/metabolism ; Cholesterol ; Cerebrovascular Circulation/physiology
    Chemical Substances PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1338458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The SARS-CoV-2 main protease M

    Wenzel, Jan / Lampe, Josephine / Müller-Fielitz, Helge / Schuster, Raphael / Zille, Marietta / Müller, Kristin / Krohn, Markus / Körbelin, Jakob / Zhang, Linlin / Özorhan, Ümit / Neve, Vanessa / Wagner, Julian U G / Bojkova, Denisa / Shumliakivska, Mariana / Jiang, Yun / Fähnrich, Anke / Ott, Fabian / Sencio, Valentin / Robil, Cyril /
    Pfefferle, Susanne / Sauve, Florent / Coêlho, Caio Fernando Ferreira / Franz, Jonas / Spiecker, Frauke / Lembrich, Beate / Binder, Sonja / Feller, Nina / König, Peter / Busch, Hauke / Collin, Ludovic / Villaseñor, Roberto / Jöhren, Olaf / Altmeppen, Hermann C / Pasparakis, Manolis / Dimmeler, Stefanie / Cinatl, Jindrich / Püschel, Klaus / Zelic, Matija / Ofengeim, Dimitry / Stadelmann, Christine / Trottein, François / Nogueiras, Ruben / Hilgenfeld, Rolf / Glatzel, Markus / Prevot, Vincent / Schwaninger, Markus

    Nature neuroscience

    2021  Volume 24, Issue 11, Page(s) 1522–1533

    Abstract: Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular ... ...

    Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models, we found an increased number of empty basement membrane tubes, so-called string vessels representing remnants of lost capillaries. We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M
    MeSH term(s) Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain/metabolism ; Brain/pathology ; Chlorocebus aethiops ; Coronavirus 3C Proteases/genetics ; Coronavirus 3C Proteases/metabolism ; Cricetinae ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mesocricetus ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microvessels/metabolism ; Microvessels/pathology ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Vero Cells
    Chemical Substances Intracellular Signaling Peptides and Proteins ; NEMO protein, mouse ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-021-00926-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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