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  1. Article ; Online: Linear accelerator stereotactic radiosurgery can modulate the clinical course of Hemangioblastoma: Case series and review of the literature.

    Zibly, Z / Cohen, Z R / Peled, A / Zach, L / Nissim, U / Attia, Moshe / Graves, Christian / Camphausen, K / Spiegelman, R

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2020  Volume 82, Issue Pt A, Page(s) 162–165

    Abstract: Hemangioblastomas (HB) are benign low grade vascular tumors most frequently occurring in the cerebellum, brain stem, and spinal cord. Often associated with Von Hippel Lindau disease (VHL), the lesions are often multifocal requiring complex resection and ... ...

    Abstract Hemangioblastomas (HB) are benign low grade vascular tumors most frequently occurring in the cerebellum, brain stem, and spinal cord. Often associated with Von Hippel Lindau disease (VHL), the lesions are often multifocal requiring complex resection and are difficult to control. Linear Accelerator (LINAC) Stereotactic Radiosurgery (SRS) has been demonstrated to provide additional tumor control. In this case series, we present our multi-center experience utilizing LINAC SRS in fourteen patients with 23 lesions. We observed a tumor control rate of 87% and found interval changes in the peritumoral enhancement to correlate with treatment outcome. In our study, SRS treatment was also well-tolerated in both cystic and noncystic patients with multifocal disease. Disease control was achieved in all but three patients post-resection and no longitudinal radiation-induced secondary malignancy was observed. SRS response correlated highly with lesion size and radiation dose. We conclude that LINAC SRS is safe and effective for patients with HB and should be considered in addition to surgery in asymptomatic, VHL patients, deep seated lesions and isolated lesions.
    MeSH term(s) Adolescent ; Adult ; Brain Neoplasms/pathology ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/therapy ; Cerebellum/pathology ; Child ; Female ; Hemangioblastoma/pathology ; Hemangioblastoma/radiotherapy ; Hemangioblastoma/surgery ; Humans ; Male ; Middle Aged ; Particle Accelerators ; Radiosurgery ; Spinal Cord/pathology ; Treatment Outcome ; Young Adult ; von Hippel-Lindau Disease/complications
    Language English
    Publishing date 2020-11-11
    Publishing country Scotland
    Document type Case Reports ; Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2020.09.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Stereotactic pallidotomy--effective surgery for Parkinson's disease].

    Spiegelman, R

    Harefuah

    1996  Volume 131, Issue 9, Page(s) 324–326

    MeSH term(s) Globus Pallidus/surgery ; Humans ; Parkinson Disease/surgery ; Stereotaxic Techniques
    Language Hebrew
    Publishing date 1996-11-01
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms.

    Hadani, M / Spiegelman, R / Feldman, Z / Berkenstadt, H / Ram, Z

    Neurosurgery

    2001  Volume 48, Issue 4, Page(s) 799–807; discussion 807–9

    Abstract: Objective: Preliminary clinical experience with a novel, compact, intraoperative magnetic resonance imaging (MRI)-guided system that can be used in an ordinary operating room is presented.: Description of instrumentation: The system features an MRI ... ...

    Abstract Objective: Preliminary clinical experience with a novel, compact, intraoperative magnetic resonance imaging (MRI)-guided system that can be used in an ordinary operating room is presented.
    Description of instrumentation: The system features an MRI scanner integrated with an optical and MRI tracking system. Scanning and navigation, which are operated by the surgeon, are controlled by an in-room computer workstation with a liquid crystal display screen. The scanner includes a 0.12-T permanent magnet with a 25-cm vertical gap, accommodating the patient's head. The field of view is 11 x 16 cm, encompassing the surgical area of interest. The magnet is mounted on a transportable gantry that can be positioned under the surgical table when not in use for scanning, thus rendering the surgical environment unmodified and allowing the use of standard instruments. The features of the integrated navigation system allow flap planning and intraoperative tracking based on updated images acquired during surgery.
    Operative technique: Twenty patients with brain tumors were surgically treated using craniotomy or trans-sphenoidal approaches. One patient underwent conscious craniotomy with cortical mapping, and two underwent electrocorticography.
    Experience and results: Planning was accurate. Resection control images were obtained for all patients during surgery, with precise localization of residual tumor tissue. There were no surgical complications related to the use of the system.
    Conclusion: This intraoperative MRI system can function in a normal operating room modified only to eliminate radiofrequency interference. The operative environment is normal, and standard instruments can be used. The scanning and navigation capabilities of the system eliminate the inaccuracies that may result from brain shift. This novel type of intraoperative MRI system represents another step toward the introduction of the modality as a standard method in neurosurgery.
    MeSH term(s) Adolescent ; Adult ; Aged ; Brain/pathology ; Brain/surgery ; Brain Diseases/diagnosis ; Brain Diseases/surgery ; Brain Neoplasms/diagnosis ; Brain Neoplasms/surgery ; Child ; Child, Preschool ; Craniotomy/instrumentation ; Equipment Design ; Female ; Humans ; Image Processing, Computer-Assisted/instrumentation ; Magnetic Resonance Imaging/instrumentation ; Male ; Middle Aged ; Operating Rooms ; Stereotaxic Techniques/instrumentation ; Surgical Equipment ; User-Computer Interface
    Language English
    Publishing date 2001-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1097/00006123-200104000-00021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hyperglycemia is associated with increased hospital complications and mortality during parenteral nutrition.

    Pasquel, Francisco J / Smiley, Dawn / Spiegelman, Ronnie / Lin, Erica / Peng, Limin / Umpierrez, Guillermo E

    Hospital practice (1995)

    2011  Volume 39, Issue 2, Page(s) 81–88

    Abstract: Objective: Hyperglycemia is a recognized complication of parenteral nutrition (PN). We aimed to determine the impact of hyperglycemia during PN unaccompanied by tight blood glucose (BG) control on hospital complications and mortality.: Methods: We ... ...

    Abstract Objective: Hyperglycemia is a recognized complication of parenteral nutrition (PN). We aimed to determine the impact of hyperglycemia during PN unaccompanied by tight blood glucose (BG) control on hospital complications and mortality.
    Methods: We reviewed the medical records of 276 medical and surgical patients receiving PN to determine the impact of hyperglycemia on survival after adjusting for known prognostic factors, and to determine whether BG levels before initiation of PN, within 24 hours of PN initiation, or during PN therapy are predictive of adverse outcomes.
    Results: A total of 276 medical (35%) and surgical (65%) patients receiving PN initiated 12 ± 12 days after admission for a mean of 15 ± 24 days. Deceased patients (27.2%) were older, had higher Acute Physiology and Chronic Health Evaluation II scores, and had higher BG levels during PN therapy versus survivors (all, P < 0.01). Deceased patients had higher BG levels within 24 hours of PN initiation (162 ± 55 mg/dL vs 139 ± 37 mg/dL; P = 0.003) and higher BG levels during days 2 to 10 of PN (161 ± 53 mg/dL vs 142 ± 34 mg/dL; P = 0.013) compared with survivors. Blood glucose levels were associated with increased odds ratio (OR) for mortality pre-PN (P = 0.008), within 24 hours of PN initiation (P < 0.001), and during days 2 to 10 of PN (P < 0.001). In multiple regression models adjusted for age, sex, and history of diabetes, mortality was independently associated with pre-PN BG levels 121 to 150 mg/dL (OR, 2.2; 95% confidence interval [CI], 1.1-4.4), 151 to 180 mg/dL (OR, 3.41; 95% CI, 1.3-8.7,), and > 180 mg/dL (OR, 2.2; 95% CI, 0.9-5.2), and with BG levels within 24 hours of PN initiation > 180 mg/dL (OR, 2.8; 95% CI, 1.2-6.8). A BG level > 180 mg/dL within 24 hours of PN initiation was associated with increased risk of pneumonia (OR, 3.1; 95% CI, 1.4-7.1) and acute renal failure (OR, 2.3; 95% CI, 1.1-5.0).
    Conclusion: Hyperglycemia during PN without tight BG control is associated with increased risk of hospital complications and mortality. Randomized controlled trials are needed to determine benefits of intensified glycemic control on clinical outcomes in hospitalized subjects receiving PN.
    MeSH term(s) Blood Glucose/analysis ; Comorbidity ; Georgia/epidemiology ; Hospital Mortality ; Humans ; Hyperglycemia/blood ; Hyperglycemia/etiology ; Hyperglycemia/mortality ; Logistic Models ; Medical Records ; Parenteral Nutrition/adverse effects ; Retrospective Studies ; Risk Factors
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2011-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2570453-9
    ISSN 2377-1003 ; 2154-8331 ; 8750-2836
    ISSN (online) 2377-1003
    ISSN 2154-8331 ; 8750-2836
    DOI 10.3810/hp.2011.04.397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration. Case report.

    Ram, Z / Spiegelman, R / Findler, G / Hadani, M

    Journal of neurosurgery

    1989  Volume 71, Issue 4, Page(s) 605–607

    Abstract: Sodium nitroprusside is commonly used for the induction of hypotension during neurosurgical procedures. Its toxicity stems from hemodynamic compromise as well as from its metabolites, especially the formation of cyanide. A patient is described who ... ...

    Abstract Sodium nitroprusside is commonly used for the induction of hypotension during neurosurgical procedures. Its toxicity stems from hemodynamic compromise as well as from its metabolites, especially the formation of cyanide. A patient is described who underwent craniotomy for hypertensive intracerebral hemorrhage. He gradually recovered following the operation, but needed continued administration of sodium nitroprusside for control of hypertension. On the 7th postoperative day, he deteriorated into coma with evidence of severe edema and herniation on the computerized tomography scan. Cessation of sodium nitroprusside and treatment for cyanide poisoning resulted in resolution of his symptoms within hours. The potential toxicity of sodium nitroprusside, measures to prevent toxicity, and therapeutic steps are discussed.
    MeSH term(s) Brain Edema/chemically induced ; Brain Edema/diagnostic imaging ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/surgery ; Coma/chemically induced ; Craniotomy ; Cyanides/poisoning ; Ferricyanides/adverse effects ; Hematoma/etiology ; Hematoma/surgery ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Infusions, Intravenous ; Male ; Middle Aged ; Nitroprusside/administration & dosage ; Nitroprusside/adverse effects ; Nitroprusside/therapeutic use ; Propranolol/therapeutic use ; Radiography
    Chemical Substances Cyanides ; Ferricyanides ; Nitroprusside (169D1260KM) ; Propranolol (9Y8NXQ24VQ)
    Language English
    Publishing date 1989-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/jns.1989.71.4.0605
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  6. Article: Delayed nonhemorrhagic encephalopathy following mild head trauma. Case report.

    Ram, Z / Hadani, M / Spiegelman, R / Tadmor, R / Shacked, I

    Journal of neurosurgery

    1989  Volume 71, Issue 4, Page(s) 608–610

    Abstract: Delayed nonhemorrhagic encephalopathy following mild head trauma is a rare condition with an unknown etiology. The few cases reported in the literature are in young adults, all of them in the era before computerized tomography (CT) became available, and ... ...

    Abstract Delayed nonhemorrhagic encephalopathy following mild head trauma is a rare condition with an unknown etiology. The few cases reported in the literature are in young adults, all of them in the era before computerized tomography (CT) became available, and all had a devastating clinical course with multifocal ischemia or necrotic lesions found at autopsy. A case is presented of a young man with this syndrome who survived the acute encephalopathic phase with severe residual neurological deficits. Repeat CT scans during and following the acute phase as well as magnetic resonance imaging showed diffuse multifocal lesions compatible with ischemic changes and demyelination in the "watershed" areas of the brain.
    MeSH term(s) Adult ; Atrophy ; Brain/diagnostic imaging ; Brain/pathology ; Brain Injuries/diagnostic imaging ; Brain Injuries/pathology ; Craniocerebral Trauma/complications ; Craniocerebral Trauma/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Paralysis/etiology ; Radiography
    Language English
    Publishing date 1989-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/jns.1989.71.4.0608
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  7. Article ; Online: A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition.

    Umpierrez, Guillermo E / Spiegelman, Ronnie / Zhao, Vivian / Smiley, Dawn D / Pinzon, Ingrid / Griffith, Daniel P / Peng, Limin / Morris, Timothy / Luo, Menghua / Garcia, Hermes / Thomas, Christopher / Newton, Christopher A / Ziegler, Thomas R

    Critical care medicine

    2012  Volume 40, Issue 6, Page(s) 1792–1798

    Abstract: Objective: Parenteral nutrition has been associated with metabolic and infectious complications in intensive care unit patients. The underlying mechanism for the high risk of complications is not known but may relate to the proinflammatory effects of ... ...

    Abstract Objective: Parenteral nutrition has been associated with metabolic and infectious complications in intensive care unit patients. The underlying mechanism for the high risk of complications is not known but may relate to the proinflammatory effects of soybean oil-based lipid emulsions, the only Food and Drug Administration-approved lipid formulation for clinical use.
    Design: Prospective, double-blind, randomized, controlled trial.
    Setting: Medical-surgical intensive care units from a major urban teaching hospital and a tertiary referral university hospital.
    Patients: Adult medical-surgical intensive care unit patients.
    Intervention: Parenteral nutrition containing soybean oil-based (Intralipid) or olive oil-based (ClinOleic) lipid emulsions.
    Measurements: Differences in hospital clinical outcomes (nosocomial infections and noninfectious complications), hospital length of stay, glycemic control, inflammatory and oxidative stress markers, and granulocyte and monocyte functions between study groups.
    Results: A total of 100 patients were randomized to either soybean oil-based parenteral nutrition or olive oil-based parenteral nutrition for up to 28 days. A total of 49 patients received soybean oil-based parenteral nutrition (age 51 ± 15 yrs, body mass index 27 ± 6 kg/m2, and Acute Physiology and Chronic Health Evaluation II score 15.5 ± 7 [±SD]), and a total of 51 patients received olive oil-based lipid emulsion in parenteral nutrition (age 46 ± 19 yrs, body mass index 27 ± 8 kg/m2, and Acute Physiology and Chronic Health Evaluation II score 15.1 ± 6 [±SD]) for a mean duration of 12.9 ± 8 days. The mean hospital blood glucose concentration during parenteral nutrition was 129 ± 14 mg/dL, without differences between groups. Patients treated with soybean oil-based and olive oil-based parenteral nutrition had a similar length of stay (47 ± 47 days and 41 ± 36 days, p = .49), mortality (16.3% and 9.8%, p = .38), nosocomial infections (43% vs. 57%, p = .16), and acute renal failure (26% vs. 18%, p = .34). In addition, there were no differences in inflammatory and oxidative stress markers or in granulocyte and monocyte functions between groups.
    Conclusion: The administration of parenteral nutrition containing soybean oil-based and olive oil-based lipid emulsion resulted in similar rates of infectious and noninfectious complications and no differences in glycemic control, inflammatory and oxidative stress markers, and immune function in critically ill adults.
    MeSH term(s) Adult ; Aged ; Critical Care ; Double-Blind Method ; Fat Emulsions, Intravenous/administration & dosage ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Olive Oil ; Parenteral Nutrition/methods ; Plant Oils/administration & dosage ; Prospective Studies ; Soybean Oil/administration & dosage ; Surgical Procedures, Operative ; Treatment Outcome
    Chemical Substances Fat Emulsions, Intravenous ; Olive Oil ; Plant Oils ; Soybean Oil (8001-22-7)
    Language English
    Publishing date 2012-04-06
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0b013e3182474bf9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects.

    Siqueira, Joselita / Smiley, Dawn / Newton, Christopher / Le, Ngoc-Anh / Gosmanov, Aidar R / Spiegelman, Ronnie / Peng, Limin / Osteen, Samantha J / Jones, Dean P / Quyyumi, Arshed A / Ziegler, Thomas R / Umpierrez, Guillermo E

    The Journal of clinical endocrinology and metabolism

    2011  Volume 96, Issue 10, Page(s) 3207–3216

    Abstract: Context: Soybean oil-based lipid emulsions are the only Food and Drug Administration-approved lipid formulation for clinical use in parenteral nutrition (PN). Recently concerns with its use have been raised due to the proinflammatory effects that may ... ...

    Abstract Context: Soybean oil-based lipid emulsions are the only Food and Drug Administration-approved lipid formulation for clinical use in parenteral nutrition (PN). Recently concerns with its use have been raised due to the proinflammatory effects that may lead to increased complications because they are rich in ω-6 polyunsaturated fatty acids.
    Methods: This was a prospective, randomized, controlled, crossover study comparing the vascular, metabolic, immune, and inflammatory effects of 24-h infusion of PN containing soybean oil-based lipid emulsion (Intralipid), olive oil-based (ClinOleic), lipid free, and normal saline in 12 healthy subjects.
    Results: Soybean oil-PN increased systolic blood pressure compared with olive oil-PN (P < 0.05). Soybean oil PN reduced brachial artery flow-mediated dilatation from baseline (-23% at 4 h and -25% at 24 h, both P < 0.01); in contrast, olive oil PN, lipid free PN, and saline did not change either systolic blood pressure or flow-mediated dilatation. Compared with saline, soybean oil PN, olive oil PN, and lipid free PN similarly increased glucose and insulin concentrations during infusion (P < 0.05). There were no significant changes in plasma free fatty acids, lipid profile, inflammatory and oxidative stress markers, immune function parameters, or sympathetic activity between soybean oil- and olive oil-based lipid emulsions.
    Conclusion: The 24-h infusion of PN containing soybean oil-based lipid emulsion increased blood pressure and impaired endothelial function compared with PN containing olive oil-based lipid emulsion and lipid-free PN in healthy subjects. These vascular changes may have significant implications in worsening outcome in subjects receiving nutrition support. Randomized controlled trials with relevant clinical outcome measures are needed in patients receiving PN with olive oil-based and soybean oil-based lipid emulsions.
    MeSH term(s) Adult ; Autonomic Nervous System/drug effects ; Blood Glucose/metabolism ; Blood Pressure/drug effects ; Blood Vessels/drug effects ; C-Peptide/metabolism ; Dilatation ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiology ; Fat Emulsions, Intravenous/analysis ; Fatty Acids, Nonesterified/blood ; Female ; Food, Formulated ; Heart Rate/drug effects ; Humans ; Immunity/drug effects ; Inflammation/chemically induced ; Insulin/blood ; Lipids/blood ; Male ; Metabolism/drug effects ; Middle Aged ; Olive Oil ; Oxidative Stress/drug effects ; Parenteral Nutrition ; Plant Oils/adverse effects ; Plant Oils/pharmacology ; Soybean Oil/adverse effects ; Soybean Oil/pharmacology ; Sympathetic Nervous System/drug effects
    Chemical Substances Blood Glucose ; C-Peptide ; Fat Emulsions, Intravenous ; Fatty Acids, Nonesterified ; Insulin ; Lipids ; Olive Oil ; Plant Oils ; Soybean Oil (8001-22-7)
    Language English
    Publishing date 2011-08-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2011-0480
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  9. Article: Intermittent priapism in spinal canal stenosis.

    Ram, Z / Findler, G / Spiegelman, R / Shacked, I / Tadmor, R / Sahar, A

    Spine

    1987  Volume 12, Issue 4, Page(s) 377–378

    Abstract: A case of spontaneous intermittent priapism in a patient with spinal canal stenosis is presented. Erection, as well as intermittent neurogenic claudication and urinary incontinence were provoked by physical exertion, mainly walking. The symptoms ... ...

    Abstract A case of spontaneous intermittent priapism in a patient with spinal canal stenosis is presented. Erection, as well as intermittent neurogenic claudication and urinary incontinence were provoked by physical exertion, mainly walking. The symptoms completely resolved after decompressive lumbar laminectomy.
    MeSH term(s) Aged ; Humans ; Male ; Priapism/etiology ; Spinal Stenosis/complications
    Language English
    Publishing date 1987-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 752024-4
    ISSN 1528-1159 ; 0362-2436
    ISSN (online) 1528-1159
    ISSN 0362-2436
    DOI 10.1097/00007632-198705000-00013
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  10. Article ; Online: Hyperglycemia during total parenteral nutrition: an important marker of poor outcome and mortality in hospitalized patients.

    Pasquel, Francisco J / Spiegelman, Ronnie / McCauley, Megan / Smiley, Dawn / Umpierrez, Denise / Johnson, Rachel / Rhee, Mary / Gatcliffe, Chelsea / Lin, Erica / Umpierrez, Erica / Peng, Limin / Umpierrez, Guillermo E

    Diabetes care

    2009  Volume 33, Issue 4, Page(s) 739–741

    Abstract: Objective: To determine the effect of total parenteral nutrition (TPN)-induced hyperglycemia on hospital outcome.: Research design and methods: The study determined whether blood glucose values before, within 24 h, and during days 2-10 of TPN are ... ...

    Abstract Objective: To determine the effect of total parenteral nutrition (TPN)-induced hyperglycemia on hospital outcome.
    Research design and methods: The study determined whether blood glucose values before, within 24 h, and during days 2-10 of TPN are predictive of hospital complications and mortality.
    Results: Subjects included a total of 276 patients receiving TPN for a mean duration of 15 +/- 24 days (+/-SD). In multiple regression models adjusted for age, sex, and diabetes status, mortality was independently predicted by pre-TPN blood glucose of 121-150 mg/dl (odds ratio [OR] 2.2, 95% CI 1.1-4.4, P = 0.030), 151-180 mg/dl (3.41, 1.3-8.7, P = 0.01), and >180 mg/dl (2.2, 0.9-5.2, P = 0.077) and by blood glucose within 24 h of >180 mg/dl (2.8, 1.2-6.8, P = 0.020). A blood glucose within 24 h of >180 mg/dl was associated with increased risk of pneumonia (OR 3.1, 95% CI 1.4-7.1) and acute renal failure (2.3, 1.1-5.0).
    Conclusions: Hyperglycemia is associated with increased hospital complications and mortality in patients receiving TPN.
    MeSH term(s) Adult ; Aged ; Blood Glucose/analysis ; Female ; Hospitalization/statistics & numerical data ; Humans ; Hyperglycemia/complications ; Male ; Middle Aged ; Multivariate Analysis ; Parenteral Nutrition, Total/adverse effects ; Parenteral Nutrition, Total/mortality ; Retrospective Studies ; Risk Factors
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2009-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc09-1748
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