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  1. Article ; Online: Expert Commentary on Ileoanal Pouch Construction for IBD.

    Spinelli, Antonino

    Diseases of the colon and rectum

    2024  Volume 67, Issue 6, Page(s) 753–754

    MeSH term(s) Humans ; Colonic Pouches/adverse effects ; Proctocolectomy, Restorative/methods ; Proctocolectomy, Restorative/adverse effects ; Inflammatory Bowel Diseases/surgery ; Colitis, Ulcerative/surgery
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000003330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Conference proceedings: Artistry in Bronze: The Greeks and Their Legacy XIXth International Congress on Ancient Bronzes

    Spinelli, Ambra / Lapatin, Kenneth / Daehner, Jens M

    2017  

    Abstract: The papers in this volume derive from the proceedings of the nineteenth International Bronze Congress, held at the Getty Center and Villa in October 2015 in connection with the exhibition Power and Pathos: Bronze Sculpture of the Hellenistic World. The ... ...

    Abstract The papers in this volume derive from the proceedings of the nineteenth International Bronze Congress, held at the Getty Center and Villa in October 2015 in connection with the exhibition Power and Pathos: Bronze Sculpture of the Hellenistic World. The study of large-scale ancient bronzes has long focused on aspects of technology and production. Analytical work of materials, processes, and techniques has significantly enriched our understanding of the medium. Most recently, the restoration history of bronzes has established itself as a distinct area of investigation. How does this scholarship bear on the understanding of bronzes within the wider history of ancient art? How do these technical data relate to our ideas of styles and development? How has the material itself affected ancient and modern perceptions of form, value, and status of works of art?
    Keywords History of the arts
    Size 1 electronic resource (409 pages)
    Publisher Getty Publications
    Document type Book ; Online ; Conference proceedings
    Note English ; Open Access
    HBZ-ID HT020589426
    ISBN 9781606065426 ; 1606065424
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Commentary on: Salvage surgery is an effective alternative for J pouch afferent limb stricture treatment.

    Spinelli, Antonino / Carvello, Michele

    Surgery

    2023  Volume 174, Issue 4, Page(s) 758

    MeSH term(s) Humans ; Colonic Pouches ; Constriction, Pathologic/surgery ; Proctocolectomy, Restorative ; Postoperative Complications/surgery ; Salvage Therapy ; Colitis, Ulcerative/surgery ; Anastomosis, Surgical
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Legionella pneumonia in hospitalized adults with respiratory failure: Quinolones or macrolides?

    Ruiz-Spinelli, Alfonsina / Rello, Jordi

    European journal of internal medicine

    2023  Volume 120, Page(s) 62–68

    Abstract: The optimal antimicrobial regimen for adults with respiratory failure due to Legionella pneumonia remains controversial. A systematic review was performed to assess the impact on outcomes comparing quinolones versus macrolides. A literature search was ... ...

    Abstract The optimal antimicrobial regimen for adults with respiratory failure due to Legionella pneumonia remains controversial. A systematic review was performed to assess the impact on outcomes comparing quinolones versus macrolides. A literature search was conducted in PubMed, Cochrane Library and Web of Science between 2012 and 2022. It yielded 124 potentially articles and ten observational studies met the inclusion criteria. A total of 4271 patients were included, 2879 (67 %) were male. A total of 1797 (42 %) subjects required intensive care unit (ICU) admission and 942 (52 %) mechanical ventilation. Fluoroquinolones and macrolides alone were administered in 1397 (33 %) and 1500 (35 %) subjects, respectively; combined therapy in 204 (4.8 %) patients. Overall mortality was 7.4 % (319 patients), with no difference between antibiotics. When data from the three studies with severe pneumonia were pooled together, mortality with fluoroquinolones alone was statistically superior to macrolides alone (72.8 % vs 30.8 %, p value 0.027). Hospital length of stay and complications were comparable. Our findings suggest that macrolides and quinolones were comparable for hospitalized Legionella pneumonia. However, in severe pneumonia, a randomized clinical trial is an unmet clinical need. PROSPERO registration number: CRD42023389308.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Macrolides/therapeutic use ; Quinolones/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Legionnaires' Disease/complications ; Legionnaires' Disease/drug therapy ; Fluoroquinolones/therapeutic use ; Legionella ; Respiratory Insufficiency ; Randomized Controlled Trials as Topic
    Chemical Substances Macrolides ; Quinolones ; Anti-Bacterial Agents ; Fluoroquinolones
    Language English
    Publishing date 2023-09-18
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Advocating for the use of "near-TME" to describe a surgical technique: a plea to use consistent terminology.

    Garcia-Granero, A / Pellino, G / Spinelli, A / Gonzalez-Argente, X

    Techniques in coloproctology

    2023  Volume 27, Issue 5, Page(s) 427–428

    MeSH term(s) Humans ; Rectum/surgery ; Proctectomy ; Rectal Neoplasms/surgery ; Laparoscopy ; Treatment Outcome
    Language English
    Publishing date 2023-01-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-023-02754-w
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  6. Article ; Online: The rationale for expanding transanal transection and single-stapled anastomosis from transanal total mesorectal excision to open, laparoscopic and robotic resections.

    Spinelli, Antonino

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2019  Volume 21, Issue 9, Page(s) 991

    MeSH term(s) Anastomosis, Surgical ; Humans ; Laparoscopy ; Rectal Neoplasms/surgery ; Robotic Surgical Procedures ; Surgical Stapling ; Transanal Endoscopic Surgery
    Language English
    Publishing date 2019-09-13
    Publishing country England
    Document type Editorial
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5799: Show issues Location:
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  7. Article ; Online: COVID-19 pandemic: perspectives on an unfolding crisis.

    Spinelli, A / Pellino, G

    The British journal of surgery

    2020  Volume 107, Issue 7, Page(s) 785–787

    MeSH term(s) Ambulatory Care/methods ; Ambulatory Care/standards ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Critical Pathways ; Emergencies ; Global Health ; Health Care Rationing/methods ; Health Care Rationing/standards ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Surgical Procedures, Operative/methods ; Surgical Procedures, Operative/standards ; Telemedicine/methods ; Telemedicine/standards
    Keywords covid19
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11627
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  8. Article: Severe Legionnaires' disease.

    Rello, Jordi / Allam, Camille / Ruiz-Spinelli, Alfonsina / Jarraud, Sophie

    Annals of intensive care

    2024  Volume 14, Issue 1, Page(s) 51

    Abstract: Background: Legionnaires' disease (LD) is a common but under-diagnosed cause of community-acquired pneumonia (CAP), although rapid detection of urine antigen testing (UAT) and advances in molecular testing have improved the diagnosis. LD entails ... ...

    Abstract Background: Legionnaires' disease (LD) is a common but under-diagnosed cause of community-acquired pneumonia (CAP), although rapid detection of urine antigen testing (UAT) and advances in molecular testing have improved the diagnosis. LD entails intensive care unit (ICU) admission in almost one-third of cases, and the mortality rate ranges from 4% to 40%. This review aims to discuss recent advances in the study of this condition and to provide an update on the diagnosis, pathogenesis and management of severe LD.
    Results: The overall incidence of LD has increased worldwide in recent years due to the higher number of patients with risk factors, especially immunosuppression, and to improvements in diagnostic methods. Although LD is responsible for only around 5% of all-cause CAP, it is one of the three most common causes of CAP requiring ICU admission. Mortality in ICU patients, immunocompromised patients or patients with a nosocomial source of LD can reach 40% despite appropriate antimicrobial therapy. Regarding pathogenesis, no Legionella-specific virulence factors have been associated with severity; however, recent reports have found high pulmonary Legionella DNA loads, and impairments in immune response and lung microbiome in the most severe cases. The clinical picture includes severe lung injury requiring respiratory and/or hemodynamic support, extrapulmonary symptoms and non-specific laboratory findings. LD diagnostic methods have improved due to the broad use of UAT and the development of molecular methods allowing the detection of all Lp serogroups. Therapy is currently based on macrolides, quinolones, or a combination of the two, with prolonged treatment in severe cases.
    Conclusions: Numerous factors influence the mortality rate of LD, such as ICU admission, the underlying immune status, and the nosocomial source of the infection. The host immune response (hyperinflammation and/or immunoparalysis) may also be associated with increased severity. Given that the incidence of LD is rising, studies on specific biomarkers of severity may be of great interest. Further assessments comparing different regimens and/or evaluating host-directed therapies are nowadays needed.
    Language English
    Publishing date 2024-04-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-024-01252-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Severe community-acquired pneumonia in the post COVID-19 era.

    Ruiz-Spinelli, Alfonsina / Waterer, Grant / Rello, Jordi

    Current opinion in critical care

    2023  Volume 29, Issue 5, Page(s) 400–406

    Abstract: Purpose of review: The aim was to examine and summarize the most recent published literature in the last years stating the advances for treatment options and adjunctive therapies in patients hospitalized with severe community-acquired pneumonia (sCAP). ... ...

    Abstract Purpose of review: The aim was to examine and summarize the most recent published literature in the last years stating the advances for treatment options and adjunctive therapies in patients hospitalized with severe community-acquired pneumonia (sCAP). Search was performed in PubMed, including observational studies, randomized controlled trials, systematic reviews and meta-analyses, and international guidelines.
    Recent findings: Regardless of a large number of published CAP guidelines, most of their recommendations are based on low-level evidence.Viruses have an increasing role as sCAP etiology with an impact on mortality. Accordingly, it is imperative to strengthen the demand for vaccines and newer antivirals. Considering an early monitoring of the immune response in patients with severe Influenza, may help to evaluate a personalized immunomodulatory strategy. Despite growing evidence, the use of corticosteroids as an adjunctive therapy in bacterial sCAP continues to be controversial.
    Summary: Mortality due to sCAP still remains undesirably high. This fact strengthens the need for more high-quality research to increase evidence. It also highlights the need for clinicians to be aware of the level of evidence of the stated recommendations, taking this into consideration before decision making.
    MeSH term(s) Humans ; COVID-19 ; Pneumonia/drug therapy ; Community-Acquired Infections/drug therapy ; Immunomodulation ; Influenza, Human
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ureteric identification with indocyanine green fluorescence in laparoscopic redo pouch surgery.

    Foppa, C / Spinelli, A

    Techniques in coloproctology

    2018  Volume 22, Issue 8, Page(s) 627–628

    MeSH term(s) Colonic Pouches ; Coloring Agents ; Digestive System Surgical Procedures/adverse effects ; Humans ; Indocyanine Green ; Intraoperative Complications/diagnostic imaging ; Laparoscopy/methods ; Optical Imaging/methods ; Reoperation/methods ; Ureter/diagnostic imaging ; Ureter/injuries
    Chemical Substances Coloring Agents ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2018-08-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-018-1838-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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