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Article: [Clinical case: early connection of valsartan/sacubitril in the treatment of hypertension].

Lozhkina, N G / Spiridonov, A N

2022 Volume 62, Issue 5, Page(s) 72–74

Abstract: Metabolic syndrome is a disease the World Health Organization has called a new pandemic of the 21st century. Arterial hypertension is one of the criteria for this diagnosis and a determinant of damage to major target organs. The present clinical case ... ...

Abstract	Metabolic syndrome is a disease the World Health Organization has called a new pandemic of the 21st century. Arterial hypertension is one of the criteria for this diagnosis and a determinant of damage to major target organs. The present clinical case demonstrates an experience of treatment of arterial hypertension associated with metabolic syndrome with a valsartan/sacubitril molecular complex.
MeSH term(s)	Aminobutyrates/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Antihypertensive Agents/therapeutic use ; Biphenyl Compounds/pharmacology ; Biphenyl Compounds/therapeutic use ; Blood Pressure ; Double-Blind Method ; Drug Combinations ; Heart Failure/drug therapy ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Metabolic Syndrome/drug therapy ; Stroke Volume ; Tetrazoles/therapeutic use ; Valsartan/therapeutic use
Chemical Substances	Aminobutyrates ; Angiotensin Receptor Antagonists ; Antihypertensive Agents ; Biphenyl Compounds ; Drug Combinations ; Tetrazoles ; sacubitril (17ERJ0MKGI) ; Valsartan (80M03YXJ7I)
Language	Russian
Publishing date	2022-05-31
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	131029-x
ISSN	0022-9040
ISSN	0022-9040
DOI	10.18087/cardio.2022.5.n1977
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Article ; Online: Life rather than climate influences diversity at scales greater than 40 million years.

Spiridonov, Andrej / Lovejoy, Shaun

Nature

2022 Volume 607, Issue 7918, Page(s) 307–312

Abstract: The diversity of life on Earth is controlled by hierarchical processes that interact over wide ranges of ... ...

Abstract	The diversity of life on Earth is controlled by hierarchical processes that interact over wide ranges of timescales
MeSH term(s)	Animals ; Aquatic Organisms ; Biological Evolution ; Biota ; Climate ; Earth, Planet ; Extinction, Biological ; Seawater ; Temperature ; Time Factors
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04867-y
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Article: Analiz predoperatsionnykh faktorov riska degenerativnogo zabolevaniya smezhnogo segmenta posle vypolneniya transforaminal'nogo poyasnichnogo spondilodeza.

Byvaltsev, V A / Kalinin, A A / Pestryakov, Yu Ya / Spiridonov, A V

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko

2023 Volume 87, Issue 2, Page(s) 48–55

Abstract: Currently, there is no information on the combined effect of body mass index (BMI), age, gender, main spinal-pelvic parameters and parameters of adjacent functional spinal unit (FSU) degeneration according to magnetic resonance imaging on development of ... ...

Title translation	Analysis of preoperative risk factors of adjacent segment disease after transforaminal lumbar interbody fusion.
Abstract	Currently, there is no information on the combined effect of body mass index (BMI), age, gender, main spinal-pelvic parameters and parameters of adjacent functional spinal unit (FSU) degeneration according to magnetic resonance imaging on development of adjacent segment degenerative disease (ASDd). Objective: To evaluate the effect of preoperative biometric and instrumental parameters of adjacent FSU on the risk of ASDd after transforaminal lumbar interbody fusion and determine personalized neurosurgical approach. Material and methods: We retrospectively studied patients after single-level transforaminal lumbar interbody fusion (group I, Results: Paired correlation analysis established the main predictors of ASDd. Regression analysis determined absolute values of these predictors for each type of surgical intervention. Conclusion: Surgical intervention at the level of asymptomatic proximal adjacent segment is recommended as interspinous stabilization for moderate degenerative lesions, BMI <25 kg/m
MeSH term(s)	Humans ; Lordosis/diagnostic imaging ; Lordosis/surgery ; Lordosis/etiology ; Retrospective Studies ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Risk Factors ; Treatment Outcome
Language	Russian
Publishing date	2023-03-28
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	603458-5
ISSN	0042-8817
ISSN	0042-8817
DOI	10.17116/neiro20238702148
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Article: Longitudinal expansion fitness of brachiopod genera controlled by the Wilson cycle

Spiridonov, Andrej / Balakauskas, Lauras / Lovejoy, Shaun

Global and planetary change. 2022 Sept., v. 216

2022

Abstract: The brachiopods constitute one of the major components of the marine metazoan fossil record. On the other hand their apparent decline in importance in forming benthic communities through the Phanerozoic is one of the most striking macroevolutionary and ... ...

Abstract	The brachiopods constitute one of the major components of the marine metazoan fossil record. On the other hand their apparent decline in importance in forming benthic communities through the Phanerozoic is one of the most striking macroevolutionary and macroecological patterns. Here we analyzed changes in average latitudinal and longitudinal ranges – indices for success of spatial expansion of brachiopod genera – during post-Cambrian Phanerozoic, and compared their fluctuation and scaling behaviour to the changes in continental fragmentation. The results revealed that latitudinal ranges on the longest time scales were highly constrained, while longitudinal ranges shown persistent decrease. The scale-by-scale correlation analysis of Haar fluctuations revealed that there is positive functional dependence of longitudinal ranges at the longest time scales with continental fragmentation. Moreover the ratio of average longitudinal to latitudinal ranges was positively correlated to the continental fragmentation at all time scales. The long term minima in longitudinal ranges and the least elongated shapes in E-W direction of geographic ranges were found during the maximal amalgamation of the Pangaea during Triassic and Jurassic. The failure for brachiopods to regain the dominance in marine biosphere after P-Tr extinction should be related to the tectonic restrictions on their longitudinal ranges during the maximally supercontinental conditions of the planet. Therefore, the pattern exemplified by brachiopods shows that the spatial expansion success (fitness) of a major clade at an eon time scale could be a direct consequence of the multi-scale tectonic reconfigurations.
Keywords	Animalia ; Jurassic period ; Triassic period ; biosphere ; extinction ; fossils ; tectonics
Language	English
Dates of publication	2022-09
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2016967-X
ISSN	0921-8181
ISSN	0921-8181
DOI	10.1016/j.gloplacha.2022.103926
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Building the Bridge of Schr\"odinger

Gushchin, Nikita / Kolesov, Alexander / Mokrov, Petr / Karpikova, Polina / Spiridonov, Andrey / Burnaev, Evgeny / Korotin, Alexander

A Continuous Entropic Optimal Transport Benchmark

2023

Abstract: Over the last several years, there has been significant progress in developing neural solvers for the Schr\"odinger Bridge (SB) problem and applying them to generative modelling. This new research field is justifiably fruitful as it is interconnected ... ...

Abstract	Over the last several years, there has been significant progress in developing neural solvers for the Schr\"odinger Bridge (SB) problem and applying them to generative modelling. This new research field is justifiably fruitful as it is interconnected with the practically well-performing diffusion models and theoretically grounded entropic optimal transport (EOT). Still, the area lacks non-trivial tests allowing a researcher to understand how well the methods solve SB or its equivalent continuous EOT problem. We fill this gap and propose a novel way to create pairs of probability distributions for which the ground truth OT solution is known by the construction. Our methodology is generic and works for a wide range of OT formulations, in particular, it covers the EOT which is equivalent to SB (the main interest of our study). This development allows us to create continuous benchmark distributions with the known EOT and SB solutions on high-dimensional spaces such as spaces of images. As an illustration, we use these benchmark pairs to test how well existing neural EOT/SB solvers actually compute the EOT solution. Our code for constructing benchmark pairs under different setups is available at: https://github.com/ngushchin/EntropicOTBenchmark.
Keywords	Computer Science - Machine Learning
Subject code	006
Publishing date	2023-06-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: FIANCEE

Karpikova, Polina / Ekaterina, Radionova / Yaschenko, Anastasia / Spiridonov, Andrei / Kostyushko, Leonid / Fabbricatore, Riccardo / Ivakhnenko, Aleksei

Faster Inference of Adversarial Networks via Conditional Early Exits

2023

Abstract: Generative DNNs are a powerful tool for image synthesis, but they are limited by their computational load. On the other hand, given a trained model and a task, e.g. faces generation within a range of characteristics, the output image quality will be ... ...

Abstract	Generative DNNs are a powerful tool for image synthesis, but they are limited by their computational load. On the other hand, given a trained model and a task, e.g. faces generation within a range of characteristics, the output image quality will be unevenly distributed among images with different characteristics. It follows, that we might restrain the models complexity on some instances, maintaining a high quality. We propose a method for diminishing computations by adding so-called early exit branches to the original architecture, and dynamically switching the computational path depending on how difficult it will be to render the output. We apply our method on two different SOTA models performing generative tasks: generation from a semantic map, and cross-reenactment of face expressions; showing it is able to output images with custom lower-quality thresholds. For a threshold of LPIPS <=0.1, we diminish their computations by up to a half. This is especially relevant for real-time applications such as synthesis of faces, when quality loss needs to be contained, but most of the inputs need fewer computations than the complex instances. Comment: 12 pages, 22 figures
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence
Subject code	006
Publishing date	2023-04-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relations between the Leukocyte Profile and the Energy State, Hematocrit, and Blood Metabolites in the Great Tit (Parus major)

Volkova, A. A. / Berezantseva, M. S. / Afonov, K. I. / Spiridonov, A. V. / Polikarpova, D. R. / Zhukova, E. A. / Demina, I. V. / Tsvey, A. L.

Biol Bull Russ Acad Sci. 2022 Dec., v. 49, no. 8 p.1171-1185

2022

Abstract: The health of animal populations can reflect ongoing changes in their environment. Various physiological parameters can be used to assess individual and population conditions. These parameters may be interrelated or independent, allowing for organisms to ...

Abstract	The health of animal populations can reflect ongoing changes in their environment. Various physiological parameters can be used to assess individual and population conditions. These parameters may be interrelated or independent, allowing for organisms to respond flexibly to environmental changes. We investigated the dynamics of the leukocyte profile (total number and relative proportions of various types of leukocytes) in an urban population of the Great tit (Parus major) during two stages of the annual cycle: autumn migration and wintering. We also analyzed the relations between the leukocyte profile and the energy state, hematocrit, and the levels of blood metabolites (glucose and β-hydroxybutyrate). We found the total number of leukocytes and lymphocytes to be higher during autumn migration compared to wintering, which indicates a more active state of the immune system in Great tits during migration. An increased number of lymphocytes (specific immunity) can reflect high probability of encountering already familiar infections during the relatively short-distance migrations typical for this species. The ratio of heterophils to lymphocytes (H : L ratio, a measure of long-term physiological stress) in this population was higher in winter than during autumn migration. We assume that this may be caused by low temperatures and increased competition for food in wintering birds. The total number of leukocytes correlated positively with energy reserves and negatively with the blood glucose level, possibly indicating a coordinated response of these physiological parameters to environmental cues. Our results also show that birds that have adequate energy reserves and low blood glucose concentrations (i.e., are in good condition) maintain a more active immune system. Reduced energy reserves (e.g., due to unfavorable feeding conditions, higher energy costs of both locomotor activity and thermogenesis in cold weather) caused an increase in blood glucose concentrations and a decrease in the number of leukocytes. The H : L ratio was not correlated with other physiological parameters, showing that the level of long-term physiological stress was related to neither the individual energetic condition nor the level of metabolism in Great tits under the observed environmental conditions. Taken together, our results show a low level of long-term physiological stress in the studied population of Great tits.
Keywords	Parus major ; autumn ; blood glucose ; bulls ; cold ; energy ; glucose ; heat production ; hematocrit ; heterophils ; immunity ; locomotion ; metabolism ; metabolites ; probability ; urban population ; weather ; winter
Language	English
Dates of publication	2022-12
Size	p. 1171-1185.
Publishing place	Pleiades Publishing
Document type	Article ; Online
ZDB-ID	1161709-3
ISSN	1062-3590
ISSN	1062-3590
DOI	10.1134/S1062359022080222
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Article: Time hierarchical analysis of the conodont paleocommunities and environmental change before and during the onset of the lower Silurian Mulde bioevent – A preliminary report

Spiridonov, Andrej / Antanas Brazauskas / Donatas Kaminskas / Sigitas Radzevičius

Global and planetary change. 2017 Oct., v. 157

2017

Abstract: The Silurian period, and the Wenlock epoch in particular, experienced a series of powerful bioevents, among which was the Mulde event (upper Homerian). Here, the results of a study of the mid- to late Wenlock conodont paleocommunities in the shallow ... ...

Abstract	The Silurian period, and the Wenlock epoch in particular, experienced a series of powerful bioevents, among which was the Mulde event (upper Homerian). Here, the results of a study of the mid- to late Wenlock conodont paleocommunities in the shallow platform environments of the Lithuanian part of the Silurian Baltic Basin are presented. The analyses are based on a detailed quantitative description of the abundance and diversity patterns of the conodonts, as well as the geochemical and geophysical environmental proxies in the Ledai-179 core (central Lithuania). A model selection analysis of the conodont rank abundance distributions revealed episodic and progressive change from the complex communities of the early Jaagarahu time (lower Homerian), to the simple and much more even communities of the early Gėluva time (lower part of the upper Homerian). Spectral and cross-spectral analyses of the conodont species' apparent richness, evenness and abundance, as well as the δ13C and natural gamma ray trends, revealed transient episodes of 5th order periodic fluctuations. It is shown that the transitions in the community states and the transient episodes of the oscillations approximately coincided with the onset of the Mulde event (latest Jaagarahu and early Gėluva time).
Keywords	basins ; carbon ; gamma radiation ; geochemistry ; geophysics ; models ; paleoecology ; Wenlock epoch ; Lithuania
Language	English
Dates of publication	2017-10
Size	p. 153-164.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2016967-X
ISSN	0921-8181
ISSN	0921-8181
DOI	10.1016/j.gloplacha.2017.09.002
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Article: Quantifying the community turnover of the uppermost Wenlock and Ludlow (Silurian) conodonts in the Baltic Basin

Spiridonov, Andrej / Jovita Samsonė / Antanas Brazauskas / Robertas Stankevič / Tõnu Meidla / Leho Ainsaar / Sigitas Radzevičius

Palaeogeography, palaeoclimatology, palaeoecology. 2019 Mar. 18,

2019

Abstract: The Homerian to Ludfordian interval of the mid to late Silurian Period was a time of significant changes in conodont communities, global climate, oceanographic patterns and biogeochemical cycles. The Mulde and the Lau events are preeminent examples of ... ...

Abstract	The Homerian to Ludfordian interval of the mid to late Silurian Period was a time of significant changes in conodont communities, global climate, oceanographic patterns and biogeochemical cycles. The Mulde and the Lau events are preeminent examples of globally recognized conodont extinction episodes from this interval in Earth's history. The Silurian Baltic Basin is the most suitable locality, globally, for studying these perturbations to the ocean-atmosphere system, since there is an extensive record of conodont taxa occurrences, their communities, and their environments spanning across shore-face to open-ocean settings. In this study, we present new conodont and δ13C data from the upper Homerian to Ludlow interval from two core sections – Gėluva-99 and Gėluva-118, representing shelfal environments, and the numerical conodont data from the Viduklė-61 section, from deep-water settings, and compare them with patterns of conodont diversity change, as revealed in the data-rich Milaičiai-103 core section. For this purpose, we explored the stratigraphically tied time series of conodont diversity changes employing recurrence and cross-recurrence plots – the binary similarity matrices that are used for deciphering complex spatial and temporal dynamic patterns. The cross-recurrence plots were used as a means of synchronizing the geological sections by applying dynamic time warping and the newly described moving window median recurrence point search algorithms. The results revealed that the conodont community compositional data are sufficiently temporally and spatially coherent to be reasonably used for synchronizing geological records. Moreover, the sudden state transitions detected in the cross-recurrence plots suggest that the Lau Event was of great importance for conodont community evolution in the studied time slice.
Keywords	Ludlow epoch ; Wenlock epoch ; algorithms ; basins ; biogeochemical cycles ; carbon ; climate ; extinction ; stable isotopes ; time series analysis
Language	English
Dates of publication	2019-0318
Size	p. .
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	417718-6
ISSN	0031-0182
ISSN	0031-0182
DOI	10.1016/j.palaeo.2019.03.029
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Holocene vegetation patterns in southern Lithuania indicate astronomical forcing on the millennial and centennial time scales.

Spiridonov, Andrej / Balakauskas, Lauras / Stankevič, Robertas / Kluczynska, Gražyna / Gedminienė, Laura / Stančikaitė, Miglė

Scientific reports

2019 Volume 9, Issue 1, Page(s) 14711

Abstract: The Earth's biota originated and developed to its current complex state through interacting with multilevel physical forcing of our planet's climate and near and outer space phenomena. In the present study, we focus on the time scale of hundreds to ... ...

Abstract	The Earth's biota originated and developed to its current complex state through interacting with multilevel physical forcing of our planet's climate and near and outer space phenomena. In the present study, we focus on the time scale of hundreds to thousands of years in the most recent time interval - the Holocene. Using a pollen paleocommunity dataset from southern Lithuania (Čepkeliai bog) and applying spectral analysis techniques, we tested this record for the presence of statistically significant cyclicities, which can be observed in past solar activity. The time series of non-metric multidimensional scaling (NMDS) scores, which in our case are assumed to reflect temperature variations, and Tsallis entropy-related community compositional diversity estimates q* revealed the presence of cycles on several time scales. The most consistent periodicities are characterized by periods lasting between 201 and 240 years, which is very close to the DeVries solar cycles (208 years). A shorter-term periodicity of 176 years was detected in the NMDS scores that can be putatively linked to the subharmonics of the Gleissberg solar cycle. In addition, periodicities of ≈3,760 and ≈1,880 years were found in both parameters. These periodic patterns could be explained either as originating as a harmonic nonlinear response to precession forcing, or as resulting from the long-term solar activity quasicycles that were reported in previous studies of solar activity proxies.
Language	English
Publishing date	2019-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-51321-7
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