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  1. Article ; Online: A rose is a rose is a rose, or not.

    Spitalnik, Steven L

    Blood

    2019  Volume 134, Issue 13, Page(s) 995–996

    MeSH term(s) Erythrocyte Transfusion ; Hemoglobins ; Humans
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2019-09-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019002592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The senescent antigen hypothesis of RBC evanescence: 50 years of correlation without causation.

    Zimring, James C / Spitalnik, Steven L / Hudson, Krystalyn E

    Transfusion

    2022  Volume 62, Issue 11, Page(s) 2414–2415

    MeSH term(s) Humans ; Erythrocyte Aging ; Erythrocytes
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Conquering erythroblastosis fetalis: 50 years of RhIG.

    Vossoughi, Sarah / Spitalnik, Steven L

    Transfusion

    2019  Volume 59, Issue 7, Page(s) 2195–2196

    MeSH term(s) Erythroblastosis, Fetal/history ; Erythroblastosis, Fetal/prevention & control ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Pregnancy ; Rho(D) Immune Globulin/history
    Chemical Substances Rho(D) Immune Globulin
    Language English
    Publishing date 2019-07-03
    Publishing country United States
    Document type Historical Article ; Journal Article ; Portrait
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.15307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring unconventional attributes of red blood cells and their potential applications in biomedicine.

    Anastasiadi, Alkmini T / Arvaniti, Vasiliki-Zoi / Hudson, Krystalyn E / Kriebardis, Anastasios G / Stathopoulos, Constantinos / D'Alessandro, Angelo / Spitalnik, Steven L / Tzounakas, Vassilis L

    Protein & cell

    2024  

    Language English
    Publishing date 2024-01-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2543451-2
    ISSN 1674-8018 ; 1674-8018
    ISSN (online) 1674-8018
    ISSN 1674-8018
    DOI 10.1093/procel/pwae001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hitchhiker's guide to the red blood cell storage lesion.

    Thomas, Tiffany / Spitalnik, Steven L

    Blood transfusion = Trasfusione del sangue

    2019  Volume 17, Issue 1, Page(s) 1–3

    MeSH term(s) Blood Preservation ; Erythrocytes ; Humans
    Language English
    Publishing date 2019-01-09
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/2019.0257-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Translating red cell "omics" into new perspectives in transfusion medicine: mining the gems in the data mountains.

    Spitalnik, Steven L / Devine, Dana V

    Transfusion

    2019  Volume 59, Issue 1, Page(s) 2–5

    MeSH term(s) Erythrocyte Transfusion ; Erythrocytes ; Personnel Selection ; Sweat ; Transfusion Medicine
    Language English
    Publishing date 2019-01-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.15066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Stored red blood cell transfusions: iron, inflammation, immunity, and infection.

    Spitalnik, Steven L

    Transfusion

    2014  Volume 54, Issue 10, Page(s) 2365–2371

    Abstract: Emily Cooley was a highly regarded medical technologist and morphologist. The "Emily Cooley Lectureship and Award" was established to honor her, in particular, and medical technologists, in general. This article reviews some basic concepts about the " ... ...

    Abstract Emily Cooley was a highly regarded medical technologist and morphologist. The "Emily Cooley Lectureship and Award" was established to honor her, in particular, and medical technologists, in general. This article reviews some basic concepts about the "life of a red blood cell" (RBC) and uses these to discuss the actual and potential consequences that occur in patients after clearance of transfused refrigerator storage-damaged RBCs by extravascular hemolysis.
    MeSH term(s) Animals ; Blood Preservation/adverse effects ; Blood Preservation/methods ; Erythrocyte Transfusion ; Erythrocytes/physiology ; Hemolysis/physiology ; Humans ; Immunity/physiology ; Infections/blood ; Infections/transmission ; Inflammation/blood ; Iron/blood
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2014-09-04
    Publishing country United States
    Document type Journal Article ; Lecture ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.12848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Iron: a double-edged sword.

    Youssef, Lyla A / Spitalnik, Steven L

    Transfusion

    2017  Volume 57, Issue 10, Page(s) 2293–2297

    MeSH term(s) Anemia/therapy ; Animals ; Critical Illness ; Disease Models, Animal ; Dogs ; Erythrocyte Transfusion ; Humans ; Iron/therapeutic use
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2017-09-09
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.14296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transfusion-related immunomodulation: a reappraisal.

    Youssef, Lyla A / Spitalnik, Steven L

    Current opinion in hematology

    2017  Volume 24, Issue 6, Page(s) 551–557

    Abstract: Purpose of review: This review summarizes current and prior observations regarding transfusion-related immunomodulation (TRIM) and puts these ideas into a modern immunological context, incorporating concepts from innate, adaptive, and nutritional ... ...

    Abstract Purpose of review: This review summarizes current and prior observations regarding transfusion-related immunomodulation (TRIM) and puts these ideas into a modern immunological context, incorporating concepts from innate, adaptive, and nutritional immunity. We propose that TRIM research focus on determining whether there are specific, well-defined immunosuppressive effects from transfusing 'pure' red blood cells (RBCs) themselves, along with the by-products produced by the stored RBCs as a result of the 'storage lesion.' Macrophages are a key cell type involved in physiological and pathological RBC clearance and iron recycling. The plasticity and diversity of macrophages makes these cells potential mediators of immune suppression that could constitute TRIM.
    Recent findings: Recent reports identified the capacity of macrophages and monocytes to exhibit 'memory.' Exposure to various stimuli, such as engulfment of apoptotic cells and interactions with ß-glucan and lipopolysaccharide, were found to induce epigenetic, metabolic, and functional changes in certain myeloid cells, particularly macrophages and monocytes.
    Summary: Macrophages may mediate the immunosuppressive aspects of TRIM that arise as a result of transfused RBCs and their storage lesion induced by-products.
    MeSH term(s) Blood Preservation ; Erythrocyte Transfusion ; Erythrocytes/immunology ; Humans ; Immune Tolerance ; Immunosuppression ; Macrophages/immunology
    Language English
    Publishing date 2017-08-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Large retrospective effects, clear differences in animals, and multiple negative randomised controlled trials: this is exactly how it is supposed to work.

    Zimring, James C / Spitalnik, Steven L

    Blood transfusion = Trasfusione del sangue

    2017  Volume 15, Issue 2, Page(s) 104–106

    Language English
    Publishing date 2017
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2135732-8
    ISSN 1723-2007 ; 0041-1787
    ISSN 1723-2007 ; 0041-1787
    DOI 10.2450/2017.0307-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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