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  1. Article ; Online: KCC2-Mediated Cl

    Spoljaric, Inkeri / Spoljaric, Albert / Mavrovic, Martina / Seja, Patricia / Puskarjov, Martin / Kaila, Kai

    Cell reports

    2019  Volume 26, Issue 5, Page(s) 1073–1081.e3

    Abstract: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that ... ...

    Abstract It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl
    MeSH term(s) Action Potentials/drug effects ; Animals ; Animals, Newborn ; Chlorides/metabolism ; Hippocampus/metabolism ; Mice, Inbred ICR ; Pyramidal Cells/metabolism ; Rats, Wistar ; Symporters/metabolism ; gamma-Aminobutyric Acid/pharmacology ; K Cl- Cotransporters
    Chemical Substances Chlorides ; Symporters ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density.

    Bertling, Enni / Blaesse, Peter / Seja, Patricia / Kremneva, Elena / Gateva, Gergana / Virtanen, Mari A / Summanen, Milla / Spoljaric, Inkeri / Uvarov, Pavel / Blaesse, Michael / Paavilainen, Ville O / Vutskits, Laszlo / Kaila, Kai / Hotulainen, Pirta / Ruusuvuori, Eva

    EMBO reports

    2021  Volume 22, Issue 4, Page(s) e50145

    Abstract: Intracellular pH is a potent modulator of neuronal functions. By catalyzing (de)hydration of ... ...

    Abstract Intracellular pH is a potent modulator of neuronal functions. By catalyzing (de)hydration of CO
    MeSH term(s) Actin Cytoskeleton/metabolism ; Actins/genetics ; Actins/metabolism ; Carbonic Anhydrases/genetics ; Dendritic Spines/metabolism ; Hippocampus/metabolism ; Neurons/metabolism
    Chemical Substances Actins ; Carbonic Anhydrases (EC 4.2.1.1)
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202050145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

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  3. Article ; Online: Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth.

    Spoljaric, Albert / Seja, Patricia / Spoljaric, Inkeri / Virtanen, Mari A / Lindfors, Jenna / Uvarov, Pavel / Summanen, Milla / Crow, Ailey K / Hsueh, Brian / Puskarjov, Martin / Ruusuvuori, Eva / Voipio, Juha / Deisseroth, Karl / Kaila, Kai

    Proceedings of the National Academy of Sciences of the United States of America

    2017  Volume 114, Issue 50, Page(s) E10819–E10828

    Abstract: During birth in mammals, a pronounced surge of fetal peripheral stress hormones takes place to promote survival in the transition to the extrauterine environment. However, it is not known whether the hormonal signaling involves central pathways with ... ...

    Abstract During birth in mammals, a pronounced surge of fetal peripheral stress hormones takes place to promote survival in the transition to the extrauterine environment. However, it is not known whether the hormonal signaling involves central pathways with direct protective effects on the perinatal brain. Here, we show that arginine vasopressin specifically activates interneurons to suppress spontaneous network events in the perinatal hippocampus. Experiments done on the altricial rat and precocial guinea pig neonate demonstrated that the effect of vasopressin is not dependent on the level of maturation (depolarizing vs. hyperpolarizing) of postsynaptic GABA
    MeSH term(s) Animals ; Brain/embryology ; Brain/growth & development ; Evoked Potentials ; Female ; Guinea Pigs ; Hippocampus/embryology ; Hippocampus/growth & development ; Hippocampus/physiology ; Interneurons/physiology ; Male ; Nerve Net/physiology ; Parturition ; Rats ; Rats, Wistar ; Vasopressins/physiology ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Vasopressins (11000-17-2) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2017-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1717337114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Corrigendum to "Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's antiseizure efficacy" [Neuropharmacology 143 (2018) 186-204].

    Brandt, Claudia / Seja, Patricia / Töllner, Kathrin / Römermann, Kerstin / Hampel, Philip / Kalesse, Markus / Kipper, Andi / Feit, Peter W / Lykke, Kasper / Toft-Bertelsen, Trine Lisberg / Paavilainen, Pauliina / Spoljaric, Inkeri / Puskarjov, Martin / MacAulay, Nanna / Kaila, Kai / Löscher, Wolfgang

    Neuropharmacology

    2018  Volume 143, Page(s) 349–350

    Language English
    Publishing date 2018-10-19
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2018.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.242: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy.

    Brandt, Claudia / Seja, Patricia / Töllner, Kathrin / Römermann, Kerstin / Hampel, Philip / Kalesse, Markus / Kipper, Andi / Feit, Peter W / Lykke, Kasper / Toft-Bertelsen, Trine Lisberg / Paavilainen, Pauliina / Spoljaric, Inkeri / Puskarjov, Martin / MacAulay, Nanna / Kaila, Kai / Löscher, Wolfgang

    Neuropharmacology

    2018  Volume 143, Page(s) 186–204

    Abstract: Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and NKCC2, has been tested as an adjunct with phenobarbital to suppress seizures. However, because of ...

    Abstract Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and NKCC2, has been tested as an adjunct with phenobarbital to suppress seizures. However, because of its physicochemical properties, bumetanide only poorly penetrates through the blood-brain barrier. Thus, concentrations needed to inhibit NKCC1 in hippocampal and neocortical neurons are not reached when using doses (0.1-0.5 mg/kg) in the range of those approved for use as a diuretic in humans. This prompted us to search for a bumetanide derivative that more easily penetrates into the brain. Here we show that bumepamine, a lipophilic benzylamine derivative of bumetanide, exhibits much higher brain penetration than bumetanide and is more potent than the parent drug to potentiate phenobarbital's anticonvulsant effect in two rodent models of chronic difficult-to-treat epilepsy, amygdala kindling in rats and the pilocarpine model in mice. However, bumepamine suppressed NKCC1-dependent giant depolarizing potentials (GDPs) in neonatal rat hippocampal slices much less effectively than bumetanide and did not inhibit GABA-induced Ca
    MeSH term(s) Animals ; Anticonvulsants/chemical synthesis ; Anticonvulsants/chemistry ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/pharmacology ; Benzylamines/chemical synthesis ; Benzylamines/chemistry ; Benzylamines/pharmacokinetics ; Benzylamines/pharmacology ; Brain/drug effects ; Brain/metabolism ; Bumetanide/analogs & derivatives ; Bumetanide/chemistry ; Bumetanide/pharmacokinetics ; Bumetanide/pharmacology ; Drug Evaluation, Preclinical ; Drug Synergism ; Epilepsy/drug therapy ; Epilepsy/metabolism ; Female ; Mice ; Oocytes ; Phenobarbital/pharmacokinetics ; Phenobarbital/pharmacology ; Rats, Wistar ; Seizures/drug therapy ; Seizures/metabolism ; Sodium Potassium Chloride Symporter Inhibitors/chemistry ; Sodium Potassium Chloride Symporter Inhibitors/pharmacokinetics ; Sodium Potassium Chloride Symporter Inhibitors/pharmacology ; Solute Carrier Family 12, Member 2/metabolism ; Tissue Culture Techniques ; Xenopus laevis
    Chemical Substances Anticonvulsants ; Benzylamines ; Bumepamine ; Sodium Potassium Chloride Symporter Inhibitors ; Solute Carrier Family 12, Member 2 ; Bumetanide (0Y2S3XUQ5H) ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2018-09-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2018.09.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.242: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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