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  1. Article ; Online: Follow-up von spheno-orbitalen Meningeomen--wie und wie lange?

    Spuler, A

    HNO

    2010  Volume 58, Issue 1, Page(s) 35–36

    Title translation Spheno-orbital meningiomas: how to follow up and for how long?.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Meningioma/diagnosis ; Meningioma/therapy ; Middle Aged ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/therapy ; Skull Neoplasms/diagnosis ; Skull Neoplasms/therapy ; Sphenoid Bone ; Time Factors ; Treatment Outcome
    Language German
    Publishing date 2010-01-13
    Publishing country Germany
    Document type Comment ; Journal Article
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-009-2047-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Zur Kopplung von Energiestoffwechsel und neuronaler Kaliumleitfähigkeit

    Spuler, Andreas

    1989  

    Keywords Hippocampus / metabolism ; Glucose / metabolism ; Oxygen / deficiency ; Adenosine / physiology ; Potassium / physiology ; Potassium Channels / metabolism ; Na(+)-K(+)-Exchanging ATPase / physiology ; Electric Conductivity ; Rats ; Guinea Pigs
    Size 82 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1989
    HBZ-ID HT003605250
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Follow-up von sphenoorbitalen Meningeomen - wie und wie lange? Spheno-orbital meningiomas. How to follow up and for how long?

    Spuler, A.

    HNO

    2010  Volume 58, Issue 1, Page(s) 35

    Language German
    Document type Article
    ZDB-ID 200040-4
    ISSN 0017-6192
    Database Current Contents Medicine

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  4. Article ; Online: Geometric uncertainty in intracranial aneurysm rupture status discrimination: a two-site retrospective study.

    Hellmeier, Florian / Brüning, Jan / Berg, Philipp / Saalfeld, Sylvia / Spuler, Andreas / Sandalcioglu, Ibrahim Erol / Beuing, Oliver / Larsen, Naomi / Schaller, Jens / Goubergrits, Leonid

    BMJ open

    2022  Volume 12, Issue 11, Page(s) e063051

    Abstract: Objectives: Assessing the risk associated with unruptured intracranial aneurysms (IAs) is essential in clinical decision making. Several geometric risk parameters have been proposed for this purpose. However, performance of these parameters has been ... ...

    Abstract Objectives: Assessing the risk associated with unruptured intracranial aneurysms (IAs) is essential in clinical decision making. Several geometric risk parameters have been proposed for this purpose. However, performance of these parameters has been inconsistent. This study evaluates the performance and robustness of geometric risk parameters on two datasets and compare it to the uncertainty inherent in assessing these parameters and quantifies interparameter correlations.
    Methods: Two datasets containing 244 ruptured and unruptured IA geometries from 178 patients were retrospectively analysed. IAs were stratified by anatomical region, based on the PHASES score locations. 37 geometric risk parameters representing four groups (size, neck, non-dimensional, and curvature parameters) were assessed. Analysis included standardised absolute group differences (SADs) between ruptured and unruptured IAs, ratios of SAD to median relative uncertainty (MRU) associated with the parameters, and interparameter correlation.
    Results: The ratio of SAD to MRU was lower for higher dimensional size parameters (ie, areas and volumes) than for one-dimensional size parameters. Non-dimensional size parameters performed comparatively well with regard to SAD and MRU. SAD was higher in the posterior anatomical region. Correlation of parameters was strongest within parameter (sub)groups and between size and curvature parameters, while anatomical region did not strongly affect correlation patterns.
    Conclusion: Non-dimensional parameters and few parameters from other groups were comparatively robust, suggesting that they might generalise better to other datasets. The data on discriminative performance and interparameter correlations presented in this study may aid in developing and choosing robust geometric parameters for use in rupture risk models.
    MeSH term(s) Humans ; Intracranial Aneurysm ; Retrospective Studies ; Uncertainty ; Aneurysm, Ruptured ; Neck ; Risk Factors ; Cerebral Angiography/methods
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-063051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reproducibility of image-based analysis of cerebral aneurysm geometry and hemodynamics: an in-vitro study of magnetic resonance imaging, computed tomography, and three-dimensional rotational angiography.

    Goubergrits, L / Schaller, J / Kertzscher, U / Petz, Ch / Hege, H-Ch / Spuler, A

    Journal of neurological surgery. Part A, Central European neurosurgery

    2013  Volume 74, Issue 5, Page(s) 294–302

    Abstract: Background and study aims: Image-based computational fluid dynamics (CFD) provides a means for analysis of biofluid mechanical parameters of cerebral aneurysms. This may enable patient-specific rupture risk analysis and facilitate treatment decisions. ... ...

    Abstract Background and study aims: Image-based computational fluid dynamics (CFD) provides a means for analysis of biofluid mechanical parameters of cerebral aneurysms. This may enable patient-specific rupture risk analysis and facilitate treatment decisions. Application of different imaging methods may, however, alter the geometrical basis of these studies. The present study compares geometry and hemodynamics of an aneurysm phantom model acquired by means of magnetic resonance imaging (MRI), computed tomography (CT), and rotational angiography (3DRA).
    Materials and methods: The phantom model of a basilaris artery aneurysm was fabricated based on data generated by CT angiography. This model underwent imaging by means of CT, MRI, and 3DRA. We compared the geometrical reconstructions using the original dataset with those obtained from CT, MRI, and 3DRA. Similarly, CFD analyses were performed using the four reconstructions (3DRA, MRI, CT, and original dataset).
    Results: MRI and the 3DRA-based reconstructions yield mean reconstruction errors of 0.097 mm and 0.1 mm, which are by a factor of 2.5 better than the CT reconstruction. The maximal error for the aneurysm radius (7.11 mm) measurement was found in the 3DRA reconstruction and was 3.8% (0.28 mm). A comparison of calculated time-averaged wall shear stress (WSS) shows good correlations for the entire surface and, separately, for the surface of the aneurysmal sack. The maximal error of 8% of the mean WSS calculation of the whole surface was found for the CT reconstruction. The calculations of the aneurysmal sack mean WSS from the MRI reconstruction were estimated to have a maximal error of 7%.
    Conclusion: All three imaging techniques (CT, MRI, 3DRA) adequately reproduce aneurysm geometry and allow meaningful CFD analyses.
    MeSH term(s) Aged ; Cerebral Angiography/methods ; Cerebrovascular Circulation/physiology ; Female ; Hemodynamics/physiology ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Intracranial Aneurysm/pathology ; Intracranial Aneurysm/physiopathology ; Magnetic Resonance Angiography/methods ; Phantoms, Imaging ; Reproducibility of Results ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2013-09
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2651663-9
    ISSN 2193-6323 ; 2193-6315
    ISSN (online) 2193-6323
    ISSN 2193-6315
    DOI 10.1055/s-0033-1342937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Completely ossified pseudomeningocele, a rare complication after spinal surgery.

    Youssef, F / Markovic, D / López, H / Spuler, A / Kiwit, J

    Central European neurosurgery

    2009  Volume 70, Issue 4, Page(s) 211–213

    Abstract: Background: We report the rare case of an ossified pseudomeningocele following laminectomy. The extradural pseudocyst has completely ossified without an overt communication to the subarachnoid space.: Case report: In 1986, a 41 year-old woman ... ...

    Abstract Background: We report the rare case of an ossified pseudomeningocele following laminectomy. The extradural pseudocyst has completely ossified without an overt communication to the subarachnoid space.
    Case report: In 1986, a 41 year-old woman suffered from spinal stenosis at levels L3-5 and was treated by laminectomy. A cerebrospinal fluid (CSF) leakage was observed postoperatively. A follow-up CT scan eleven years after surgery showed an ossified pseudomeningocele in the operated region. However, in our case no surgical resection was performed since the patient suffered only from diffuse back pain without sciatica or any neurological deficit. In 2009 the patient continues to be neurologically intact without a change in clinical complaints. Hence, the file was closed after 23 years without neurosurgical intervention.
    Discussion: Seven cases of ossified pseudomeningocele have been previously described in the literature and all were operated on. However, our case shows that ossified extradural pseudocysts do not require operation in every case.
    MeSH term(s) Adult ; Back Pain/etiology ; Dura Mater/pathology ; Female ; Humans ; Laminectomy ; Meningocele/etiology ; Meningocele/pathology ; Neurosurgical Procedures ; Ossification, Heterotopic/etiology ; Ossification, Heterotopic/pathology ; Postoperative Complications/etiology ; Postoperative Complications/pathology ; Spinal Stenosis/surgery ; Spine/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2009-11
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2041774-3
    ISSN 1868-4912 ; 1438-9746 ; 0044-4251
    ISSN (online) 1868-4912 ; 1438-9746
    ISSN 0044-4251
    DOI 10.1055/s-0029-1224160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Images in clinical medicine. Astrocytoma following the pyramidal tract.

    Spuler, A / Atkinson, J L

    The New England journal of medicine

    2000  Volume 343, Issue 23, Page(s) 1702

    MeSH term(s) Astrocytoma/complications ; Astrocytoma/pathology ; Brain Neoplasms/complications ; Brain Neoplasms/pathology ; Fatal Outcome ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Paresis/etiology ; Pyramidal Tracts/pathology
    Language English
    Publishing date 2000-12-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM200012073432306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Retroperitoneal paravertebral ganglioneuroma: a multidisciplinary approach facilitates less radical surgery.

    Paasch, Christoph / Harder, Anja / Gatzky, Esther Jasmin / Ghadamgahi, Ehssan / Spuler, Andreas / Siegel, Robert

    World journal of surgical oncology

    2016  Volume 14, Issue 1, Page(s) 194

    Abstract: Background: Ganglioneuroma (GN) of the adult is a rare benign tumour originating from neural crest-derived cells. In most cases, GN is found in the mediastinum or retroperitoneum incidentally and may present with unspecific symptoms caused by space- ... ...

    Abstract Background: Ganglioneuroma (GN) of the adult is a rare benign tumour originating from neural crest-derived cells. In most cases, GN is found in the mediastinum or retroperitoneum incidentally and may present with unspecific symptoms caused by space-occupying effects. The correct diagnosis of a retroperitoneal mass is still a challenge. Nevertheless, a preoperatively confirmed diagnosis of GN may support the concept of a less radical approach and may help to prevent unnecessary morbidity or loss of function.
    Case presentation: We report a case of a symptomatic retroperitoneal paravertebral GN in a 33-year-old woman. She has been referred with abdominal discomfort, lancinating pain in the right leg, headache and nausea. Magnetic resonance imaging revealed a solid paravertebral tumour adjacent to the psoas muscle. Computed tomography-guided core needle biopsy yielded the diagnosis of GN. The tumour was resected completely via a laparotomy. Immunohistopathological examinations confirmed a benign GN.
    Conclusions: Diagnostic studies and therapeutic interventions of retroperitoneal GN are discussed. In our case, a core needle biopsy preceding complete resection was helpful to prevent too extensive surgical approach.
    MeSH term(s) Adult ; Biopsy, Large-Core Needle ; Cancer Pain/etiology ; Female ; Ganglioneuroma/blood ; Ganglioneuroma/diagnosis ; Ganglioneuroma/diagnostic imaging ; Ganglioneuroma/surgery ; Hot Flashes/etiology ; Humans ; Image-Guided Biopsy ; Laparotomy ; Magnetic Resonance Imaging ; Microsurgery ; Retroperitoneal Neoplasms/blood ; Retroperitoneal Neoplasms/diagnosis ; Retroperitoneal Neoplasms/diagnostic imaging ; Retroperitoneal Neoplasms/surgery ; Retroperitoneal Space/pathology ; Retroperitoneal Space/surgery ; Tomography, X-Ray Computed ; Ultrasonography ; Watchful Waiting
    Language English
    Publishing date 2016-07-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-016-0953-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: First interchromosomal insertion in a patient with cerebral and spinal cavernous malformations.

    Pilz, Robin A / Schwefel, Konrad / Weise, Anja / Liehr, Thomas / Demmer, Philipp / Spuler, Andreas / Spiegler, Stefanie / Gilberg, Eberhard / Hübner, Christian A / Felbor, Ute / Rath, Matthias

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 6306

    Abstract: Autosomal dominant cerebral cavernous malformations (CCM) are leaky vascular lesions that can cause epileptic seizures and stroke-like symptoms. Germline mutations in either CCM1, CCM2 or CCM3 are found in the majority of patients with multiple CCMs or a ...

    Abstract Autosomal dominant cerebral cavernous malformations (CCM) are leaky vascular lesions that can cause epileptic seizures and stroke-like symptoms. Germline mutations in either CCM1, CCM2 or CCM3 are found in the majority of patients with multiple CCMs or a positive family history. Recently, the first copy number neutral inversion in CCM2 has been identified by whole genome sequencing in an apparently mutation-negative CCM family. We here asked the question whether further structural genomic rearrangements can be detected within NGS gene panel data of unsolved CCM cases. Hybrid capture NGS data of eight index patients without a pathogenic single nucleotide, indel or copy number variant were analyzed using two bioinformatics pipelines. In a 58-year-old male with multiple CCMs in his brain and spinal cord, we identified a 294 kb insertion within the coding sequence of CCM2. Fine mapping of the breakpoints, molecular cytogenetic studies, and multiplex ligation-dependent probe amplification verified that the structural variation was an inverted unbalanced insertion that originated from 1p12-p11.2. As this rearrangement disrupts exon 6 of CCM2 on 7p13, it was classified as pathogenic. Our study demonstrates that efforts to detect structural variations in known disease genes increase the diagnostic sensitivity of genetic analyses for well-defined Mendelian disorders.
    MeSH term(s) Brain/abnormalities ; Brain/blood supply ; Brain/diagnostic imaging ; Carrier Proteins/genetics ; Chromosome Inversion ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 7/genetics ; Genetic Counseling ; Genetic Testing ; Hemangioma, Cavernous, Central Nervous System/diagnosis ; Hemangioma, Cavernous, Central Nervous System/genetics ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pedigree ; Spinal Cord/abnormalities ; Spinal Cord/blood supply ; Spinal Cord/diagnostic imaging ; Whole Genome Sequencing
    Chemical Substances CCM2 protein, human ; Carrier Proteins
    Language English
    Publishing date 2020-04-14
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-63337-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Transdermale therapeutische Systeme: Möglichkeiten und Grenzen

    Groth, H. / Spuler, A. / Vetter, W.

    DMW - Deutsche Medizinische Wochenschrift

    2008  Volume 113, Issue 20, Page(s) 819–821

    Language German
    Publishing date 2008-03-25
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-2008-1067729
    Database Thieme publisher's database

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