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  1. Article ; Online: Doing Good Research Is Difficult, Doing No Research Is More Difficult.

    Spuls, Phyllis I

    The Journal of investigative dermatology

    2017  Volume 137, Issue 5, Page(s) 993–995

    MeSH term(s) Career Choice ; Congresses as Topic ; Dermatology/education ; Dermatology/history ; Dermatology/methods ; Evidence-Based Medicine ; Faculty, Medical ; History, 20th Century ; History, 21st Century ; Humans ; International Cooperation ; Mentors ; Netherlands ; Outcome Assessment (Health Care) ; Psoriasis/therapy ; Translational Medical Research/education ; Translational Medical Research/history ; Translational Medical Research/methods
    Language English
    Publishing date 2017-02-21
    Publishing country United States
    Document type Autobiography ; Editorial ; Historical Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2017.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Methotrexate dosing regimen for plaque-type psoriasis: an update of a systematic review.

    van Huizen, Astrid M / Sikkel, Rosie / Caron, Anouk G M / Menting, Stef P / Spuls, Phyllis I

    The Journal of dermatological treatment

    2022  , Page(s) 1–15

    Abstract: Background: Methotrexate (MTX) is a systemic treatment for plaque-type psoriasis. At the time of approval, no dose-ranging studies were performed. Nowadays, a uniform dosing regimen is lacking. This might contribute to suboptimal treatment with the drug. ...

    Abstract Background: Methotrexate (MTX) is a systemic treatment for plaque-type psoriasis. At the time of approval, no dose-ranging studies were performed. Nowadays, a uniform dosing regimen is lacking. This might contribute to suboptimal treatment with the drug.
    Objective: To summarize the literature involving the MTX dosing regimens in psoriasis patients.
    Methods: In this SR, RCTs and documents with aggregated evidence (AgEv) on the MTX dosing regimen in psoriasis were summarized. All randomized controlled trials (RCTs) in which oral, subcutaneous or intramuscular MTX was used in patients with psoriasis and AgEv, were included. The MEDLINE, EMBASE and CENTRAL databases were searched up to June 20, 2022. This SR was registered in PROSPERO.
    Results: Thirty-nine RCTs had a high risk of bias. Test dosages were given in only 3 RCTs. In the RCTs, MTX was usually prescribed in a start dose of 7.5 mg/week (
    Conclusions: There is a lack of high-quality evidence and available data for dosing MTX in psoriasis is heterogeneous.
    Language English
    Publishing date 2022-09-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2022.2117539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protocol of a scoping review of outcome domains in dermatology.

    Nadir, Umer / Ahmed, Areeba / Yi, Michael D / Hisham, Farhana Ikmal / Dave, Loma / Kottner, Jan / Ezzedine, K / Garg, Amit / Ingram, John R / Jemec, Gregor Borut Ernst / Spuls, Phyllis I / Kirkham, Jamie J / Cahn, Brian / Alam, Murad

    BMJ open

    2024  Volume 14, Issue 2, Page(s) e079632

    Abstract: Introduction: Core outcome sets (COSs) are agreed outcomes (domains (subdomains) and instruments) that should be measured as a minimum in clinical trials or practice in certain diseases or clinical fields. Worldwide, the number of COSs is increasing and ...

    Abstract Introduction: Core outcome sets (COSs) are agreed outcomes (domains (subdomains) and instruments) that should be measured as a minimum in clinical trials or practice in certain diseases or clinical fields. Worldwide, the number of COSs is increasing and there might be conceptual overlaps of domains (subdomains) and instruments within disciplines. The aim of this scoping review is to map and to classify all outcomes identified with COS projects relating to skin diseases.
    Methods and analysis: We will conduct a scoping review of outcomes of skin disease-related COS initiatives to identify all concepts and their definitions. We will search PubMed, Embase and Cochrane library. The search dates will be 1 January 2010 (the point at which Core Outcome Measures in Effectiveness Trials (COMET) was established) to 1 January 2024. We will also review the COMET database and C3 website to identify parts of COSs (domains and/or instruments) that are being developed and published. This review will be supplemented by querying relevant stakeholders from COS organisations, dermatology organisations and patient organisations for additional COSs that were developed. The resulting long lists of outcomes will then be mapped into conceptually similar concepts.
    Ethics and dissemination: This study was supported by departmental research funds from the Department of Dermatology at Northwestern University. An ethics committee review was waived since this protocol was done by staff researchers with no involvement of patient care. Conflicts of interests, if any, will be addressed by replacing participants with relevant conflicts or reassigning them. The results will be disseminated through publication in peer-reviewed journals, social media posts and promotion by COS organisations.
    MeSH term(s) Humans ; Dermatology ; Research Design ; Delphi Technique ; Outcome Assessment, Health Care ; Skin Diseases/therapy ; Treatment Outcome ; Review Literature as Topic
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-079632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Selection Process for a Web-Based Application to Measure Patient-Reported Outcomes Following the Example of the TREAT NL Registry.

    de Groot, Rowdy / Bosma, Angela L / Cornet, Ronald / Spuls, Phyllis I

    The Journal of investigative dermatology

    2020  Volume 141, Issue 6, Page(s) 1592–1595.e1

    MeSH term(s) Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/therapy ; Humans ; Immunologic Factors/therapeutic use ; Internet/standards ; Internet/statistics & numerical data ; Netherlands ; Patient Reported Outcome Measures ; Phototherapy/methods ; Phototherapy/statistics & numerical data ; Registries/standards ; Registries/statistics & numerical data ; Research Design/standards ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Letter
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2020.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: From the Cochrane Library: Phototherapy for atopic eczema.

    O'Connell, Katie A / Kim, Lori S / Szeto, Mindy D / Sivesind, Torunn / Dellavalle, Robert P / Musters, Annelie H / Spuls, Phyllis I

    Journal of the American Academy of Dermatology

    2022  Volume 87, Issue 1, Page(s) e23–e26

    MeSH term(s) Dermatitis, Atopic/radiotherapy ; Eczema ; Humans ; Phototherapy
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2022.03.010
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  6. Article ; Online: Shifting focus from "what we do" to the "impact of what we do": Application of outcome measures to routine clinical care in dermatology.

    Garg, Amit / Dirr, McKenzie A / Jemec, Gregor B E / Ingram, John R / Schmitt, Jochen / Spuls, Phyllis / Alam, Murad

    Journal of the American Academy of Dermatology

    2022  Volume 87, Issue 2, Page(s) e83–e84

    MeSH term(s) Dermatology ; Humans ; Outcome Assessment, Health Care ; Quality of Life
    Language English
    Publishing date 2022-04-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2022.04.042
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  7. Article ; Online: The clinical relevance of dupilumab serum concentration in patients with atopic dermatitis: a two-center prospective cohort study.

    Bosma, Angela L / Gerbens, Louise A A / El Khattabi, Hajar / Loeff, Floris C / Duckworth, Michael / Woolf, Richard T / Rispens, Theo / Smith, Catherine H / Spuls, Phyllis I

    The Journal of dermatological treatment

    2023  Volume 34, Issue 1, Page(s) 2193663

    Abstract: Background: Dupilumab is prescribed in one dosage across adult atopic dermatitis patients. Differences in drug exposure may explain variation in treatment response.: Objective: Investigating the clinical relevance of dupilumab serum concentration in ... ...

    Abstract Background: Dupilumab is prescribed in one dosage across adult atopic dermatitis patients. Differences in drug exposure may explain variation in treatment response.
    Objective: Investigating the clinical relevance of dupilumab serum concentration in atopic dermatitis in real-world practice.
    Methods: In two centers (Netherlands, UK), adults treated with dupilumab for atopic dermatitis were evaluated for effectiveness and safety pretreatment and at 2, 12, 24, and 48 weeks; trough serum samples were analyzed for dupilumab concentration at corresponding time points.
    Results: In 149 patients, median dupilumab levels during follow-up ranged from 57.4 to 72.4 μg/mL. Levels showed high inter-patient and low intra-patient variability. No correlation was found between levels and ΔEASI. At 2 weeks, levels of ≥64.1 μg/mL predict EASI ≤7 at 24 weeks (specificity:100%, sensitivity:60%;
    Conclusion: At the on-label dosage, the measured range of dupilumab levels does not seem to yield differences in treatment effectiveness. However, disease activity does seem to influence dupilumab levels - higher baseline disease activity results in lower levels at follow-up.
    MeSH term(s) Adult ; Humans ; Dermatitis, Atopic/drug therapy ; Clinical Relevance ; Prospective Studies ; Injections, Subcutaneous ; Severity of Illness Index ; Treatment Outcome ; Double-Blind Method
    Chemical Substances dupilumab (420K487FSG)
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2023.2193663
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  8. Article ; Online: The wide variety of methotrexate dosing regimens for the treatment of atopic dermatitis: a systematic review.

    Caron, Anouk G M / Bloem, Manja / El Khattabi, Hajar / de Waal, Ayla C / van Huizen, Astrid M / Denswil, Nerissa P / Gerbens, Louise A A / Spuls, Phyllis I

    The Journal of dermatological treatment

    2023  Volume 35, Issue 1, Page(s) 2292962

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Child ; Humans ; Methotrexate/therapeutic use ; Methotrexate/adverse effects ; Dermatitis, Atopic/drug therapy
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2023.2292962
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  9. Article ; Online: Sex differences in adverse drug reactions from Adalimumab and etanercept in patients with inflammatory rheumatic diseases.

    Gosselt, Helen R / van Lint, Jette A / Kosse, Leanne J / Spuls, Phyllis I / Vonkeman, Harald E / Tas, Sander W / Hoentjen, Frank / Nurmohamed, Michael T / van den Bemt, Bart J F / van Doorn, Martijn B A / Jessurun, Naomi T

    Expert opinion on drug safety

    2023  Volume 22, Issue 6, Page(s) 501–507

    Abstract: Background: We examine sex differences in relation to the nature, frequency, and burden of patient-reported adverse drug reactions (ADRs) in patients with inflammatory rheumatic diseases.: Research design and methods: Rheumatoid arthritis, psoriatic ... ...

    Abstract Background: We examine sex differences in relation to the nature, frequency, and burden of patient-reported adverse drug reactions (ADRs) in patients with inflammatory rheumatic diseases.
    Research design and methods: Rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis patients using etanercept or adalimumab from the Dutch Biologic Monitor were sent bimonthly questionnaires concerning experienced ADRs. Sex differences in the proportion and nature of reported ADRs were assessed. Additionally, 5-point Likert-type scales reported for the burden of ADRs, were compared between sexes.
    Results: In total 748 consecutive patients were included (59% female). From the women 55% reported ≥1 ADR, which was significantly higher than 38% of the men that reported ≥1 ADR (p < 0.001). A total of 882 ADRs were reported comprising 264 distinct ADRs. The nature of the reported ADRs differed significantly between both sexes (p = 0.02). Women in particular reported more injection site reactions than men. The burden of ADRs was similar between sexes.
    Conclusions: Sex differences in the frequency and nature of ADRs, but not in ADR burden, exist during treatment with adalimumab and etanercept in patients with inflammatory rheumatic diseases. This should be taken into consideration when investigating and reporting results on ADRs and when counseling patients in daily clinical practice.
    MeSH term(s) Humans ; Female ; Male ; Adalimumab/adverse effects ; Etanercept/adverse effects ; Sex Characteristics ; Drug-Related Side Effects and Adverse Reactions ; Arthritis, Rheumatoid/drug therapy ; Adverse Drug Reaction Reporting Systems
    Chemical Substances Adalimumab (FYS6T7F842) ; Etanercept (OP401G7OJC)
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2023.2181340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reporting of Harmonising Outcome Measures for Eczema (HOME) core outcome set instruments in randomized clinical trials for systemic treatments in atopic dermatitis.

    Lam, Megan / Spuls, Phyllis I / Leshem, Yael A / Gerbens, Louise A A / Thomas, Kim S / Arents, Bernd / Burton, Tim / Flohr, Carsten / Drucker, Aaron M

    The British journal of dermatology

    2023  Volume 189, Issue 4, Page(s) 494–496

    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Randomized Controlled Trials as Topic ; Outcome Assessment, Health Care ; Severity of Illness Index ; Eczema/drug therapy
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad237
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