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  1. Article ; Online: Can Nutrition Play a Role as a Stimulant for COVID 19 in Children?

    Kesavelu, Dhanasekhar / Franklyn, Nithya / Sreedharan, Lekha

    Reviews on recent clinical trials

    2020  Volume 16, Issue 2, Page(s) 146–150

    Abstract: Background: Nutrition plays a major role in the growth and well-being of children and forms the basis of their existence. A pandemic like COVID19 poses some serious questions and challenges in the minds of practicing pediatricians as to what support ... ...

    Abstract Background: Nutrition plays a major role in the growth and well-being of children and forms the basis of their existence. A pandemic like COVID19 poses some serious questions and challenges in the minds of practicing pediatricians as to what support they should offer children, their parents and carers alleviating their anxiety about their children's diet and nutrition, that is critical at this time of crisis. Although the evidence for pediatric nutrition and COVID19 is not strong, this article aims to critically look into pediatric nutrition during the COVID19 pandemic and bring the most recent evidence into the limelight to facilitate making the right choices with respect to pediatric nutrition.
    Methods: We performed a search on recent literature using the search terms "Covid19" + "Children" + "Nutrition" to analyze the current evidence supporting nutrition as a stimulant for covid19. A review article based on the above search results was written to highlight the importance of nutrition during this pandemic.
    Results: Strong recommendations remain unchanged for breastfeeding, healthy complementary feeding, use of supplemental formula where appropriate, oral nutritional supplements, zinc, n-3& n- 6 fatty acids, and probiotics all have a certain role to play as a stimulant for Covid19 in children.
    Conclusion: Current evidence emphasizes the use of additional nutritional supplements, especially in the "at risk" groups, low socio-economic status and children with chronic medical problems. Paediatric nutrition should never be overlooked and "one size does not fit all" as every child is different and children's individual nutritional needs vary. This review points to the importance of nutrition as a stimulant to covid19 in the pediatric population.
    MeSH term(s) Adolescent ; COVID-19/etiology ; COVID-19/prevention & control ; Child ; Child, Preschool ; Diet ; Guidelines as Topic ; Humans ; Infant ; Nutritional Status ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-12-04
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2251879-4
    ISSN 1876-1038 ; 1574-8871
    ISSN (online) 1876-1038
    ISSN 1574-8871
    DOI 10.2174/1574887115666201104154713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6436: Show issues Location:
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  2. Article ; Online: Resolution of adhesive small bowel obstruction with a protocol based on Gastrografin administration.

    Paily, Abhilash / Kotecha, Jalpa / Sreedharan, Loveena / Kumar, Bhaskar

    Journal of medicine and life

    2019  Volume 12, Issue 1, Page(s) 10–14

    Abstract: The use of Gastrografin may have a therapeutic effect on resolving adhesive small bowel obstruction. Adhesive Small Bowel obstruction (ASBO) accounts for the majority of patients with small bowel obstruction. Most patients are managed conservatively; ... ...

    Abstract The use of Gastrografin may have a therapeutic effect on resolving adhesive small bowel obstruction. Adhesive Small Bowel obstruction (ASBO) accounts for the majority of patients with small bowel obstruction. Most patients are managed conservatively; frequent admissions create a considerable burden. We sought to examine the adherence to the Bologna guidelines for the management of ASBO in a high volume tertiary center and whether or not Gastrografin had a therapeutic effect. A comparison was made between an initial retrospective audit looking at ASBO and a prospective re-audit after applying standards derived from the Bologna guidelines. During re-audit it was found that more patients underwent conservative management and fewer patients had surgery as first line management. In the re-audit, those who had to undergo surgery within/after a period of 72h of conservative management were also fewer. Whether they were managed surgically primarily or after a period of conservative management, the average length of stay was also shorter. In comparison to the preliminary audit, there appeared to be no change in the way that medical history and physical examination was documented during the re-audit. However, there was a marked difference in the use of appropriate blood tests and CT scans. Changes were made successfully following the initial audit results and have been implemented, thus closing the audit loop. This study shows that the use of Gastrografin has decreased the need for surgical intervention in a group of patients with small bowel obstruction.
    MeSH term(s) Diatrizoate Meglumine/administration & dosage ; Diatrizoate Meglumine/pharmacology ; Diatrizoate Meglumine/therapeutic use ; Humans ; Intestinal Obstruction/complications ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/drug therapy ; Prospective Studies ; Reference Standards ; Retrospective Studies ; Tissue Adhesions/complications ; Tissue Adhesions/diagnostic imaging ; Tissue Adhesions/drug therapy
    Chemical Substances Diatrizoate Meglumine (3X9MR4N98U)
    Language English
    Publishing date 2019-05-23
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2559353-5
    ISSN 1844-3117 ; 1844-3109 ; 1844-122X
    ISSN (online) 1844-3117 ; 1844-3109
    ISSN 1844-122X
    DOI 10.25122/jml-2018-0082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Postsurgical gastroparesis syndrome (PGS) following sleeve resection of a giant (6.1 kg) gastric gastrointestinal stromal tumour (GIST).

    Leow, Tze Hao / Lam, Stephen / Sreedharan, Loveena / Kumar, Bhaskar

    BMJ case reports

    2020  Volume 13, Issue 11

    MeSH term(s) Aftercare ; Aged ; Anastomosis, Roux-en-Y/methods ; Endoscopy, Digestive System/methods ; Female ; Gastrectomy/adverse effects ; Gastrointestinal Stromal Tumors/surgery ; Gastroparesis/diagnosis ; Gastroparesis/etiology ; Gastroparesis/surgery ; Humans ; Postoperative Complications ; Treatment Outcome
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-238267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Splenic artery pseudoaneurysm causing delayed gastrointestinal bleeding after gastrocolonic fistula following sleeve gastrectomy.

    Ball, J F / Sreedharan, L / Reddy, S / Tan, Bhl / Sujendran, V

    Annals of the Royal College of Surgeons of England

    2017  Volume 100, Issue 1, Page(s) e15–e17

    Abstract: Delayed gastrointestinal bleeding in the context of a gastric fistula is a very rare complication of longitudinal sleeve gastrectomy. We report the case of a patient who presented with massive gastrointestinal bleeding from a pseudoaneurysm arising from ... ...

    Abstract Delayed gastrointestinal bleeding in the context of a gastric fistula is a very rare complication of longitudinal sleeve gastrectomy. We report the case of a patient who presented with massive gastrointestinal bleeding from a pseudoaneurysm arising from the splenic artery following complications after a longitudinal sleeve gastrectomy several months previously. The case was successfully managed with angiographic embolisation and we present our experience with recommendations for managing this rare but life-threatening complication.
    MeSH term(s) Aneurysm, False ; Female ; Gastrectomy/adverse effects ; Gastric Fistula ; Gastrointestinal Hemorrhage ; Humans ; Middle Aged ; Splenic Artery/diagnostic imaging ; Splenic Artery/pathology ; Splenic Artery/surgery
    Language English
    Publishing date 2017-10-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2017.0179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Psoas abscess complicating endovascular aortic aneurysm repair.

    Moussa, O / Sreedharan, L / Poels, J / Ojimba, T

    Journal of surgical case reports

    2012  Volume 2012, Issue 10, Page(s) 16

    Abstract: Aortic stent graft infection is a rare but serious complication associated with high mortality. This report emphasizes the need for continued awareness of potential graft-related septic complications in patients undergoing Endovascular Aortic Repair ( ... ...

    Abstract Aortic stent graft infection is a rare but serious complication associated with high mortality. This report emphasizes the need for continued awareness of potential graft-related septic complications in patients undergoing Endovascular Aortic Repair (EVAR). We report a case in which a post-EVAR patient became unwell about 30 days post operatively and was shown on CT scanning to have a psoas abscess. The abscess was managed with percutaneous drainage and antibiotics. The patient remains well with no evidence of psoas collection or perigraft infection one year on. We review the available literature and discuss the merits of different management strategies.
    Language English
    Publishing date 2012-10-01
    Publishing country England
    Document type Journal Article
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/2012.10.16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Successful surgical repair of aorto-esophageal fistula due to fish-bone ingestion.

    Sreedharan, Lokesh / Krishna, Neethu / Gopalakrishnan, Unnikrishnan / Varma, Praveen Kerala

    Indian journal of thoracic and cardiovascular surgery : official organ, Association of Thoracic and Cardiovascular Surgeons of India

    2018  Volume 35, Issue 1, Page(s) 68–70

    Abstract: Aorto-esophageal fistula is a rare and potentially lethal disease. The main causes are ruptured aortic aneurysm, foreign body ingestion, complication of surgical or endovascular repair of thoracic aortic aneurysm, and esophageal malignancy. We report a ... ...

    Abstract Aorto-esophageal fistula is a rare and potentially lethal disease. The main causes are ruptured aortic aneurysm, foreign body ingestion, complication of surgical or endovascular repair of thoracic aortic aneurysm, and esophageal malignancy. We report a case caused by fish-bone ingestion. He underwent replacement of proximal descending aorta using circulatory arrest and trans-hiatal esophagectomy in the same sitting. A second-stage esophago-coloplasty was performed after 6 months for establishing digestive tract continuity.
    Language English
    Publishing date 2018-08-01
    Publishing country India
    Document type Case Reports
    ZDB-ID 2164386-6
    ISSN 0973-7723 ; 0970-9134
    ISSN (online) 0973-7723
    ISSN 0970-9134
    DOI 10.1007/s12055-018-0704-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Bridging clinic: The initial medical management of patients with newly diagnosed pancreatic cancer.

    Sreedharan, Loveena / Kumar, Bhaskar / Jewell, Anna / Banim, Paul / Koulouris, Andreas / Hart, Andrew R

    Frontline gastroenterology

    2018  Volume 10, Issue 3, Page(s) 261–268

    Abstract: Pancreatic cancer is the 11th most common cancer in the UK and has the worst prognosis of any tumour with minimal improvements in survival over recent decades. As most patients are either ineligible for surgery or may decline chemotherapy, the emphasis ... ...

    Abstract Pancreatic cancer is the 11th most common cancer in the UK and has the worst prognosis of any tumour with minimal improvements in survival over recent decades. As most patients are either ineligible for surgery or may decline chemotherapy, the emphasis is on control of symptoms and management of complications such as poor nutritional status. The time period between informing the patient of their diagnosis and commencing cancer treatments presents a valuable opportunity to proactively identify and treat symptoms to optimise patients' overall well-being. The 'bridging clinic', delivered by a range of healthcare professionals from gastroenterologists to nurse practitioners, can provide this interface where patients are first informed of their diagnosis and second supportive therapies offered. In this article, we provide a structure for instituting such supportive therapies at the bridging clinic. The components of the clinic are summarised using the mnemonic INDASH (Information/Nutrition/Diabetes and Depression/Analgesia/Stenting/Hereditary) and each is discussed in detail below.
    Language English
    Publishing date 2018-10-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2521857-8
    ISSN 2041-4137
    ISSN 2041-4137
    DOI 10.1136/flgastro-2018-101002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6880: Show issues Location:
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  8. Article ; Online: Effect of lyophilization on HRP-antibody conjugation: an enhanced antibody labeling technology.

    Regidi, Saikant / Ravindran, Shilpa / Vijayan, Ashitha L / Maya, Vani / Sreedharan, Lakshmi / Varghese, Jeslin / Ramaswami, Kartik / Gopi, Manoj

    BMC research notes

    2018  Volume 11, Issue 1, Page(s) 596

    Abstract: Objective: Immunoassay usually deal with the antibody labeling with various reporter molecules, one such useful reporter molecule is horseradish peroxidase (HRPO). Conjugating enzyme with antibody without losing its enzymatic activity is a challenging ... ...

    Abstract Objective: Immunoassay usually deal with the antibody labeling with various reporter molecules, one such useful reporter molecule is horseradish peroxidase (HRPO). Conjugating enzyme with antibody without losing its enzymatic activity is a challenging task. Our aim is to modify existing classical method of conjugating antibodies with HRP to enhance immunoassay techniques with better sensitivity. We used chemicals such as sodium meta periodate to generate aldehyde group by oxidation of carbohydrate moieties on HRPO. The activated form of HRPO is lyophilized and then mixed with 1 mg/ml concentration of antibodies to be conjugate.
    Results: After confirming chemical modification of conjugates via UV-Spec and SDS-PAGE independent molecules were used for conjugation and HRP-antibody conjugate. Finally, enzymatic activity of HRP-antibody conjugate was confirmed by performing direct ELISA. Functional properties were analyzed using ELISA with dilution of 1:5000, whereas the conjugate prepared by existing method of conjugation worked with as low dilution of 1:25 with a p value highly significant (< 0.001) for classical verses modified method of conjugation preparation. Collectively, this study showed the enhanced ability of antibody to bind more number of HRPO with an additional step of lyophilization in the regular conjugation protocol. Future exploration are necessary on wide range of IgG antibodies.
    MeSH term(s) Antibodies ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Freeze Drying ; Horseradish Peroxidase
    Chemical Substances Antibodies ; Horseradish Peroxidase (EC 1.11.1.-)
    Language English
    Publishing date 2018-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-018-3688-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Seeding of hepatocellular carcinoma into the stomach wall following endoscopic ultrasound and fine-needle aspiration biopsy.

    Kasi, M / Rashid, Samin / Wallace, S A J / Sujendran, Vijayendran / Griffiths, Bill / Butler, Andrew / Gibbs, Paul / Sreedharan, Loveena / Zaitoun, A M / Venkatachalapathy, S / James, M W / Aithal, G P

    Oxford medical case reports

    2018  Volume 2018, Issue 7, Page(s) omy039

    Abstract: Delayed gastrointestinal metastasis is a rare complication of hepatocellular carcinoma (HCC). We present the case of a patient who presented with melaena and microcytic anaemia 6 years after receiving an orthotopic liver transplant for hepatitis B- ... ...

    Abstract Delayed gastrointestinal metastasis is a rare complication of hepatocellular carcinoma (HCC). We present the case of a patient who presented with melaena and microcytic anaemia 6 years after receiving an orthotopic liver transplant for hepatitis B-induced HCC. Oesophagogastroduodenoscopy revealed a fungating gastric mass at the lesser curve and histology from biopsies confirmed metastatic recurrence of HCC in the stomach. The route of metastasis is likely due to iatrogenic seeding of tumour cells during pre-transplant endoscopic ultrasound (EUS) and fine needle aspiration (FNA) biopsy. Subsequent positron emission tomography and magnetic resonance imaging failed to reveal further metastatic disease and the patient was managed with a total gastrectomy. This is the first reported description in the literature of needle-track metastasis in the stomach due to liver EUS-FNA for HCC.
    Language English
    Publishing date 2018-07-18
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omy039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus.

    Sreedharan, Loveena / Mayne, George C / Watson, David I / Bright, Timothy / Lord, Reginald V / Ansar, Alfiya / Wang, Tingting / Kist, Jakob / Astill, David StJ / Hussey, Damian J

    World journal of gastroenterology

    2017  Volume 23, Issue 30, Page(s) 5508–5518

    Abstract: Aim: To investigate the microRNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.: Methods: High throughput screening using TaqMan: Results: Forty-four microRNAs were ... ...

    Abstract Aim: To investigate the microRNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.
    Methods: High throughput screening using TaqMan
    Results: Forty-four microRNAs were differentially expressed between control squamous mucosa
    Conclusion: Neosquamous mucosa arising after ablation of Barrett's esophagus expresses microRNAs that may contribute to decreased barrier function and microRNAs that may be involved in the regulation of survival signaling pathways.
    Language English
    Publishing date 2017-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v23.i30.5508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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