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  1. Article ; Online: Who won?

    Srikanth, Srirama

    Families, systems & health : the journal of collaborative family healthcare

    2024  Volume 42, Issue 1, Page(s) 139

    Abstract: This poem describes the ugly face of misinformation and lies-spewing bile as COVID shook us and humanity came undone. Vaccines were rejected and lockdowns were broken. We barely withstood. Who won? No one. (PsycInfo Database Record (c) 2024 APA, all ... ...

    Abstract This poem describes the ugly face of misinformation and lies-spewing bile as COVID shook us and humanity came undone. Vaccines were rejected and lockdowns were broken. We barely withstood. Who won? No one. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19/psychology ; COVID-19/epidemiology ; SARS-CoV-2 ; Deception ; Communication ; Pandemics
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 1326859-4
    ISSN 1939-0602 ; 1091-7527 ; 0736-1718
    ISSN (online) 1939-0602
    ISSN 1091-7527 ; 0736-1718
    DOI 10.1037/fsh0000844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book: Air pollution and health effects

    Nadadur, Srikanth S.

    (Molecular and integrative toxicology)

    2015  

    Series title Molecular and integrative toxicology
    Keywords Carcinogens ; Air pollutants ; Inflammation ; Pulmonary disease ; Cardio-metabolic disease ; Epigenetic
    Language English
    Size XV, 439 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018662312
    ISBN 978-1-4471-6668-9 ; 1-4471-6668-X ; 9781447166696 ; 1447166698
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 2113 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Histopathological analysis of meningioma and its variants: A study of fifty cases.

    Srikanth, S

    publication RETRACTED

    Indian journal of cancer

    2017  Volume 54, Issue 1, Page(s) 313–315

    Abstract: Background: The study was conducted to know the various histopathological variants of meningiomas, the age incidence and sex ratio.: Materials and methods: A retrospective and prospective analysis of all the samples sent for histopathology for 2 ... ...

    Abstract Background: The study was conducted to know the various histopathological variants of meningiomas, the age incidence and sex ratio.
    Materials and methods: A retrospective and prospective analysis of all the samples sent for histopathology for 2 years during June 2013-May 2015 was done to diagnose meningioma and its variants. Cases were analyzed in detail about the complete clinical history, exact location, and clinical and radiological diagnosis. The majority of the cases were clinically and radiologically diagnosed as meningioma.
    Results: Of 50 cases which were diagnosed as meningiomas, 21 were meningothelial variant, 15 were psammomatous, 8 were fibroblastic, 4 were transitional, and 1 case each of anaplastic and atypical variant. The most common age group was between 41 and 50 years. The youngest age group was 16 years and oldest was 70. The male:female ratio was 1:1.5.
    Conclusion: The majority of the meningiomas have been observed between 41 and 50 years. Their proper recognition is therefore important to allow appropriate treatment. Histopathological study plays a major role by which we can diagnose the lesion. Meningiomas typically develop in middle-aged individuals and occur more frequently in women than men. These lesions may also occur in children.
    MeSH term(s) Adolescent ; Adult ; Aged ; Carcinoma/classification ; Carcinoma/epidemiology ; Carcinoma/pathology ; Female ; Humans ; India/epidemiology ; Male ; Meningioma/classification ; Meningioma/epidemiology ; Meningioma/pathology ; Middle Aged ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2017-01
    Publishing country India
    Document type Journal Article ; Retracted Publication
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.IJC_119_17
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  4. Article ; Online: Gender difference in parasympathetic function by HRR1min after graded treadmill exercise in healthy obese young adults

    Parimala H Krishnamurthy / Srikanth S

    Asian Journal of Medical Sciences, Vol 14, Iss 6, Pp 206-

    2023  Volume 210

    Abstract: Background: Heart rate recovery at 1st min (HRR1min) following exercise, an indicator of parasympathetic function is found to be impaired in obese children, adolescents, and elderly people. In children, adolescents and elderly people impaired that ... ...

    Abstract Background: Heart rate recovery at 1st min (HRR1min) following exercise, an indicator of parasympathetic function is found to be impaired in obese children, adolescents, and elderly people. In children, adolescents and elderly people impaired that HRR1min was significantly associated with obese females (OF) than in males. This study aims at establishing the gender difference in HRR1min among obese young adults (18–30 years age). Aims and Objectives: This study was conducted to assess parasympathetic function by HRR1min after graded exercise, in apparently healthy obese young adult males and females and to evaluate for gender difference in them. Materials and Methods: Fifty obese young adults (25 males and 25 females with body mass index [BMI] ≥30) and 50 age- and gender-matched controls (25 males and 25 females with BMI ≤24.9) were subjected to graded treadmill exercise. Maximum heart rate reached during exercise and heart rate at 1st min of recovery phase were recorded and HRR1min was calculated as the difference of above. The data were analyzed. Results: The study showed significant decrease in mean HRR1min in obese males compared to OF (mean 18.04±3.6 vs. 30.00±8.55, P<0.001), there is significant delay in HRR1min when OF and males were compared with their gender-matched controls. Conclusion: Parasympathetic function by HRR1min after exercise is significantly decreased in male obese young adults when compared with female obese young adults and are at higher risk of developing metabolic syndrome and cardiovascular disorders.
    Keywords heart rate recovery at 1st min ; parasympathetic function ; male and female obese young adults ; Medicine ; R
    Subject code 796 ; 590
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Spectrum of cervical lesions observed in 500 cases: Carcinoma cervix the leading cause of death in females.

    Srikanth, S

    Indian journal of cancer

    2016  Volume 53, Issue 1, Page(s) 61–62

    Abstract: Introduction: The present study was done to know the various histopathological variants in cervical lesions, to know the age incidence and to know the preventive measures and early detection of cervical cancer.: Materials and methods: This is a ... ...

    Abstract Introduction: The present study was done to know the various histopathological variants in cervical lesions, to know the age incidence and to know the preventive measures and early detection of cervical cancer.
    Materials and methods: This is a retrospective and prospective study done on all the hysterectomy specimens and on punch biopsy samples sent for histopathology. We studied a total of 500 cases for a period of 3 years.
    Results: Out of the 500 cases, 395 cases were non-neoplastic and 105 cases were neoplastic lesions. Chronic cervicitis was the most common non-neoplastic lesion and large cell non-keratinizing squamous cell carcinoma was the most common malignant lesion.
    Conclusion: The main aim of presenting this study is to highlight the various histopthological variants, age incidence and to educate about the preventive measures and early detection of cervical cancer.
    MeSH term(s) Cervix Uteri/pathology ; Female ; Humans ; Prospective Studies ; Retrospective Studies ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/pathology
    Language English
    Publishing date 2016-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/0019-509X.180818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.

    Srikanth, Sunandha / Narayanan, Rishikesh

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1241450

    Abstract: How do neurons that implement cell-autonomous self-regulation of calcium react to knockout of individual ion-channel conductances? To address this question, we used a heterogeneous population of 78 conductance-based models of hippocampal pyramidal ... ...

    Abstract How do neurons that implement cell-autonomous self-regulation of calcium react to knockout of individual ion-channel conductances? To address this question, we used a heterogeneous population of 78 conductance-based models of hippocampal pyramidal neurons that maintained cell-autonomous calcium homeostasis while receiving theta-frequency inputs. At calcium steady-state, we individually deleted each of the 11 active ion-channel conductances from each model. We measured the acute impact of deleting each conductance (one at a time) by comparing intrinsic electrophysiological properties before and immediately after channel deletion. The acute impact of deleting individual conductances on physiological properties (including calcium homeostasis) was heterogeneous, depending on the property, the specific model, and the deleted channel. The underlying many-to-many mapping between ion channels and properties pointed to ion-channel degeneracy. Next, we allowed the other conductances (barring the deleted conductance) to evolve towards achieving calcium homeostasis during theta-frequency activity. When calcium homeostasis was perturbed by ion-channel deletion, post-knockout plasticity in other conductances ensured resilience of calcium homeostasis to ion-channel deletion. These results demonstrate degeneracy in calcium homeostasis, as calcium homeostasis in knockout models was implemented in the absence of a channel that was earlier involved in the homeostatic process. Importantly, in reacquiring homeostasis, ion-channel conductances and physiological properties underwent heterogenous plasticity (dependent on the model, the property, and the deleted channel), even introducing changes in properties that were not directly connected to the deleted channel. Together, post-knockout plasticity geared towards maintaining homeostasis introduced heterogenous off-target effects on several channels and properties, suggesting that extreme caution be exercised in interpreting experimental outcomes involving channel knockouts.
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1241450
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  7. Article ; Online: Inflammation resolution in environmental pulmonary health and morbidity.

    Marzec, Jacqui / Nadadur, Srikanth S

    Toxicology and applied pharmacology

    2022  Volume 459, Page(s) 116343

    MeSH term(s) Humans ; Lung ; Inflammation ; Environmental Health ; Morbidity
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Letter
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2022.116343
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  8. Article ; Online: Inflammation resolution in environmental pulmonary health and morbidity.

    Marzec, Jacqui M / Nadadur, Srikanth S

    Toxicology and applied pharmacology

    2022  Volume 449, Page(s) 116070

    Abstract: Inflammation and resolution are dynamic processes comprised of inflammatory activation and neutrophil influx, followed by mediator catabolism and efferocytosis. These critical pathways ensure a return to homeostasis and promote repair. Over the past ... ...

    Abstract Inflammation and resolution are dynamic processes comprised of inflammatory activation and neutrophil influx, followed by mediator catabolism and efferocytosis. These critical pathways ensure a return to homeostasis and promote repair. Over the past decade research has shown that diverse mediators play a role in the active process of resolution. Specialized pro-resolving mediators (SPMs), biosynthesized from fatty acids, are released during inflammation to facilitate resolution and are deficient in a variety of lung disorders. Failed resolution results in remodeling and cellular deposition through pro-fibrotic myofibroblast expansion that irreversibly narrows the airways and worsens lung function. Recent studies indicate environmental exposures may perturb and deregulate critical resolution pathways. Environmental xenobiotics induce lung inflammation and generate reactive metabolites that promote oxidative stress, injuring the respiratory mucosa and impairing gas-exchange. This warrants recognition of xenobiotic associated molecular patterns (XAMPs) as new signals in the field of inflammation biology, as many environmental chemicals generate free radicals capable of initiating the inflammatory response. Recent studies suggest that unresolved, persistent inflammation impacts both resolution pathways and endogenous regulatory mediators, compromising lung function, which over time can progress to chronic lung disease. Chronic ozone (O
    MeSH term(s) Asthma ; Humans ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Lung/metabolism ; Lung Diseases/chemically induced ; Lung Diseases/metabolism ; Morbidity ; Pulmonary Disease, Chronic Obstructive
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2022.116070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Evaluation of Flow Rate, pH, and Buffering Capacity of Saliva in Children with Caries, Fluorosis, and Caries with Fluorosis.

    Rajendra, R E / Srikanth, S / Kiranmayi, M / Swathi, S P / Dutta, Lalitha D / Kumar, Anil

    International journal of clinical pediatric dentistry

    2023  Volume 16, Issue 4, Page(s) 587–590

    Abstract: Background: Saliva is one of the most important aids in the diagnosis of various oral diseases. Few physicochemical properties of saliva such as flow rate, pH, and buffering capacity often vary with the occurrence of dental caries, fluorosis, and other ... ...

    Abstract Background: Saliva is one of the most important aids in the diagnosis of various oral diseases. Few physicochemical properties of saliva such as flow rate, pH, and buffering capacity often vary with the occurrence of dental caries, fluorosis, and other systemic conditions.
    Purpose: The aim of the study was to evaluate the relationship between the salivary flow rate, pH, and buffering capacity in healthy children, children with caries, children with fluorosis, and children with both caries + fluorosis.
    Materials and methods: The study population consisted of 144 children aged 7-14 years and were divided into four groups of 36 children each. Group I, 36 healthy children with no caries and fluorosis; group II, 36 children with caries (dmfs ≤ 10); group III, 36 children with fluorosis (moderate to severe); and group IV, 36 children with caries + fluorosis. Unstimulated saliva is collected from all the selected subjects and evaluated for the salivary flow rate, pH, and buffering capacity. The recorded data were tabulated and statistically analyzed using a paired
    Results: The mean salivary flow rate and buffering capacity were found to be highest in group III when compared with all the other groups. The mean pH was greater in group I when compared with groups I, II, and III.
    Conclusion: The physicochemical properties of saliva like pH, buffering capacity, and salivary flow rate alter with caries and fluorosis conditions. Hence, more clinical and laboratory studies are needed to determine the exact relationship between these physicochemical properties of saliva in dental caries and fluorosis.
    How to cite this article: E RR, S S, M K,
    Language English
    Publishing date 2023-09-14
    Publishing country India
    Document type Journal Article
    ISSN 0974-7052
    ISSN 0974-7052
    DOI 10.5005/jp-journals-10005-2645
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  10. Article: Study of Thyroid Profi le in Patients with Type 2 Diabetes Mellitus.

    Srikanth, S / Munganda, Hariharan Rs / Eswar, G

    The Journal of the Association of Physicians of India

    2020  Volume 68, Issue 1, Page(s) 45

    MeSH term(s) Diabetes Mellitus, Type 2 ; Humans ; Thyroid Gland
    Language English
    Publishing date 2020-02-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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