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  1. Article ; Online: Corrigendum to "Beneficial immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in Duchenne muscular dystrophy: Results of an open-label, prospective, exploratory case-control clinical study" [IBRO Neurosci. Rep. 15 (2023), pp. 90-99].

    Raghavan, Kadalraja / Dedeepiya, Vidyasagar Devaprasad / Srinivasan, Subramaniam / Pushkala, Subramanian / Bharatidasan, Sudhakar S / Ikewaki, Nobunao / Iwasaki, Masaru / Senthilkumar, Rajappa / Preethy, Senthilkumar / Abraham, Samuel J K

    IBRO neuroscience reports

    2023  Volume 15, Page(s) 149–150

    Language English
    Publishing date 2023-08-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2421
    ISSN (online) 2667-2421
    DOI 10.1016/j.ibneur.2023.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Beneficial immune-modulatory effects of the N-163 strain of

    Raghavan, Kadalraja / Dedeepiya, Vidyasagar Devaprasad / Srinivasan, Subramaniam / Pushkala, Subramanian / Bharatidasan, Sudhakar S / Ikewaki, Nobunao / Iwasaki, Masaru / Senthilkumar, Rajappa / Preethy, Senthilkumar / Abraham, Samuel J K

    IBRO neuroscience reports

    2023  Volume 15, Page(s) 90–99

    Abstract: Background: This exploratory case-control study is to evaluate the effects of supplementation of : Methods: Twenty-seven male subjects aged 5-19 years with DMD were included, nine in the control arm and 18 in the treatment arm to receive N-163 beta ... ...

    Abstract Background: This exploratory case-control study is to evaluate the effects of supplementation of
    Methods: Twenty-seven male subjects aged 5-19 years with DMD were included, nine in the control arm and 18 in the treatment arm to receive N-163 beta glucan along with conventional therapies for 45 days. While performing the analysis, steroid usage was also taken into consideration, those not administered steroids (Steroid -ve) (Control, n = 5; treatment, n = 9), those administered steroids (Steroid +ve) (Control, n = 4; treatment, n = 9).
    Results: IL-6 showed a significant decrease in the treatment groups, especially the N-163 Steroid -ve group. IL-13 decreased in both treatment groups and TGF-β levels showed a significant decrease in the treatment groups, especially the N-163 Steroid -ve group, (p < 0.05). Dystrophin levels increased by up to 32% in the treatment groups compared to the control. Medical research council (MRC) grading showed slight improvement in muscle strength improvement in 12 out of 18 patients (67%) in the treatment group and four out of nine (44%) subjects in the control group.
    Conclusion: Supplementation with the N-163 beta glucan food supplement produced beneficial effects: a significant decrease in inflammation and fibrosis markers, increase in serum dystrophin and slight improvement in muscle strength in DMD subjects over 45 days, thus making this a potential adjunct treatment for DMD after validation.
    Trial registration: The study was registered in Clinical trials registry of India, CTRI/2021/05/033346. Registered on 5th May, 2021.
    Language English
    Publishing date 2023-07-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2421
    ISSN (online) 2667-2421
    DOI 10.1016/j.ibneur.2023.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Distilling Big Data

    Sivaraman Ramachandramurthy / Srinivasan Subramaniam / Chandrasekeran Ramasamy

    The Scientific World Journal, Vol

    Refining Quality Information in the Era of Yottabytes

    2015  Volume 2015

    Abstract: Big Data is the buzzword of the modern century. With the invasion of pervasive computing, we live in a data centric environment, where we always leave a track of data related to our day to day activities. Be it a visit to a shopping mall or hospital or ... ...

    Abstract Big Data is the buzzword of the modern century. With the invasion of pervasive computing, we live in a data centric environment, where we always leave a track of data related to our day to day activities. Be it a visit to a shopping mall or hospital or surfing Internet, we create voluminous data related to credit card transactions, user details, location information, and so on. These trails of data simply define an individual and form the backbone for user-profiling. With the mobile phones and their easy access to online social networks on the go, sensor data such as geo-taggings and events and sentiments around them contribute to the already overwhelming data containers. With reductions in the cost of storage and computational devices and with increasing proliferation of Cloud, we never felt any constraints in storing or processing such data. Eventually we end up having several exabytes of data and analysing them for their usefulness has introduced new frontiers of research. Effective distillation of these data is the need of the hour to improve the veracity of the Big Data. This research targets the utilization of the Fuzzy Bayesian process model to improve the quality of information in Big Data.
    Keywords Science (General) ; Q1-390
    Subject code 306
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential applications in human health and disease.

    Preethy, Senthilkumar / Ikewaki, Nobunao / Levy, Gary A / Raghavan, Kadalraja / Dedeepiya, Vidyasagar Devaprasad / Yamamoto, Naoki / Srinivasan, Subramaniam / Ranganathan, Natarajan / Iwasaki, Masaru / Senthilkumar, Rajappa / Abraham, Samuel J K

    BMJ open gastroenterology

    2022  Volume 9, Issue 1

    Abstract: Objective: The gut microbiome and its metabolites are influenced by age and stress and reflect the metabolism and health of the immune system. We assessed the gut microbiota and faecal metabolome in a static animal model of non-alcoholic steatohepatitis ...

    Abstract Objective: The gut microbiome and its metabolites are influenced by age and stress and reflect the metabolism and health of the immune system. We assessed the gut microbiota and faecal metabolome in a static animal model of non-alcoholic steatohepatitis (NASH).
    Design: This model was subjected to the following treatments: reverse osmosis water, AFO-202, N-163, AFO-202+N-163 and telmisartan treatment. Faecal samples were collected at 6 and 9 weeks of age. The gut microbiome was analysed using 16S ribosomal RNA sequences acquired by next-generation sequencing, and the faecal metabolome was analysed using gas chromatography-mass spectrometry.
    Results: Gut microbial diversity increased greatly in the AFO-202+N-163 group. Postintervention, the abundance of Firmicutes decreased, whereas that of Bacteroides increased and was the highest in the AFO-202+N-163 group. The decrease in the abundance of Enterobacteriaceae and other Firmicutes and the abundance of Turicibacter and Bilophila were the highest in the AFO-202 and N-163 groups, respectively. Lactobacillus abundance was highest in the AFO-202+N-163 group. The faecal metabolite spermidine, which is beneficial against inflammation and NASH, was significantly decreased (p=0.012) in the N-163 group. Succinic acid, which is beneficial in neurodevelopmental and neurodegenerative diseases, was increased in the AFO-202 group (p=0.06). The decrease in fructose was the highest in the N-163 group (p=0.0007). Isoleucine and Leucine decreased with statistical significance (p=0.004 and 0.012, respectively), and tryptophan also decreased (p=0.99), whereas ornithine, which is beneficial against chronic immune-metabolic-inflammatory pathologies, increased in the AFO-202+N-163 group.
    Conclusion: AFO-202 treatment in mice is beneficial against neurodevelopmental and neurodegenerative diseases, and has prophylactic potential against metabolic conditions. N-163 treatment exerts anti-inflammatory effects against organ fibrosis and neuroinflammation. In combination, these compounds exhibit anticancer activity.
    MeSH term(s) Animals ; Anti-Inflammatory Agents ; Disease Models, Animal ; Firmicutes/genetics ; Fructose ; Gastrointestinal Microbiome/genetics ; Glucans ; Humans ; Isoleucine ; Leucine ; Metabolome ; Mice ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/pathology ; Ornithine ; RNA, Ribosomal, 16S/genetics ; Spermidine ; Succinic Acid ; Telmisartan ; Tryptophan ; Water
    Chemical Substances Anti-Inflammatory Agents ; Glucans ; RNA, Ribosomal, 16S ; Isoleucine (04Y7590D77) ; Water (059QF0KO0R) ; Fructose (30237-26-4) ; Tryptophan (8DUH1N11BX) ; Succinic Acid (AB6MNQ6J6L) ; Ornithine (E524N2IXA3) ; Leucine (GMW67QNF9C) ; Telmisartan (U5SYW473RQ) ; Spermidine (U87FK77H25)
    Language English
    Publishing date 2022-09-24
    Publishing country England
    Document type Journal Article
    ISSN 2054-4774
    ISSN 2054-4774
    DOI 10.1136/bmjgast-2022-000985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: β‑glucan vaccine adjuvant approach for cancer treatment through immune enhancement (B‑VACCIEN) in specific immunocompromised populations (Review).

    Ikewaki, Nobunao / Dedeepiya, Vidyasagar Devaprasad / Raghavan, Kadalraja / Rao, Kosagi-Sharaf / Vaddi, Suryaprakash / Osawa, Hiroshi / Kisaka, Tomohiko / Kurosawa, Gene / Srinivasan, Subramaniam / Kumar, Seydunganallu Ramasamy Balaganesa / Senthilkumar, Rajappa / Iwasaki, Masaru / Preethy, Senthilkumar / Abraham, Samuel J K

    Oncology reports

    2021  Volume 47, Issue 1

    Abstract: The incidence of cancer, which is the second leading cause of mortality globally, continues to increase, although continued efforts are being made to identify effective treatments with fewer side‑effects. Previous studies have reported that chronic ... ...

    Abstract The incidence of cancer, which is the second leading cause of mortality globally, continues to increase, although continued efforts are being made to identify effective treatments with fewer side‑effects. Previous studies have reported that chronic microinflammation, which occurs in diseases, including diabetes, along with weakened immune systems, may ultimately lead to cancer development. Chemotherapy, radiotherapy and surgery are the mainstream approaches to treatment; however, they all lead to immune system weakness, which in turn increases the metastatic spread. The aim of the present review was to provide evidence of a biological response modifier β‑glucan [β‑glucan vaccine adjuvant approach to treating cancer via immune enhancement (B‑VACCIEN)] and its beneficial effects, including vaccine‑adjuvant potential, balancing metabolic parameters (including blood glucose and lipid levels), increasing peripheral blood cell cytotoxicity against cancer and alleviating chemotherapy side effects in animal models. This suggests its value as a potential strategy to provide long‑term prophylaxis in immunocompromised individuals or genetically prone to cancer.
    MeSH term(s) Adjuvants, Vaccine/administration & dosage ; Animals ; Humans ; Immunocompromised Host/immunology ; Neoplasms/immunology ; Neoplasms/prevention & control ; beta-Glucans/immunology
    Chemical Substances Adjuvants, Vaccine ; beta-Glucans
    Language English
    Publishing date 2021-11-15
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2021.8225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Comparative analysis of detecting cervical lymph node metastasis with fine needle aspiration cytology.

    Shakeel, Mohammed Kamran / Daniel, Mariappan Jonathan / Srinivasan, Subramaniam Vasudevan / Koliyan, Ramadoss / Kumar, Jimsha Vannathan

    Journal of natural science, biology, and medicine

    2015  Volume 6, Issue Suppl 1, Page(s) S7–9

    Abstract: Objectives: We correlated the results of cervical lymph node (LN) status by T-tumor size, N-nodal metastasis, M-distant metastasis (TNM) staging, and fine needle aspiration cytology (FNAC) in oral cancer patients to assess the discrepancy index (DI) ... ...

    Abstract Objectives: We correlated the results of cervical lymph node (LN) status by T-tumor size, N-nodal metastasis, M-distant metastasis (TNM) staging, and fine needle aspiration cytology (FNAC) in oral cancer patients to assess the discrepancy index (DI) between nodal metastasis (N) and FNAC results of cervicofacial LNs.
    Materials and methods: A total of 63 patients (29 females and 34 males) aged from 30 to 85 years were included in our study. Cervical LN status through TNM staging and FNAC results were matched and DI was calculated.
    Results: DI in case of nodal status was 64.10% and 43.47% for TNMN1 and N2, respectively, indicating that tendency for observation of positive result on FNAC increased from N1 to N2.
    Conclusion: Hence, we suggest that relying solely on clinical examination and routine diagnostic tests like FNAC may not be appropriate and additional diagnostic imaging modalities should be considered.
    Language English
    Publishing date 2015-09-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2638867-4
    ISSN 2229-7707 ; 0976-9668
    ISSN (online) 2229-7707
    ISSN 0976-9668
    DOI 10.4103/0976-9668.166050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Comparative Analysis of Linear and Angular Measurements on Digital Orthopantomogram with Calcaneus Bone Mineral Density.

    Shakeel, Mohammed Kamran / Daniel, Mariappan Jonathan / Srinivasan, Subramaniam Vasudevan / Koliyan, Ramadoss / Kumar, Jimsha Vannathan

    Journal of clinical and diagnostic research : JCDR

    2015  Volume 9, Issue 7, Page(s) ZC12–6

    Abstract: Background: Bone remodeling is a continuous and complex process which occurs throughout life. Radiomorphometric and radioangular indices on the orthopantomogram are the predictors of bone remodeling associated with mandible. Bone mineral density is the ... ...

    Abstract Background: Bone remodeling is a continuous and complex process which occurs throughout life. Radiomorphometric and radioangular indices on the orthopantomogram are the predictors of bone remodeling associated with mandible. Bone mineral density is the amount of calcified tissue in a certain volume of the bone.
    Materials and methods: Fifty normal healthy individuals within the age range of 25-55 years were included in the study. Linear measurements including mandibular cortical width (MCW) and panoramic mandibular index (PMI); and angular measurements including mandibular angle (MA) and antegonial angle (AGA) were recorded. Quantitative ultrasound bone mineral density (BMD) scan of the heel bone (calcaneus) of the same patient were also performed.
    Results: In our study, for both males and females, antegonial angle (AGA) had highest correlation with calcaneus bone mineral density. In the age group of less than 35 years, PMI in males, and AGA in females had highest correlation. In the age range of more than 35 years, MA in males and AGA in females had highest correlation.
    Conclusion: There is a correlation between the mandibular bone remodelling changes and calcaneal bone mineral density in case of elder subjects and thus these parameters may be used as an inexpensive alternative screening method to assess the bone mineral density and identify individuals at risk for osteoporosis and fractures and also for dental treatment planning.
    Language English
    Publishing date 2015-07-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2015/13606.6163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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