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  1. AU="Srivastava, Abhay Krishna"
  2. AU=Serrano Luis A
  3. AU="D'Orio, Vincent"
  4. AU="Davies, Neville"
  5. AU="Wise, J.C."
  6. AU="Mazer, Benjamin L"
  7. AU="Vellore J. Karthikeyan"

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  1. Artikel ; Online: Low serum vitamin D in North Indian multi-drug resistant pulmonary tuberculosis patients: the role of diet and sunlight.

    Rathored, Jaishriram / Sharma, Surendra Kumar / Chauhan, Aarti / Singh, Bhagteshwar / Banavaliker, Jayant Nagesh / Sreenivas, V / Srivastava, Abhay Krishna

    Annals of medicine

    2023  Band 55, Heft 2, Seite(n) 2291554

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Humans ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/epidemiology ; Calcium/therapeutic use ; Vitamin D ; Diet ; Vitamins ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/complications ; Sunlight ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/epidemiology
    Chemische Substanzen Calcium (SY7Q814VUP) ; Vitamin D (1406-16-2) ; Vitamins
    Sprache Englisch
    Erscheinungsdatum 2023-12-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2291554
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Nanotamoxifen Delivery System: Toxicity Assessment After Oral Administration and Biodistribution Study After Intravenous Delivery of Radiolabeled Nanotamoxifen.

    Shukla, Jaya / Dinda, Amit Kumar / Srivastava, Abhay Krishna / Srivastava, Kamna / Mittal, Bhagwant Rai / Bandopadhyaya, Guru Pad

    World journal of nuclear medicine

    2016  Band 15, Heft 1, Seite(n) 7–11

    Abstract: Tamoxifen is the most prescribed anticancer oral drug for increasing overall survival and decreasing recurrence and the risk of contralateral disease. However, some side effects, such as endometrial and liver tumors, thromboembolic disorders, and drug ... ...

    Abstract Tamoxifen is the most prescribed anticancer oral drug for increasing overall survival and decreasing recurrence and the risk of contralateral disease. However, some side effects, such as endometrial and liver tumors, thromboembolic disorders, and drug resistance, are associated with long-term tamoxifen treatment. We assessed the hematologic and organ toxicity after oral administration of three different doses of nanotamoxifen formulations. We also performed biodistribution studies of Technetium-99m ((99m)Tc)-nanotamoxifen after intravenous administration. The results demonstrated that nanotamoxifen was well-tolerated, with no adverse effect on biochemical parameters of blood and at the cellular level. Nitric oxide (NO) levels indicated no free radical formation. Oral nanotamoxifen is well-tolerated, with no hepatic or renal toxicity. Intravenous nanotamoxifen has potential to escape the liver, and is known for producing the harmful metabolite 4-hydroxytamoxifen (4OH-tamoxifen), which can cause uterine cancer.
    Sprache Englisch
    Erscheinungsdatum 2016-02-25
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2911903-0
    ISSN 1607-3312 ; 1450-1147
    ISSN (online) 1607-3312
    ISSN 1450-1147
    DOI 10.4103/1450-1147.167594
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Emblica officinalis exerts antihypertensive effect in a rat model of DOCA-salt-induced hypertension: role of (p) eNOS, NO and oxidative stress.

    Bhatia, Jagriti / Tabassum, Fauzia / Sharma, Ashok Kumar / Bharti, Saurabh / Golechha, Mahaveer / Joshi, Sujata / Sayeed Akhatar, Md / Srivastava, Abhay Krishna / Arya, Dharamvir Singh

    Cardiovascular toxicology

    2011  Band 11, Heft 3, Seite(n) 272–279

    Abstract: Emblica officinalis (EO) has antioxidant properties that could improve redox-sensitive vascular, cardiac and renal changes associated with deoxycorticosterone acetate/1% NaCl high salt (DOCA/HS)-induced hypertension. We determined whether hydroalcoholic ... ...

    Abstract Emblica officinalis (EO) has antioxidant properties that could improve redox-sensitive vascular, cardiac and renal changes associated with deoxycorticosterone acetate/1% NaCl high salt (DOCA/HS)-induced hypertension. We determined whether hydroalcoholic lyophilized extract of EO may influence DOCA/HS-induced hypertension by modulating activity of (p) eNOS and endogenous antioxidants. Hypertension was induced in rats by DOCA-salt (20 mg/kg, s.c.) twice weekly for 5 weeks and replacing drinking water with 1% NaCl solution. These rats received cotreatment of different doses of EO (75, 150 and 300 mg/kg/day) for 5 weeks. EO significantly decreased arterial blood pressure and heart rate along with cardiac and renal hypertrophy in a dose-dependent fashion as compared to DOCA control rats. Increased TBARS and decreased endogenous antioxidants including GSH, SOD and GSHPx activity in serum, heart and kidney tissues of hypertensive rats were also normalized. Furthermore, this antihypertensive activity of EO was also linked with increased serum NO, K(+) levels and decreased Na(+) levels. Moreover, EO robustly increased activated eNOS expression in heart. Our results demonstrate that EO reduces oxidative stress, prevents development and progression of hypertension as well as cardiac and renal hypertrophy in DOCA/HS-induced hypertension via modulation of activated eNOS, endogenous antioxidants, serum NO and electrolyte levels.
    Mesh-Begriff(e) Animals ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Cardiomegaly/enzymology ; Cardiomegaly/prevention & control ; Desoxycorticosterone ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Hypertension/chemically induced ; Hypertension/drug therapy ; Hypertension/enzymology ; Hypertension/physiopathology ; Kidney Diseases/enzymology ; Kidney Diseases/prevention & control ; Male ; Nitric Oxide/blood ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Phosphorylation ; Phyllanthus emblica ; Plant Extracts/pharmacology ; Potassium/blood ; Rats ; Sodium Chloride, Dietary/blood ; Superoxide Dismutase/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism ; Time Factors
    Chemische Substanzen Antihypertensive Agents ; Plant Extracts ; Sodium Chloride, Dietary ; Thiobarbituric Acid Reactive Substances ; Nitric Oxide (31C4KY9ESH) ; Desoxycorticosterone (40GP35YQ49) ; Glutathione Peroxidase (EC 1.11.1.9) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Nos3 protein, rat (EC 1.14.13.39) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione (GAN16C9B8O) ; Potassium (RWP5GA015D)
    Sprache Englisch
    Erscheinungsdatum 2011-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036765-X
    ISSN 1559-0259 ; 1530-7905
    ISSN (online) 1559-0259
    ISSN 1530-7905
    DOI 10.1007/s12012-011-9122-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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