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Book ; Online: Modellierung der Auswirkungen von unterschiedlichen mineralischen und organischen Düngergaben auf Erträge und Umwelt in betriebstypischen Anbausystemen ausgewählter Regionen von NRW

Gaiser, Thomas / Srivastava, Amit Kumar / Enders, Andreas

(Forschungsbericht / Lehr- und Forschungsschwerpunkt "Umweltverträgliche und Standortgerechte Landwirtschaft" an der Landwirtschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität ; Nr. 191)

2019

Abstract: ger: Das Forschungsvorhaben „Modellierung der Auswirkungen von unterschiedlichen mineralischen und organischen Düngergaben auf Erträge und Umwelt in betriebstypischen Anbausystemen ausgewählter Regionen von NRW“ war Teil des Clusterprojektes „ ... ...

Institution	Rheinische Friedrich-Wilhelms-Universität Bonn / Lehr- und Forschungsschwerpunkt Umweltverträgliche und Standortgerechte Landwirtschaft
Author's details	Verfasser: Dr. Thomas Gaiser (Projektleiter), Dr. Amit Srivastava, Dipl. Geoökologe Andreas Enders
Series title	Forschungsbericht / Lehr- und Forschungsschwerpunkt "Umweltverträgliche und Standortgerechte Landwirtschaft" an der Landwirtschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität ; Nr. 191 Forschungsbericht / Rheinische Friedrich-Wilhelms-Universität Bonn, Landwirtschaftliche Fakultät, Landwirtschaftliche Fakultät, Lehr- und Forschungsschwerpunkt "Umweltverträgliche und Standortgerechte Landwirtschaft"
Collection	Forschungsbericht / Rheinische Friedrich-Wilhelms-Universität Bonn, Landwirtschaftliche Fakultät, Landwirtschaftliche Fakultät, Lehr- und Forschungsschwerpunkt "Umweltverträgliche und Standortgerechte Landwirtschaft"
Abstract	ger: Das Forschungsvorhaben „Modellierung der Auswirkungen von unterschiedlichen mineralischen und organischen Düngergaben auf Erträge und Umwelt in betriebstypischen Anbausystemen ausgewählter Regionen von NRW“ war Teil des Clusterprojektes „Skalenübergreifende Modellierung von Änderungen der Agrarstruktur und landwirtschaftlichen Stoffflüssen in Regionen von Nordrhein- Westfalen“. Anlass für das Clusterprojekt war die im Juni 2017 verabschiedete, überarbeitete Düngeverordnung DüV2017 (BMEL, 2017) nach einem mehrjährigen Novellierungsprozess der DüV2007. Ziel des Clusters war die gekoppelte Simulation und Analyse von Nährstoffflüssen auf Ebene des Pflanzenbestandes (Teilprojekt TP1), des landwirtschaftlichen Betriebes (Teilprojekt TP2) und der Region unter expliziter Betrachtung des Nährstoffaustausches zwischen typischen landwirtschaftlichen Betrieben (Teilprojekt TP3). Ziel des Teilprojektes TP1 („Modellierung der Auswirkungen von unterschiedlichen mineralischen und organischen Düngergaben auf Erträge und Umwelt in betriebstypischen Anbausystemen ausgewählter Regionen von NRW “) war die Abschätzung von standortspezifischen Nährstoffflüssen in betriebstypischen Anbausystemen der Boden- Klima -Regionen Nordrhein- Westfalens mit Hilfe der Modellplattform SIMPLACE (Scientific Impact Assessment and Modelling Platform for Advanced Crop and Ecosystem Management). Gemeinsam mit Teilprojekt TP2 wurden in jeder Boden -Klima -Region Betriebe mit typischer betriebswirtschaftlicher Ausrichtung und einer betriebstypischen Fruchtfolge definiert, um eine konsistente Modellierung von Erträgen und Nährstoffflüssen auf der Standort - und Betriebsebene zu erreichen. Außerdem wurden gemeinsam mit TP2 108 Düngeszenarien für jede Fruchtart bzw. Fruchtfolge definiert. In der Modellplattform SIMPLACE wurde eine komplexe Modell -Solution entwickelt, die in der Lage ist alle ... eng: The research project "Modelling of the effects of different mineral and organic fertiliser applications on yields and the environment in typical farming systems of selected regions of NRW" was part of the cluster project "Cross-scale modelling of changes in agricultural structure and agricultural material flows in regions of North Rhine-Westphalia". The aim of the cluster was the coupled simulation and analysis of nutrient fluxes at the level of the field (subproject TP1), the farm (subproject TP2) and the region with explicit consideration of nutrient exchange between typical, region- specific farm types (subproject TP3). The aim of subproject TP1 ("Modelling of the effects of different mineral and organic fertiliser applications on yields and environment in typical farming systems of selected regions of North Rhine -Westphalia") was the assessment of site- specific nutrient flows in typical farming systems of the soil- climate regions of North Rhine -Westphalia using the modelling platform SIMPLACE (Scientific Impact Assessment and Modelling Platform for Advanced Crop and Ecosystem Management). Together with subproject TP2, farms with a typical farm management and a typical crop rotation were defined in each soil - climate region in order to achieve consistent modelling of yields and nutrient flows at the site and farm level. In addition, 108 fertiliser scenarios for each crop type and crop rotation were defined together with TP2. In the model platform SIMPLACE a complex model solution was developed, which is able to calculate all 108 fertiliser scenarios in combination with all crop rotations at three locations in each soil-climate region. The three locations were the three most important arable soils with the highest share in the cropland area of each region. This led to more than 3,000,000 simulation runs over a period of 26 simulation years (18 years spin- up phase and 8 years evaluation ...
Keywords	Deutschland ; Nordrhein-Westfalen ; Düngungsversuch ; Ernteertrag ; Umweltbelastung
Subject	Ökologische Belastung ; Umweltbeeinträchtigung ; Umweltproblem ; Umwelt ; Ertrag ; Pflanzenertrag ; Düngung
Subject code	630
Language	German
Size	1 Online-Ressource (IV, 65 Seiten)
Publisher	Lehr - und Forschungsschwerpunkt "Umweltverträgliche und Standort - gerechte Landwirtschaft", Landwirtschaftliche Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn
Publishing place	Bonn
Publishing country	Germany
Document type	Book ; Online
Note	Open Access
HBZ-ID	HT020191022
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Stem cell technologies in neuroscience

Srivastava, Amit K. / Snyder, Evan / Teng, Yang D.

(Neuromethods ; 126)

2017

Author's details	edited by Amit K. Srivastava, Evan Snyder, Yang D. Teng
Series title	Neuromethods ; 126
Collection
Keywords	pluripotence ; microvesicles ; in vitro stem cell-based neurological disease model ; neural stem cells ; stem cell genetic engineering ; intra-organ transplantation ; donor stem cells
Subject code	610
Language	English
Size	xiv, 240 Seiten, Illustrationen, 25.4 cm x 17.8 cm
Publisher	Humana Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book
HBZ-ID	HT019355045
ISBN	978-1-4939-7022-3 ; 1-4939-7022-4 ; 9781493970247 ; 1493970240
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2017 A 945	available for loan (reading room)	Lesesaal EG

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Article: Hybrid Immunity to SARS-CoV-2 from Infection and Vaccination-Evidence Synthesis and Implications for New COVID-19 Vaccines.

Spinardi, Julia R / Srivastava, Amit

Biomedicines

2023 Volume 11, Issue 2

Abstract: COVID-19 has taken a severe toll on the global population through infections, hospitalizations, and deaths. Elucidating SARS-CoV-2 infection-derived immunity has led to the development of multiple effective COVID-19 vaccines and their implementation into ...

Abstract	COVID-19 has taken a severe toll on the global population through infections, hospitalizations, and deaths. Elucidating SARS-CoV-2 infection-derived immunity has led to the development of multiple effective COVID-19 vaccines and their implementation into mass-vaccination programs worldwide. After ~3 years, a substantial proportion of the human population possesses immunity from infection and/or vaccination. With waning immune protection over time against emerging SARS-CoV-2 variants, it is essential to understand the duration of protection, breadth of coverage, and effects on reinfection. This targeted review summarizes available research literature on SARS-CoV-2 infection-derived, vaccination-elicited, and hybrid immunity. Infection-derived immunity has shown 93-100% protection against severe COVID-19 outcomes for up to 8 months, but reinfection is observed with some virus variants. Vaccination elicits high levels of neutralizing antibodies and a breadth of CD4+ and CD8+ T-cell responses. Hybrid immunity enables strong, broad responses, with high-quality memory B cells generated at 5- to 10-fold higher levels, versus infection or vaccination alone and protection against symptomatic disease lasting for 6-8 months. SARS-CoV-2 evolution into more transmissible and immunologically divergent variants has necessitated the updating of COVID-19 vaccines. To ensure continued protection against SARS-CoV-2 variants, regulators and vaccine technical committees recommend variant-specific or bivalent vaccines.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11020370
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Article ; Online: Acute Thrombolysis-Resistant Occlusive Left Femoral and Iliac Venous Thrombosis Treated with Mechanical Thrombectomy via the ClotTriever Device.

Srivastava, Amit

Annals of vascular surgery

2019 Volume 65, Page(s) 284.e7–284.e12

Abstract: Background: Deep vein thrombosis (DVT) is frequently treated by anticoagulation, which helps to prevent new thrombus formation, but to restore venous flow, additional efforts might be needed. Thrombolytic agents can help clear acute thrombus, but ... ...

Abstract	Background: Deep vein thrombosis (DVT) is frequently treated by anticoagulation, which helps to prevent new thrombus formation, but to restore venous flow, additional efforts might be needed. Thrombolytic agents can help clear acute thrombus, but increased bleeding risk is a concern; frequent contraindications are another. One lesser discussed potential limitation is thrombus age, which can affect efficiency of treatment. Case: A 62-year-old female patient with extensive DVT affecting the inferior vena cava (IVC) through the left femoral vein was initially treated with EKOS catheter directed thrombolysis (CDT) for 24 hr. Subsequent venogram revealed persistent, occlusive femoral and iliac thrombus. We decided on mechanical thrombectomy via the ClotTriever catheter (Inari Medical, Irvine, California), a nitinol coring element with an attached collection bag that can remove wall-adherent thrombus. We performed three passes with the device and removed large amounts of organized thrombus. Subsequent venography showed complete resolution of the occlusion. Finally, an underlying compression was treated via stenting. Conclusions: ClotTriever was effective in removing subacute and chronic thrombus, as demonstrated in this case with persistent extensive thrombus after 24 h of CDT. The ClotTriever System adds a valuable option for vascular interventionalists to treat DVT.
MeSH term(s)	Equipment Design ; Female ; Femoral Vein/diagnostic imaging ; Humans ; Iliac Vein/diagnostic imaging ; Middle Aged ; Thrombectomy/instrumentation ; Thrombolytic Therapy ; Treatment Outcome ; Vascular Access Devices ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/therapy
Language	English
Publishing date	2019-11-09
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2019.10.097
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Article ; Online: Neil 1 deficiency facilitates chemoresistance through upregulation of RAD18 expression in ovarian cancer stem cells.

Shukla, Devendra / Mandal, Tanima / Srivastava, Amit Kumar

Biochemical and biophysical research communications

2024 Volume 712-713, Page(s) 149907

Abstract: Over the past decades, cancer stem cells (CSCs) have emerged as a critical subset of tumor cells associated with tumor recurrence and resistance to chemotherapy. Understanding the mechanisms underlying CSC-mediated chemoresistance is imperative for ... ...

Abstract	Over the past decades, cancer stem cells (CSCs) have emerged as a critical subset of tumor cells associated with tumor recurrence and resistance to chemotherapy. Understanding the mechanisms underlying CSC-mediated chemoresistance is imperative for improving cancer therapy outcomes. This study delves into the regulatory role of NEIL1, a DNA glycosylase, in chemoresistance in ovarian CSCs. We first observed a decreased expression of NEIL1 in ovarian CSCs, suggesting its potential involvement in CSC regulation. Using pan-cancer analysis, we confirmed the diminished NEIL1 expression in ovarian tumors compared to normal tissues. Furthermore, NEIL1 downregulation correlated with an increase in stemness markers and enrichment of CSCs, highlighting its role in modulating CSC phenotype. Further mechanistic investigation revealed an inverse correlation between NEIL1 and RAD18 expression in ovarian CSCs. NEIL1 depletion led to heightened RAD18 expression, promoting chemoresistance possibly via enhancing Translesion DNA Synthesis (TLS)-mediated DNA lesion bypass. Moreover, dowregulation of NEIL1 results in reduced DNA damage accumulation and suppressed apoptosis in ovarian cancer. Overall, our findings unveil a novel mechanism involving NEIL1 and RAD18 in regulating chemoresistance in ovarian CSCs. Targeting this NEIL1-RAD18 axis may offer promising therapeutic strategies for combating chemoresistance and improving ovarian cancer treatment outcomes.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149907
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Article ; Online: Inheritable nanotubes boost bioimaging and photovoltaics in cyanobacteria.

Srivastava, Amit / Selim, Khaled A

Nature nanotechnology

2022 Volume 17, Issue 10, Page(s) 1046–1047

MeSH term(s)	Cyanobacteria/genetics ; Nanotubes
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2254964-X
ISSN	1748-3395 ; 1748-3387
ISSN (online)	1748-3395
ISSN	1748-3387
DOI	10.1038/s41565-022-01212-2
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Article ; Online: Cyanobacterial Peptides: Metabolic Potential and Environmental Fate.

Srivastava, Amit / Shukla, Pratyoosh

Protein and peptide letters

2022 Volume 29, Issue 5, Page(s) 375–378

MeSH term(s)	Cyanobacteria ; Peptides
Chemical Substances	Peptides
Language	English
Publishing date	2022-06-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1280776-x
ISSN	1875-5305 ; 0929-8665
ISSN (online)	1875-5305
ISSN	0929-8665
DOI	10.2174/0929866529666220314111105
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Article: Emerging tools and strategies in cyanobacterial omics

Srivastava, Amit / Shukla, Pratyoosh

Elsevier Ltd Trends in biotechnology. 2022 Jan., v. 40, no. 1

2022

Abstract: Cyanobacteria are emerging as a popular system in both basic and applied microbial research. However, the incomplete understanding of their molecular biology hinders their practical applications in the industrial, agricultural, and environmental sectors. ...

Abstract	Cyanobacteria are emerging as a popular system in both basic and applied microbial research. However, the incomplete understanding of their molecular biology hinders their practical applications in the industrial, agricultural, and environmental sectors. We present the potential of recently developed omics approaches to obtain deeper insights into cyanobacterial molecular physiology.
Keywords	Cyanobacteria ; biotechnology ; molecular biology ; physiology
Language	English
Dates of publication	2022-01
Size	p. 4-7.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2021.05.004
Database	NAL-Catalogue (AGRICOLA)

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Article: Hydrogen Bond Dynamics and Phase Transitions of Water inside Carbon Nanotubes.

Srivastava, Amit / Hassan, Jamal / Homouz, Dirar

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: Water dynamics in nanochannels are altered by confinement, particularly in small carbon nanotubes (CNTs). However, the mechanisms behind these effects remain unclear. To address these issues, we carried out extensive molecular dynamics (MD) simulations ... ...

Abstract	Water dynamics in nanochannels are altered by confinement, particularly in small carbon nanotubes (CNTs). However, the mechanisms behind these effects remain unclear. To address these issues, we carried out extensive molecular dynamics (MD) simulations to investigate the structure and dynamics of water inside CNTs of different sizes (length of 20 nm and diameters vary from 0.8 nm to 5.0 nm) at different temperatures (from 200 K to 420 K). The radial density profile of water inside CNTs shows a single peak near the CNT walls for small nanotubes. For CNTs with larger sizes, water molecules are arranged into coaxial tubular sheets, the number of which increases with the CNT size. Subdiffusive behavior is observed for ultranarrow CNTs with diameters of 0.8 nm and 1 nm. As the size of CNTs increases, Fickian diffusion becomes evident. The hydrogen bond correlation function of water inside CNT decays slower than in bulk water, and the decay rate decreases as we increase the diameter of the CNTs. In large CNTs, the hydrogen bond lifetime of the innermost layer is shorter than the other layers and depends on temperature. Additional analysis of our results reveals that water molecules along the CNT axis show a non-Arrhenius to Arrhenius diffusion crossover. In general, the diffusion transition temperature is higher than that of bulk water, but it depends on the size of the CNT.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13020284
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Article: Modified Technique of Percutaneous Tracheostomy Using Borescope Camera: A Case Series.

Mustahsin, Mohd / Srivastava, Amit / Manchanda, Jay / Kaushik, Ravi

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2023 Volume 26, Issue 7, Page(s) 881–883

Abstract: Percutaneous dilatational tracheostomy (PDT) is a routinely performed procedure in the intensive care unit (ICU). Bronchoscopy guidance is recommended which requires expertise to use it, and also it is not readily available in all ICUs. Moreover, it can ... ...

Abstract	Percutaneous dilatational tracheostomy (PDT) is a routinely performed procedure in the intensive care unit (ICU). Bronchoscopy guidance is recommended which requires expertise to use it, and also it is not readily available in all ICUs. Moreover, it can lead to carbondioxide (CO How to cite this article: Mustahsin M, Srivastava A, Manchanda J, Kaushik R. Modified Technique of Percutaneous Tracheostomy Using Borescope Camera: A Case Series. Indian J Crit Care Med 2022;26(7):881-883.
Language	English
Publishing date	2023-02-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24265
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