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  1. Book ; Online ; E-Book: Multi-pronged omics technologies to understand COVID-19

    Srivastava, Sanjeeva

    2022  

    Abstract: COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better ... ...

    Author's details edited by Sanjeeva Srivastava
    Abstract ""COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns. The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both "Omics technology" and "COVID-19" as a disease. The book covers the most recent understanding of COVID-19 and the applications of cutting-edge studies, making it accessible to a large multidisciplinary readership. The book explains how high-throughput technologies and systems biology might assist to solve the pandemic's challenges and deconstruct and appreciate the substantial contributions that omics technologies have made in predicting the path of this unforeseeable pandemic. Features: In-depth summary of clinical presentation, epidemiological impact, and long-term sequelae of COVID-19 pandemic; a systematic overview of omics-based approaches to the study of COVID-19 biology; recent research results and some pointers to future advancements in methodologies used; detailed examples from recent studies on COVID-19 encompassing different omics methodologies; and a detailed description of methodologies and notes on the applications of state-of-the-art technologies. This book is intended for scientists who need to understand the biology of COVID-19 from the perspective of omics investigations, as well as researchers who want to employ omics-based technologies in disease biology"--
    Keywords Technological innovations
    Subject code 614.592414
    Language English
    Size 1 online resource (237 pages)
    Publisher CRC Press
    Publishing place Boca Raton, Florida
    Document type Book ; Online ; E-Book
    Note Description based upon print version of record.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-322078-9 ; 1-003-22078-9 ; 1-000-59569-2 ; 1-000-59560-9 ; 9781032116266 ; 978-1-00-322078-7 ; 978-1-003-22078-7 ; 978-1-000-59569-7 ; 978-1-000-59560-4 ; 1032116269
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: From proteins to proteomics

    Srivastava, Sanjeeva

    basic concepts, techniques, and applications

    2023  

    Abstract: This book provides a detailed understanding of the basics of proteins and proteomics, Gel based-proteomics techniques, basics of mass-spectrometry and quantitative proteomics, Interactomics: basics and applications, and advancement in proteomics. ...

    Author's details Sanjeeva Srivastava
    Abstract This book provides a detailed understanding of the basics of proteins and proteomics, Gel based-proteomics techniques, basics of mass-spectrometry and quantitative proteomics, Interactomics: basics and applications, and advancement in proteomics.
    Keywords Proteomics. ; Proteomics
    Subject code 572.6
    Language English
    Size 1 online resource (272 pages)
    Publisher CRC Press
    Publishing place Boca Raton ; London
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-309864-9 ; 1-003-09864-9 ; 1-000-64867-2 ; 1-000-64870-2 ; 9780367566173 ; 978-1-00-309864-5 ; 978-1-003-09864-5 ; 978-1-000-64867-6 ; 978-1-000-64870-6 ; 0367566176
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: From Proteins to Proteomics

    Srivastava, Sanjeeva

    Basic Concepts, Techniques, and Applications

    2023  

    Abstract: Proteomics aims to study all the proteins of human and other living systems, as well as their properties to provide an integrated view of cellular processes. The study of proteomics involves the application of rapidly evolving high-throughput ... ...

    Author's details Prof. Sanjeeva Srivastava is a professor and the group leader of the Proteomics Laboratory at the Department of Biosciences and Bioengineering at the Indian Institute of Technology, Bombay. High-throughput proteomics, protein microarrays, and mass spectrometry are among his specialties. He has implemented ground-breaking AI-driven data analytics on big biological datasets. He has been at the forefront of biomedical research based on big data. His group's current research focuses on the development of clinical biomarkers for infectious diseases and malignancies. His group also pioneered therapeutic target identification efforts and decoded protein interaction networks in human illnesses like gliomas and contagious diseases like COVID-19 and malaria. His group has developed reliable diagnostic biomarkers and described the pathophysiology of severe malaria (falciparum and vivax) and COVID-19, especially the underlying mechanisms that lead to the development of severe sequelae.§ Dr. Sri
    Abstract Proteomics aims to study all the proteins of human and other living systems, as well as their properties to provide an integrated view of cellular processes. The study of proteomics involves the application of rapidly evolving high-throughput technologies and new platforms that are coming forward regularly, providing versatile novel tools for biomedical and pharmaceutical applications. -- This book provides a detailed understanding of the basics of proteins and proteomics, gel based-proteom...
    Keywords polyacrylamide gel ; SDS-PAGE ; Mass Spectrometry ; Differential Gel Electrophoresis ; Gel-based proteomics ; SILAC ; Protein Microarrays ; Clinical Proteomics ; DIGE ; Nappa ; SPRi ; Biomolecular Interactions ; Mass Analyzer ; IPG Strip ; Protein Protein Interactions ; Mass Spectrometry Based Quantitative Proteomics ; Array Surface ; Sample Preparation ; MS Data Analysis ; Cell Free Expression Systems ; Studying Protein Protein Interaction ; Label Free Technique ; SPR ; Proteomics Research ; Low Abundance Analytes ; anti-GST Antibodies ; Stable Isotope Labeling ; HUPO ; Protein Arrays ; DIA
    Language English
    Size 272 p.
    Edition 1
    Publisher Taylor & Francis Ltd
    Document type Book
    Note PDA Manuell_17
    Format 178 x 254
    ISBN 9780367566173 ; 0367566176
    Database PDA

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  4. Book: Protein microarrays for disease analysis

    Barderas, Rodrigo / LaBaer, Joshua / Srivastava, Sanjeeva

    methods and protocols

    (Methods in molecular biology ; 2344 ; Springer protocols)

    2021  

    Author's details edited by Rodrigo Barderas, Joshua LaBaer, Sanjeeva Srivastava
    Series title Methods in molecular biology ; 2344
    Springer protocols
    Collection
    Language English
    Size xiv, 282 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020973248
    ISBN 978-1-0716-1561-4 ; 9781071615621 ; 1-0716-1561-0 ; 1071615629
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Proteomics-Based Investigations of Neglected and Tropical Diseases.

    Srivastava, Sanjeeva

    Proteomics. Clinical applications

    2018  Volume 12, Issue 4, Page(s) e1800076

    MeSH term(s) Humans ; Neglected Diseases/metabolism ; Neglected Diseases/physiopathology ; Proteome/analysis ; Proteomics/methods ; Tropical Medicine
    Chemical Substances Proteome
    Language English
    Publishing date 2018-06-14
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2261788-7
    ISSN 1862-8354 ; 1862-8346
    ISSN (online) 1862-8354
    ISSN 1862-8346
    DOI 10.1002/prca.201800076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Molecular Mechanisms and the Interplay of Important Chronic Obstructive Pulmonary Disease Biomarkers Reveals Novel Therapeutic Targets.

    Sharma, Gautam / Banerjee, Rinti / Srivastava, Sanjeeva

    ACS omega

    2023  Volume 8, Issue 49, Page(s) 46376–46389

    Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a progressive, age-dependent, and unmet chronic inflammatory disease of the peripheral airways, leading to difficulty in exhalation. Several biomarkers have been tested in general towards the resolution for ...

    Abstract Chronic Obstructive Pulmonary Disease (COPD) is a progressive, age-dependent, and unmet chronic inflammatory disease of the peripheral airways, leading to difficulty in exhalation. Several biomarkers have been tested in general towards the resolution for a long time, but no apparent success was achieved. Ongoing therapies of COPD have only symptomatic relief but no cure. Reactive oxygen species (ROS) are highly reactive species which include oxygen radicals and nonradical derivatives, and are the prominent players in COPD. They are produced as natural byproducts of cellular metabolism, but their levels can vary due to exposure to indoor air pollution, occupational pollution, and environmental pollutants such as cigarette smoke. In COPD, the lungs are continuously exposed to high levels of ROS thus leading to oxidative stress. ROS can cause damage to cells, proteins, lipids, and DNA which further contributes to the chronic inflammation in COPD and exacerbates the disease condition. Excessive ROS production can overwhelm cellular antioxidant systems and act as signaling molecules that regulate cellular processes, including antioxidant defense mechanisms involving glutathione and sirtuins which further leads to cellular apoptosis, cellular senescence, inflammation, and sarcopenia. In this review paper, we focused on COPD from different perspectives including potential markers and different cellular processes such as apoptosis, cellular senescence, inflammation, sirtuins, and sarcopenia, and tried to connect the dots between them so that novel therapeutic strategies to evaluate and target the possible underlying mechanisms in COPD could be explored.
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: "Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome.

    Naik, Akul / Srivastava, Sanjeeva / Wiita, Arun P

    Journal of visualized experiments : JoVE

    2023  , Issue 193

    Abstract: Over the past decade, mass spectrometry-based proteomics has enabled an in-depth characterization of biological systems across a broad array of applications. The cell surface proteome ("surfaceome") in human disease is of significant interest, as plasma ... ...

    Abstract Over the past decade, mass spectrometry-based proteomics has enabled an in-depth characterization of biological systems across a broad array of applications. The cell surface proteome ("surfaceome") in human disease is of significant interest, as plasma membrane proteins are the primary target of most clinically approved therapeutics, as well as a key feature by which to diagnostically distinguish diseased cells from healthy tissues. However, focused characterization of membrane and surface proteins of the cell has remained challenging, primarily due to the complexity of cellular lysates, which mask proteins of interest by other high-abundance proteins. To overcome this technical barrier and accurately define the cell surface proteome of various cell types using mass spectrometry proteomics, it is necessary to enrich the cell lysate for cell surface proteins prior to analysis on the mass spectrometer. This paper presents a detailed workflow for labeling cell surface proteins from cancer cells, enriching these proteins out of the cell lysate, and subsequent sample preparation for mass spectrometry analysis.
    MeSH term(s) Humans ; Proteome/analysis ; Workflow ; Mass Spectrometry/methods ; Cell Membrane/metabolism ; Membrane Proteins/metabolism
    Chemical Substances Proteome ; Membrane Proteins
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/64952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Protein arrays: promises and potential for the translational research.

    Srivastava, Sanjeeva

    Proteomics

    2016  Volume 16, Issue 8, Page(s) 1191–1192

    MeSH term(s) Humans ; Protein Array Analysis/instrumentation ; Protein Array Analysis/methods ; Protein Binding ; Proteome/metabolism ; Proteomics/instrumentation ; Proteomics/methods ; Translational Medical Research/instrumentation ; Translational Medical Research/methods ; Translational Medical Research/trends
    Chemical Substances Proteome
    Language English
    Publishing date 2016-04
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.201600131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Biomarker discovery in the developing world

    Srivastava, Sanjeeva

    dissecting the pipeline for meeting the challenges

    2016  

    Author's details Sanjeeva Srivastava, editor
    MeSH term(s) Biomedical Research ; Biomarkers, Tumor/therapeutic use ; Developing Countries ; Translational Medical Research
    Language English
    Size xi, 118 pages :, illustrations
    Document type Book
    ISBN 9788132228356 ; 9788132228370 ; 8132228359 ; 8132228375
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Giant Virus Global Proteomics Innovation: Comparative Evaluation of In-Gel and In-Solution Digestion Methods.

    Upadhyay, Monica / Nair, Divya / Moseley, Gregory W / Srivastava, Sanjeeva / Kondabagil, Kiran

    Omics : a journal of integrative biology

    2024  Volume 28, Issue 4, Page(s) 170–181

    Abstract: With their unusually large genome and particle sizes, giant viruses (GVs) defy the conventional definition of viruses. Although most GVs isolated infect unicellular protozoans, such as amoeba, studies in the last decade have established their much wider ... ...

    Abstract With their unusually large genome and particle sizes, giant viruses (GVs) defy the conventional definition of viruses. Although most GVs isolated infect unicellular protozoans, such as amoeba, studies in the last decade have established their much wider prevalence infecting most eukaryotic supergroups and some giant viral families with the potential to be human pathogens. Their complexity, almost autonomous life cycle, and enigmatic evolution necessitate the study of GVs. The accurate assessment of GV proteome is a veritable challenge. We have compared the coverage of global protein identification using different methods for GVs isolated in Mumbai, Mimivirus Bombay (MVB), Powai Lake Megavirus (PLMV), and Kurlavirus (KV), along with two previously studied GVs, Acanthamoeba polyphaga Mimivirus (APMV) and Marseillevirus (MV). Our study shows that the simultaneous use of in-gel and in-solution digestion methods can significantly increase the coverage of protein identification in the global proteome analysis of purified GV particles. Combining the two methods of analyses, we identified an additional 72 proteins in APMV and 114 in MV compared with what have been previously reported. Similarly, proteomes of MVB, PLMV, and KV were analyzed, and a total of 242 proteins in MVB, 287 proteins in PLMV, and 174 proteins in KV were identified. Our results suggest that a combined methodology of in-gel and in-solution methods is more efficient and opens up new avenues for innovation in global proteome analysis of GVs. Future planetary health research on GVs can benefit from consideration of a broader range of proteomics methodologies as illustrated by the present study.
    MeSH term(s) Proteomics/methods ; Giant Viruses/genetics ; Giant Viruses/metabolism ; Proteome ; Viral Proteins/metabolism
    Chemical Substances Proteome ; Viral Proteins
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2030312-9
    ISSN 1557-8100 ; 1536-2310
    ISSN (online) 1557-8100
    ISSN 1536-2310
    DOI 10.1089/omi.2024.0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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