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  1. Article ; Online: Transition of Care in Children with Chronic Kidney Disease, Dialysis, and Transplantation.

    Riar, Sandeep / Srivastava, Tarak / George, Roshan

    Indian journal of pediatrics

    2023  Volume 90, Issue 12, Page(s) 1237–1244

    Abstract: Improvement in management of pediatric renal disorders has led to patient survival rates of 85-90%, increasing the number of adolescent and young adult (AYA) patients with childhood onset chronic kidney disease (CKD) transitioning to adult care settings. ...

    Abstract Improvement in management of pediatric renal disorders has led to patient survival rates of 85-90%, increasing the number of adolescent and young adult (AYA) patients with childhood onset chronic kidney disease (CKD) transitioning to adult care settings. Pediatric CKD patients differ from adults with CKD in view of early onset of disease (sometimes with fetal onset), different disease spectrum, the potential effect of CKD on neurodevelopment, and substantial involvement of parents in medical decision making. In addition to the usual challenges of emerging adulthood (graduation from school to work, independent living, peak in impulsivity and risk-taking behaviors), young adults with pediatric CKD need to learn to manage a serious medical condition independently. In kidney transplant patients, regardless of the age at transplantation, graft failure rates are higher during adolescence and young adulthood than at any other age. All pediatric CKD patients must move from a pediatric to adult-focused settings and this transition is a longitudinal process requiring collaboration and interactions of AYA patients, their families, providers, health care environment and agencies. Consensus guidelines have provided recommendations to pediatric and adult renal teams to enable successful transition. Suboptimal transition is a risk factor for poor adherence to treatment and unfavorable health outcomes. The authors discuss the process of transition as it applies to pediatric CKD patients and review challenges faced by patients/families, pediatric and adult nephrology teams. They provide some suggestions and available tools to optimize the transition of pediatric CKD patients to adult-oriented care.
    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Young Adult ; Kidney Transplantation ; Patient Transfer ; Renal Dialysis ; Renal Insufficiency, Chronic ; Transition to Adult Care
    Language English
    Publishing date 2023-06-09
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-023-04629-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rickets, elevated fibroblast growth factor-23 and mild anemia: Answers.

    VanSickle, Judith Sebestyen / Srivastava, Tarak / Monachino, Penny / Alon, Uri S

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 36, Issue 8, Page(s) 2301–2304

    Language English
    Publishing date 2021-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05012-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rickets, elevated fibroblast growth factor-23 and mild anemia: Questions.

    VanSickle, Judith Sebestyen / Srivastava, Tarak / Monachino, Penny / Alon, Uri S

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 36, Issue 8, Page(s) 2299

    Language English
    Publishing date 2021-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05000-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association of mental health-related patient reported outcomes with blood pressure in adults and children with primary proteinuric glomerulopathies.

    Schuchman, Matthew / Brady, Tammy M / Glenn, Dorey A / Tuttle, Katherine R / Cara-Fuentes, Gabriel / Levy, Rebecca V / Gonzalez-Vicente, Agustin / Alakwaa, Fadhl M / Srivastava, Tarak / Sethna, Christine B

    Journal of nephrology

    2024  

    Abstract: Introduction: The prevalence of mental health disorders including anxiety and depression is increasing and is linked to hypertension in healthy individuals. However, the relationship of psychosocial patient-reported outcomes on blood pressure (BP) in ... ...

    Abstract Introduction: The prevalence of mental health disorders including anxiety and depression is increasing and is linked to hypertension in healthy individuals. However, the relationship of psychosocial patient-reported outcomes on blood pressure (BP) in primary proteinuric glomerulopathies is not well characterized. This study explored longitudinal relationships between psychosocial patient-reported outcomes and BP status among individuals with proteinuric glomerulopathies.
    Methods: An observational cohort study was performed using data from 745 adults and children enrolled in the Nephrotic Syndrome Study Network (NEPTUNE). General Estimating Equations for linear regression and binary logistic analysis for odds ratios were performed to analyze relationships between the exposures, longitudinal Patient-Reported Outcome Measurement Information System (PROMIS) measures and BP and hypertension status as outcomes.
    Results: In adults, more anxiety was longitudinally associated with higher systolic and hypertensive BP. In children, fatigue was longitudinally associated with increased odds of hypertensive BP regardless of the PROMIS report method. More stress, anxiety, and depression were longitudinally associated with higher systolic BP index, higher diastolic BP index, and increased odds of hypertensive BP index in children with parent-proxy patient-reported outcomes.
    Discussion/conclusion: Chronically poor psychosocial patient-reported outcomes may be significantly associated with higher BP and hypertension in adults and children with primary proteinuric glomerulopathies. This interaction appears strong in children but should be interpreted with caution, as multiple confounders related to glomerular disease may influence both mental health and BP independently. That said, access to mental health resources may help control BP, and proper disease and BP management may improve overall mental health.
    Language English
    Publishing date 2024-03-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-024-01919-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Solving an unusual case of acute kidney injury: Questions.

    Garg, Uttam / Taboada, Eugenio / Kurzinski, Katherine L / Frazee, Clarence C / Weidemann, Darcy K / Srivastava, Tarak

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 36, Issue 12, Page(s) 4135–4136

    Language English
    Publishing date 2021-10-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05258-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Solving an unusual case of acute kidney injury: Answers.

    Garg, Uttam / Taboada, Eugenio / Kurzinski, Katherine L / Frazee, Clarence C / Weidemann, Darcy K / Srivastava, Tarak

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 36, Issue 12, Page(s) 4137–4140

    Language English
    Publishing date 2021-10-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05263-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Use of calcimimetics in children with normal kidney function.

    VanSickle, Judith Sebestyen / Srivastava, Tarak / Alon, Uri S

    Pediatric nephrology (Berlin, Germany)

    2018  Volume 34, Issue 3, Page(s) 413–422

    Abstract: The calcium-sensing receptor (CaSR) plays an important role in the homeostasis of serum ionized calcium by regulating parathyroid hormone (PTH) secretion and tubular calcium handling. Calcimimetics, which act by allosteric modulation of the CaSR, mimic ... ...

    Abstract The calcium-sensing receptor (CaSR) plays an important role in the homeostasis of serum ionized calcium by regulating parathyroid hormone (PTH) secretion and tubular calcium handling. Calcimimetics, which act by allosteric modulation of the CaSR, mimic hypercalcemia resulting in suppression of PTH release and increase in calciuria. Mostly used in children to treat secondary hyperparathyroidism associated with advanced renal failure, we have shown that calcimimetics can also be successfully used in children with bone and mineral disorders in which elevated PTH plays a detrimental role in skeletal pathophysiology in the face of normal kidney function. The current review briefly discusses the role of the CaSR and calcimimetics in calcium homeostasis, and then addresses the potential applications of calcimimetics in children with normal kidney function with disorders in which suppression of PTH is beneficial.
    MeSH term(s) Allosteric Regulation/drug effects ; Bone Diseases, Metabolic/blood ; Bone Diseases, Metabolic/drug therapy ; Bone Diseases, Metabolic/urine ; Calcimimetic Agents/pharmacology ; Calcimimetic Agents/therapeutic use ; Calcium/blood ; Calcium/metabolism ; Calcium/urine ; Child ; Humans ; Hyperparathyroidism/blood ; Hyperparathyroidism/drug therapy ; Hyperparathyroidism/urine ; Parathyroid Hormone/antagonists & inhibitors ; Parathyroid Hormone/blood ; Parathyroid Hormone/metabolism ; Receptors, Calcium-Sensing/metabolism ; Renal Elimination/drug effects ; Treatment Outcome ; Vitamin D/metabolism
    Chemical Substances CASR protein, human ; Calcimimetic Agents ; Parathyroid Hormone ; Receptors, Calcium-Sensing ; Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-03-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-018-3935-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Risk Factors for Short- and Long-Term Outcomes in Children With STEC-HUS/D

    VanSickle, Judith Sebestyen / Srivastava, Tarak / Alon, Uri S

    Global pediatric health

    2018  Volume 5, Page(s) 2333794X18816920

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2018-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785531-4
    ISSN 2333-794X ; 2333-794X
    ISSN (online) 2333-794X
    ISSN 2333-794X
    DOI 10.1177/2333794X18816920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Glomerular Biomechanical Stress and Lipid Mediators during Cellular Changes Leading to Chronic Kidney Disease.

    Sharma, Mukut / Singh, Vikas / Sharma, Ram / Koul, Arnav / McCarthy, Ellen T / Savin, Virginia J / Joshi, Trupti / Srivastava, Tarak

    Biomedicines

    2022  Volume 10, Issue 2

    Abstract: Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD). These include obesity, diabetes, hypertension, focal segmental ... ...

    Abstract Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD). These include obesity, diabetes, hypertension, focal segmental glomerulosclerosis (FSGS), congenital abnormalities and reduced renal mass (low nephron number). Hyperfiltration-associated biomechanical forces directly impact the cell membrane, generating tensile and fluid flow shear stresses in multiple segments of the nephron. Ongoing research suggests these biomechanical forces as the initial mediators of hyperfiltration-induced deterioration of podocyte structure and function leading to their detachment and irreplaceable loss from the glomerular filtration barrier. Membrane lipid-derived polyunsaturated fatty acids (PUFA) and their metabolites are potent transducers of biomechanical stress from the cell surface to intracellular compartments. Omega-6 and ω-3 long-chain PUFA from membrane phospholipids generate many versatile and autacoid oxylipins that modulate pro-inflammatory as well as anti-inflammatory autocrine and paracrine signaling. We advance the idea that lipid signaling molecules, related enzymes, metabolites and receptors are not just mediators of cellular stress but also potential targets for developing novel interventions. With the growing emphasis on lifestyle changes for wellness, dietary fatty acids are potential adjunct-therapeutics to minimize/treat hyperfiltration-induced progressive glomerular damage and CKD.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10020407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The effect of burosumab on intact and C-terminal FGF23 measurements.

    Ashrafzadeh-Kian, Susan Louise / Ito, Nobuaki / Srivastava, Tarak / Garg, Uttam / Kato, Hajime / Algeciras-Schimnich, Alicia / Bornhorst, Joshua A

    Clinical endocrinology

    2022  Volume 99, Issue 2, Page(s) 152–157

    Abstract: Objective: To investigate the effect of CRYSVITA® (burosumab-twza) on FGF23 measurements in an intact and a C-terminal immunoassay.: Methods: An intact serum FGF23 (MedFrontier) and a C-terminal plasma FGF23 assay (Immutopics) were used. Serum/plasma ...

    Abstract Objective: To investigate the effect of CRYSVITA® (burosumab-twza) on FGF23 measurements in an intact and a C-terminal immunoassay.
    Methods: An intact serum FGF23 (MedFrontier) and a C-terminal plasma FGF23 assay (Immutopics) were used. Serum/plasma pools were spiked to span the burosumab therapeutic range (1.4-11.3 μg/ml) and FGF23 recovery was assessed. Patient serum and plasma samples obtained pre and post-burosumab treatment were evaluated on both assays and compared with corresponding phosphorus measurements RESULTS: Spiking burosumab (1.4-11.3 μg/ml) into sample pools resulted in a dose-dependent negative analytical interference on intact FGF23 measurements and no significant interference for C-terminal FGF23 measurements. However, more than a 500-fold median increase (post- vs. pre-burosumab administration) in in vivo FGF23 concentrations were observed by both assays.
    Conclusions: Therapeutic concentrations of burosumab result in a negative analytical interference of the intact, but not the C-terminal FGF23 immunoassay. Despite this in vitro analytical interference in the intact assay, relatively large elevations of both intact FGF23 and C-terminal FGF23 measurements were observed in vivo following burosumab administration. Following burosumab administration, FGF23 measurements must be interpreted within the clinical context of the patient and other relevant biomarker results.
    Summary: This article describes a negative analytical interference by burosumab in an intact FGF23 immunoassay. The recovery of C-terminal FGF23 is not significantly affected by the presence of burosumab. In vivo, both assays demonstrate extreme FGF23 elevations in the presence of the drug. Furthermore, the measurement of FGF23 blocked by burosumab is not clinically useful regarding hypophosphataemia.
    MeSH term(s) Humans ; Fibroblast Growth Factors ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Biomarkers ; Biological Assay ; Familial Hypophosphatemic Rickets/drug therapy
    Chemical Substances burosumab (G9WJT6RD29) ; Fibroblast Growth Factors (62031-54-3) ; Antibodies, Monoclonal, Humanized ; Biomarkers
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14832
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