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  1. Article ; Conference proceedings: Molecular cell biology of the endothelium in development and diseases

    Stürzl, Michael

    conference program ; [abstracts]

    2002  

    Institution Symposium on the Biology of Endothelial Cells
    Author's details 4th Symposium on the Biology of Endothelial Cells, July 18 - 20, 2003, Munich, Germany. Org. by Michael Stürzl
    Language English
    Publishing country Netherlands
    Document type Article ; Conference proceedings
    Note In: Angiogenesis. - ISSN 0969-6970. - 5 (2002),4, S. 275 - 354
    HBZ-ID HT013745034
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 5094 -5- not available for loan Zeitschriften-Lesesaal

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  2. Book ; Online ; Thesis: Permeabilitätsanalyse und dreidimensionale Bildgebung des Interferon-gamma-induzierten Barrierezusammenbruchs in Darm-Organoiden

    Bardenbacher, Marco [Verfasser] / Stürzl, Michael [Akademischer Betreuer] / Stürzl, Michael [Gutachter]

    2023  

    Author's details Marco Bardenbacher ; Gutachter: Michael Stürzl ; Betreuer: Michael Stürzl
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
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  3. Book ; Online ; Thesis: The addition of bisecting GlcNAcs to the IFNgRa restores IFN-g responsiveness in colorectal carcinoma cells.

    Straube, Julia [Verfasser] / Stürzl, Michael [Akademischer Betreuer] / Stürzl, Michael [Gutachter]

    2023  

    Author's details Julia Straube ; Gutachter: Michael Stürzl ; Betreuer: Michael Stürzl
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
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  4. Article: Blood Vessel-Targeted Therapy in Colorectal Cancer: Current Strategies and Future Perspectives.

    Jacobsen, Anne / Siebler, Jürgen / Grützmann, Robert / Stürzl, Michael / Naschberger, Elisabeth

    Cancers

    2024  Volume 16, Issue 5

    Abstract: The vasculature is a key player and regulatory component in the multicellular microenvironment of solid tumors and, consequently, a therapeutic target. In colorectal carcinoma (CRC), antiangiogenic treatment was approved almost 20 years ago, but there ... ...

    Abstract The vasculature is a key player and regulatory component in the multicellular microenvironment of solid tumors and, consequently, a therapeutic target. In colorectal carcinoma (CRC), antiangiogenic treatment was approved almost 20 years ago, but there are still no valid predictors of response. In addition, treatment resistance has become a problem. Vascular heterogeneity and plasticity due to species-, organ-, and milieu-dependent phenotypic and functional differences of blood vascular cells reduced the hope of being able to apply a standard approach of antiangiogenic therapy to all patients. In addition, the pathological vasculature in CRC is characterized by heterogeneous perfusion, impaired barrier function, immunosuppressive endothelial cell anergy, and metabolic competition-induced microenvironmental stress. Only recently, angiocrine proteins have been identified that are specifically released from vascular cells and can regulate tumor initiation and progression in an autocrine and paracrine manner. In this review, we summarize the history and current strategies for applying antiangiogenic treatment and discuss the associated challenges and opportunities, including normalizing the tumor vasculature, modulating milieu-dependent vascular heterogeneity, and targeting functions of angiocrine proteins. These new strategies could open perspectives for future vascular-targeted and patient-tailored therapy selection in CRC.
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases.

    Britzen-Laurent, Nathalie / Weidinger, Carl / Stürzl, Michael

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders with a complex etiology, which represent a clinical challenge due to their often therapy-refractory nature. In IBD, inflammation of the intestinal mucosa is ... ...

    Abstract Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders with a complex etiology, which represent a clinical challenge due to their often therapy-refractory nature. In IBD, inflammation of the intestinal mucosa is characterized by strong and sustained leukocyte infiltration, resulting in the loss of epithelial barrier function and subsequent tissue destruction. This is accompanied by the activation and the massive remodeling of mucosal micro-vessels. The role of the gut vasculature in the induction and perpetuation of mucosal inflammation is receiving increasing recognition. While the vascular barrier is considered to offer protection against bacterial translocation and sepsis after the breakdown of the epithelial barrier, endothelium activation and angiogenesis are thought to promote inflammation. The present review examines the respective pathological contributions of the different phenotypical changes observed in the microvascular endothelium during IBD, and provides an overview of potential vessel-specific targeted therapy options for the treatment of IBD.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases/pathology ; Inflammation/metabolism ; Intestinal Mucosa/metabolism ; Mucositis/pathology ; Leukocytes/metabolism
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065517
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  6. Book ; Online ; Thesis: Structure and function analysis of the human Guanylate binding protein-1 (GBP-1) – a novel actin binding-protein (ABP)

    Hupfer, Isabella [Verfasser] / Stürzl, Michael [Akademischer Betreuer] / Stürzl, Michael [Gutachter]

    2022  

    Author's details Isabella Hupfer ; Gutachter: Michael Stürzl ; Betreuer: Michael Stürzl
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Book ; Online ; Thesis: Interferon-gamma-impaired vascular barrier function contributes to IBD pathogenesis

    Pürzer, Victoria [Verfasser] / Stürzl, Michael [Akademischer Betreuer] / Stürzl, Michael [Gutachter]

    2020  

    Author's details Victoria Pürzer ; Gutachter: Michael Stürzl ; Betreuer: Michael Stürzl
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Book ; Online ; Thesis: Reduzierte Expression von miRNA-21 in Lebermetastasen im Vergleich zu den kolorektalen Primärtumoren

    Feiersinger, Fabian [Verfasser] / Croner, Roland [Akademischer Betreuer] / Stürzl, Michael [Gutachter]

    2022  

    Author's details Fabian Feiersinger ; Gutachter: Michael Stürzl ; Betreuer: Roland Croner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease.

    Stürzl, Michael / Kunz, Meik / Krug, Susanne M / Naschberger, Elisabeth

    Frontiers in medicine

    2021  Volume 8, Page(s) 643607

    Abstract: Inflammatory bowel disease describes chronic inflammatory disorders. The incidence of the disease is rising. A major step in disease development is the breakdown of the epithelial cell barrier. Numerous blood vessels are directly located underneath this ... ...

    Abstract Inflammatory bowel disease describes chronic inflammatory disorders. The incidence of the disease is rising. A major step in disease development is the breakdown of the epithelial cell barrier. Numerous blood vessels are directly located underneath this barrier. Diseased tissues are heavily vascularized and blood vessels significantly contribute to disease progression. The gut-vascular barrier (GVB) is an additional barrier controlling the entry of substances into the portal circulation and to the liver after passing the first epithelial barrier. The presence of the GVB rises the question, whether the vascular and endothelial barriers may communicate bi-directionally in the regulation of selective barrier permeability. Communication from epithelial to endothelial cells is well-accepted. In contrast, little is known on the respective backwards communication. Only recently, perfusion-independent angiocrine functions of endothelial cells were recognized in a way that endothelial cells release specific soluble factors that may directly act on the epithelial barrier. This review discusses the putative involvement of angiocrine inter-barrier communication in the pathogenesis of IBD.
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.643607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The large GTPase AtGBPL3 links nuclear envelope formation and morphogenesis to transcriptional repression.

    Reimann, Theresa Maria / Müdsam, Christina / Schachtler, Christina / Ince, Semra / Sticht, Heinrich / Herrmann, Christian / Stürzl, Michael / Kost, Benedikt

    Nature plants

    2023  Volume 9, Issue 5, Page(s) 766–784

    Abstract: Guanylate binding proteins (GBPs) are prominent regulators of immunity not known to be required for nuclear envelope formation and morphogenesis. Here we identify the Arabidopsis GBP orthologue AtGBPL3 as a lamina component with essential functions in ... ...

    Abstract Guanylate binding proteins (GBPs) are prominent regulators of immunity not known to be required for nuclear envelope formation and morphogenesis. Here we identify the Arabidopsis GBP orthologue AtGBPL3 as a lamina component with essential functions in mitotic nuclear envelope reformation, nuclear morphogenesis and transcriptional repression during interphase. AtGBPL3 is preferentially expressed in mitotically active root tips, accumulates at the nuclear envelope and interacts with centromeric chromatin as well as with lamina components transcriptionally repressing pericentromeric chromatin. Reduced expression of AtGBPL3 or associated lamina components similarly altered nuclear morphology and caused overlapping transcriptional deregulation. Investigating the dynamics of AtGBPL3-GFP and other nuclear markers during mitosis (1) revealed that AtGBPL3 accumulation on the surface of daughter nuclei precedes nuclear envelope reformation and (2) uncovered defects in this process in roots of AtGBPL3 mutants, which cause programmed cell death and impair growth. AtGBPL3 functions established by these observations are unique among dynamin-family large GTPases.
    MeSH term(s) Nuclear Envelope/metabolism ; GTP Phosphohydrolases/metabolism ; Cell Nucleus/metabolism ; Mitosis ; Chromatin/metabolism
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-) ; Chromatin
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2055-0278
    ISSN (online) 2055-0278
    DOI 10.1038/s41477-023-01400-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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