Article ; Online: Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation.
Journal of molecular medicine (Berlin, Germany)
2022 Volume 100, Issue 6, Page(s) 933–946
Abstract: Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous system (CNS) and in the retina. Conversely, AQP4 might be upregulated in astrocytes as a ... ...
| Abstract | Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous system (CNS) and in the retina. Conversely, AQP4 might be upregulated in astrocytes as a compensatory event in multiple sclerosis. Thus, the functional relevance of AQP4 in neuroinflammation needs to be defined. Here, we tested the role of AQP4 in the retina in MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE) using optical coherence tomography (OCT), OCT angiography, immunohistology, flow cytometry, and gene expression analysis in wild-type and Aqp4 |
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| MeSH term(s) | Albumins/metabolism ; Animals ; Aquaporin 4/genetics ; Aquaporin 4/metabolism ; Cicatrix/pathology ; Encephalomyelitis, Autoimmune, Experimental ; Gliosis/metabolism ; Gliosis/pathology ; Inflammation/metabolism ; Mice ; Retina/metabolism | |||||
| Chemical Substances | Albumins ; Aquaporin 4 | |||||
| Language | English | |||||
| Publishing date | 2022-05-10 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1223802-8 | |||||
| ISSN | 1432-1440 ; 0946-2716 | |||||
| ISSN (online) | 1432-1440 | |||||
| ISSN | 0946-2716 | |||||
| DOI | 10.1007/s00109-022-02202-6 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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