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  1. Book ; Online ; E-Book: Advances in understanding Kingella kingae

    St. Geme, Joseph W.

    (SpringerBriefs in immunology)

    2016  

    Author's details Joseph W. St. Geme, III editor
    Series title SpringerBriefs in immunology
    Keywords Kingella kingae
    Language English
    Size 1 Online-Ressource (vii, 97 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019457996
    ISBN 978-3-319-43729-3 ; 9783319437286 ; 3-319-43729-1 ; 3319437283
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The 2020 Joseph W. St Geme, Jr. Leadership Award Address: On Leadership and the Joy of Pediatrics.

    St Geme, Joseph W

    Pediatrics

    2021  Volume 148, Issue 6

    MeSH term(s) Awards and Prizes ; Career Choice ; History, 20th Century ; Humans ; Leadership ; Pediatrics
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Address ; Biography ; Historical Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-053872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Advances in understanding Kingella kingae

    St. Geme, Joseph W

    (Springer briefs in immunology,)

    2016  

    Author's details Joseph W. St. Geme, III, editor
    Series title Springer briefs in immunology,
    MeSH term(s) Kingella kingae
    Language English
    Size vii, 97 pages :, illustrations
    Document type Book
    ISBN 9783319437286 ; 9783319437293 ; 3319437283 ; 3319437291
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article ; Online: The

    Sacharok, Alexandra L / Porsch, Eric A / St Geme, Joseph W

    Infection and immunity

    2022  Volume 91, Issue 1, Page(s) e0033822

    Abstract: Kingella kingae is an emerging pathogen that has recently been identified as a leading cause of osteoarticular infections in young children. Colonization with K. kingae is common, with approximately 10% of young children carrying this organism in the ... ...

    Abstract Kingella kingae is an emerging pathogen that has recently been identified as a leading cause of osteoarticular infections in young children. Colonization with K. kingae is common, with approximately 10% of young children carrying this organism in the oropharynx at any given time. Adherence to epithelial cells represents the first step in K. kingae colonization of the oropharynx, a prerequisite for invasive disease. Type IV pili and the pilus-associated PilC1 and PilC2 proteins have been shown to mediate K. kingae adherence to epithelial cells, but the molecular mechanism of this adhesion has remained unknown. Metal ion-dependent adhesion site (MIDAS) motifs are commonly found in integrins, where they function to promote an adhesive interaction with a ligand. In this study, we identified a potential MIDAS motif in K. kingae PilC1 which we hypothesized was directly involved in mediating type IV pilus adhesive interactions. We found that the K. kingae PilC1 MIDAS motif was required for bacterial adherence to epithelial cell monolayers and extracellular matrix proteins and for twitching motility. Our results demonstrate that K. kingae has co-opted a eukaryotic adhesive motif for promoting adherence to host structures and facilitating colonization.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Fimbriae Proteins/genetics ; Fimbriae Proteins/metabolism ; Kingella kingae/genetics ; Kingella kingae/metabolism ; Bacterial Adhesion ; Fimbriae, Bacterial/metabolism ; Epithelial Cells/microbiology ; Metals/metabolism ; Neisseriaceae Infections/microbiology
    Chemical Substances Fimbriae Proteins (147680-16-8) ; Metals
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00338-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The indirect effects of COVID-19 on pediatric research.

    Teach, Stephen J / St Geme, Joseph W

    Pediatric research

    2021  Volume 90, Issue 2, Page(s) 246–247

    MeSH term(s) COVID-19/pathology ; COVID-19/virology ; Child ; Humans ; Pediatrics ; Research ; SARS-CoV-2/isolation & purification
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-021-01563-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acquisition, co-option, and duplication of the rtx toxin system and the emergence of virulence in Kingella.

    Morreale, Daniel P / Porsch, Eric A / Kern, Brad K / St Geme, Joseph W / Planet, Paul J

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4281

    Abstract: The bacterial genus Kingella includes two pathogenic species, namely Kingella kingae and Kingella negevensis, as well as strictly commensal species. Both K. kingae and K. negevensis secrete a toxin called RtxA that is absent in the commensal species. ... ...

    Abstract The bacterial genus Kingella includes two pathogenic species, namely Kingella kingae and Kingella negevensis, as well as strictly commensal species. Both K. kingae and K. negevensis secrete a toxin called RtxA that is absent in the commensal species. Here we present a phylogenomic study of the genus Kingella, including new genomic sequences for 88 clinical isolates, genotyping of another 131 global isolates, and analysis of 52 available genomes. The phylogenetic evidence supports that the toxin-encoding operon rtxCA was acquired by a common ancestor of the pathogenic Kingella species, and that a preexisting type-I secretion system was co-opted for toxin export. Subsequent genomic reorganization distributed the toxin machinery across two loci, with 30-35% of K. kingae strains containing two copies of the rtxA toxin gene. The rtxA duplication is largely clonal and is associated with invasive disease. Assays with isogenic strains show that a single copy of rtxA is associated with reduced cytotoxicity in vitro. Thus, our study identifies key steps in the evolutionary transition from commensal to pathogen, including horizontal gene transfer, co-option of an existing secretion system, and gene duplication.
    MeSH term(s) Phylogeny ; Virulence/genetics ; Bacterial Toxins/genetics ; Kingella/genetics ; Kingella kingae/genetics
    Chemical Substances Bacterial Toxins
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39939-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Kingella negevensis shares multiple putative virulence factors with Kingella kingae.

    Porsch, Eric A / Yagupsky, Pablo / St Geme, Joseph W

    PloS one

    2020  Volume 15, Issue 10, Page(s) e0241511

    Abstract: Kingella negevensis is a newly described gram-negative bacterium in the Neisseriaceae family and is closely related to Kingella kingae, an important cause of pediatric osteoarticular infections and other invasive diseases. Like K. kingae, K. negevensis ... ...

    Abstract Kingella negevensis is a newly described gram-negative bacterium in the Neisseriaceae family and is closely related to Kingella kingae, an important cause of pediatric osteoarticular infections and other invasive diseases. Like K. kingae, K. negevensis can be isolated from the oropharynx of young children, although at a much lower rate. Due to the potential for misidentification as K. kingae, the burden of disease due to K. negevensis is currently unknown. Similarly, there is little known about virulence factors present in K. negevensis and how they compare to virulence factors in K. kingae. Using a variety of approaches, we show that K. negevensis produces many of the same putative virulence factors that are present in K. kingae, including a polysaccharide capsule, a secreted exopolysaccharide, a Knh-like trimeric autotransporter, and type IV pili, suggesting that K. negevensis may have significant pathogenic potential.
    MeSH term(s) Bacterial Proteins/analysis ; Fimbriae, Bacterial/chemistry ; Fimbriae, Bacterial/microbiology ; Humans ; Kingella/chemistry ; Kingella/pathogenicity ; Kingella kingae/chemistry ; Kingella kingae/pathogenicity ; Neisseriaceae Infections/microbiology ; Polysaccharides, Bacterial/analysis ; Virulence ; Virulence Factors/analysis
    Chemical Substances Bacterial Proteins ; Polysaccharides, Bacterial ; Virulence Factors
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0241511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Kingella kingae PilC1 and PilC2 are adhesive multifunctional proteins that promote bacterial adherence, twitching motility, DNA transformation, and pilus biogenesis.

    Sacharok, Alexandra L / Porsch, Eric A / Yount, Taylor A / Keenan, Orlaith / St Geme, Joseph W

    PLoS pathogens

    2022  Volume 18, Issue 3, Page(s) e1010440

    Abstract: The gram-negative bacterium Kingella kingae is a leading cause of osteoarticular infections in young children and initiates infection by colonizing the oropharynx. Adherence to respiratory epithelial cells represents an initial step in the process of K. ... ...

    Abstract The gram-negative bacterium Kingella kingae is a leading cause of osteoarticular infections in young children and initiates infection by colonizing the oropharynx. Adherence to respiratory epithelial cells represents an initial step in the process of K. kingae colonization and is mediated in part by type IV pili. In previous work, we observed that elimination of the K. kingae PilC1 and PilC2 pilus-associated proteins resulted in non-piliated organisms that were non-adherent, suggesting that PilC1 and PilC2 have a role in pilus biogenesis. To further define the functions of PilC1 and PilC2, in this study we eliminated the PilT retraction ATPase in the ΔpilC1ΔpilC2 mutant, thereby blocking pilus retraction and restoring piliation. The resulting strain was non-adherent in assays with cultured epithelial cells, supporting the possibility that PilC1 and PilC2 have adhesive activity. Consistent with this conclusion, purified PilC1 and PilC2 were capable of saturable binding to epithelial cells. Additional analysis revealed that PilC1 but not PilC2 also mediated adherence to selected extracellular matrix proteins, underscoring the differential binding specificity of these adhesins. Examination of deletion constructs and purified PilC1 and PilC2 fragments localized adhesive activity to the N-terminal region of both PilC1 and PilC2. The deletion constructs also localized the twitching motility property to the N-terminal region of these proteins. In contrast, the deletion constructs established that the pilus biogenesis function of PilC1 and PilC2 resides in the C-terminal region of these proteins. Taken together, these results provide definitive evidence that PilC1 and PilC2 are adhesins and localize adhesive activity and twitching motility to the N-terminal domain and biogenesis to the C-terminal domain.
    MeSH term(s) Adhesins, Bacterial/genetics ; Adhesives ; Bacterial Adhesion ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Child ; Child, Preschool ; DNA ; Fimbriae Proteins/genetics ; Fimbriae Proteins/metabolism ; Fimbriae, Bacterial/genetics ; Fimbriae, Bacterial/metabolism ; Humans ; Kingella kingae/genetics
    Chemical Substances Adhesins, Bacterial ; Adhesives ; Bacterial Proteins ; Fimbriae Proteins (147680-16-8) ; DNA (9007-49-2)
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: It Takes a Team to Make Team Science a Success: Career Development within Multicenter Networks.

    Collaco, Joseph M / St Geme, Joseph W / Abman, Steven H / Furth, Susan L

    The Journal of pediatrics

    2022  Volume 252, Page(s) 3–6.e1

    MeSH term(s) Humans ; Interdisciplinary Research ; Achievement ; Cooperative Behavior
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Multicenter Study ; Editorial
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.08.040
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  10. Article ; Online: Raising the Bar: The Need for Increased Financial Support to Sustain and Expand the Community of Pediatric Subspecialists.

    Lakshminrusimha, Satyan / Cheng, Tina L / Leonard, Mary B / Devaskar, Sherin U / Vinci, Robert J / Degnon, Laura / St Geme, Joseph W

    The Journal of pediatrics

    2023  Volume 267, Page(s) 113758

    MeSH term(s) Pediatrics ; Specialization
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2023.113758
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