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  1. AU="St John, Maie"
  2. AU=Gerhardy A
  3. AU="Qi, Huixin"
  4. AU="Dobosiewicz, May"
  5. AU="Srivastava, Rakesh"
  6. AU="Grevtsov K.I."

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  1. Book ; Online ; E-Book: Novel therapies in head and neck cancer

    St. John, Maie A. / Park, No-Hee

    beyond the horizon

    (Cancer sensitizing agents for chemotherapy ; 9)

    2020  

    Author's details edited by Maie A. St. John, No-Hee Park
    Series title Cancer sensitizing agents for chemotherapy ; 9
    Collection
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xx, 245 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020536465
    ISBN 978-0-12-820929-5 ; 9780128206799 ; 0-12-820929-1 ; 0128206799
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Multidisciplinary approach to head and neck cancer

    St. John, Maie A.

    (Otolaryngologic clinics of North America ; volume 50, number 4 (August 2017))

    2017  

    Author's details editor Maie A. St. John
    Series title Otolaryngologic clinics of North America ; volume 50, number 4 (August 2017)
    Collection
    Language English
    Size xviii Seiten, Seite 680-874, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019470643
    ISBN 978-0-323-53249-5 ; 0-323-53249-7
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Is p16 Testing Sufficient as a Surrogate for HPV-Related Squamous Cell Carcinoma?

    Bommakanti, Krishna K / St John, Maie A

    The Laryngoscope

    2024  

    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Inflammatory mediators drive metastasis and drug resistance in head and neck squamous cell carcinoma

    St. John, Maie A.

    (The laryngoscope ; 125,3, Suppl. 3)

    2015  

    Author's details Maie A. St. John
    Series title The laryngoscope ; 125,3, Suppl. 3
    Collection
    Language English
    Size S11 S.
    Publisher Wiley-Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT018634002
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Can Calcitonin Levels Guide Prophylactic Neck Dissection in Sporadic Medullary Thyroid Carcinoma?

    Han, Ethan J / Bommakanti, Krishna K / St John, Maie A

    The Laryngoscope

    2024  

    Abstract: Medullary thyroid carcinoma (MTC) comprises less than 5% of thyroid cancers but is responsible for over 10% of deaths related to thyroid cancer. Regional lymph node metastasis is common and associated with mortality, thus total thyroidectomy with central ...

    Abstract Medullary thyroid carcinoma (MTC) comprises less than 5% of thyroid cancers but is responsible for over 10% of deaths related to thyroid cancer. Regional lymph node metastasis is common and associated with mortality, thus total thyroidectomy with central compartment lymph node dissection is the standard surgical treatment for MTC. In this best practice submission, we aim to review the existing literature and determine whether calcitonin levels can serve as a reliable method for risk-stratifying MTC without overt lymph node involvement.
    Language English
    Publishing date 2024-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In Response to Should the Contralateral Tonsil Be Removed in Cases of HPV-Positive Squamous Cell Carcinoma of the Tonsil?

    St John, Maie A

    The Laryngoscope

    2019  Volume 129, Issue 6, Page(s) E195

    MeSH term(s) Carcinoma, Squamous Cell ; Humans ; Palatine Tonsil ; Papillomavirus Infections ; Tonsillar Neoplasms
    Language English
    Publishing date 2019-03-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.27875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Speech and Swallowing Outcomes of Surgically Managed Cervical Chordoma: A Case Series.

    Yu, Alice C / Ko, Myungjun / Han, Albert Y / St John, Maie / Chhetri, Dinesh K

    The Laryngoscope

    2024  

    Abstract: Objectives: Cervical chordoma is a rare, low-grade primary bone tumor occurring in the axial skeleton. Due to challenges in surgical exposure caused by anatomic location, patients may experience dysfunction in speech and swallowing. The objective of ... ...

    Abstract Objectives: Cervical chordoma is a rare, low-grade primary bone tumor occurring in the axial skeleton. Due to challenges in surgical exposure caused by anatomic location, patients may experience dysfunction in speech and swallowing. The objective of this study was to characterize speech and swallowing outcomes for patients undergoing surgical resection of cervical chordoma. Moreover, we detail in-depth two cases with similar initial presentations to compare prognostic factors and management strategies.
    Methods: Eleven patients with histologically confirmed cervical chordoma treated between 1993 and 2020 were included in this retrospective case series. Outcomes measured included overall survival, disease-free survival, need for enteral feeds, as well as results of modified barium swallow study (MBSS) and fiberoptic laryngoscopy.
    Results: The mean age at diagnosis was 55.9 years. The patient population was 81.8% male. Mean survival after diagnosis was 96 months. Four (36.4%) patients required post-operative MBSS and demonstrated aspiration. All four of these patients presented with tumors in the superior cervical spine and received surgeries utilizing anterior approaches. Of the four, 2 required enteral feeds long-term. Four (36.4%) patients endorsed dysphonia. One patient developed post-operative right vocal fold paresis. The remaining three patients experienced stable dysphonia pre- and post-operatively. Additionally, three (27%) patients required tracheostomy placement, two of which remained in place long-term.
    Conclusions: Dysphagia is a common side effect of cervical chordoma resection. It is associated with the use of an anterior approach during resection and with tumors located in the superior cervical spine. Patients with postoperative dysphagia should receive early multidisciplinary swallow rehabilitation.
    Level of evidence: 4 Laryngoscope, 2024.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association of Safety-Net Hospital Status With Outcomes Following Head and Neck Cancer Operations.

    Madrigal, Josef / Mukdad, Laith / Verma, Arjun / Benharash, Peyman / St John, Maie A

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2024  

    Abstract: Objective: To assess perioperative and readmission outcomes of patients undergoing head and neck cancer (HNCA) surgery at safety-net hospitals (SNHs) in a modern cohort.: Study design: Retrospective cohort study.: Setting: Nationwide Readmissions ... ...

    Abstract Objective: To assess perioperative and readmission outcomes of patients undergoing head and neck cancer (HNCA) surgery at safety-net hospitals (SNHs) in a modern cohort.
    Study design: Retrospective cohort study.
    Setting: Nationwide Readmissions Database (NRD), 2010 to 2019.
    Methods: All elective adult (≥18 years) admissions involving HNCA resection were identified from the NRD. To calculate safety-net burden, the proportion of Medicaid or uninsured patients admitted to each hospital for any indication was tabulated annually, with centers in the highest quartile defined as SNHs. To perform risk adjustment in assessing perioperative and readmission outcomes, multivariable regression models were developed.
    Results: Of an estimated 133,018 head and neck surgical patients, 26.5% (n = 35,268) received treatment at a SNH. Utilization of SNHs increased over the decade-long study period, with 29.8% of individuals treated at these sites in 2019. After multivariable adjustment, several patient factors were noted to be associated with SNHs, including younger age, lower comorbidity burden, and income within the lowest quartile. Although incidence of adverse events decreased at both SNHs and non-SNHs during the study period, treatment at SNHs remained associated with these events after risk adjustment (adjusted odds ratio: 1.17, 95% confidence interval: 1.08-1.28, P < .001).
    Conclusion: SNHs continue to provide valuable specialty care to underserved populations, often with limited financial resources. Despite promising results from prior decades demonstrating comparable perioperative outcomes, the present study noted increased adverse events following HNCA surgery at these sites. Such findings underscore the need for continued advocacy to secure necessary funding for these centers.
    Language English
    Publishing date 2024-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Positive Outcome Bias in the Influential Otolaryngology Clinical Trial Literature.

    Yang, Hong-Ho / Tsai, Matthew / Mukdad, Laith / St John, Maie

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 170, Issue 3, Page(s) 812–820

    Abstract: Objective: To assess for the presence of positive outcome bias in the otolaryngology clinical trial literature. Specifically, we investigate the prevalence of clinical trials with positive findings (CTP) and clinical trials with negative findings (CTN), ...

    Abstract Objective: To assess for the presence of positive outcome bias in the otolaryngology clinical trial literature. Specifically, we investigate the prevalence of clinical trials with positive findings (CTP) and clinical trials with negative findings (CTN), as well as their quality of evidence and subsequent impact.
    Study design: Retrospective analysis.
    Setting: Clinical Trials in the Influential Otolaryngology Literature.
    Methods: We reviewed all clinical trials published in 4 major otolaryngology journals between 2000 and 2020. We constructed several multivariable regression models to investigate the relationship of finding direction with randomization status and citation count. Subsequently, we incorporated an interaction term between year and the primary covariate of each model to assess the temporal trajectory of these relationships. All models accounted for sample size, journal, subspecialty, and the affiliated program prestige.
    Results: Of the 1367 trials analyzed, 1143 (84%) were CTPs, a rate that persisted throughout the study period (aOR 1.00, 95% CI 0.98-1.03). CTPs were significantly less likely to be randomized compared to CTNs (aOR 0.25, 0.17-0.37), a relationship that persisted over time (aOR 1.05, 0.99-1.03). CTPs received significantly more citations compared to CTNs (aIRR 1.41, 1.25-1.60), a disparity that also persisted over time (aIRR 0.99, 0.97-1.01).
    Conclusion: The otolaryngology clinical trial literature has been heavily dominated by positive findings. CTPs were more frequently cited and published even with a lower level of evidence compared to CTNs. This bias may influence the objectivity of evidence used to guide clinical practice and warrants attention when reviewing findings and changing practices.
    MeSH term(s) Humans ; Retrospective Studies ; Otolaryngology ; Publication Bias ; Publications ; Bias
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: What is the Role of Induction Chemotherapy in the Treatment of Locally Advanced Sinonasal Squamous Cell Carcinoma?

    Abiri, Arash / St John, Maie A / Kuan, Edward C

    The Laryngoscope

    2022  Volume 133, Issue 2, Page(s) 214–215

    MeSH term(s) Humans ; Induction Chemotherapy ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Head and Neck Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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