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Article ; Online: Evaluation of myenteric neurons in the colon of rats exposed to 2,4 dichlorophenoxyacetic acid herbicide.

Nanni, Wagner / Porto, Gisele da Silva / Pereira, Joice Naiara Bertaglia / Gonçalves, Alexandre Rodrigo Nascimento / Marinsek, Gabriela Pustiglione / Stabille, Sandra Regina / Favetta, Paula Montanhini / Germano, Ricardo de Melo / Mari, Renata de Britto

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

2022 Volume 57, Issue 5, Page(s) 421–429

Abstract: The assessment of the enteric nervous system provides a better understanding of the effects that contaminants can have on the health and well-being of organisms. It has been reported that 2,4-dichlorophenoxyacetic acid (2,4-D) is a highly persistent ... ...

Abstract	The assessment of the enteric nervous system provides a better understanding of the effects that contaminants can have on the health and well-being of organisms. It has been reported that 2,4-dichlorophenoxyacetic acid (2,4-D) is a highly persistent herbicide in the environment that is responsible for neurotoxic changes in different myenteric neuronal subpopulations. The current study aimed to evaluate the effects of 2,4-D on myenteric neurons in the colon of
MeSH term(s)	2,4-Dichlorophenoxyacetic Acid/toxicity ; Animals ; Colon/metabolism ; Herbicides/metabolism ; Herbicides/toxicity ; Humans ; Myenteric Plexus/metabolism ; Nitrergic Neurons/metabolism ; Rats
Chemical Substances	Herbicides ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262)
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	197072-0
ISSN	1532-4109 ; 0360-1234
ISSN (online)	1532-4109
ISSN	0360-1234
DOI	10.1080/03601234.2022.2064674
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Article: Evaluation of myenteric neurons in the colon of rats exposed to 2,4 dichlorophenoxyacetic acid herbicide

Journal of environmental science and health. 2022 May 4, v. 57, no. 5

2022

Abstract	The assessment of the enteric nervous system provides a better understanding of the effects that contaminants can have on the health and well-being of organisms. It has been reported that 2,4-dichlorophenoxyacetic acid (2,4-D) is a highly persistent herbicide in the environment that is responsible for neurotoxic changes in different myenteric neuronal subpopulations. The current study aimed to evaluate the effects of 2,4-D on myenteric neurons in the colon of Rattus norvegicus for the first time. A dose of 2,4-D (5 mg/kg/day) was administered to the experimental group (2,4-D) for 15 days. Then, the proximal colon was collected and submitted to Giemsa and NADPH-d histochemical techniques for the disclosure of total and nitrergic neurons. The 2,4-D group presented a higher density of total neurons (p = 0.05, t-test), which together with the maintenance of nitrergic neuronal density, may be related to the increase in the expression of the neurotransmitter acetylcholine by colocalization, responsible for stimulating the intestinal smooth muscle and increasing the chances of the expulsion of the harmful content present in the lumen. Over 15 days, the neurotoxic effects of 2,4-D in the myenteric plexus influenced an increase in the general population of myenteric neurons in the colon.
Keywords	2,4-D ; Rattus norvegicus ; acetylcholine ; colon ; environmental science ; neurons ; neurotoxicity ; neurotransmitters ; smooth muscle ; t-test
Language	English
Dates of publication	2022-0504
Size	p. 421-429.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	197072-0
ISSN	1532-4109 ; 0360-1234
ISSN (online)	1532-4109
ISSN	0360-1234
DOI	10.1080/03601234.2022.2064674
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Article: Balanced Caloric Restriction Minimizes Changes Caused by Aging on the Colonic Myenteric Plexus

Mari, Renata de Britto / Stabille, Sandra Regina / de Faria, Haroldo Garcia / Pereira, Joice Naiara Bertaglia / Guimarães, Juliana Plácido / Marinsek, Gabriela Pustiglione / de Souza, Romeu Rodrigues

Journal of dietary supplements. 2018 May 4, v. 15, no. 3

2018

Abstract: Aging can promote significant morphofunctional changes in the gastrointestinal tract (GIT). Regulation of GIT motility is mainly controlled by the myenteric neurons of the enteric nervous system. Actions that aim at decreasing the aging effects in the ... ...

Abstract	Aging can promote significant morphofunctional changes in the gastrointestinal tract (GIT). Regulation of GIT motility is mainly controlled by the myenteric neurons of the enteric nervous system. Actions that aim at decreasing the aging effects in the GIT include those related to diet, with caloric restriction (CR). The CR is achieved by controlling the amount of food or by manipulating the components of the diet. Therefore, the objective of this study was to evaluate different levels of CR on the plasticity of nicotinamide adenine dinucleotide phosphate– (NADPH-) reactive myenteric neurons in the colon of Wistar rats during the aging process using ultrastructural (transmission electron microscopy) and morphoquantitative analysis. Wistar male rats (Rattus norvegicus) were distributed into 4 groups (n = 10/group): C, 6-month-old animals; SR, 18-month-old animals fed a normal diet; CRI, 18-month-old animals fed a 12% CR diet; CRII, 18-month-old animals fed a 31% CR diet. At 6 months of age, animals were transferred to the laboratory animal facility, where they remained until 18 months of age. Animals of the CRI and CRII groups were submitted to CR for 6 months. In the ultrastructural analysis, a disorganization of the periganglionar matrix with the aging was observed, and this characteristic was not observed in the animals that received hypocaloric diet. It was observed that the restriction of 12.5% and 31% of calories in the diet minimized the increase in density and cell profile of the reactive NADPH neurons, increased with age. This type of diet may be adapted against gastrointestinal disturbances that commonly affect aging individuals.
Keywords	NAD (coenzyme) ; Rattus norvegicus ; colon ; digestive tract ; laboratory animals ; low calorie diet ; males ; plasticity ; transmission electron microscopy
Language	English
Dates of publication	2018-0504
Size	p. 285-299.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2017.1341446
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Article ; Online: Balanced Caloric Restriction Minimizes Changes Caused by Aging on the Colonic Myenteric Plexus.

Journal of dietary supplements

2017 Volume 15, Issue 3, Page(s) 285–299

Abstract	Aging can promote significant morphofunctional changes in the gastrointestinal tract (GIT). Regulation of GIT motility is mainly controlled by the myenteric neurons of the enteric nervous system. Actions that aim at decreasing the aging effects in the GIT include those related to diet, with caloric restriction (CR). The CR is achieved by controlling the amount of food or by manipulating the components of the diet. Therefore, the objective of this study was to evaluate different levels of CR on the plasticity of nicotinamide adenine dinucleotide phosphate- (NADPH-) reactive myenteric neurons in the colon of Wistar rats during the aging process using ultrastructural (transmission electron microscopy) and morphoquantitative analysis. Wistar male rats (Rattus norvegicus) were distributed into 4 groups (n = 10/group): C, 6-month-old animals; SR, 18-month-old animals fed a normal diet; CRI, 18-month-old animals fed a 12% CR diet; CRII, 18-month-old animals fed a 31% CR diet. At 6 months of age, animals were transferred to the laboratory animal facility, where they remained until 18 months of age. Animals of the CRI and CRII groups were submitted to CR for 6 months. In the ultrastructural analysis, a disorganization of the periganglionar matrix with the aging was observed, and this characteristic was not observed in the animals that received hypocaloric diet. It was observed that the restriction of 12.5% and 31% of calories in the diet minimized the increase in density and cell profile of the reactive NADPH neurons, increased with age. This type of diet may be adapted against gastrointestinal disturbances that commonly affect aging individuals.
MeSH term(s)	Aging ; Animals ; Biomarkers/metabolism ; Caloric Restriction ; Cell Count ; Colon/growth & development ; Colon/innervation ; Colon/physiology ; Colon/ultrastructure ; Colon, Ascending/growth & development ; Colon, Ascending/innervation ; Colon, Ascending/physiology ; Colon, Ascending/ultrastructure ; Colon, Descending/growth & development ; Colon, Descending/innervation ; Colon, Descending/physiology ; Colon, Descending/ultrastructure ; Ganglia, Autonomic/cytology ; Ganglia, Autonomic/growth & development ; Ganglia, Autonomic/physiology ; Ganglia, Autonomic/ultrastructure ; Male ; Microscopy, Electron, Transmission ; Myenteric Plexus/cytology ; Myenteric Plexus/growth & development ; Myenteric Plexus/physiology ; Myenteric Plexus/ultrastructure ; NADPH Dehydrogenase/metabolism ; Nerve Tissue Proteins/metabolism ; Neuronal Plasticity ; Neuroprotection ; Nitrergic Neurons/cytology ; Nitrergic Neurons/physiology ; Nitrergic Neurons/ultrastructure ; Organ Size ; Organ Specificity ; Rats, Wistar
Chemical Substances	Biomarkers ; Nerve Tissue Proteins ; NADPH Dehydrogenase (EC 1.6.99.1)
Language	English
Publishing date	2017-07-31
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2017.1341446
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Article ; Online: Supplementation action with ascorbic acid in the morphology of the muscular layer and reactive acetylcholinesterase neurons of ileum of mdx mice.

Lisboa, Marcelo José Santiago / De Oliveira Lima, Marília Fabiana / Stabille, Sandra Regina / Zanoni, Jacqueline Nelisis / Gagliardo, Karina Martinez / Souto, Melyna Soares / Souza, Renivaldo / Da Silva, Jodonai Barbosa / De Almeida Yokomizo, Sônia Regina / Liberti, Edson Aparecido / Clebis, Naianne Kelly

Autonomic neuroscience : basic & clinical

2017 Volume 205, Page(s) 57–66

Abstract: The Duchenne Muscular Dystrophy (DMD) is a genetic disorder characterized by the absence of dystrophin protein, causing severe myopathy from increases of oxidative stress. Injuries of intestinal muscle can compromise the myenteric plexus. This study ... ...

Abstract	The Duchenne Muscular Dystrophy (DMD) is a genetic disorder characterized by the absence of dystrophin protein, causing severe myopathy from increases of oxidative stress. Injuries of intestinal muscle can compromise the myenteric plexus. This study aimed to evaluate the disorders occurred in the muscular layer and in the acetylcholinesterase myenteric neurons (ACHE-r) of ileum of mdx mice, and the effects of supplementation with ascorbic acid (AA) in both components. 30 male mice C57BL/10, and 30 male mice C57BL/10Mdx were separated according to the age and treatment (n=10/group): 30-days-old control group (C30); 30-days-old dystrophic group (D30); 60-days-old control group (C60); 60-days-old dystrophic group (D60); 60-days-old control group supplemented with AA (CS60); and 60-days-old dystrophic group supplemented with AA (DS60). The animals were euthanized and the ileum was collected and processed. Semi-serial sections were stained by Masson's trichrome, and acetylcholinesterase histochemical technique in whole-mounts preparations to identify the myenteric neurons. The muscular layer thickness and the area of smooth muscle of ileum were lower in dystrophic groups, especially in D30 group. The DS60 group showed the muscular layer thickness similar to C60. The density of ACHE-r neurons of myenteric plexus of ileum was lower in D30 animals; however, it was similar in animals of 60-days-old without treatment (C60 and D60) and, higher in DS60. The cell body profile area of ACHE-r neurons was similar in C30-D30 and C60-D60; however, it was higher in DS60. DMD caused damage to the ileum's musculature and myenteric plexus, and the AA prevented the ACHE-r neuronal loss.
Language	English
Publishing date	2017-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2017.05.001
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Article: Exercise reduces inhibitory neuroactivity and protects myenteric neurons from age-related neurodegeneration.

Martinez Gagliardo, Karina / Clebis, Naianne Kelly / Stabille, Sandra Regina / De Britto Mari, Renata / De Sousa, Jacira Maria Andrade / De Souza, Romeu Rodrigues

Autonomic neuroscience : basic & clinical

2008 Volume 141, Issue 1-2, Page(s) 31–37

Abstract: The practice of regular exercise is indicated to prevent some motility disturbances in the gastrointestinal tract, such as constipation, during aging. The motility alterations are intimately linked with its innervations. The goal of this study is to ... ...

Abstract	The practice of regular exercise is indicated to prevent some motility disturbances in the gastrointestinal tract, such as constipation, during aging. The motility alterations are intimately linked with its innervations. The goal of this study is to determine whether a program of exercise (running on the treadmill), during 6 months, has effects in the myenteric neurons (NADH- and NADPH-diaphorase stained neurons) in the colon of rats during aging. Male Wistar rats 6 months (adult) and 12 months (middle-aged) old were divided into 3 different groups: AS (adult sedentary), MS (middle-aged sedentary) and MT (middle-aged submitted to physical activity). The aging did not cause a decline significant (p>0.05) of the number of NADH-diaphorase stained neurons in sedentary rats (AS vs. MS group). In contrast, a decline of 31% was observed to NADPH-diaphorase stained neurons. Thus, animals that underwent physical activity (AS vs. MT group) rescued neurons from degeneration caused by aging (total number, density and profile of neurons did not change with age--NADH-diaphorase method). On the other hand, physical activity augmented the decline of NADPH-diaphorase positive neurons (total number, density and profile of neurons decreased). Collectively, the results show that exercise inhibits age-related decline of myenteric neurons however, exercise augments the decline of neurons with inhibitory activity (nitric oxide) in the colon of the rats.
MeSH term(s)	Aging/physiology ; Animals ; Cell Count ; Cell Size ; Colon/innervation ; Colon/metabolism ; Colon/pathology ; Dihydrolipoamide Dehydrogenase/metabolism ; Histocytochemistry/methods ; Male ; Myenteric Plexus/enzymology ; Myenteric Plexus/pathology ; NADPH Dehydrogenase/metabolism ; Nerve Degeneration/metabolism ; Nerve Degeneration/pathology ; Nerve Degeneration/physiopathology ; Neurons/enzymology ; Neurons/pathology ; Physical Conditioning, Animal/methods ; Physical Conditioning, Animal/physiology ; Rats ; Rats, Wistar
Chemical Substances	NADPH Dehydrogenase (EC 1.6.99.1) ; Dihydrolipoamide Dehydrogenase (EC 1.8.1.4)
Language	English
Publishing date	2008-06-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2008.04.009
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Article ; Online: Effect of caloric restriction on myenteric neuroplasticity in the rat duodenum during aging.

da Silva Porto, Gisele / Bertaglia Pereira, Joice Naiara / Tibúrcio, Vanessa Graciele / Stabille, Sandra Regina / Garcia de Faria, Haroldo / de Melo Germano, Ricardo / de Britto Mari, Renata

Autonomic neuroscience : basic & clinical

2012 Volume 168, Issue 1-2, Page(s) 43–47

Abstract: The objective of this study was to evaluate the effects of caloric restriction (CR) on myenteric neurons in the duodenum of Wistar rats during aging. Thirty rats were divided into three groups: the C group (six-month-old animals that were fed a normal ... ...

Abstract	The objective of this study was to evaluate the effects of caloric restriction (CR) on myenteric neurons in the duodenum of Wistar rats during aging. Thirty rats were divided into three groups: the C group (six-month-old animals that were fed a normal diet from weaning until six months of age), the SR group (18-month-old animals that were fed a normal diet from weaning until 18 months of age) and the CR group (18-month-old animals that were fed a 30% CR diet after six months of age). After 12 months, the animals were euthanized. Whole-mount preparations of the duodenums were either stained with Giemsa or underwent NADPH-diaphorase histochemistry to determine the general myenteric neuron population and the nitrergic neuron subpopulation (NADPH-d+), respectively. The NADPH-d-negative (NADPH-d-) neuron population was estimated based on the difference between the Giemsa-stained and NADPH-d+ neurons. The neurons were counted, and the cell body areas were measured. Aging was associated with neuronal loss in the SR group, which was minimized by caloric restriction in the CR group. The density (mm(2)) of the Giemsa-stained neurons was higher in the SR group (79.09 ± 6.25) than in the CR (92.37 ± 11.6) and C (111.68 ± 15.26) groups. The density of the NADPH-d+ neurons was higher in the SR group (44.90 ± 5.88) than in the C (35.75 ± 1.6) and RC (39.14 ± 7.02) groups. The density of NADPH-d- neurons was higher in the CR (49.73 ± 12.08) and C (75.64 ± 17.05) groups than in the SR group (33.82 ± 4.5). In the C group, 32% and 68% of the Giemsa-stained myenteric neurons were NADPH-d+ or NADPH-d-, respectively. With aging (SR group), the percentage of nitrergic neurons (56.77%) increased, whereas the percentage of NADPH-d- neurons (43.22%) decreased. In the CR group, the change in the percentage of nitrergic (42.37%) and NADPH-d- (57.62%) neurons was lower. As NADPH-d- neurons will be mostly cholinergic neurons, CR appears to reduce the loss of cholinergic neurons during aging. The cell body dimensions (μm(2)) were not altered by aging or CR. Thus, CR had a protective effect on myenteric neurons during aging.
MeSH term(s)	Aging/physiology ; Animals ; Azure Stains ; Caloric Restriction ; Cell Count ; Cell Size ; Diet ; Duodenum/growth & development ; Duodenum/innervation ; Duodenum/physiology ; Ganglia, Autonomic/cytology ; Ganglia, Parasympathetic/cytology ; Ganglia, Parasympathetic/growth & development ; Immunohistochemistry ; Male ; Myenteric Plexus/physiology ; NADPH Dehydrogenase/metabolism ; Neuronal Plasticity/physiology ; Neurons/enzymology ; Neurons/physiology ; Neurons/ultrastructure ; Rats ; Rats, Wistar
Chemical Substances	Azure Stains ; NADPH Dehydrogenase (EC 1.6.99.1)
Language	English
Publishing date	2012-05-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2012.01.006
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Article ; Online: Morphologic and quantitative study of the myenteric neurons of the jejunum of malnourished rats (Rattus norvegicus)

MIRANDA NETO MARCÍLIO HUBNER DE / MOLINARI SONIA LUCY / STABILLE SANDRA REGINA / SANT'ANA DÉBORA DE MELLO GONÇALES / NATALI MARIA RAQUEL MARÇAL

Arquivos de Neuro-Psiquiatria, Vol 57, Iss 2B, Pp 387-

1999 Volume 391

Abstract: We studied the effects of maternal proteic desnutrition on the neurons of the myenteric plexus of the jejunum of rats from Rattus norvegicus species. It was used litters of female rats which received diet with normal proteic level during gestation and ... ...

Abstract	We studied the effects of maternal proteic desnutrition on the neurons of the myenteric plexus of the jejunum of rats from Rattus norvegicus species. It was used litters of female rats which received diet with normal proteic level during gestation and lactation (group NN), normal diet during gestation and hypoproteic diet during lactation (group ND); hypoproteic diet during gestation and normal diet during lactation (group DN); hypoproteic diet during both gestation and lactation (group DD). After weaning all the animals received diet of normal proteic level until the 60th day of age, when they were killed. The jejunum of the animals was subjected to whole-mount preparations stained by the method of Giemsa and used for the morphologic and quantitative analyses of the neurons of the myenteric plexus. We verified that maternal proteic malnutrition does not cause decrease on the number of myenteric neurons per unit area of jejunum in rats, but elicits mechanisms which assure that, when the animal again receives normal proteic level diet (22%) there occurs storage of proteic material on the cytoplasm of the neurons, thus rendering them larger and strongly basophylic.
Keywords	jejunum ; myenteric neuron ; maternal malnutrition ; proteic desnutrition ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	590
Language	English
Publishing date	1999-01-01T00:00:00Z
Publisher	Academia Brasileira de Neurologia - ABNEURO
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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