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Book ; Thesis: Wpływ sprzężonych dienów kwasu linolowego na syntezę pochodnych kwasu arachidonowego i linolowego w monocytach makrofagach

Stachowska, Ewa

= Influence of conjugated linoleic acids on the synthesis of the arachidonic and linoleic acid derivatives in monocytes macrophages

(Annales Academiae Medicae Stetinensis : Suplement ; 118)

2007

Title variant	Influence of conjugated linoleic acids on the synthesis of the arachidonic and linoleic acid derivatives in monocytes macrophages
Author's details	Ewa Stachowska
Series title	Annales Academiae Medicae Stetinensis : Suplement ; 118 Annales Academiae Medicae Stetinensis Annales Academiae Medicae Stetinensis ; Suplement
Collection	Annales Academiae Medicae Stetinensis Annales Academiae Medicae Stetinensis ; Suplement
Language	Polish
Size	105 S. : graph. Darst.
Publisher	Pomorska Akademia Medyczna
Publishing place	Szczecin
Publishing country	Poland
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Szczecin, Habil.-Schr
HBZ-ID	HT015547549
ISBN	978-83-89318-78-7 ; 83-89318-78-4
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Zs B 895 -Supl.118-	verfügbar in Königswinter	Königswinter

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Article: Compliance with the WCRF/AICR Recommendations in Qualitative Adaptation and the Occurrence of Breast Cancer: A Case-Control Study.

Stasiewicz, Beata / Wadolowska, Lidia / Biernacki, Maciej / Slowinska, Malgorzata Anna / Stachowska, Ewa

Cancers

2024 Volume 16, Issue 2

Abstract: Purpose: The aim of the study was twofold: (1) the qualitative adaptation of the 2018 WCRF/AICR (QAd-WCRF/AICR) score, and (2) the assessment of the association between the level of compliance with the WCRF/AICR recommendations and the occurrence of ... ...

Abstract	Purpose: The aim of the study was twofold: (1) the qualitative adaptation of the 2018 WCRF/AICR (QAd-WCRF/AICR) score, and (2) the assessment of the association between the level of compliance with the WCRF/AICR recommendations and the occurrence of breast cancer in peri- and postmenopausal women. Methods: This case-control study involved 420 women, aged 40-79 years, from northeastern Poland, including 190 newly diagnosed breast cancer cases. Data related to the WCRF/AICR recommendations were collected in face-to-face interviews with 409 women, including 179 women with breast cancer. The frequency of food consumption data were collected using the FFQ-6 Results: The moderate (4-5 points) and maximal (6-8 points) compliance with the qualitative adaptation of the WRCF/AICR recommendations reduced the odds of breast cancer by 54% and 72%, respectively, compared to the results noted for minimal compliance (≤3 points). Lower odds of breast cancer were associated with moderate or high physical activity, consumption of a minimum of four serving per day of vegetables/fruits/whole grains/nuts/seeds/legumes, and limiting the consumption of highly processed food/fast foods and red/processed meat to a maximum of 1-3 times/month. Higher odds of breast cancer were associated with a higher waist circumference and alcohol abstinence. Conclusions: These findings may prove useful in establishing cancer prevention recommendations based on simple suggestions regarding the frequency of food consumption.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020468
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Article ; Online: Anti-cancer management of head and neck cancers and oral microbiome-what can we clinically obtain?

Makarewicz, Jakub / Kaźmierczak-Siedlecka, Karolina / Sobocki, Bartosz Kamil / Dobrucki, Iwona T / Kalinowski, Leszek / Stachowska, Ewa

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1329057

Abstract: Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include ... ...

Abstract	Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include human papilloma virus (HPV) (notably type 16), Epstein-Barr virus, tobacco, alcohol, and poor oral hygiene with approximately 4.5% of global cancers linked to HPV. Notably, differences in the microbiome between healthy individuals and patients with head and neck cancers (HNCs) have been identified. Recent studies highlight the significance of certain oral microbes in risk assessment and the potential of the microbiome as a biomarker for HNCs. Additionally, role of the microbiome in metastasis has been acknowledged. Treatment for HNCs includes local methods, such as surgery and radiotherapy, and systemic approaches, such as immunotherapy. Numerous side effects accompany these treatments. Emerging research suggests the beneficial role of preoperative immunonutrition and probiotics in patient outcomes, emphasizing the influence of the microbiome on treatment efficacy. This review explores the reciprocal effects of HNC treatment and the gut microbiome using radiotherapy, brachytherapy, surgery, immunotherapy, and chemotherapy.
MeSH term(s)	Male ; Humans ; Epstein-Barr Virus Infections ; Papillomavirus Infections ; Herpesvirus 4, Human ; Head and Neck Neoplasms/therapy ; Microbiota
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1329057
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Article ; Online: Dysbiosis and nutrition in steatotic liver disease: addressing the unrecognized small intestinal bacterial overgrowth (SIBO) challenge.

Stachowska, Ewa / Gudan, Anna / Mańkowska-Wierzbicka, Dorota / Liebe, Roman / Krawczyk, Marcin

Internal and emergency medicine

2024

Abstract: Steatotic liver disease (SLD) is characterized by hepatic fat accumulation, potentially causing major consequences such as liver decompensation. Currently, we lack medications for the treatment of SLD. Therapeutic recommendations for patients include a ... ...

Abstract	Steatotic liver disease (SLD) is characterized by hepatic fat accumulation, potentially causing major consequences such as liver decompensation. Currently, we lack medications for the treatment of SLD. Therapeutic recommendations for patients include a hypocaloric diet, weight loss, and physical activity. In particular, the Mediterranean diet is frequently recommended. However, this diet might exacerbate intestinal problems in a subset of patients with coexisting small intestinal bacterial overgrowth (SIBO). Previous studies have reported that SIBO is more predominant in patients with fatty liver than in healthy individuals. Both our research and the findings of others have highlighted a challenge related to nutritional therapy in patients with fatty liver who also suffer from SIBO inasmuch as SIBO induces several phenomena (like bloating or abdominal pain) that can adversely affect patients' quality of life and might be exacerbated by the Mediterranean diet. This may lower their adherence to the intervention. As a solution, we suggest introducing additional diagnostics (e.g., breath test) in patients with SLD who complain of SIBO-like symptoms. The next step is to modify their diets temporarily starting with several weeks of "elimination and sanitation." This would involve restricting products rich in fermentable sugars and polyols, while simultaneously treating the bacterial overgrowth. In summary, while the hypocaloric Mediterranean diet is beneficial for patients with fatty liver, those with coexisting SIBO may experience exacerbated symptoms. It is vital to consider additional diagnostics and dietary modifications for this subset of patients to address both liver and intestinal health concurrently.
Language	English
Publishing date	2024-03-18
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-024-03533-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A non-destructive technique using digital holographic vibrometry and Lamb waves for quality determination of polymer-metal laminates.

Nowak-Grzebyta, Jagoda / Stachowska, Ewa / Meijer, Frans / Sterzyǹski, Tomasz

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18041

Abstract: We used digital holographic vibrometry (DHV) as a non-destructive method to detect debonding areas in laminates made of aluminum and polymer (polylactide, polyvinylidene fluoride or polycarbonate). At low frequencies (up to 30 kHz) [Formula: see text] ... ...

Abstract	We used digital holographic vibrometry (DHV) as a non-destructive method to detect debonding areas in laminates made of aluminum and polymer (polylactide, polyvinylidene fluoride or polycarbonate). At low frequencies (up to 30 kHz) [Formula: see text] Lamb waves were excited and the amplitude and the phase patterns of the vibration of the sample were simultaneously registered for metal and polymer side of the laminate. Based on these patterns debonding areas in laminates were localized. The transmission properties at low frequencies were also studied in terms of: the frequency range for which regular Lamb waves have been observed, Lamb wave amplitudes and Lamb wave propagation velocity depending on the frequency. We have shown that these properties also change when a defect occures in the laminate. Even when we could not localize the defect it was still possible to detect if a sample was damaged based on the behaviour of the Lamb waves.
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-22853-2
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Article: Enzymatic Catalysis in Favor of Blocky Structure and Higher Crystallinity of Poly(Butylene Succinate)-Co-(Dilinoleic Succinate) (PBS-DLS) Copolymers of Variable Segmental Composition.

Sokołowska, Martyna / Nowak-Grzebyta, Jagoda / Stachowska, Ewa / El Fray, Miroslawa

Materials (Basel, Switzerland)

2022 Volume 15, Issue 3

Abstract: To systematically investigate the synthesis of poly(butylene succinate)-co-(dilinoleic succinate) (PBS-DLS) copolymers and to enrich the library of polyesters synthesized via a sustainable route, we conducted a two-step polycondensation using fully ... ...

Abstract	To systematically investigate the synthesis of poly(butylene succinate)-co-(dilinoleic succinate) (PBS-DLS) copolymers and to enrich the library of polyesters synthesized via a sustainable route, we conducted a two-step polycondensation using fully biobased monomers such as diethyl succinate (DS), 1,4-butanediol (1,4-BD) and dilinoleic diol (DLD) in diphenyl ether, using
Language	English
Publishing date	2022-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15031132
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Article: Gut microbiome in intracranial aneurysm growth, subarachnoid hemorrhage, and cerebral vasospasm: a systematic review with a narrative synthesis.

Klepinowski, Tomasz / Skonieczna-Żydecka, Karolina / Pala, Bartłomiej / Stachowska, Ewa / Sagan, Leszek

Frontiers in neuroscience

2023 Volume 17, Page(s) 1247151

Abstract: Intracranial aneurysms (IA) are the most common cerebral vascular pathologies. Their rupture leads to the most dangerous subtype of stroke-aneurysmal subarachnoid hemorrhage (aSAH), which may be followed by cerebral vasospasm and ischemic sequelae. ... ...

Abstract	Intracranial aneurysms (IA) are the most common cerebral vascular pathologies. Their rupture leads to the most dangerous subtype of stroke-aneurysmal subarachnoid hemorrhage (aSAH), which may be followed by cerebral vasospasm and ischemic sequelae. Recently, an imbalance within the intestinal microbiota, referred to as dysbiosis, was suggested to play a role in the formation, progression, and rupture of IA. As no systematic review on this topic exists, considering the significance of this matter and a lack of effective prophylaxis against IA or cerebral vasospasm, we aim to sum up the current knowledge regarding their associations with intestinal microbiome, identify the gaps, and determine future prospects. Scientific databases were systematically and independently searched by two authors from inception to 1st May 2023 for original articles regarding the role of intestinal microbiota in intracranial aneurysmal growth, aSAH occurrence, as well as in cerebral vasospasm following aSAH. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist was followed in an abstraction process. The STROBE tool was applied to assess the risk of bias. This research was funded by the National Science Centre, Poland (grant number 2021/41/N/NZ2/00844). Of 302 records, four studies were included that fully met eligibility criteria. Studies reported (1) that the relative abundance of
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1247151
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Article ; Online: Editorial "Nutrition and Dietary Intake for Liver-Related Diseases".

Stachowska, Ewa / Jakubczyk, Karolina / Maciejewska-Markiewicz, Dominika

Nutrients

2021 Volume 13, Issue 2

Abstract: In this special issue, we focus on the role of nutrition in the therapy of nonalcoholic liver disease (NAFLD) [ ... ]. ...

Abstract	In this special issue, we focus on the role of nutrition in the therapy of nonalcoholic liver disease (NAFLD) [...].
MeSH term(s)	Alanine Transaminase/metabolism ; Aspartate Aminotransferases/metabolism ; Bile Acids and Salts/metabolism ; Body Mass Index ; Diet ; Dietary Fiber/administration & dosage ; Gastrointestinal Microbiome ; Humans ; Non-alcoholic Fatty Liver Disease/diet therapy ; Nutrition Assessment ; Nutritional Status
Chemical Substances	Bile Acids and Salts ; Dietary Fiber ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2021-01-27
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13020390
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Article ; Online: Small Intestinal Bacterial Overgrowth and Non-Alcoholic Fatty Liver Disease: What Do We Know in 2023?

Gudan, Anna / Kozłowska-Petriczko, Katarzyna / Wunsch, Ewa / Bodnarczuk, Tomasz / Stachowska, Ewa

Nutrients

2023 Volume 15, Issue 6

Abstract: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with the pathological accumulation of lipids inside hepatocytes. Untreated NAFL can progress to non-alcoholic hepatitis (NASH), followed by fibrosis, cirrhosis, and ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with the pathological accumulation of lipids inside hepatocytes. Untreated NAFL can progress to non-alcoholic hepatitis (NASH), followed by fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The common denominator of the above-mentioned metabolic disorders seems to be insulin resistance, which occurs in NAFLD patients. Obesity is the greatest risk factor for lipid accumulation inside hepatocytes, but a part of the NAFLD patient population has a normal body weight according to the BMI index. Obese people with or without NAFLD have a higher incidence of small intestinal bacterial overgrowth (SIBO), and those suffering from NAFLD show increased intestinal permeability, including a more frequent presence of bacterial overgrowth in the small intestine (SIBO). The health consequences of SIBO are primarily malabsorption disorders (vitamin B12, iron, choline, fats, carbohydrates and proteins) and bile salt deconjugation. Undetected and untreated SIBO may lead to nutrient and/or energy malnutrition, thus directly impairing liver function (e.g., folic acid and choline deficiency). However, whether SIBO contributes to liver dysfunction, decreased intestinal barrier integrity, increased inflammation, endotoxemia and bacterial translocation is not yet clear. In this review, we focus on gut-liver axis and discuss critical points, novel insights and the role of nutrition, lifestyle, pre- and probiotics, medication and supplements in the therapy and prevention of both SIBO and NAFLD.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/etiology ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/metabolism ; Liver/metabolism ; Risk Factors ; Obesity/metabolism ; Fibrosis
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061323
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Article ; Online: Altered lipid metabolism in patients with acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.

Tyszka, Martyna / Maciejewska-Markiewicz, Dominika / Styburski, Daniel / Biliński, Jarosław / Tomaszewska, Agnieszka / Stachowska, Ewa / Basak, Grzegorz W

Leukemia research

2024 Volume 137, Page(s) 107435

Abstract: Allogeneic hematopoietic cell transplantation (allo-HCT) remains the sole curative option for many hematological malignancies and other diseases. Nevertheless, its application is limited due to the risk of life-threatening complications, mainly graft- ... ...

Abstract	Allogeneic hematopoietic cell transplantation (allo-HCT) remains the sole curative option for many hematological malignancies and other diseases. Nevertheless, its application is limited due to the risk of life-threatening complications, mainly graft-versus-host disease (GVHD). Currently, in clinical practice, the risk of developing GVHD is estimated for every patient based on factors related to the donor and the host. In our prospective, observational study, we analyzed serum from 38 patients undergoing allo-HCT at our institution. We compared the metabolic profiles of patients who developed acute GVHD (aGVHD) with those without such complication by identification and comparison of metabolites masses on the XCMS platform. We observed that patients diagnosed with aGVHD had different metabolic profiles compared to the remaining patients and this alteration was noticeable already 7 days before the procedure. We identified dysregulated metabolites involved in bile acid transformation and cholesterol synthesis. Our study of the untargeted metabolome in allo-HCT recipients has revealed a potential link between lipid metabolism, specifically involving bile acid transformation and cholesterol synthesis, and the development of aGVHD. This finding might be an important indication for future research focused on understanding GVHD development, discovering prediction models, and investigating possible prophylactic interventions.
MeSH term(s)	Humans ; Lipid Metabolism ; Prospective Studies ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Bile Acids and Salts ; Cholesterol ; Acute Disease
Chemical Substances	Bile Acids and Salts ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2024.107435
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