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  1. Article ; Online: Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw.

    Caserta, Santino / Stagno, Fabio / Gangemi, Sebastiano / Allegra, Alessandro

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Osteonecrosis of the jaw is the progressive loss and destruction of bone affecting the maxilla or mandible in patients treated with antiresorptive and antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves the ... ...

    Abstract Osteonecrosis of the jaw is the progressive loss and destruction of bone affecting the maxilla or mandible in patients treated with antiresorptive and antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves the inflammatory pathway of receptor activator of nuclear factor NF-kB ligand and the macrophage colony-stimulating factor, essential for osteoclast precursors survival and proliferation and acting through its receptor c-Fms. Evidence has shown the role of non-coding RNAs in the pathogenesis of osteonecrosis of the jaw and this finding might be useful in diagnosis since these small RNAs could be considered as biomarkers of apoptotic activity in bone. Interestingly, it has been proved that miR-29 and miR-31-5p, acting on specific targets such as CALCR and RhoA, promote programmed-cell death and consequently the necrosis of bone tissue. Specific long non-coding RNAs, instead, have been detected both at reduced levels in patients with multiple myeloma and osteonecrosis, and associated with suppression of osteoblast differentiation, with consequences in the progression of mandible lesions. Among non-coding genic material, circular RNAs have the capability to modify the expression of specific mRNAs responsible for the inhibition of bisphosphonates activity on osteoclastogenesis.
    MeSH term(s) Humans ; Diphosphonates ; Osteonecrosis/metabolism ; Bone Density Conservation Agents ; Multiple Myeloma ; MicroRNAs/genetics
    Chemical Substances Diphosphonates ; Bone Density Conservation Agents ; MicroRNAs
    Language English
    Publishing date 2024-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors.

    Allegra, Alessandro / Mirabile, Giuseppe / Caserta, Santino / Stagno, Fabio / Russo, Sabina / Pioggia, Giovanni / Gangemi, Sebastiano

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This ...

    Abstract The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This aberrant protein affects several signaling pathways connected to both apoptosis and cell proliferation. It has been demonstrated that tyrosine kinase inhibitor treatment in chronic myeloid leukemia acts by inducing oxidative stress and, depending on its level, can activate signaling pathways responsible for either apoptosis or survival in leukemic cells. Additionally, oxidative stress and reactive oxygen species generation also mediate apoptosis through genomic activation. Furthermore, it was shown that oxidative stress has a role in both BCR-ABL-independent and BCR-ABL-dependent resistance pathways to tyrosine kinases, while patients with chronic myeloid leukemia were found to have a significantly reduced antioxidant level. The ideal environment for tyrosine kinase inhibitor therapy is produced by a favorable oxidative status. We discuss the latest studies that aim to manipulate the redox system to alter the apoptosis of cancerous cells.
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Efficient irrigation systems in citrus plantations in Sicily (BIOFRUITNET Video)

    Alföldi, Thomas / Verrastro, Vincenzo / Stagno, Fiorella

    2023  

    Abstract: In this video, Fiorella Stagno from CREA in Acireale talks about her experiences with different irrigation systems in citrus cultivation in Sicily. ...

    Abstract In this video, Fiorella Stagno from CREA in Acireale talks about her experiences with different irrigation systems in citrus cultivation in Sicily.
    Keywords Fruit and berries ; Irrigation and drainage
    Language Italian
    Publishing country dk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: On the road to treatment-free remission in chronic myeloid leukemia: what about 'the others'?

    Stagno, Fabio / Breccia, Massimo / Di Raimondo, Francesco

    Expert review of anticancer therapy

    2020  Volume 20, Issue 12, Page(s) 1075–1081

    Abstract: Introduction: The treatment of chronic myeloid leukemia (CML) has been drastically changed by the approval of tyrosine kinase inhibitors (TKIs). CML is now managed as a chronic disease requiring both long-term treatment and close molecular monitoring in ...

    Abstract Introduction: The treatment of chronic myeloid leukemia (CML) has been drastically changed by the approval of tyrosine kinase inhibitors (TKIs). CML is now managed as a chronic disease requiring both long-term treatment and close molecular monitoring in the majority of patients.
    Areas covered: Evidence suggests that in a substantial number of patients who have achieved a stable deep molecular response (DMR), TKI treatment can be safely discontinued without loss of response. Therefore, treatment-free remission (TFR), through the achievement of a DMR, is increasingly regarded as a feasible treatment goal in about 20% to 40% CML patients. Nevertheless, a proportion of patients with chronic-phase CML treated with TKIs remain in stable MMR and do not achieve a DMR.
    Expert opinion: We provide prospective views on how it is possible to optimize treatment for patients in stable MMR but not in DMR in order to finalize the therapeutic strategy.
    MeSH term(s) Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Protein Kinase Inhibitors/pharmacology ; Remission Induction ; Treatment Outcome
    Chemical Substances Protein Kinase Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-10-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2020.1829483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5907: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Retinal Vessel Analysis and Microvascular Abnormalities in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms.

    Roszkowska, Anna Maria / Leanza, Rossana / Aragona, Emanuela / Gargiulo, Ludovica / Alibrandi, Angela / Arrigo, Alessandro / Bottaro, Adele / Barone, Paola / Stagno, Fabio / Allegra, Alessandro

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: On the road to treatment-free remission in chronic myeloid leukemia: what about "the others"?

    Stagno, Fabio / Breccia, Massimo / Di Raimondo, Francesco

    Abstract: INTRODUCTION: The treatment of chronic myeloid leukemia (CML) has been drastically changed by the approval of tyrosine kinase inhibitors (TKIs). CML is now managed as a chronic disease requiring both long-term treatment and close molecular monitoring in ... ...

    Abstract INTRODUCTION: The treatment of chronic myeloid leukemia (CML) has been drastically changed by the approval of tyrosine kinase inhibitors (TKIs). CML is now managed as a chronic disease requiring both long-term treatment and close molecular monitoring in the majority of patients. AREAS COVERED: Evidence suggests that in a substantial number of patients who have achieved a stable deep molecular response (DMR), TKI treatment can be safely discontinued without loss of response. Therefore, treatment-free remission (TFR), through the achievement of a DMR, is increasingly regarded as a feasible treatment goal in about 20 to 40% CML patients. Nevertheless, a proportion of patients with chronic phase CML treated with TKIs remain in stable MMR and do not achieve a DMR. EXPERT OPINION: We provide prospective views on how it is possible to optimize treatment for patients in stable MMR but not in DMR in order to finalize the therapeutic strategy.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32985290
    Database COVID19

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  7. Article: Innovative system for mulberry fruit harvesting

    Assirelli, A. / Stagno, F. / Cocchi, A. / Sini, S. / Saviane, A. / Giovannini, D. / Cappellozza, S.

    Journal of berry research

    2019  Volume 9, Issue 4, Page(s) 615

    Language English
    Document type Article
    ZDB-ID 2897035-4
    ISSN 1878-5093
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 7974: Show issues

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  8. Article: High

    Massimino, Michele / Stella, Stefania / Tirrò, Elena / Pennisi, Maria Stella / Stagno, Fabio / Vitale, Silvia Rita / Romano, Chiara / Tomarchio, Cristina / Parrinello, Nunziatina Laura / Manzella, Livia / Di Raimondo, Francesco / Vigneri, Paolo

    OncoTargets and therapy

    2023  Volume 16, Page(s) 803–816

    Abstract: Purpose: Chronic Myeloid Leukemia (CML) is a clonal disorder of the hematopoietic stem cell caused by expression of the : Methods: Leukemic cells were collected from CML patients showing, at diagnosis, high or low : Results: We found that : ... ...

    Abstract Purpose: Chronic Myeloid Leukemia (CML) is a clonal disorder of the hematopoietic stem cell caused by expression of the
    Methods: Leukemic cells were collected from CML patients showing, at diagnosis, high or low
    Results: We found that
    Conclusion: Higher
    Language English
    Publishing date 2023-10-03
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S413825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Italian Physicians' Perceptions about the Role of Asciminib in Later Lines Chronic Myeloid Leukemia in Clinical Practice: A GIMEMA Survey.

    Breccia, Massimo / Piciocchi, Alfonso / Abruzzese, Elisabetta / Cilloni, Daniela / Messina, Monica / Soddu, Stefano / Castagnetti, Fausto / Stagno, Fabio / Fazi, Paola / Iurlo, Alessandra / Caocci, Giovanni / Gozzini, Antonella / Intermesoli, Tamara / D'Adda, Mariella / Pane, Fabrizio

    Journal of clinical medicine

    2023  Volume 12, Issue 16

    Abstract: Unmet needs remain in later lines chronic myeloid leukemia (CML): the response rate and the overall survival of resistant patients in the chronic phase who changed a second-generation TKI in the second line with another TKI with similar action are ... ...

    Abstract Unmet needs remain in later lines chronic myeloid leukemia (CML): the response rate and the overall survival of resistant patients in the chronic phase who changed a second-generation TKI in the second line with another TKI with similar action are usually poor, while the off-target toxicities and the potential development of mutations increase. The recent approval of asciminib, a STAMP inhibitor, in the third line, has the potential to soon change the therapeutic algorithm for this subset of patients. Here, we report the results of a GIMEMA survey assessing the number of patients currently treated in the third line in Italy, the current approach in later lines by Italian physicians, and the future role of this drug according to the reason to switch to asciminib (resistance and/or intolerance), as well as the perceptions about the future position of this agent.
    Language English
    Publishing date 2023-08-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12165267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Canopy temperature as an indicator of water status in citrus trees

    Stagno, F / Giuffrida, A / Intrigliolo, F

    Acta horticulturae. 2011 Mar., , no. 889

    2011  

    Abstract: Measurements of midday stem water potential ((psi)md) and midday canopy temperature (IR(md)) were carried out during three seasons in a fully irrigated citrus orchard [Citrus sinensis (L.) Osbeck] ‘Valencia Late’. The aim of the work was to assess the ... ...

    Abstract Measurements of midday stem water potential ((psi)md) and midday canopy temperature (IR(md)) were carried out during three seasons in a fully irrigated citrus orchard [Citrus sinensis (L.) Osbeck] ‘Valencia Late’. The aim of the work was to assess the relationship between these parameters. The data of infrared thermometer were used to build an empirical model. The data obtained in the first two years allowed to calculate a linear function [(psi)md=f(IR(md))] with a correlation coefficient (r) of -0.865. In the third year of the study, the regression model was tested with a validation procedure. During the period of observation, (psi)md data (observed and fitted) did not show significant statistical differences demonstrating the accuracy of the model.
    Keywords Citrus sinensis ; canopy ; correlation ; irrigation rates ; regression analysis ; temperature ; trees ; water potential
    Language English
    Size p. 347-353.
    Publishing place International Society for Horticultural Science
    Document type Article
    Note Paper presented at the Sixth International Symposium on Irrigation of Horticultural Crops, held November 2-6, 2009, Vina del Mar, Chile.
    ISSN 0567-7572
    Database NAL-Catalogue (AGRICOLA)

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