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  1. Book: Motivation zur Hoffnung für Krebskranke, Angehörige, Pflegende und Ärzte

    Müller-Stahl, Martin / Wolfrum, Dirk-Ingo

    (Naturheilkunde fundiert)

    2013  

    Institution Karl-und-Veronica-Carstens-Stiftung
    Author's details Martin Müller-Stahl und Dirk Ingo Wolfrum. Mit Erfahrungsberichten von Patientinnen und Patienten: Otto Baas ... [Karl-und-Veronica-Carstens-Stiftung]
    Series title Naturheilkunde fundiert
    Keywords Krebs ; Alternative Medizin
    Subject Außerschulische Medizin ; Außenseitermedizin ; Außenseiterverfahren ; Alternativmedizin ; Komplementärmedizin ; Komplementäre Medizin ; Alternative Therapie ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language German
    Size XII, 289 S. : Ill.
    Edition 3., überarb. Aufl.
    Publisher KVC-Verl
    Publishing place Essen
    Publishing country Germany
    Document type Book
    HBZ-ID HT017528071
    ISBN 978-3-86864-004-5 ; 3-86864-004-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 10670 order for loan Magazin

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  2. Book: Natürlich zu Fuß

    Müller-Stahl, Martin

    Gesund unterwegs im Alltag und beim Wandern

    (Naturheilkunde fundiert)

    2008  

    Author's details Martin Müller-Stahl
    Series title Naturheilkunde fundiert
    Keywords Wandern
    Subject Fernwandern ; Wanderung
    Language German
    Size VII, 188 S., Ill.
    Publisher KVC-Verl
    Publishing place Essen
    Publishing country Germany
    Document type Book
    HBZ-ID HT015659733
    ISBN 978-3-933351-80-7 ; 3-933351-80-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 6567 order for loan Magazin

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  3. Book: Motivation zur Hoffnung für Krebskranke, Angehörige, Pflegende und Ärzte

    Müller-Stahl, Martin / Wolfrum, Dirk-Ingo

    (Naturheilkunde fundiert)

    2004  

    Institution Karl-und-Veronica-Carstens-Stiftung
    Author's details [Karl-und-Veronica-Carstens-Stiftung]. Martin Müller-Stahl und Dirk-Ingo Wolfrum. Mit Erfahrungsberichten von Patientinnen und Patienten: Otto Baas
    Series title Naturheilkunde fundiert
    Language German
    Size X, 273 S., Ill.
    Edition 2., bearb. und erw. Aufl.
    Publisher KVC-Verl
    Publishing place Essen
    Publishing country Germany
    Document type Book
    Note Literaturverz. S. 253 - 259
    HBZ-ID HT014609916
    ISBN 3-933351-50-2 ; 978-3-933351-50-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 6190 order for loan Magazin

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  4. Article ; Online: Making good decisions in early drug discovery.

    Sandrin, Virginie / Wörsdörfer, Bigna / Vardy, Sam / Coopersmith, Ellen / Stahl, Martin

    Drug discovery today

    2024  , Page(s) 104016

    Abstract: The earliest phases of drug discovery require diverse scientific disciplines to work hand in hand to address many unknowns. Good decision making is crucial for success in this context and, yet, the topic of sound planning has rarely been addressed for ... ...

    Abstract The earliest phases of drug discovery require diverse scientific disciplines to work hand in hand to address many unknowns. Good decision making is crucial for success in this context and, yet, the topic of sound planning has rarely been addressed for the earliest stages of drug discovery. We propose a tailored, qualitative 'decision quality' process that can serve as a guide toward generating project plans optimized to address a given project situation. Furthermore, we propose a visual flow-chart format for the selected plan that includes key decisions and activities, together forming a decision roadmap of the plan. We illustrate each step of the process by means of a real-life example and provide recommendations for its implementation.
    Language English
    Publishing date 2024-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2024.104016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Beeinflussung einiger Funktionen neutrophiler Granulozyten des Schweines durch echinaceahaltige Präparate

    Stahl, Martin

    1988  

    Author's details von Martin Stahl
    Size 107 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1988
    HBZ-ID HT005014018
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    AY 13242 order for loan Geschlossenes Magazin (U2)

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    Inter-library loan at ZB MED

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  6. Article: Details Matter in Structure-based Drug Design.

    Kuhn, Bernd / Peters, Jens-Uwe / Rudolph, Markus G / Mohr, Peter / Stahl, Martin / Tosstorff, Andreas

    Chimia

    2023  Volume 77, Issue 7-8, Page(s) 489–493

    Abstract: Successful structure-based drug design (SBDD) requires the optimization of interactions with the target protein and the minimization of ligand strain. Both factors are often modulated by small changes in the chemical structure which can lead to profound ... ...

    Abstract Successful structure-based drug design (SBDD) requires the optimization of interactions with the target protein and the minimization of ligand strain. Both factors are often modulated by small changes in the chemical structure which can lead to profound changes in the preferred conformation and interaction preferences of the ligand. We draw from examples of a Roche project targeting phosphodiesterase 10 to highlight that details matter in SBDD. Data mining in crystal structure databases can help to identify these sometimes subtle effects, but it is also a great resource to learn about molecular recognition in general and can be used as part of molecular design tools. We illustrate the use of the Cambridge Structural Database for identifying preferred structural motifs for intramolecular hydrogen bonding and of the Protein Data Bank for deriving propensities for protein-ligand interactions.
    MeSH term(s) Ligands ; Data Mining ; Databases, Factual ; Drug Design ; Learning
    Chemical Substances Ligands
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1516-7
    ISSN 0009-4293
    ISSN 0009-4293
    DOI 10.2533/chimia.2023.489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4.5: Show issues

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    Inter-library loan at ZB MED

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  7. Book: Motivation zur Hoffnung

    Müller-Stahl, Martin / Wolfrum, Dirk-Ingo / Baas, Otto

    für Kresbskranke, Angehörige, Pflegende und Ärzte

    2001  

    Author's details Martin Müller-Stahl und Dirk-Ingo Wolfrum. Mit Erfahrungsberichten von Patientinnen und Patienten: Otto Baas
    Language German
    Size IX, 251 S. : Ill., graph. Darst.
    Publisher KVC-Verl
    Publishing place Essen
    Publishing country Germany
    Document type Book
    HBZ-ID HT013094443
    ISBN 3-933351-20-0 ; 978-3-933351-20-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 1874 order for loan Magazin

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  8. Article ; Online: The Torsion Library: Semiautomated Improvement of Torsion Rules with SMARTScompare.

    Penner, Patrick / Guba, Wolfgang / Schmidt, Robert / Meyder, Agnes / Stahl, Martin / Rarey, Matthias

    Journal of chemical information and modeling

    2022  Volume 62, Issue 7, Page(s) 1644–1653

    Abstract: The Torsion Library is a collection of torsion motifs associated with angle distributions, derived from crystallographic databases. It is used in strain assessment, conformer generation, and geometry optimization. A hierarchical structure of expert ... ...

    Abstract The Torsion Library is a collection of torsion motifs associated with angle distributions, derived from crystallographic databases. It is used in strain assessment, conformer generation, and geometry optimization. A hierarchical structure of expert curated SMARTS defines the chemical environments of rotatable bonds and associates these with preferred angles. SMARTS can be very complex and full of implications, which make them difficult to maintain manually. Recent developments in automatically comparing SMARTS patterns can be applied to the Torsion Library to ensure its correctness. We specifically discuss the implementation and the limits of such a procedure in the context of torsion motifs and show several examples of how the Torsion Library benefits from this. All automated changes are validated manually and then shown to have an effect on the angle distributions by correcting matching behavior. The corrected Torsion Library itself is available including both PDB as well as CSD histograms in the Supporting Information and can be used to evaluate rotatable bonds at https://torsions.zbh.uni-hamburg.de.
    MeSH term(s) Databases, Factual ; Gene Library ; Molecular Conformation
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.2c00043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: What We Learned in 25 Years of Interactive Molecular Design Sessions.

    Kuhn, Bernd / Haap, Wolfgang / Obst-Sander, Ulrike / Kramer, Christian / Stahl, Martin

    ChemMedChem

    2021  Volume 16, Issue 18, Page(s) 2760–2763

    Abstract: We retrace Prof. François Diederich's consultancy work for Roche and its impact over the years he worked with us. François Diederich uniquely shaped our approach to molecular design, and interactions with him and his research group at ETH Zurich have ... ...

    Abstract We retrace Prof. François Diederich's consultancy work for Roche and its impact over the years he worked with us. François Diederich uniquely shaped our approach to molecular design, and interactions with him and his research group at ETH Zurich have created deep insights into molecular recognition. Herein we share how his style and approach continue to inspire us.
    MeSH term(s) Cysteine Endopeptidases/chemical synthesis ; Cysteine Endopeptidases/chemistry ; Humans ; Macrocyclic Compounds/chemical synthesis ; Macrocyclic Compounds/chemistry ; Molecular Structure
    Chemical Substances Macrocyclic Compounds ; Cysteine Endopeptidases (EC 3.4.22.-) ; rhodesain (EC 3.4.22.-)
    Language English
    Publishing date 2021-08-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202100351
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6280: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Culture methods to study apical-specific interactions using intestinal organoid models

    Stroulios, Georgios / Stahl, Martin / Elstone, Fisal / Chang, Wing / Louis, Sharon / Eaves, Allen / Simmini, Salvatore / Conder, Ryan K.

    Journal of visualized experiments. 2021 Mar. 23, , no. 169

    2021  

    Abstract: The lining of the gut epithelium is made up of a simple layer of specialized epithelial cells that expose their apical side to the lumen and respond to external cues. Recent optimization of in vitro culture conditions allows for the re-creation of the ... ...

    Abstract The lining of the gut epithelium is made up of a simple layer of specialized epithelial cells that expose their apical side to the lumen and respond to external cues. Recent optimization of in vitro culture conditions allows for the re-creation of the intestinal stem cell niche and the development of advanced 3-dimensional (3D) culture systems that recapitulate the cell composition and the organization of the epithelium. Intestinal organoids embedded in an extracellular matrix (ECM) can be maintained for long-term and self-organize to generate a well-defined, polarized epithelium that encompasses an internal lumen and an external exposed basal side. This restrictive nature of the intestinal organoids presents challenges in accessing the apical surface of the epithelium in vitro and limits the investigation of biological mechanisms such as nutrient uptake and host-microbiota/host-pathogen interactions. Here, we describe two methods that facilitate access to the apical side of the organoid epithelium and support the differentiation of specific intestinal cell types. First, we show how ECM removal induces an inversion of the epithelial cell polarity and allows for the generation of apical-out 3D organoids. Second, we describe how to generate 2-dimensional (2D) monolayers from single cell suspensions derived from intestinal organoids, comprised of mature and differentiated cell types. These techniques provide novel tools to study apical-specific interactions of the epithelium with external cues in vitro and promote the use of organoids as a platform to facilitate precision medicine.
    Keywords cell polarity ; epithelial cells ; epithelium ; extracellular matrix ; intestines ; nutrient uptake ; organoids ; precision medicine ; stem cells
    Language English
    Dates of publication 2021-0323
    Size p. e62330.
    Publishing place Journal of Visualized Experiments
    Document type Article
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/62330
    Database NAL-Catalogue (AGRICOLA)

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