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  1. Article ; Online: Letter: Irritable bowel syndrome and antibiotics-Authors' reply.

    Staller, Kyle / Ludvigsson, Jonas F

    Alimentary pharmacology & therapeutics

    2024  Volume 59, Issue 3, Page(s) 422

    MeSH term(s) Humans ; Irritable Bowel Syndrome/drug therapy ; Anti-Bacterial Agents
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Letter
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17839
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    Zs.A 2206: Show issues Location:
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  2. Article ; Online: Starting from the Bottom: Unraveling Obesity's Impact on Anorectal Function.

    Luo, Yuying / Staller, Kyle

    Digestive diseases and sciences

    2024  Volume 69, Issue 3, Page(s) 664–666

    MeSH term(s) Humans ; Obesity/epidemiology
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-08244-1
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  3. Article ; Online: Letter: Antibiotics prescription and new-onset irritable bowel syndrome-Authors' reply.

    Staller, Kyle / Ludvigsson, Jonas F

    Alimentary pharmacology & therapeutics

    2023  Volume 59, Issue 2, Page(s) 300–301

    MeSH term(s) Humans ; Irritable Bowel Syndrome/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Letter
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17827
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  4. Article ; Online: High Comorbidity of Gastrointestinal Disorders Among Those Seeking Care for Dyspareunia.

    Silvernale, Casey / Harris, Grace / Staller, Kyle

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Abstract: Dyspareunia, defined as genital pain that occurs before, during, or after sexual intercourse, is the most commonly diagnosed form of female sexual dysfunction. As high as 43% of women experience some form of sexual dysfunction, but the etiology of these ... ...

    Abstract Dyspareunia, defined as genital pain that occurs before, during, or after sexual intercourse, is the most commonly diagnosed form of female sexual dysfunction. As high as 43% of women experience some form of sexual dysfunction, but the etiology of these conditions is not well understood.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.01.002
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  5. Article ; Online: Refractory Constipation: What is the Clinician to Do?

    Staller, Kyle

    Journal of clinical gastroenterology

    2018  Volume 52, Issue 6, Page(s) 490–501

    Abstract: Most clinicians will agree that chronic constipation is characterized by abnormal bowel movement consistency and/or frequency plus or minus evacuation symptoms, but patient perception of constipation varies widely and includes symptoms that may or may ... ...

    Abstract Most clinicians will agree that chronic constipation is characterized by abnormal bowel movement consistency and/or frequency plus or minus evacuation symptoms, but patient perception of constipation varies widely and includes symptoms that may or may not meet official defining criteria. Although intermittent constipation is extremely common, only a small minority of patients seek care for their symptoms. Among these patients, dissatisfaction with the currently available laxative options is not uncommon, and many patients will require specialized care for severe or refractory symptoms-especially those with abdominal pain, irritable bowel syndrome overlap, bloating or distention, and psychological comorbidities. This review outlines a physiological assessment of the patient with refractory constipation, exploring treatment options among patients with slow transit, rectal evacuation disorders, and normal transit. In addition, we explore nonlaxative approaches to normal-transit patients bothered by ongoing symptoms, with an emphasis on the biopsychosocial model of functional gastrointestinal disease and treatment of visceral hypersensitivity using neuromodulators. Finally, we propose a comprehensive evaluation algorithm for the management of patients with refractory slow-transit constipation considering surgery and examine surgical options including colectomy and cecostomy using an antegrade continent enema.
    MeSH term(s) Algorithms ; Chronic Disease ; Clinical Decision-Making ; Constipation/diagnosis ; Constipation/physiopathology ; Constipation/therapy ; Critical Pathways ; Defecation/drug effects ; Diagnostic Techniques, Digestive System ; Digestive System Surgical Procedures ; Drug Resistance ; Drug Substitution ; Gastrointestinal Motility/drug effects ; Humans ; Intestines/drug effects ; Intestines/physiopathology ; Intestines/surgery ; Laxatives/adverse effects ; Laxatives/therapeutic use ; Patient Selection ; Predictive Value of Tests ; Recovery of Function ; Risk Reduction Behavior ; Treatment Outcome
    Chemical Substances Laxatives
    Language English
    Publishing date 2018-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001049
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    Zs.A 1523: Show issues Location:
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  6. Article ; Online: Towards Improving Diagnosis of Dyssynergic Defecation: A Small Step or a New Paradigm?

    Buchanan, Kelly L / Staller, Kyle

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2022  Volume 21, Issue 4, Page(s) 902–906

    MeSH term(s) Humans ; Defecation ; Constipation/diagnosis ; Constipation/etiology ; Ataxia/diagnosis ; Manometry ; Biofeedback, Psychology ; Anal Canal
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2022.06.036
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    Zs.A 5836: Show issues Location:
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  7. Article ; Online: Real-world outcomes for a digital prescription mobile application for adults with irritable bowel syndrome.

    Pathipati, Mythili P / Scott, Luisa L / Griser, Allen Cameron / Staller, Kyle

    Neurogastroenterology and motility

    2024  , Page(s) e14811

    Abstract: Background: Mahana™ IBS is a Food and Drug Administration-cleared prescription mobile application designed to deliver 3 months of gut-directed cognitive behavioral therapy (CBT) to adults ≥22 years old with irritable bowel syndrome (IBS). We assessed ... ...

    Abstract Background: Mahana™ IBS is a Food and Drug Administration-cleared prescription mobile application designed to deliver 3 months of gut-directed cognitive behavioral therapy (CBT) to adults ≥22 years old with irritable bowel syndrome (IBS). We assessed whether gut-directed CBT delivered digitally improved outcomes in IBS management.
    Methods: We studied users who had a dispensed physician prescription for Mahana™ IBS between August 2021 and August 2023. The primary outcome was change in IBS symptom severity (IBS-SSS) score.
    Key results: For the 843 patients, 324 (38%) completed half of the program up to session 5, and 162 (19%) of participants completed the full program up to session 10. Median age was 41 years, median IBS-SSS was 270 (moderate severity), IBS-mixed subtype was most common (23%) followed by IBS-C (20%) and IBS-D (19%). The change in IBS-SSS was -81.0 (p = < 0.001) after session 5 and - 104.4 (p = < 0.001) after session 10. In multivariate analyses, a higher baseline IBS-SSS (OR 1.59; 95% CI 1.26-2.01) and high baseline Perceived Stress Scale (PSS) score predicted non-response (OR 0.95; 95% CI 0.91-0.98) while older age (OR 1.10 per decade; 95% CI 1.01-1.20), prescription source from a healthcare provider (as opposed to third party telehealth encounter, OR 1.48; 95% CI 1.07-2.05), and payment for the app (OR 1.93; 95% CI 1.41-2.63) predicted adherence.
    Conclusions & inferences: Use of a digital mobile application for gut-directed CBT improved symptoms of IBS. Digital health applications have the potential to democratize CBT and allow integrated care to scale for patients with IBS.
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.14811
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    Zs.A 2979: Show issues Location:
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  8. Article ; Online: Pancreatitis and the Risk of Developing Gastric Neuromuscular Dysfunction.

    Pasricha, Trisha S / Staller, Kyle / Kuo, Braden

    Clinical and translational gastroenterology

    2023  Volume 14, Issue 2, Page(s) e00562

    Abstract: Introduction: Most gastroparesis and functional dyspepsia cases (collectively, gastric neuromuscular dysfunction [GND]) remain idiopathic. It is believed that some idiopathic cases of GND may be triggered by an inflammatory insult to the ... ...

    Abstract Introduction: Most gastroparesis and functional dyspepsia cases (collectively, gastric neuromuscular dysfunction [GND]) remain idiopathic. It is believed that some idiopathic cases of GND may be triggered by an inflammatory insult to the gastrointestinal tract. We theorized that the profound foregut inflammation induced by pancreatitis could result in increased risk of GND.
    Methods: This was a case-control study of all patients undergoing gastric emptying scintigraphy between October 2017 and 2020 in an urban medical center with presumed GND. These were age-, sex-, and comparative health-matched to control patients with newly diagnosed microscopic colitis. Adjusted odds ratios (aORs) were calculated using conditional logistic regression.
    Results: Among the 650 patients with GND, 359 had gastroparesis, and 9.2% had a history of acute pancreatitis (vs 3.1% of controls). Patients with GND demonstrated increased odds of having a history of acute pancreatitis (aOR 2.27, 95% confidence interval [CI] 1.33-4.03, P = 0.004) and recurrent pancreatitis (aOR 2.08, 95% CI 1.67-3.48, P = 0.002). Median time to GND diagnosis after first acute pancreatitis episode was 1,544 days (477.5, 3,832). Patients with a history of pancreatitis-associated GND had increased mortality vs controls (aOR 3.41, 95% CI 0.96-5.48). In addition, patients with pancreatitis-associated GND had more hospitalizations vs GND alone (13.8 vs 3.7, P < 0.0001) during the study period.
    Discussion: This is the first study demonstrating an independent association between pancreatitis and the risk of GND, which occurred ∼4.2 years after the first episode of acute pancreatitis. Pancreatitis should therefore be regarded as a possible risk factor for developing GND with important consequences for healthcare utilization.
    MeSH term(s) Humans ; Pancreatitis/chemically induced ; Gastroparesis ; Case-Control Studies ; Acute Disease ; Risk Factors
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000562
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  9. Article ; Online: The intersection between eating disorders and gastrointestinal disorders: a narrative review and practical guide.

    Staller, Kyle / Abber, Sophie R / Burton Murray, Helen

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 6, Page(s) 565–578

    Abstract: Eating disorders include a spectrum of disordered thinking patterns and behaviours around eating. There is increasing recognition of the bi-directional relationship between eating disorders and gastrointestinal disease. Gastrointestinal symptoms and ... ...

    Abstract Eating disorders include a spectrum of disordered thinking patterns and behaviours around eating. There is increasing recognition of the bi-directional relationship between eating disorders and gastrointestinal disease. Gastrointestinal symptoms and structural issues might arise from eating disorders, and gastrointestinal disease might be a risk factor for eating disorder development. Cross-sectional research suggests that individuals with eating disorders are disproportionately represented among people seeking care for gastrointestinal symptoms, with avoidant-restrictive food intake disorder in particular garnering attention for high rates among individuals with functional gastrointestinal disorders. This Review aims to describe the research to date on the relationship between gastrointestinal disorders and eating disorders, highlight research gaps, and provide brief, practical guidance for the gastroenterology provider in detecting, potentially preventing, and treating gastrointestinal symptoms in eating disorders.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Feeding and Eating Disorders/complications ; Gastrointestinal Diseases ; Gastroenterology
    Language English
    Publishing date 2023-02-28
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00351-X
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  10. Article ; Online: Reply.

    Lee, Tsung-Chun / Staller, Kyle / Kuo, Braden

    Gastroenterology

    2023  Volume 166, Issue 1, Page(s) 221–222

    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Letter
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.10.009
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