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  1. Book ; Online ; E-Book: Glaucoma

    Traverso, Carlo E. / Stalmans, Ingeborg / Topouzis, Fotis / Bagnasco, Luca

    (ESASO course series ; 8)

    2016  

    Author's details volume editors Carlo E. Traverso, Ingeborg Stalmans, Fotis Topouzis, Luca Bagnasco
    Series title ESASO course series ; 8
    Collection
    Keywords Glaucoma
    Language English
    Size 1 Online-Ressource (125 Seiten), Illustrationen
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019147152
    ISBN 978-3-318-05891-8 ; 9783318058901 ; 3-318-05891-2 ; 3318058904
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Treatment Outcomes Comparing the Paul and Baerveldt Glaucoma Implants After One Year of Follow-Up.

    Berteloot, Sophie / Correia Barão, Rafael / Abegão Pinto, Luís / Vandewalle, Evelien / Stalmans, Ingeborg / Lemmens, Sophie

    Journal of glaucoma

    2024  

    Abstract: Prcis: In reducing intraocular pressure (IOP), Paul (PGI) and Baerveldt (BGI) glaucoma implants are safe and effective in patients with glaucoma.: Objective: To compare efficacy and safety profiles of the PGI and BGI in the treatment of medically ... ...

    Abstract Prcis: In reducing intraocular pressure (IOP), Paul (PGI) and Baerveldt (BGI) glaucoma implants are safe and effective in patients with glaucoma.
    Objective: To compare efficacy and safety profiles of the PGI and BGI in the treatment of medically uncontrolled glaucoma at 1 year of follow-up.
    Methods: Retrospective analysis of patients implanted with a PGI or BGI with a minimum of 12 months follow-up. The primary outcome was surgical success defined as IOP ≥6 and ≤18 mm Hg and at least 20% IOP reduction from baseline. Secondary outcomes included IOP measurements, number of medications, and complications.
    Results: Twenty-three patients implanted with PGI and 27 with BGI were included. At last visit (12 mo), mean IOP had decreased from 23.7 ± 6.9 to 0.1 ± 2.9 mm Hg in the PGI group versus 26 ± 7.3 to 10.4 ± 4.9 mm Hg with the BGI ( P < 0.001 for both comparisons). Overall qualified success rates were similar between groups (PGI 91% vs BGI 89%, P = 0.784). IOP was significantly lower in the PGI at week 1 and month 1 of follow-up versus the BGI (13.6 ± 6.1 vs 20.1 ± 7.4; 14.6±3.8 vs 21.2 ± 5.8 mm Hg; P < 0.002 for both) with a lower number of medications (1.57 ± 1.47 vs 2.52 ± 1.16 at mo 1, P = 0.015). Most complications were minor and similar in both groups.
    Conclusion: Both PGI and BGI are safe and effective in reducing IOP in patients with glaucoma, with similar success rates.
    Language English
    Publishing date 2024-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000002366
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  3. Article ; Online: Differentiating Ischemic Optic Neuropathy from Glaucoma Using Diagnostic Tests.

    Smeets, Frédéric / Margot, Astrid / Barbosa-Breda, João / Stalmans, Ingeborg / Lemmens, Sophie

    Ophthalmic research

    2024  Volume 67, Issue 1, Page(s) 154–171

    Abstract: Introduction: Anterior ischemic optic neuropathy (AION) can mimic glaucoma and consequently cause difficulties in differential diagnosis. The purpose of this paper was to summarize differences in diagnostic tests that can help perform a correct ... ...

    Abstract Introduction: Anterior ischemic optic neuropathy (AION) can mimic glaucoma and consequently cause difficulties in differential diagnosis. The purpose of this paper was to summarize differences in diagnostic tests that can help perform a correct diagnosis.
    Methods: The search strategy was performed according to the PRISMA 2009 guidelines, and four databases were used: MEDLINE, Embase, Web of Science, and Cochrane. Totally, 772 references were eligible; 39 were included after screening with respect to inclusion criteria that included English language and published in the 20 years before search date.
    Results: Ninety percent (n = 35) of included studies used optical coherence tomography (OCT). Glaucomatous eyes had a significantly greater cup area, volume and depth, cup-to-disk ratio, a lower rim volume and area, and a thinner Bruch's membrane opening-minimum rim width. Retinal nerve fiber layer (RNFL) thinning in glaucomatous eyes occurred primarily at the superotemporal, inferotemporal, and inferonasal sectors, while AION eyes demonstrated mostly superonasal thinning. Glaucoma eyes showed greater macular ganglion cell layer thickness, except at the inferotemporal sector. OCT angiography measurements demonstrated a significant decrease in superficial and deep macular vessel density (VD) in glaucoma compared to AION with similar degree of visual field damage; the parapapillary choroidal VD was spared in AION eyes compared to glaucomatous eyes.
    Conclusion: By use of OCT imaging, optic nerve head parameters seem most informative to distinguish between glaucoma and AION. Although both diseases affect the RNFL thickness, it seems to do so in different sectors. Differences in structure and vascularity of the macula can also help in making the differential diagnosis.
    MeSH term(s) Humans ; Optic Neuropathy, Ischemic/diagnosis ; Diagnosis, Differential ; Tomography, Optical Coherence/methods ; Nerve Fibers/pathology ; Retinal Ganglion Cells/pathology ; Optic Disk/pathology ; Optic Disk/diagnostic imaging ; Optic Disk/blood supply ; Glaucoma/diagnosis ; Visual Fields/physiology ; Intraocular Pressure/physiology
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 205708-6
    ISSN 1423-0259 ; 0030-3747
    ISSN (online) 1423-0259
    ISSN 0030-3747
    DOI 10.1159/000535568
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    Zs.A 559: Show issues Location:
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  4. Article: The Effects of Intranasal, Inhaled and Systemic Glucocorticoids on Intraocular Pressure: A Literature Review.

    Wijnants, Dries / Stalmans, Ingeborg / Vandewalle, Evelien

    Journal of clinical medicine

    2022  Volume 11, Issue 7

    Abstract: Topical glucocorticoids are a well-known risk factor of intraocular pressure (IOP) elevation in one third of the general population and in up to 90% of glaucomatous patients. Whether this steroid response is caused by intranasal, inhaled or systemic ... ...

    Abstract Topical glucocorticoids are a well-known risk factor of intraocular pressure (IOP) elevation in one third of the general population and in up to 90% of glaucomatous patients. Whether this steroid response is caused by intranasal, inhaled or systemic glucocorticoids, is less known. This study presents an overview of the current literature on the topic, thereby providing guidance on when ophthalmological follow-up is indicated. A literature study was performed in Medline, and 31 studies were included for analysis. Twelve out of fourteen studies discussing intranasal glucocorticoids show no significant association with an elevated IOP. Regarding inhaled glucocorticoids, only three out of twelve studies show a significant association. The observed increase was either small or was only observed in patients treated with high inhaled doses or in patients with a family history of glaucoma. An elevated IOP caused by systemic glucocorticoids is reported by four out of the five included studies, with one study reporting a clear dose-response relationship. This review concludes that a steroid response can be triggered in patients treated with systemic glucocorticoids. Inhaled glucocorticoids may cause a significant IOP elevation when administered in high doses or in patients with a family history of glaucoma. At present, there is no evidence for a clinically significant steroid response caused by intranasally administered glucocorticoids.
    Language English
    Publishing date 2022-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11072007
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  5. Article ; Online: The natural history of untreated ocular hypertension and glaucoma.

    Lauwers, Amelien / Barbosa Breda, João / Stalmans, Ingeborg

    Survey of ophthalmology

    2022  Volume 68, Issue 3, Page(s) 388–424

    Abstract: Glaucoma is a chronic, progressive disease leading to irreversible blindness if left untreated; however, since reducing intraocular pressure has proven to be successful in slowing disease progression, little is known about the natural history of ... ...

    Abstract Glaucoma is a chronic, progressive disease leading to irreversible blindness if left untreated; however, since reducing intraocular pressure has proven to be successful in slowing disease progression, little is known about the natural history of untreated glaucoma. This knowledge can be valuable in guiding management decisions in the era of personalized medicine. A systematic search was performed in Medline (PubMed), Embase, and Web of Science in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRIMSA) guidelines. The rate of structural and/or functional progression and conversion to glaucoma or to a more advanced stage of glaucoma are discussed for ocular hypertension and different types of open-angle glaucoma. Forty-three studies were included. Different rates of progression were found both among and within the different diagnostic groups that belong to the open-angle glaucoma spectrum. The highest rate was found in pseudoexfoliation glaucoma, followed by high tension glaucoma, normal tension glaucoma, and ocular hypertension, in decreasing order. The lowest rate was observed in glaucoma suspects. The known rates of progression provide valuable prognostic information for ophthalmologists and patients. Nonetheless, due to high variability among patients, individual progression cannot be accurately predicted and repeated follow-up examinations are required to estimate individual progression.
    MeSH term(s) Humans ; Glaucoma, Open-Angle/complications ; Glaucoma, Open-Angle/diagnosis ; Glaucoma ; Ocular Hypertension ; Intraocular Pressure ; Eye
    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391346-6
    ISSN 1879-3304 ; 0039-6257
    ISSN (online) 1879-3304
    ISSN 0039-6257
    DOI 10.1016/j.survophthal.2022.12.001
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    Zs.A 283: Show issues Location:
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  6. Article ; Online: Preservative-free Bimatoprost 0.01% Ophthalmic Gel for Glaucoma Therapy. A Phase III Randomized Controlled Trial.

    Muñoz-Negrete, Francisco J / Topouzis, Fotis / Oddone, Francesco / Nisslé, Sylvie / Rokicki, Dariusz / Januleviciene, Ingrida / Harasymowycz, Paul / Stalmans, Ingeborg

    Journal of glaucoma

    2024  

    Abstract: Purpose: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of a preservative-free bimatoprost 0.01% ophthalmic gel (PFB 0.01% gel) compared with preserved bimatoprost 0.01% (PB 0.01%).: Design: Phase III, international, ... ...

    Abstract Purpose: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of a preservative-free bimatoprost 0.01% ophthalmic gel (PFB 0.01% gel) compared with preserved bimatoprost 0.01% (PB 0.01%).
    Design: Phase III, international, multicenter, randomized, 2-parallel group, investigator-masked, 3-month treatment duration.
    Methods: Patients with glaucoma or ocular hypertension were randomized after a 7 week run-in/washout period to receive once-daily PFB 0.01% gel (n=236) or PB 0.01% (n=249) for 3 months. The primary efficacy measure was change from baseline in IOP at Week 12. Safety measures included adverse events (AEs) and assessment of conjunctival hyperemia.
    Results: Mean change from baseline in IOP at Week 12 in the PFB 0.01% gel and PB 0.01% were -9.72±2.97 mmHg and -9.47±3.06, respectively at 8 am, -9.41±3.03 and -9.19±3.12 mmHg at 10 am, and -8.99±3.36 and -8.54±3.44 mmHg at 4 pm. Noninferiority of PFB 0.01% gel to PB 0.01% was demonstrated at Week 12 based on predetermined criteria (upper 95% confidence interval margin of 1.5 mmHg at all timepoints). The most frequently reported AE was conjunctival hyperemia; 13 (5.5%) patients with PFB 0.01% gel and 17 (6.8%) patients with PB 0.01%. The percentage of patients experiencing a worsening from baseline in conjunctival hyperemia score was lower with PFB 0.01% gel compared to PB 0.01% at Week 6 (20.1% vs 29.3%, respectively) and Week 12 (18.3% vs 30.4%, respectively).
    Conclusions: PFB 0.01% ophthalmic gel has the same efficacy in lowering IOP as PB 0.01% and demonstrated less aggravation of conjunctival hyperemia at Week 6 and Week 12.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000002371
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    Zs.A 3795: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Leuven-Haifa High-Resolution Fundus Image Dataset for Retinal Blood Vessel Segmentation and Glaucoma Diagnosis.

    Van Eijgen, Jan / Fhima, Jonathan / Billen Moulin-Romsée, Marie-Isaline / Behar, Joachim A / Christinaki, Eirini / Stalmans, Ingeborg

    Scientific data

    2024  Volume 11, Issue 1, Page(s) 257

    Abstract: The Leuven-Haifa dataset contains 240 disc-centered fundus images of 224 unique patients (75 patients with normal tension glaucoma, 63 patients with high tension glaucoma, 30 patients with other eye diseases and 56 healthy controls) from the University ... ...

    Abstract The Leuven-Haifa dataset contains 240 disc-centered fundus images of 224 unique patients (75 patients with normal tension glaucoma, 63 patients with high tension glaucoma, 30 patients with other eye diseases and 56 healthy controls) from the University Hospitals of Leuven. The arterioles and venules of these images were both annotated by master students in medicine and corrected by a senior annotator. All senior segmentation corrections are provided as well as the junior segmentations of the test set. An open-source toolbox for the parametrization of segmentations was developed. Diagnosis, age, sex, vascular parameters as well as a quality score are provided as metadata. Potential reuse is envisioned as the development or external validation of blood vessels segmentation algorithms or study of the vasculature in glaucoma and the development of glaucoma diagnosis algorithms. The dataset is available on the KU Leuven Research Data Repository (RDR).
    MeSH term(s) Humans ; Algorithms ; Fundus Oculi ; Glaucoma/diagnostic imaging ; Retinal Vessels/diagnostic imaging
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-024-03086-6
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  8. Article ; Online: Artificial intelligence for glaucoma: state of the art and future perspectives.

    Correia Barão, Rafael / Hemelings, Ruben / Abegão Pinto, Luís / Pazos, Marta / Stalmans, Ingeborg

    Current opinion in ophthalmology

    2023  Volume 35, Issue 2, Page(s) 104–110

    Abstract: Purpose of review: To address the current role of artificial intelligence (AI) in the field of glaucoma.: Recent findings: Current deep learning (DL) models concerning glaucoma diagnosis have shown consistently improving diagnostic capabilities, ... ...

    Abstract Purpose of review: To address the current role of artificial intelligence (AI) in the field of glaucoma.
    Recent findings: Current deep learning (DL) models concerning glaucoma diagnosis have shown consistently improving diagnostic capabilities, primarily based on color fundus photography and optical coherence tomography, but also with multimodal strategies. Recent models have also suggested that AI may be helpful in detecting and estimating visual field progression from different input data. Moreover, with the emergence of newer DL architectures and synthetic data, challenges such as model generalizability and explainability have begun to be tackled.
    Summary: While some challenges remain before AI is routinely employed in clinical practice, new research has expanded the range in which it can be used in the context of glaucoma management and underlined the relevance of this research avenue.
    MeSH term(s) Humans ; Artificial Intelligence ; Deep Learning ; Glaucoma/diagnosis ; Diagnostic Techniques, Ophthalmological ; Visual Fields
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000001022
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    Zs.A 3047: Show issues Location:
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  9. Article ; Online: Patient creates filtering bleb: hypotony following traumatic rupture of an old scleral incision for intracapsular cataract surgery.

    Lemmens, Sophie / Hua, Minh-Tri / Stalmans, Ingeborg

    BMJ case reports

    2021  Volume 14, Issue 1

    Abstract: An 86-year-old woman presented with symptomatic hypotony on the left eye since a few weeks, blurry vision and a very sensitive eye. She had a history of bilateral intracapsular cataract extraction (ICCE) in 1982 and secondary intraocular lens ... ...

    Abstract An 86-year-old woman presented with symptomatic hypotony on the left eye since a few weeks, blurry vision and a very sensitive eye. She had a history of bilateral intracapsular cataract extraction (ICCE) in 1982 and secondary intraocular lens implantation in 1988. The patient mentioned a fall on the left side of the head 6 months earlier. The diagnosis of a superior scleral fistula was made, confirmed by gonioscopy and anterior segment optical coherence tomography. Direct surgical repair of the fistula led to a favourable outcome. This case demonstrates the occurrence of symptomatic hypotony due to the traumatic creation of a scleral fistula with an inadvertent filtering bleb many years after ICCE, and the resolution of signs and symptoms after surgical repair. Conventional as well as contemporary modalities can be valuable in the assessment of such fistulae. Management depends on the clinical course and the mechanism and extent of fistulation.
    MeSH term(s) Aged, 80 and over ; Female ; Humans ; Cataract Extraction/adverse effects ; Fistula/diagnosis ; Fistula/etiology ; Lens Implantation, Intraocular/adverse effects ; Ocular Hypotension/diagnosis ; Ocular Hypotension/etiology ; Sclera/injuries
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-239035
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  10. Article ; Online: The influence of altitude on the differences between Goldmann tonometry and Pascal dynamic contour tonometry: An ecological meta-analysis.

    Albis-Donado, Oscar / Ramirez-Neria, Paulina / Rios-Acosta, Nadia / Stalmans, Ingeborg

    Indian journal of ophthalmology

    2023  Volume 72, Issue Suppl 3, Page(s) S398–S403

    Abstract: Purpose: A meta-analysis found that including atmospheric pressure as altitude in generalized linear models reveals higher differences between Goldmann tonometry and Pascal dynamic contour tonometry at higher altitudes, with the difference increasing in ...

    Abstract Purpose: A meta-analysis found that including atmospheric pressure as altitude in generalized linear models reveals higher differences between Goldmann tonometry and Pascal dynamic contour tonometry at higher altitudes, with the difference increasing in thinner corneas. To examine the difference in intraocular pressure (IOP) measurements by using Goldman applanation tonometry (GAT) and dynamic contour tonometer (DCT) tonometry in published literature and determine the influence of central corneal thickness (CCT), age, and altitude on that difference.
    Methods: Articles that compare GAT and DCT were selected for an extensive literature review, and the location and altitude of the research centers were found online. CCT and age were analyzed as covariates, when available.
    Results: A total of 157 studies including 24,211 eyes of 20,214 patients were included in the study. The results showed that the difference between DCT and GAT was higher at higher altitudes above sea level and increased with thinner corneas. However, the results were different in eyes with corneal transplants, where altitude and CCT had less influence, and in those post-refractive surgery where age was found to influence the difference. Theoretical correction formulas using altitude, CCT, and age were derived from this meta-analysis, but their accuracy and usefulness in clinical practice need validation.
    Conclusion: The findings suggest that there is a higher risk of underestimating IOP when the Goldmann tonometer is used at a higher altitude, particularly in eyes with glaucoma, thinner corneas, or corneal refractive surgery. Further research is needed to validate the accuracy of the correction formulas derived from this meta-analysis in clinical practice.
    Language English
    Publishing date 2023-12-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_907_23
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