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  1. Article ; Online: The birth of the American Society of Gene Therapy.

    Stamatoyannopoulos, George

    Molecular therapy : the journal of the American Society of Gene Therapy

    2010  Volume 18, Issue 3, Page(s) 462–465

    MeSH term(s) Biotechnology/methods ; Genetic Therapy/methods ; Genetic Vectors ; Genetics/history ; Genetics/organization & administration ; History, 20th Century ; Humans ; Societies, Medical ; United States
    Language English
    Publishing date 2010-02-25
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1038/mt.2010.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
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  2. Book: The molecular basis of blood diseases

    Stamatoyannopoulos, George

    2001  

    Author's details George Stamatoyannopoulos
    Keywords Hematologic Diseases / genetics ; Blutkrankheit ; Molekularbiologie
    Subject Molekulare Biologie ; Hämopathie ; Blutkrankheiten ; Hämatologische Krankheit
    Language English
    Size XV, 1028 S. : Ill.
    Edition 3. ed.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012830751
    ISBN 0-7216-7671-5 ; 978-0-7216-7671-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 4615 order for loan Magazin

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  3. Article: Control of globin gene expression during development and erythroid differentiation.

    Stamatoyannopoulos, George

    Experimental hematology

    2005  Volume 33, Issue 3, Page(s) 259–271

    Abstract: Extensive studies during the last 30 years have led to considerable understanding of cellular and molecular control of hemoglobin switching. Cell biology studies in the 1970s defined the control of globin genes during erythroid differentiation and led to ...

    Abstract Extensive studies during the last 30 years have led to considerable understanding of cellular and molecular control of hemoglobin switching. Cell biology studies in the 1970s defined the control of globin genes during erythroid differentiation and led to development of therapies for sickle cell disease. Molecular investigations of the last 20 years have delineated the two basic mechanisms that control globin gene activity during development--autonomous silencing and gene competition. Studies of hemoglobin switching have provided major insights on the control of gene loci by remote regulatory elements. Research in this field has an impact on understanding regulatory mechanisms in general and is of particular importance for eventual development of molecular cures for sickle cell disease and beta thalassemia.
    MeSH term(s) Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/therapy ; Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Erythropoiesis/genetics ; Fetal Hemoglobin/genetics ; Fetal Hemoglobin/physiology ; Gene Expression Regulation, Developmental ; Gene Silencing/physiology ; Globins/genetics ; Humans ; Transcription, Genetic/physiology ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
    Chemical Substances Globins (9004-22-2) ; Fetal Hemoglobin (9034-63-3)
    Language English
    Publishing date 2005-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0301-472X ; 0531-5573
    ISSN (online) 1873-2399
    ISSN 0301-472X ; 0531-5573
    DOI 10.1016/j.exphem.2004.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Molecular biology of hemoglobin switching

    Stamatoyannopoulos, George

    (Proceedings of the 9th Conference on Hemoglobin Switsching ; 1)

    1995  

    Author's details ed.: George Stamatoyannopoulos
    Series title Proceedings of the 9th Conference on Hemoglobin Switsching ; 1
    Proceedings of the 9th Conference on Hemoglobin Switching
    Proceedings of the 9th Conference on Hemoglobin Switsching
    Collection Proceedings of the 9th Conference on Hemoglobin Switching
    Proceedings of the 9th Conference on Hemoglobin Switsching
    Keywords Globin / genetics / congresses ; Gene Expression Regulation / congresses ; Transcription Factors / congresses ; Hämoglobin ; Molekulargenetik
    Subject Molekulare Genetik ; Biochemische Genetik ; Roter Blutfarbstoff
    Language English
    Size XVIII, 433 S. : Ill., graph. Darst.
    Publisher Intercept
    Publishing place Andover
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007185882
    ISBN 1-898298-35-1 ; 978-1-898298-35-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 5071 -1- order for loan Magazin

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  5. Book: Biology of hematopoiesis and stem cell gene transfer

    Stamatoyannopoulos, George

    (Proceedings of the 9th Conference on Hemoglobin Switching ; 2)

    1995  

    Author's details ed.: George Stamatoyannopoulos
    Series title Proceedings of the 9th Conference on Hemoglobin Switching ; 2
    Proceedings of the 9th Conference on Hemoglobin Switching
    Proceedings of the 9th Conference on Hemoglobin Switching
    Collection Proceedings of the 9th Conference on Hemoglobin Switching
    Proceedings of the 9th Conference on Hemoglobin Switching
    Keywords Hematopoietic Stem Cell Transplantation / congresses ; Hematopoietic System / embryology / congresses ; Hematopoiesis / genetics / congresses ; Transduction, Genetic / congresses ; Hämatopoese ; Blutstammzelle ; Gentransfer
    Subject Genübertragung ; Transfer ; Hämatopoetische Stammzelle ; Blutstammzellen ; Blutbildung ; Hämopoese
    Language English
    Size XVI, 273 S. : Ill., graph. Darst.
    Publisher Intercept
    Publishing place Andover
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007167170
    ISBN 1-898298-36-X ; 978-1-898298-36-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  6. Book: The molecular basis of blood diseases

    Stamatoyannopoulos, George

    2001  

    Author's details [edited by] George Stamatoyannopoulos ... [et al.]
    MeSH term(s) Hematologic Diseases/genetics
    Language English
    Size xv, 1028 p. :, ill.
    Edition 3rd ed.
    Publisher W.B. Saunders
    Publishing place Philadelphia
    Document type Book
    ISBN 9780721676715 ; 0721676715
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: The molecular basis of blood diseases

    Stamatoyannopoulos, George

    2001  

    Author's details [ed. by] George Stamatoyannopoulos
    Language English
    Size XV, 1028 S, Ill., graph. Darst
    Edition 3. ed
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Document type Book
    Note Literaturangaben ; Previous ed.: 1994
    ISBN 0721676715 ; 9780721676715
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: The molecular basis of blood diseases

    Stamatoyannopoulos, George

    1994  

    Author's details George Stamatoyannopoulos
    Keywords Hematologic Diseases ; Molecular Biology ; Blutkrankheit ; Molekularbiologie
    Subject Molekulare Biologie ; Hämopathie ; Blutkrankheiten ; Hämatologische Krankheit
    Language English
    Size XIX, 986 S. : Ill., graph. Darst., Kt.
    Edition 2. ed., 1. print
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006333822
    ISBN 0-7216-4735-9 ; 978-0-7216-4735-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 2931 order for loan Magazin

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  9. Article ; Online: Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease.

    Yannaki, Evangelia / Stamatoyannopoulos, George

    Annals of the New York Academy of Sciences

    2010  Volume 1202, Page(s) 59–63

    Abstract: Effective gene therapy for hemoglobinopathies will require high numbers of autologous gene-engineered hematopoetic stem cells to be reintroduced into the patients. Stem cell mobilization using G-CSF is the most convenient and effective approach to ... ...

    Abstract Effective gene therapy for hemoglobinopathies will require high numbers of autologous gene-engineered hematopoetic stem cells to be reintroduced into the patients. Stem cell mobilization using G-CSF is the most convenient and effective approach to achieve this goal, but it can have severe side effects in sickle cell anemia and be potentially harmful in the case of severe thalassemia. Hence, the optimal way of collection of hematopoetic stem cells from patients with thalassemia and sickle cell disease needs to be determined. In this paper, we review the possible risks of G-CSF mobilization in hemoglobinopathies and we outline the approaches used in an on-going clinical trial in which pretreatment with hydroxyurea is used to reduce potential risks of G-CSF administration to patients with severe beta thalassemia.
    MeSH term(s) Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/therapy ; Clinical Trials as Topic ; Genetic Therapy ; Granulocyte Colony-Stimulating Factor/genetics ; Granulocyte Colony-Stimulating Factor/metabolism ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/physiology ; Humans ; Hydroxyurea/therapeutic use ; Research Design ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7) ; Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2010-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2010.05576.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 110: Show issues Location:
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  10. Book ; Conference proceedings: The regulation of hemoglobin switching

    Stamatoyannopoulos, George

    proceedings of the Seventh Conference on Hemoglobin Switching, held in Airlie, Virginia, September 8 - 11, 1990

    (Johns Hopkins series in contemporary medicine and public health)

    1991  

    Event/congress Conference on Hemoglobin Switching (7, 1990, AirlieVa.)
    Author's details ed. by George Stamatoyannopoulos
    Series title Johns Hopkins series in contemporary medicine and public health
    Keywords Gene Expression Regulation / congresses ; Globin / genetics / congresses ; Transcription Factors / congresses ; Hämoglobin F ; Hämoglobin A ; Genregulation
    Subject Genetische Regulation ; Transkription ; Genaktivität ; Hb F ; Fetales Hämoglobin
    Size XIII, 552 S. : Ill., graph. Darst.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT004203964
    ISBN 0-8018-4253-0 ; 978-0-8018-4253-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 A 2674 order for loan Magazin

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