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  1. AU="Stampar, Mojca"
  2. AU="Shinzo Iwashita"
  3. AU="Lucena, M I"
  4. AU="Colas, Luc"
  5. AU="Ramos, Paula S"
  6. AU="Song, Zhenzhi"
  7. AU="Shah, Peter"
  8. AU="Fullarton, John"
  9. AU="Jacobsen, Elisabet"
  10. AU="Sándor Hosztafi"
  11. AU="Hayder, Z."
  12. AU="Taylor, Evangeline"
  13. AU="Thomas E Morrison"
  14. AU="Hernandez-Cuebas, Lisa"
  15. AU="Juliann E Aukema"
  16. AU="Guy Melamed"
  17. AU="Raikhel, Marina"
  18. AU="Bhatti, Hakikat Bir Singh"
  19. AU="Christian Molnár"
  20. AU="Montarello, Natalie"
  21. AU="Phan Nu Dieu Hong"
  22. AU="Polliack, Michael"
  23. AU="Ye, Tianai"
  24. AU="Galenson, Walter"
  25. AU="Nisar, Muhammad K"
  26. AU="Keshavarzi, Nahid"
  27. AU="Gabig, Theodore G"
  28. AU="Nixon, Ian J"
  29. AU="Huang Xiaoting"
  30. AU="Colturato, Virgílio Antônio Rensi"
  31. AU="Mahfouz, Amira Y"
  32. AU="Ayyappan, Sabarish"
  33. AU=Wang Kevin L-C
  34. AU="Lukas T. Hirschwald"
  35. AU="Morley-Davies, A"
  36. AU="Felsberg, Gary J"
  37. AU="Bogen, Oliver"
  38. AU="de Portu, Simona"
  39. AU="Janssens, Rick"

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  1. Artikel: Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty.

    Oboti, Livio / Trova, Sara / Schellino, Roberta / Marraudino, Marilena / Harris, Natalie R / Abiona, Olubukola M / Stampar, Mojca / Lin, Weihong / Peretto, Paolo

    Frontiers in neuroanatomy

    2017  Band 11, Seite(n) 44

    Abstract: The vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex, and reproductive state, yet the ... ...

    Abstract The vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex, and reproductive state, yet the mechanisms underlying this variability are unclear. Here, by analyzing neuronal survival in the first processing nucleus of the VNS, namely the accessory olfactory bulb (AOB), through multiple bromodeoxyuridine birthdating protocols, we show that exposure of female mice to male soiled bedding material affects the integration of newborn granule interneurons mainly after puberty. This effect is induced by urine compounds produced by mature males, as bedding soiled by younger males was ineffective. The granule cell increase induced by mature male odor exposure is not prevented by pre-pubertal ovariectomy, indicating a lesser role of circulating estrogens in this plasticity. Interestingly, the intake of adult male urine-derived cues by the female vomeronasal organ increases during puberty, suggesting a direct correlation between sensory activity and AOB neuronal plasticity. Thus, as odor exposure increases the responses of newly born cells to the experienced stimuli, the addition of new GABAergic inhibitory cells to the AOB might contribute to the shaping of vomeronasal processing of male cues after puberty. Consistently, only after puberty, female mice are capable to discriminate individual male odors through the VNS.
    Sprache Englisch
    Erscheinungsdatum 2017-05-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2452969-2
    ISSN 1662-5129
    ISSN 1662-5129
    DOI 10.3389/fnana.2017.00044
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

    Rivero-Hinojosa, Samuel / Lau, Ling San / Stampar, Mojca / Staal, Jerome / Zhang, Huizhen / Gordish-Dressman, Heather / Northcott, Paul A / Pfister, Stefan M / Taylor, Michael D / Brown, Kristy J / Rood, Brian R

    Acta neuropathologica communications

    2018  Band 6, Heft 1, Seite(n) 48

    Abstract: Genomic characterization has begun to redefine diagnostic classifications of cancers. However, it remains a challenge to infer disease phenotypes from genomic alterations alone. To help realize the promise of genomics, we have performed a quantitative ... ...

    Abstract Genomic characterization has begun to redefine diagnostic classifications of cancers. However, it remains a challenge to infer disease phenotypes from genomic alterations alone. To help realize the promise of genomics, we have performed a quantitative proteomics investigation using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and 41 tissue samples spanning the 4 genomically based subgroups of medulloblastoma and control cerebellum. We have identified and quantitated thousands of proteins across these groups and find that we are able to recapitulate the genomic subgroups based upon subgroup restricted and differentially abundant proteins while also identifying subgroup specific protein isoforms. Integrating our proteomic measurements with genomic data, we calculate a poor correlation between mRNA and protein abundance. Using EPIC 850 k methylation array data on the same tissues, we also investigate the influence of copy number alterations and DNA methylation on the proteome in an attempt to characterize the impact of these genetic features on the proteome. Reciprocally, we are able to use the proteome to identify which genomic alterations result in altered protein abundance and thus are most likely to impact biology. Finally, we are able to assemble protein-based pathways yielding potential avenues for clinical intervention. From these, we validate the EIF4F cap-dependent translation pathway as a novel druggable pathway in medulloblastoma. Thus, quantitative proteomics complements genomic platforms to yield a more complete understanding of functional tumor biology and identify novel therapeutic targets for medulloblastoma.
    Mesh-Begriff(e) Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/metabolism ; Chromatography, Liquid ; DNA Methylation ; Female ; Humans ; Male ; Medulloblastoma/genetics ; Medulloblastoma/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Protein Processing, Post-Translational/physiology ; Proteogenomics/methods ; Proteome ; RNA, Messenger ; Tandem Mass Spectrometry
    Chemische Substanzen Neoplasm Proteins ; Proteome ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2018-06-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-018-0548-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor.

    Wells, Elizabeth / Kambhampati, Madhuri / Damsker, Jesse M / Gordish-Dressman, Heather / Yadavilli, Sridevi / Becher, Oren J / Gittens, Jamila / Stampar, Mojca / Packer, Roger J / Nazarian, Javad

    Oncotarget

    2016  Band 8, Heft 6, Seite(n) 9366–9374

    Abstract: Corticosteroids, such as dexamethasone, are routinely used as palliative care in neuro-oncology for their anti-inflammatory benefits, however many patients experience dose limiting side effects caused by glucocorticoid response element (GRE)-mediated ... ...

    Abstract Corticosteroids, such as dexamethasone, are routinely used as palliative care in neuro-oncology for their anti-inflammatory benefits, however many patients experience dose limiting side effects caused by glucocorticoid response element (GRE)-mediated transcription. The purpose of this study was to use a murine model to investigate a new steroid alternative, vamorolone, which promises to reduce side effects through dissociating GRE-mediated transcription and NF-κB -mediated anti-inflammatory actions. To compare vamorolone to dexamethasone in reducing pro-inflammatory signals in vitro, murine glioma cells were treated with dexamethasone, vamorolone or vehicle control. Changes in mRNA expression were assessed using the nanostring inflammatory platform. Furthermore, drug efficacy, post-treatment behavioral activity and side effects were assessed by treating two cohorts of brain tumor bearing mice with dexamethasone, vamorolone, or vehicle control. Our investigation showed that treatment with vamorolone resulted in a reduction of pro-inflammatory signals in tumor cells in vitro similar to treatment with dexamethasone. Treatment with vamorolone resulted in a better safety profile in comparison to dexamethasone treatment. Vamorolone- treated mice showed similar or better activity and survival when compared to dexamethasone-treated mice. Our data indicate vamorolone is a potential steroid-sparing alternative for treating patients with brain tumors.
    Mesh-Begriff(e) Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/toxicity ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cytokines/genetics ; Cytokines/metabolism ; Dexamethasone/pharmacology ; Dexamethasone/toxicity ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Glioma/drug therapy ; Glioma/genetics ; Glioma/metabolism ; Glioma/pathology ; Inflammation Mediators/metabolism ; Mice, Inbred NOD ; Mice, SCID ; Motor Activity/drug effects ; NF-kappa B/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction/drug effects ; Steroids/pharmacology
    Chemische Substanzen Anti-Inflammatory Agents ; Cytokines ; Inflammation Mediators ; NF-kappa B ; RNA, Messenger ; Steroids ; Dexamethasone (7S5I7G3JQL)
    Sprache Englisch
    Erscheinungsdatum 2016-11-11
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.14070
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.

    Kambhampati, Madhuri / Panditharatna, Eshini / Yadavilli, Sridevi / Saoud, Karim / Lee, Sulgi / Eze, Augustine / Almira-Suarez, M I / Hancock, Lauren / Bonner, Erin R / Gittens, Jamila / Stampar, Mojca / Gaonkar, Krutika / Resnick, Adam C / Kline, Cassie / Ho, Cheng-Ying / Waanders, Angela J / Georgescu, Maria-Magdalena / Rance, Naomi E / Kim, Yong /
    Johnson, Courtney / Rood, Brian R / Kilburn, Lindsay B / Hwang, Eugene I / Mueller, Sabine / Packer, Roger J / Bornhorst, Miriam / Nazarian, Javad

    Scientific reports

    2020  Band 10, Heft 1, Seite(n) 10954

    Abstract: Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of recurrent driver mutations in many pediatric brain tumors. However, despite these molecular ... ...

    Abstract Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of recurrent driver mutations in many pediatric brain tumors. However, despite these molecular advances, the clinical outcomes of high grade tumors, including H3K27M diffuse midline glioma (H3K27M DMG), remain poor. To address the paucity of tissue for biological studies, we have established a comprehensive protocol for the coordination and processing of donated specimens at postmortem. Since 2010, 60 postmortem pediatric brain tumor donations from 26 institutions were coordinated and collected. Patient derived xenograft models and cell cultures were successfully created (76% and 44% of attempts respectively), irrespective of postmortem processing time. Histological analysis of mid-sagittal whole brain sections revealed evidence of treatment response, immune cell infiltration and the migratory path of infiltrating H3K27M DMG cells into other midline structures and cerebral lobes. Sequencing of primary and disseminated tumors confirmed the presence of oncogenic driver mutations and their obligate partners. Our findings highlight the importance of postmortem tissue donations as an invaluable resource to accelerate research, potentially leading to improved outcomes for children with aggressive brain tumors.
    Mesh-Begriff(e) Adolescent ; Adult ; Animals ; Autopsy ; Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Child ; Child, Preschool ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/pathology ; Histones/genetics ; Humans ; Infant ; Male ; Mice, Inbred NOD ; Mice, SCID ; Mutation ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; Young Adult
    Chemische Substanzen Biomarkers, Tumor ; Histones
    Sprache Englisch
    Erscheinungsdatum 2020-07-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-67764-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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