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  1. Article ; Online: The voice of COVID-19: Breath and cough recording classification with temporal decision trees and random forests.

    Manzella, F / Pagliarini, G / Sciavicco, G / Stan, I E

    Artificial intelligence in medicine

    2023  Volume 137, Page(s) 102486

    Abstract: Symbolic learning is the logic-based approach to machine learning, and its mission is to provide algorithms and methodologies to extract logical information from data and express it in an interpretable way. Interval temporal logic has been recently ... ...

    Abstract Symbolic learning is the logic-based approach to machine learning, and its mission is to provide algorithms and methodologies to extract logical information from data and express it in an interpretable way. Interval temporal logic has been recently proposed as a suitable tool for symbolic learning, specifically via the design of an interval temporal logic decision tree extraction algorithm. In order to improve their performances, interval temporal decision trees can be embedded into interval temporal random forests, mimicking the corresponding schema at the propositional level. In this article we consider a dataset of cough and breath sample recordings of volunteer subjects, labeled with their COVID-19 status, originally collected by the University of Cambridge. By interpreting such recordings as multivariate time series, we study the problem of their automated classification using interval temporal decision trees and forests. While this problem has been approached with the same dataset as well as with other datasets, in all cases, non-symbolic learning methods (usually, deep learning-based) have been applied to solve it; in this article we apply a symbolic approach, and show that it does not only outperform the state-of-the-art obtained with the same dataset, but its results are also superior to those of most non-symbolic techniques applied on other datasets. As an added bonus, thanks to the symbolic nature of our approach, we are also able to extract explicit knowledge to help physicians characterize typical COVID-positive cough and breath.
    MeSH term(s) Humans ; Cough ; Random Forest ; COVID-19 ; Algorithms ; Machine Learning
    Language English
    Publishing date 2023-02-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645179-2
    ISSN 1873-2860 ; 0933-3657
    ISSN (online) 1873-2860
    ISSN 0933-3657
    DOI 10.1016/j.artmed.2022.102486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Graphite Nodularity Evaluation in High-Si Ductile Cast Irons.

    Riposan, Iulian / Anca, Denisa / Stan, Iuliana / Chisamera, Mihai / Stan, Stelian

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 21

    Abstract: Ferritic high-Si ductile cast irons replace an unstable mixed ferrite-pearlite matrix with a unique combination of high elongation, strength and hardness (ideal for automotive drive train components) and resistance to oxidation and corrosion at high ... ...

    Abstract Ferritic high-Si ductile cast irons replace an unstable mixed ferrite-pearlite matrix with a unique combination of high elongation, strength and hardness (ideal for automotive drive train components) and resistance to oxidation and corrosion at high temperatures (automotive exhaust and turbocharger systems). The present paper analyses the graphite parameters of 4.5%Si, un-inoculated ductile cast iron (4.7%CE, 0.035%Mg
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15217685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Graphite Compactness Degree and Nodularity of High-Si Ductile Iron Produced via Permanent Mold versus Sand Mold Casting.

    Anca, Denisa-Elena / Stan, Iuliana / Riposan, Iulian / Stan, Stelian

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 8

    Abstract: In recent years, high-Si ductile cast irons (3-6% Si) have begun to be used more and more in the automotive and maritime industries, but also in wind energy technology and mechanical engineering. Si-alloyed ferrite has high strength, hardness and ... ...

    Abstract In recent years, high-Si ductile cast irons (3-6% Si) have begun to be used more and more in the automotive and maritime industries, but also in wind energy technology and mechanical engineering. Si-alloyed ferrite has high strength, hardness and oxidation and corrosion resistance, but it has low ductility, toughness and thermal conductivity, with graphite as an important influencing factor. In this study, 4.5% Si uninoculated ductile iron solidified in thin wall castings (up to 15 mm section size) via a permanent (metal) mold versus a sand mold, was evaluated. Solidification in a metal mold led to small size, higher graphite particles (less dependent on the section size). The graphite particles' real perimeter was 3-5% higher than the convex perimeter, while the values of these parameters were 41-43% higher in the sand mold. Increasing the casting section size led to an increased graphite perimeter, with it being much higher for sand mold. The graphite particles' shape factors, involving the maximum and minimum size, were at a lower level for metal mold solidification, while by involving the difference between P
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15082712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Scalable Data Model for Traffic Congestion Avoidance in a Vehicle to Cloud Infrastructure.

    Stan, Ioan / Suciu, Vasile / Potolea, Rodica

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 15

    Abstract: Traffic congestion experience in urban areas has negative impact on our daily lives by consuming our time and resources. Intelligent Transportation Systems can provide the necessary infrastructure to mitigate such challenges. In this paper, we propose a ... ...

    Abstract Traffic congestion experience in urban areas has negative impact on our daily lives by consuming our time and resources. Intelligent Transportation Systems can provide the necessary infrastructure to mitigate such challenges. In this paper, we propose a novel and scalable solution to model, store and control traffic data based on range query data structures (K-ary Interval Tree and K-ary Entry Point Tree) which allows data representation and handling in a way that better predicts and avoids traffic congestion in urban areas. Our experiments, validation scenarios, performance measurements and solution assessment were done on Brooklyn, New York traffic congestion simulation scenario and shown the validity, reliability, performance and scalability of the proposed solution in terms of time spent in traffic, run-time and memory usage. The experiments on the proposed data structures simulated up to 10,000 vehicles having microseconds time to access traffic information and below 1.5 s for congestion free route generation in complex scenarios. To the best of our knowledge, this is the first scalable approach that can be used to predict urban traffic and avoid congestion through range query data structure traffic modelling.
    MeSH term(s) Computer Simulation ; Reproducibility of Results
    Language English
    Publishing date 2021-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21155074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.

    Bălănescu, Anca / Stan, Iustina / Codreanu, Ioana / Comănici, Valentina / Bălănescu, Eugenia / Bălănescu, Paul

    Disease markers

    2019  Volume 2019, Page(s) 9560247

    Abstract: Background: Obesity prevalence is increasing in children. It is associated with various comorbidities including nonalcoholic fatty liver disease (NAFLD). Hsp90 isoforms were identified in previous proteomic studies as potential biomarkers for NAFLD. The ...

    Abstract Background: Obesity prevalence is increasing in children. It is associated with various comorbidities including nonalcoholic fatty liver disease (NAFLD). Hsp90 isoforms were identified in previous proteomic studies as potential biomarkers for NAFLD. The aim of the study was to analyze circulating levels of Hsp90
    Methods: 68 overweight and obese children and ten age- and gender-matched controls were recruited. Hsp90
    Results: Serum Hsp90
    Conclusion: Hsp90 isoforms were confirmed on an independent cohort as biomarkers for NAFLD in overweight and obese children. In these patients, it seems to be more useful to separately analyze Hsp90 isoforms rather than total Hsp90 as the isoforms have greater discriminative capacity.
    MeSH term(s) Adolescent ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; HSP90 Heat-Shock Proteins/blood ; Humans ; Male ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/etiology ; Obesity/blood ; Obesity/complications ; Overweight/blood ; Overweight/complications ; Proteomics ; Up-Regulation
    Chemical Substances HSP90 Heat-Shock Proteins ; HSP90AA2P protein, human ; HSP90AB1 protein, human
    Language English
    Publishing date 2019-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2019/9560247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ACE Phenotyping as a Guide Toward Personalized Therapy With ACE Inhibitors.

    Danilov, Sergei M / Tovsky, Stan I / Schwartz, David E / Dull, Randal O

    Journal of cardiovascular pharmacology and therapeutics

    2017  Volume 22, Issue 4, Page(s) 374–386

    Abstract: Background: Angiotensin-converting enzyme (ACE) inhibitors (ACEI) are widely used in the management of cardiovascular diseases but with significant interindividual variability in the patient's response.: Objectives: To investigate whether ... ...

    Abstract Background: Angiotensin-converting enzyme (ACE) inhibitors (ACEI) are widely used in the management of cardiovascular diseases but with significant interindividual variability in the patient's response.
    Objectives: To investigate whether interindividual variability in the response to ACE inhibitors is explained by the "ACE phenotype"-for example, variability in plasma ACE concentration, activity, and conformation and/or the degree of ACE inhibition in each individual.
    Methods: The ACE phenotype was determined in plasma of 14 patients with hypertension treated chronically for 4 weeks with 40 mg enalapril (E) or 20 mg E + 16 mg candesartan (EC) and in 20 patients with hypertension treated acutely with a single dose (20 mg) of E with or without pretreatment with hydrochlorothiazide. The ACE phenotyping included (1) plasma ACE concentration; (2) ACE activity (with 2 substrates: Hip-His-Leu and Z-Phe-His-Leu and calculation of their ratio); (3) detection of ACE inhibitors in patient's blood (indicator of patient compliance) and the degree of ACE inhibition (ie, adherence); and (4) ACE conformation.
    Results: Enalapril reduced systolic and diastolic blood pressure in most patients; however, 20% of patients were considered nonresponders. Chronic treatment results in 40% increase in serum ACE concentrations, with the exception of 1 patient. There was a trend toward better response to ACEI among patients who had a higher plasma ACE concentration.
    Conclusion: Due to the fact that "20% of patients do not respond to ACEI by blood pressure drop," the initial blood ACE level could not be a predictor of blood pressure reduction in an individual patient. However, ACE phenotyping provides important information about conformational and kinetic changes in ACE of individual patients, and this could be a reason for resistance to ACE inhibitors in some nonresponders.
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329372-2
    ISSN 1940-4034 ; 1074-2484
    ISSN (online) 1940-4034
    ISSN 1074-2484
    DOI 10.1177/1074248416686188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Rainfall interception and redistribution by maize farmland in central Iran

    Mahtab Nazari / Seyed Mohammad Moein Sadeghi / John Toland Van Stan, II / Mohammad Reza Chaichi

    Journal of Hydrology: Regional Studies, Vol 27, Iss , Pp - (2020)

    2020  

    Abstract: Study region: Maize farmland in Varamin, located southwest of Tehran (Iran). Study focus: The aims of this study were to: (1) monitor throughfall and stemflow during rainstorms beneath maize canopies over two growing seasons (2015, 2016); (2) evaluate ... ...

    Abstract Study region: Maize farmland in Varamin, located southwest of Tehran (Iran). Study focus: The aims of this study were to: (1) monitor throughfall and stemflow during rainstorms beneath maize canopies over two growing seasons (2015, 2016); (2) evaluate the effect of maize canopy structure (leaf area index, plant height) on throughfall, stemflow, and interception; and (3) develop an analytical model of rainfall partitioning by maize from controlled rainfall simulations. New hydrological insights for the region: Rainfall or irrigation interception by crops and residues has often been overlooked in hydrologic modelling in Iran. However, our results confirm that interception by maize canopy can significantly reduce total water input to the surface (19.9 % and 11.2 % of natural and simulated rainfalls, respectively). Although rainfall amounts and rates were similar between simulations and natural rainfall, differences in interception value may still exist between simulated and natural conditions due to the formation, size distribution, and movement of water droplets emitted from simulation systems vs. natural rainfall water droplets. Throughfall and interception significantly correlated with LAI and height of the maize canopy above thresholds of 2.5 (LAI) and 180 cm (height). The analytical model performed well under natural rain conditions. These results may help farmers’ irrigation scheduling achieve higher irrigation water use efficiency for maize fields, particularly in arid agricultural lands. Keywords: Arid region, Leaf area index, Plant height, Rainfall intensity, Rainfall magnitude
    Keywords Physical geography ; GB3-5030 ; Geology ; QE1-996.5
    Subject code 910
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Lipid profile pattern in pediatric overweight population with or without NAFLD in relation to IDF criteria for metabolic syndrome: a preliminary study.

    Bălănescu, Anca / Bălănescu, Paul / Comănici, Valentina / Stan, Iustina / Acs, Beata / Prisăcariu, Laura / Brezan, Florin / Ciomârtan, Tatiana / Gherghina, Ioan

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2017  Volume 56, Issue 1, Page(s) 47–54

    Abstract: Background and aims: The aim of this study is to assess the lipid profile pattern of pediatric overweight and/or obese patients with Non-Alcoholic Fatty Liver Disease (NAFLD) in relation to IDF Consensus Criteria for Metabolic Syndrome (MetS).: ... ...

    Abstract Background and aims: The aim of this study is to assess the lipid profile pattern of pediatric overweight and/or obese patients with Non-Alcoholic Fatty Liver Disease (NAFLD) in relation to IDF Consensus Criteria for Metabolic Syndrome (MetS).
    Material and methods: We conducted a cross-sectional preliminary study on 45 consecutive pediatric patients. Overweight or obese children aged from 3 to 18 years were included. Standardized measurement of blood pressure and anthropometric parameters were performed. Biological evaluation included inflammatory status, lipid profile, glycemic profile, full blood count and liver function tests. Abdominal ultrasound was performed in all patients.
    Results: Prevalence of MetS was 44.4%. A number of 21 patients (46.7%) had NAFLD. MetS patients had higher risk for NAFLD (OR = 9.5, 95% CI = 2.42-37.24). Also patients with positive familial history of type 2 diabetes had a 6.61 fold higher risk for NAFLD (OR = 6.61, 95% CI = 1.74-25.1). We performed a subgroup analysis in patients under ten years old. Patients under the age of ten which had both NAFLD and MetS met more frequently the hypertriglyceride criterion. After adjusting for age and MetS presence, triglyceride levels independently associated with NAFLD (adjusted R square = 0.46, unstandardized B coefficient = 34.51, 95% CI = 4.01-65.02, p = 0.02).
    Conclusion: NAFLD obese patients had higher prevalence of MetS, higher BMI and particular lipid profile pattern. Triglyceride levels independently associated with NAFLD after adjusting for age and MetS presence. According to our findings we suggest early triglyceride testing (even below the age of ten) in selected patients.
    MeSH term(s) Adolescent ; Anthropometry ; Blood Cell Count ; Blood Glucose/metabolism ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Lipids/blood ; Liver/diagnostic imaging ; Liver Function Tests ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/diagnosis ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Overweight/blood ; Overweight/complications ; Pediatric Obesity/blood ; Pediatric Obesity/complications ; Triglycerides/blood ; Ultrasonography
    Chemical Substances Blood Glucose ; Lipids ; Triglycerides
    Language English
    Publishing date 2017-10-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2015966-3
    ISSN 1220-4749 ; 0035-3973 ; 1582-3296
    ISSN 1220-4749 ; 0035-3973 ; 1582-3296
    DOI 10.1515/rjim-2017-0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Analiza valorii, metoda eficienta in proiectarea masinilor si instalatiilor forestiere

    Stan, I

    Revista padurilor-industria lemnului, celuloza si hirtie; silvicultura si exploatarea padurilor. Mar/Apr 1979. v. 94 (2)

    1979  

    Title translation Value analysis, an efficient method in planning projects with machines and forest installations.
    Keywords forestry ; forest engineering
    Language Romanian
    Dates of publication 1979-03
    Size p. 100-105., ill.
    Document type Article
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Miniaturized integrated platform for electrical and optical monitoring of cell cultures.

    Moldovan, Carmen / Iosub, Rodica / Codreanu, Cecilia / Firtat, Bogdan / Necula, Daniel / Brasoveanu, Costin / Stan, Ion

    Sensors (Basel, Switzerland)

    2012  Volume 12, Issue 8, Page(s) 11372–11390

    Abstract: The following paper describes the design and functions of a miniaturized integrated platform for optical and electrical monitoring of cell cultures and the necessary steps in the fabrication and testing of a silicon microchip Micro ElectroMechanical ... ...

    Abstract The following paper describes the design and functions of a miniaturized integrated platform for optical and electrical monitoring of cell cultures and the necessary steps in the fabrication and testing of a silicon microchip Micro ElectroMechanical Systems (MEMS)-based technology for cell data recording, monitoring and stimulation. The silicon microchip consists of a MEMS machined device containing a shank of 240 μm width, 3 mm long and 50 μm thick and an enlarged area of 5 mm × 5 mm hosting the pads for electrical connections. Ten platinum electrodes and five sensors are placed on the shank and are connected with the external electronics through the pads. The sensors aim to monitor the pH, the temperature and the impedance of the cell culture. The electrodes are bidirectional and can be used both for electrical potential recording and stimulation of cells. The fabrication steps are presented, along with the electrical and optical characterization of the system. The target of the research is to develop a new and reconfigurable platform according to the particular applications needs, as a tool for the biologist, chemists and medical doctors working is the field of cell culture monitoring in terms of growth, maintenance conditions, reaction to electrical or chemical stimulation (drugs, toxicants, etc.). HaCaT (Immortalised Human Keratinocyte) cell culture has been used for demonstration purposes in order to provide information on the platform electrical and optical functions.
    MeSH term(s) Aniline Compounds/chemistry ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Cell Line, Tumor ; Electric Conductivity ; Equipment Design ; Humans ; Hydrogen-Ion Concentration ; Micro-Electrical-Mechanical Systems/instrumentation ; Micro-Electrical-Mechanical Systems/methods ; Microelectrodes ; Nanofibers ; Optical Imaging/instrumentation ; Optical Imaging/methods ; Temperature
    Chemical Substances Aniline Compounds ; polyaniline
    Language English
    Publishing date 2012-08-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s120811372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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