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Article: Current understanding of psycho-neurobiology in depressive disorders with suicidal thoughts - translational models.

Bondoc, Eduard Nicuşor / Marinescu, Dragoş / Marinescu, Ileana / Mălin, Ramona Denise / Stanca, Liliana / Zăvoi, Roxana Eugenia

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2019 Volume 60, Issue 2, Page(s) 389–402

Abstract: Epidemiological data confirm the rising incidence of depression associated with suicidal ideation and cardiovascular comorbidities of coronary type. In contradiction with the large number of antidepressant drugs, the therapeutic results are not ... ...

Abstract	Epidemiological data confirm the rising incidence of depression associated with suicidal ideation and cardiovascular comorbidities of coronary type. In contradiction with the large number of antidepressant drugs, the therapeutic results are not satisfactory, with numerous existing incomplete remissions characterized by maintained cellular dysfunctionalities that amplify the cognitive deterioration and the risk of several somatic comorbidities. The surprising fact is the relatively high number of deaths in this type of patients due to acute coronary disease (myocardial infarction - MI). The vulnerability of hippocampal and frontal cortex cerebral structures is presented as obtained on animal model consecutive to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and on theoretical model where the hypothalamic disconnectivity determines the activation in the sympathetic autonomic nervous system, leading to heart disorders: high blood pressure, left ventricular hypertrophy and coronary illness. Identifying the association of psychological risk factors, patients fitting in a model of psychosomatic dominant personality traits, where the main risk factors are represented by inflexibility, guilt and self-accusation feelings, associated with increase of biological indicators (proinflammatory factors, endothelial dysfunction and cytokine aggressiveness) and neuroimaging indicators (frontal, temporal, hippocampal atrophy, ventriculomegaly, cerebellum atrophy). Changes identified post-mortem in the arterioles from the frontal cortex were found also in the coronary vessels, suggesting a symmetric evolution The highlighted personality factors are responsible for the decrease of adherence and compliance both in the psychiatric and the cardiologic treatment, the patient being exposed to behavioral risks regarding life style and nutrition, factors that increase the risk for acute coronary accident. The psycho-neurobiological inspired theoretical models argument the importance of a differentiated and customized approach of the patients with depressive disorder and suicidal ideation, and they can be the base for initiating strategies for prevention of unfavorable evolution and risk of death by MI.
MeSH term(s)	Depression/pathology ; Depression/psychology ; Female ; Humans ; Male ; Neurobiology/methods ; Risk Factors ; Suicidal Ideation
Language	English
Publishing date	2019-10-28
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
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Article ; Online: The procoagulant status. Hypercoagulability as a risk factor of primary and secondary infertility.

Neamţu, Simona Daniela / Stanca, Liliana / Siminel, Mirela Anişoara / Neamţu, Adela Valeria / Gluhovschi, Adrian / Mateescu, Garofiţa Olivia / Dijmărescu, Anda Lorena / Săndulescu, Maria Sidonia / Istrate-Ofiţeru, Anca Maria / Trăistaru, Magdalena Rodica

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2022 Volume 62, Issue 3, Page(s) 829–834

Abstract: Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a ... ...

Abstract	Thrombophilia is a disorder that makes patients susceptible to intravascular thrombosis that may increase the risk of developing a pregnancy on a known pathology. The female patient diagnosed with hypoplastic uterus and hereditary thrombophilia had a favorable evolution under properly administered anticoagulant treatment. The homozygous status for the C677T mutation may lead to an increase in plasma homocysteine levels, especially in pregnant women, being an associated risk factor for thrombosis. The risk of developing intravascular thrombosis requires primary prevention measures by adding D-dimers in the early diagnostic algorithm, being the most accurate marker of hypercoagulability and endogenous fibrinolysis. The corroboration of the hypercoagulability status with the results of genotyping, the frequencies of the minor/major alleles studied, single mononucleotide polymorphisms (SNPs) and the establishment of preventive therapy, aims to prevent intravascular thrombosis and thromboembolic phenomena.
MeSH term(s)	Alleles ; Female ; Humans ; Infertility/complications ; Infertility/genetics ; Pregnancy ; Risk Factors ; Thrombophilia/complications ; Thrombosis/complications
Language	English
Publishing date	2022-03-09
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.62.3.21
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Article ; Online: Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.

Neamţu, Simona Daniela / Novac, Marius Bogdan / Neamţu, Adela Valeria / Stanca, Iulia Diana / Boldeanu, Mihail Virgil / Gluhovschi, Adrian / Stanca, Liliana / Dijmărescu, Anda Lorena / Manolea, Maria Magdalena / Trăistaru, Magdalena Rodica / Mateescu, Garofiţa Olivia / Siminel, Mirela Anişoara

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2022 Volume 63, Issue 1, Page(s) 229–235

Abstract: Next to A and B antigens, agglutinogen D exhibits the highest immunogenicity. Following the transfusion of D-positive red blood cells (RBCs), almost 80% of D-negative recipients develop anti-D antibodies (Abs). Subsequently, anti-D immunization further ... ...

Abstract	Next to A and B antigens, agglutinogen D exhibits the highest immunogenicity. Following the transfusion of D-positive red blood cells (RBCs), almost 80% of D-negative recipients develop anti-D antibodies (Abs). Subsequently, anti-D immunization further promotes the synthesis of Abs towards other blood group antigens in or outside the Rh system. The D antigen is also involved in 95% of cases of hemolytic disease of the newborn. Transfusions, hemotherapy, grafts, and obstetric history (abortions, ectopic pregnancy, births) are all risk factors for Rh isoimmunization. In the case of ABO compatibility between mother and fetus, Rh-positive fetal RBCs that have reached the maternal bloodstream are not destroyed by group agglutinins, and Rh antigenic sites are not hidden by the maternal immune system. But a Rh-negative mother with a homozygous Rh-positive husband will certainly have a Rh-positive fetus. As it has an irreversible evolution, the Rh isoimmunization once installed cannot be influenced in the sense of decreasing the Ab titer, therefore, injectable globulin has no effect. A particular case was that of a newborn with Rh system incompatibility associated with hereditary spherocytosis The clinical balance at birth reflects the severe jaundice of the female newborn of 3140 g, gestational age 38∕39 weeks, extracted by lower-segment transverse Caesarean section, with a double loop nuchal cord, Apgar score 8. Because the jaundice was severe and atypical (face and upper chest), we considered the possibility of coexistence of hemolytic disease of the newborn by Rh blood group incompatibility associated with hereditary spherocytosis, as it turned out to be true and mentioned. Changes in genes encoding proteins in the structure of the RBC membrane have amplified hemolysis induced by maternal-fetal isoimmunization in the Rh system. Massive hemolysis accentuated by congenital spherocytosis, confirmed later, imposed blood transfusion and dynamic monitoring.
MeSH term(s)	Blood Group Incompatibility/complications ; Cesarean Section ; Female ; Hemolysis ; Humans ; Infant ; Infant, Newborn ; Jaundice ; Pregnancy ; Pregnancy Complications ; Rh Isoimmunization/prevention & control
Language	English
Publishing date	2022-09-06
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.63.1.26
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Article ; Online: Development of a SPE-LC-MS Method for the Quantitation of Palbociclib and Abemaciclib in Human Plasma.

Calucică, Daniela Maria / Manda, Costel-Valentin / Găman, Amelia Maria / Răileanu, Ștefan / Stanca, Liliana / Popescu, Monica Denisa Elena / Mateescu, Olivia Garofița / Biță, Andrei / Croitoru, Octavian / Neamțu, Simona-Daniela

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 23

Abstract: Palbociclib and abemaciclib are two cyclin-dependent kinases 4 and 6 used for breast cancer treatment. Levels of these medicines present a significant interindividual variability, so monitoring those concentrations might be necessary in therapy. Most of ... ...

Abstract	Palbociclib and abemaciclib are two cyclin-dependent kinases 4 and 6 used for breast cancer treatment. Levels of these medicines present a significant interindividual variability, so monitoring those concentrations might be necessary in therapy. Most of the methods presented so far in the literature use simple protein precipitation of plasma proteins as sample preparation method followed by direct injection of the supernatant into the LC instrument, preceded or not by a simple filtration step. Within that approach, the probability of injecting proteins in the chromatographic system is increased. With the purpose of obtaining a cleaner extract of the drugs, we developed and validated a simple and accurate LC-MS method for determining palbociclib and abemaciclib in human plasma. Solid phase extraction (SPE) using Oasis PRiME HLB
Language	English
Publishing date	2022-12-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27238604
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Article ; Online: Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection.

Cîrstea, Andreea Elena / Buzulică, Radu Lucian / Pirici, Daniel / Ceauşu, Mihail Constantin / Iman, Radu Vasile / Gheorghe, Ovidiu Mircea / Neamţu, Simona Daniela / Stanca, Liliana / Ene, Răzvan / Kumar-Singh, Samir / Mogoantă, Laurenţiu

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2020 Volume 61, Issue 1, Page(s) 209–218

Abstract: We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the ... ...

Abstract	We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinţi County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.
MeSH term(s)	Adult ; Autopsy ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Female ; Humans ; Kidney/pathology ; Liver/pathology ; Lung/pathology ; Lung/virology ; Myocardium/pathology ; Pancreas/pathology ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Reverse Transcriptase Polymerase Chain Reaction ; Romania ; SARS-CoV-2 ; Thrombosis/pathology ; Thrombosis/virology
Keywords	covid19
Language	English
Publishing date	2020-10-19
Publishing country	Romania
Document type	Case Reports ; Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.61.1.23
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Article ; Online: Severe traumatic brain injury (TBI) - a seven-year comparative study in a Department of Forensic Medicine.

Ţolescu, Răzvan Ştefan / Zorilă, Marian Valentin / Şerbănescu, Mircea Sebastian / Kamal, Kamal Constantin / Zorilă, George Lucian / Dumitru, Ilie / Florou, Charoula / Mogoantă, Laurenţiu / Văduva, Ion Alexandru / Stanca, Liliana / Zăvoi, Roxana Eugenia

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2020 Volume 61, Issue 1, Page(s) 95–103

Abstract: Deaths caused by traumatic brain injury (TBI) increase in incidence every year worldwidely, mainly in developing countries. Thus, World Health Organization (WHO) estimates that in 2020, TBI will become the third main cause of death. In our study, we ... ...

Abstract	Deaths caused by traumatic brain injury (TBI) increase in incidence every year worldwidely, mainly in developing countries. Thus, World Health Organization (WHO) estimates that in 2020, TBI will become the third main cause of death. In our study, we evaluated the deaths caused by TBI recorded within the Institute of Forensic Medicine of Craiova, Romania, between 2011 and 2017. Therefore, according to age, the cases were divided into two groups: people aged 0-18 years old (including 18 years old) and people aged over 18 years old (a total of 1005 cases, of which 971 were adults and 34 included in the age group 0-18 years old). In both groups, most patients were males from the rural area. In adults, falling was the main legal entity of the cases, followed by car accidents (which were the most common in children). In both groups, in car accidents, most of them were pedestrians and car occupants. Various aggressions (human, animal, self-injury) were found in 94 (9.68%) of the adult cases and in four (11.76%) cases of children. Another parameter under study was the blood alcohol concentration, being observed that most of the subjects with positive blood alcohol content died from car accidents. By evaluating the Glasgow Coma Scale (GCS) score as a prognostic factor, most of the subjects presented third and fourth degree coma at admission; still, 5.14% of the adult patients who deceased had GCS score 15 at admission, death occurring probably by developing some intracranial hematomas in time. Regarding the morphology of the lesions, most patients presented various forms of cranial fractures, 185 (19.05%) adults in association with extradural hemorrhages∕hematomas, but also there were four cases with extradural hematomas without any cranial fractures. In children, there was highlighted a single case of extradural hemorrhage under the fracture line. Seventy-eight percent of the adults and 44.12% of children presented subdural hematomas associated with other meningo-cerebral lesions. Also, 83.63% of the adults and 97% of children presented brain contusions. In both groups, brain laceration was observed in approximately 50% of the cases.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brain Injuries, Traumatic/diagnosis ; Brain Injuries, Traumatic/pathology ; Child, Preschool ; Female ; Forensic Medicine/education ; Humans ; Male ; Middle Aged ; Time Factors ; Young Adult
Language	English
Publishing date	2020-08-03
Publishing country	Romania
Document type	Case Reports ; Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.61.1.10
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Article: Prognostic factors in anterior skull base meningiomas.

Ciocan, Liviu Marian / Dănăilă, Leon / Stănculescu, Diana Eugenia / Neamţu, Simona Daniela / Mateescu, Garofiţa Olivia / Stanca, Liliana

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2014 Volume 55, Issue 3 Suppl, Page(s) 1063–1069

Abstract: Aim: Histopathological and immunohistochemical study of prognostic factors in anterior skull base meningiomas in order to determine the post-operative management.: Materials and methods: The studied material consisted in resection specimens from 65 ... ...

Abstract	Aim: Histopathological and immunohistochemical study of prognostic factors in anterior skull base meningiomas in order to determine the post-operative management. Materials and methods: The studied material consisted in resection specimens from 65 patients with anterior skull base meningiomas hospitalized in Clinic of Neurosurgery, National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania, and diagnosed in the Department of Pathology of the same Institute, between 2007 and 2013. The biological material was processed by standard histological technique with Hematoxylin and Eosin staining which allowed the classification of tumors according to WHO 2007 system and the assessment of the morphological parameters of known prognostic value. Subsequently, the tumor fragments were submitted to immunohistochemistry to evaluate the proliferative activity (Ki-67 labeling index) and progesterone hormone receptor (PR) status. Results: 83.07% of the 65 anterior skull base meningiomas were WHO grade I tumors; the grade II tumors accounted 15.38%, while the grade III tumors were rare (1.53%). Mitotic activity was variable, reaching up to 14 mitoses/10 HPF (high-power field) in atypical and anaplastic tumors; mitoses were absent in 64.81% of grade I tumors; the average mitotic index in grade II tumors was 5.15 mitoses/10 HPF. Both mitotic activity and infiltrative and invasive tumor growth (the latter found in 36.92% of cases) were correlated with tumor grade. Ki-67 labeling index ranged between 1.1% and 7.7%, with the highest value found in anaplastic tumor; progesterone receptors (PR) were expressed with variable index in 84.61% of cases. The immunonegative PR tumors were represented by 16.66% of grade I tumors and by the only grade III tumor. In contrast to PR, Ki-67 expression was statistically correlated with tumor grade. The comparison between the expression of Ki-67 and PR revealed an inverse relationship between the level of PR expression and the proliferative activity intensity. Conclusions: We found that PR expression decreases as the biological behavior of tumor becomes more aggressive; it may be related with an increased risk of recurrence, making the postoperative surveillance more rigorous in these patients.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Ki-67 Antigen/metabolism ; Male ; Meningeal Neoplasms/pathology ; Meningioma/pathology ; Middle Aged ; Mitotic Index ; Neoplasm Grading ; Prognosis ; Receptors, Progesterone/metabolism ; Skull Base/pathology
Chemical Substances	Ki-67 Antigen ; Receptors, Progesterone
Language	English
Publishing date	2014
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
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Article: Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection

Cîrstea, Andreea Elena / Buzulica, Radu Lucian / Pirici, Daniel / Ceausu, Mihail Constantin / Iman, Radu Vasile / Gheorghe, Ovidiu Mircea / Neamtu, Simona Daniela / Stanca, Liliana / Ene, Razvan / Kumar-Singh, Samir / Mogoanta, Laurentiu

Rom J Morphol Embryol

Abstract	We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinti County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #693877
Database	COVID19

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Article: The contribution of laboratory investigations in diagnosis of congenital infections.

Neamţu, Simona / Găman, G / Stanca, Liliana / Buzatu, Iuliana / Dijmărescu, Lorena / Manolea, Magdalena

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2011 Volume 52, Issue 1 Suppl, Page(s) 481–484

Abstract: Congenital diseases are an important indicator of the degree of development of primary health care, because primary prevention is paramount in diagnosing and diminishing the number of those types of cases. Syphilis is a sexually transmitted chronic ... ...

Abstract	Congenital diseases are an important indicator of the degree of development of primary health care, because primary prevention is paramount in diagnosing and diminishing the number of those types of cases. Syphilis is a sexually transmitted chronic infectious disease and with an evolution, often unpredictable. Primary prevention aims to prevent infection of the fetus, while secondary prevention aims for a reduction in the severity of sequels already installed.
MeSH term(s)	Clinical Laboratory Techniques ; Humans ; Infant, Newborn ; Infection/blood ; Infection/congenital ; Infection/diagnosis ; Syphilis/blood ; Syphilis/diagnosis
Language	English
Publishing date	2011
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
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Article: Corpuscular Haemolytic Anaemias - Lepore Haemoglobinopathy.

Tudorascu, Iulia / Neamtu, Simona / Stanca, Liliana / Siminel, Mirela / Dijmarescu, Lorena / Manolea, Magdalena / Novac, Liliana / Pirgaru, Elis / Danoiu, Suzana

Current health sciences journal

2014 Volume 40, Issue 4, Page(s) 281–284

Abstract: Haemoglobinopathies are hereditary conditions in which the fundamental lesion affects the synthesis rate or the structure of the globin in normal hemoglobin. The synthesis of the polypeptide chains in globin is genetically coded. Clinically, ... ...

Abstract	Haemoglobinopathies are hereditary conditions in which the fundamental lesion affects the synthesis rate or the structure of the globin in normal hemoglobin. The synthesis of the polypeptide chains in globin is genetically coded. Clinically, haemoglobinopathies manifest most commonly in the form of hemolytic anemia and, more rarely, cyanosis and polyglobulia. They differ from "acquired haemoglobinopathies", such as methemoglobinemia, in which hemoglobin is usually compromised due to the action of toxic substances. The clinical aspects are in close relationship to the nature and level of the structural anomaly of the Hb molecule. The heterozygous form of the Lepore syndrome is hematologically characterized by a similar pattern to minor β-thalassemia and electrophoretically by abnormal Hb D fractions at a rate of 5-10% and a decreased percentage of HbA. In homozygous forms, Lepore Hb represents 10-20% on electrophoresis, the rest consisting of HbF; HbA and HbA2 are completely absent. From a clinical point of view, Hb Lepore heterozygotes are similar to those with minor β - thalassemia.
Language	English
Publishing date	2014-12-14
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2708703-7
ISSN	2069-4032 ; 2067-0656
ISSN (online)	2069-4032
ISSN	2067-0656
DOI	10.12865/CHSJ.40.04.10
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