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  1. Article: Cystic Echinococcosis in Hospitalized Children from Western Romania: A 25-Year Retrospective Study.

    Paduraru, Ana Alexandra / Lupu, Maria Alina / Popoiu, Calin Marius / Stanciulescu, Maria Corina / Tirnea, Livius / Boia, Eugen Sorin / Olariu, Tudor Rares

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused ... ...

    Abstract Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Artificial Intelligence (AI) Based Analysis of

    Salvante, Enrica Raffaella Grazia / Popoiu, Anca Voichita / Barb, Alina Cristina / Cosma, Andrei Alexandru / Fenesan, Mihaela Pasca / Saxena, Amulya K / Popoiu, Tudor Alexandru / Boia, Eugen Sorin / Stanciulescu, Maria Corina / Caplar, Borislav Dusan / Dorobantu, Florica Ramona / Cimpean, Anca Maria

    In vivo (Athens, Greece)

    2024  Volume 38, Issue 2, Page(s) 620–629

    Abstract: Background/aim: Biomaterials are essential in modern medicine, both for patients and research. Their ability to acquire and maintain functional vascularization is currently debated. The aim of this study was to evaluate the vascularization induced by ... ...

    Abstract Background/aim: Biomaterials are essential in modern medicine, both for patients and research. Their ability to acquire and maintain functional vascularization is currently debated. The aim of this study was to evaluate the vascularization induced by two collagen-based scaffolds (with 2D and 3D structures) and one non-collagen scaffold implanted on the chick embryo chorioallantoic membrane (CAM).
    Materials and methods: Classical stereomicroscopic image vascular assessment was enhanced with the IKOSA software by using two applications: the CAM assay and the Network Formation Assay, evaluating the vessel branching potential, vascular area, as well as tube length and thickness.
    Results: Both collagen-based scaffolds induced non-inflammatory angiogenesis, but the non-collagen scaffold induced a massive inflammation followed by inflammatory-related angiogenesis. Vessels branching points/Region of Interest (Px^2) and Vessel branching points/Vessel total area (Px^2), increased exponentially until day 5 of the experiment certifying a sustained and continuous angiogenic process induced by 3D collagen scaffolds.
    Conclusion: Collagen-based scaffolds may be more suitable for neovascularization compared to non-collagen scaffolds. The present study demonstrates the potential of the CAM model in combination with AI-based software for the evaluation of vascularization in biomaterials. This approach could help to reduce and replace animal experimentation in the pre-screening of biomaterials.
    MeSH term(s) Animals ; Chick Embryo ; Humans ; Tissue Scaffolds/chemistry ; Polymers ; Artificial Intelligence ; Neovascularization, Physiologic ; Biocompatible Materials/pharmacology ; Collagen/pharmacology ; Collagen/chemistry ; Neovascularization, Pathologic ; Tissue Engineering
    Chemical Substances Polymers ; Biocompatible Materials ; Collagen (9007-34-5)
    Language English
    Publishing date 2024-02-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: VEGF Pathway Gene Expression Profile of Proliferating versus Involuting Infantile Hemangiomas: Preliminary Evidence and Review of the Literature.

    Heredea, Rodica Elena / Melnic, Eugen / Cirligeriu, Laura Elena / Berzava, Patricia Lorena / Stănciulescu, Maria Corina / Popoiu, Călin Marius / Cimpean, Anca Maria

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 6

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9060908
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  4. Article ; Online: Expression of β1 adrenergic receptor in vascular anomalies in children.

    Stănciulescu, Maria-Corina / Popoiu, Marius-Călin / Cîmpean, Anca Maria / David, Vlad-Laurentiu / Heredea, Rodica / Cerbu, Simona / Boia, Eugen-Sorin

    The Journal of international medical research

    2021  Volume 49, Issue 9, Page(s) 3000605211047713

    Abstract: Objective: Controversial, heterogeneous, and inconsistent responses to beta-blockers have been reported in some cases of infantile proliferative hemangiomas. On the basis of these clinical observations, we aimed to examine the β1 adrenergic receptor (β1- ...

    Abstract Objective: Controversial, heterogeneous, and inconsistent responses to beta-blockers have been reported in some cases of infantile proliferative hemangiomas. On the basis of these clinical observations, we aimed to examine the β1 adrenergic receptor (β1-AR) protein expression distribution among different types of pediatric vascular anomalies.
    Methods: Immunohistochemistry (IHC) was performed for β1-AR on 43 surgical specimens.
    Results: We found positive β1-AR IHC staining in all intramuscular hemangiomas, capillary-lymphatic, lymphatic, venous, and combined malformations, and Masson's tumor cases, as well as in 7 of 10 cases of proliferative infantile hemangiomas.
    Conclusions: Our research demonstrates, for the first time, the degree of heterogeneous expression of β1-AR among pediatric vascular malformations. Our results support the need for β1-AR assessment in pediatric vascular anomalies to select cases with a robust response to β1-selective blockers. β1-AR assessment may have a strong impact on therapeutic refinement for pediatric vascular anomalies by selecting cases with a stronger response to beta-blockers.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Child ; Hemangioma/drug therapy ; Humans ; Immunohistochemistry ; Receptors, Adrenergic ; Vascular Malformations/genetics
    Chemical Substances Adrenergic beta-Antagonists ; Receptors, Adrenergic
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605211047713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 925: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Combined Staged Surgery and Negative-Pressure Wound Therapy for Closure of a Giant Omphalocele.

    David, Vlad Laurentiu / Neagu, Mihai Cristian / Sosoi, Aurelia / Stanciulescu, Maria Corina / Horhat, Florin George / Stroescu, Ramona Florina / Popoiu, Calin Marius / Boia, Eugen Sorin

    Case reports in pediatrics

    2021  Volume 2021, Page(s) 5234862

    Abstract: The management of giant omphaloceles had always been a point of interest for the pediatric surgeons. Many surgical techniques were proposed, but none of them succeeded to become the standard procedure in closing the congenital abdominal defect. We ... ...

    Abstract The management of giant omphaloceles had always been a point of interest for the pediatric surgeons. Many surgical techniques were proposed, but none of them succeeded to become the standard procedure in closing the congenital abdominal defect. We present a case of giant omphalocele in which we used staged surgical closure combined with a prosthetic patch, with negative-pressure therapy and, finally, definitive surgical closure. Even though a major complication occurred during the treatment, we were able to close the defect without any prosthetic material left in place.
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659094-3
    ISSN 2090-6811 ; 2090-6803
    ISSN (online) 2090-6811
    ISSN 2090-6803
    DOI 10.1155/2021/5234862
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  6. Article: "Face(s)" of a PHACE(S) Syndrome Patient before and after Therapy: Particular Case Report and Review of Literature.

    Stănciulescu, Maria-Corina / Dorobantu, Florica Ramona / Boia, Eugen Sorin / Popoiu, Marius-Călin / Cerbu, Simona / Heredea, Rodica / Iacob, Emil Radu / Cimpean, Anca Maria / Caplar, Borislav Dusan / Popoiu, Anca Voichita

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 12

    Abstract: A rare, uncommon disorder called PHACE(S) (P-posterior fossa anomalies, H-hemangioma, A-arterial anomalies, C-cardiac anomalies, E-eye anomalies, and S-sternal cleft) of unknown etiology was rarely reported. Children are susceptible to developing PHACE(S) ...

    Abstract A rare, uncommon disorder called PHACE(S) (P-posterior fossa anomalies, H-hemangioma, A-arterial anomalies, C-cardiac anomalies, E-eye anomalies, and S-sternal cleft) of unknown etiology was rarely reported. Children are susceptible to developing PHACE(S) syndrome from the moment they are born. It may be challenging for a physician to appropriately diagnose and treat children with PHACE due to the multifaceted nature of the disease and the extensive range of consequences that may be associated with it. A one-month-old newborn girl was admitted to hospital with extensive, multiple facial infantile hemangiomas, ulceration of the lower lip hemangioma-like lesion, cardiovascular, sternal, and neurological concomitant malformations. Five days following the initial application of the medication, systemic treatment with propranolol and topical treatment with silver sulfadiazine produced their first noticeable benefits. The lip ulceration was mostly healed and facial hemangioma started to regress. The regression continued under therapy and this effect persists for 6 months since Propranolol therapy ended. No cardiovascular or neurological clinical events have been registered during follow-up. The present case has three peculiarities: (1) high number of facial hemangiomas; (2) presence of subependymal cyst not yet reported in the literature associated with PHACE syndrome; and (3) lack of cardiovascular events during therapy knowing that these events frequently appear in PHACE syndrome patients.
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9121970
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  7. Article: Acute limb ischemia in neonates: etiology and morphological findings - short literature review.

    Cerbu, Simona / Bîrsăşteanu, Florin / Heredea, Elena Rodica / Iacob, Daniela / Iacob, Emil Radu / Stănciulescu, Maria Corina / Boia, Eugen Sorin

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2019  Volume 59, Issue 4, Page(s) 1041–1044

    Abstract: The acute limb ischemia (ALI) in neonates is a rare phenomenon, but with serious consequences if undiagnosed or untreated. The purpose of this review is to briefly present the etiology of ALI and morphological findings in correlation with specific causes. ...

    Abstract The acute limb ischemia (ALI) in neonates is a rare phenomenon, but with serious consequences if undiagnosed or untreated. The purpose of this review is to briefly present the etiology of ALI and morphological findings in correlation with specific causes. Etiology can be classified into two main groups: prenatal (in utero compression, thrombosis and embolism) and postnatal (iatrogenic, thromboembolism and vascular malformations). The most common cause of ALI is catheter-related thrombosis (almost 90% of thrombosis cases are associated with catheter use), but other rare causes like vascular malformations should not be overlooked. Ultrasound represents a non-invasive, inexpensive and widely available imaging technique, which provides sufficient information to evaluate the situation and establish proper therapeutic strategies. Morphological tests do not represent the standard diagnostic procedure in ALI, but they can provide useful information. The findings depend on the etiology: intraluminal thrombi, vascular changes, placental pathological modifications. Every morphological result must be correlated with the clinical picture and imagistic findings. In conclusion, ALI in neonates is a rare condition, usually associated with catheter use in intensive care unit setting, with multiple risk factors and conditions that increase the risk of occurrence.
    MeSH term(s) Extremities/blood supply ; Extremities/pathology ; Humans ; Infant, Newborn ; Ischemia/etiology ; Ischemia/pathology ; Risk Factors ; Thrombosis/complications ; Vascular Malformations/pathology
    Language English
    Publishing date 2019-02-27
    Publishing country Romania
    Document type Journal Article ; Review
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Costal cartilage overgrowth does not induce pectus-like deformation in the chest wall of a rat model.

    David, Vlad Laurentiu / Stanciulescu, Maria Corina / Horhat, Florin George / Sharma, Abhinav / Kundnani, Nilima Rajpal / Ciornei, Bogdan / Stroescu, Ramona Florina / Popoiu, Marius Calin / Boia, Eugen Sorin

    Experimental and therapeutic medicine

    2021  Volume 23, Issue 2, Page(s) 146

    Abstract: Overgrowth of the costal cartilages has been frequently reported to be an etiological factor of chest wall deformities in children. The present study aimed to investigate if induced overgrowth of the costal cartilages could lead to deformation of the ... ...

    Abstract Overgrowth of the costal cartilages has been frequently reported to be an etiological factor of chest wall deformities in children. The present study aimed to investigate if induced overgrowth of the costal cartilages could lead to deformation of the chest wall in a rat model. An insulin-like growth factor 1 (IGF1) solution was directly injected under the perichondrium of the last three costal cartilages of 2-week-old rat pups. Two different concentrations, 50 µg/ml (E50) and 100 µg/ml (E100), were applied. This procedure was repeated once per week for 5 consecutive weeks. Subsequently, 14 days after the last injection, all animals were euthanized before the shape of the thoracic cage was assessed, and the diameter was measured. In addition, the last three costal cartilages were dissected before the samples were prepared and examined by light microscopy. Rats that received E100 exhibited larger sagittal and coronal rib cage diameters compared with those in the E50 and control groups. However, no deformation could be observed in the chest wall. Microscopic examinations revealed an anabolic pattern in the E100 group. The present findings suggested that locally administered IGF1 stimulated cell proliferation and tissue growth in coastal cartilages in a dose-dependent manner
    Language English
    Publishing date 2021-12-15
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.11069
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  9. Article: Role of imagistic techniques in diagnosing soft-tissue vascular anomalies in pediatric population - a 5-year experience.

    Cerbu, Simona / Arghirescu, Teodora Smaranda / Stănciulescu, Maria Corina / Timofte, Cristian Eugen / Mussuto, Elisa / Heredea, Elena Rodica / Horhat, Ioana Delia / Iacob, Emil Radu / Bîrsăşteanu, Florin / Boia, Eugen Sorin

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2019  Volume 60, Issue 2, Page(s) 495–500

    Abstract: Soft-tissue vascular anomalies have a worldwide estimated prevalence of 4.5% in the pediatric population. From January 1, 2014 until December 31, 2018, imagistic and histological evaluations were performed in 214 patients aged between one day and 18 ... ...

    Abstract Soft-tissue vascular anomalies have a worldwide estimated prevalence of 4.5% in the pediatric population. From January 1, 2014 until December 31, 2018, imagistic and histological evaluations were performed in 214 patients aged between one day and 18 years old, who were diagnosed with different soft-tissue vascular anomalies in our Center. From the 214 patients included in the study, 36.45% (n=78) were males, 63.55% (n=136) were females and 37.38% (n=80) of the patients were less than one year of age at time of admission. Infantile hemangioma was the most frequent type of soft-tissue vascular anomaly (35.51%) and the face was the most frequent affected region (25.7%). Ultrasound (US) examination is the most used imaging technique due to its wide accessibility and for providing valuable information about the anatomical localization of the lesions, the type of vessels involved, distribution and density of vascularization. Magnetic resonance imaging (MRI) can be used for assessing the extent of deep or large lesions, but it usually requires anesthesia. Computed tomography (CT) is useful when patients present contraindications to anesthesia and it has the advantage of a shorter image acquisition time. Histological studies have an important role in establishing the diagnosis even for the atypical cases of soft-tissue vascular anomalies. Furthermore, the prognosis depends on the histological type. In conclusion, there is a need for collaboration between the clinician, radiologist, pathologist and surgeon in order to establish a precise diagnosis and therapeutic strategy for each patient.
    MeSH term(s) Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Retrospective Studies ; Time Factors ; Ultrasonography/methods ; Vascular Malformations/diagnosis ; Vascular Malformations/diagnostic imaging
    Language English
    Publishing date 2019-10-28
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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