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  1. Article ; Online: Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia.

    Membreno, Rachel / Thomas, Kelsey R / Calcetas, Amanda T / Edwards, Lauren / Bordyug, Maria / Showell, Maya / Stanfill, Morgan / Brenner, Einat K / Walker, Kayla S / Rotblatt, Lindsay J / Brickman, Adam M / Edmonds, Emily C / Bangen, Katherine J

    Alzheimer disease and associated disorders

    2023  Volume 37, Issue 4, Page(s) 303–309

    Abstract: Introduction: White matter hyperintensities (WMHs) are magnetic resonance imaging markers of small vessel cerebrovascular disease that are associated with cognitive decline and clinical Alzheimer disease. Previous studies have often focused on global or ...

    Abstract Introduction: White matter hyperintensities (WMHs) are magnetic resonance imaging markers of small vessel cerebrovascular disease that are associated with cognitive decline and clinical Alzheimer disease. Previous studies have often focused on global or total WMH; less is known about associations of regional WMHs and cognitive abilities among older adults without dementia.
    Methods: A total of 610 older adults with normal cognition (n=302) or mild cognitive impairment (n=308) from the Alzheimer's Disease Neuroimaging Initiative underwent neuropsychological testing and magnetic resonance imaging. Linear regression models examined associations between regional WMH volumes and cognition, adjusting for age, sex, education, apolipoprotein E ε4 allele frequency, and pulse pressure.
    Results: Among all participants, greater regional WMH volume in all lobes was associated with poorer performance on memory and speed/executive functioning. Among participants with normal cognition, greater temporal and occipital WMH volumes were associated with poorer memory, whereas no regional WMH volumes were associated with speed/executive function.
    Discussion: Results show that greater regional WMH volume relates to poorer cognitive functioning-even among those with normal cognition. Together with results from previous studies, our findings raise the possibility that WMH may be a useful therapeutic target and/or important effect modifier in treatment or prevention dementia trials.
    MeSH term(s) Humans ; Aged ; White Matter ; Cognition ; Cognitive Dysfunction ; Executive Function ; Alzheimer Disease
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0000000000000585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2569: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe.

    Adams, Jenna N / Maass, Anne / Berron, David / Harrison, Theresa M / Baker, Suzanne L / Thomas, Wesley P / Stanfill, Morgan / Jagust, William J

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2021  Volume 41, Issue 17, Page(s) 3917–3931

    Abstract: Tau deposition begins in the medial temporal lobe (MTL) in aging and Alzheimer's disease (AD), and MTL neural dysfunction is commonly observed in these groups. However, the association between tau and MTL neural activity has not been fully characterized. ...

    Abstract Tau deposition begins in the medial temporal lobe (MTL) in aging and Alzheimer's disease (AD), and MTL neural dysfunction is commonly observed in these groups. However, the association between tau and MTL neural activity has not been fully characterized. We investigated the effects of tau on repetition suppression, the reduction of activity for repeated stimulus presentations compared to novel stimuli. We used task-based functional MRI (fMRI) to assess MTL subregional activity in 21 young adults (YA) and 45 cognitively normal human older adults (OA; total sample: 37 females, 29 males). AD pathology was measured with position emission tomography (PET), using
    MeSH term(s) Aged ; Aged, 80 and over ; Aging/physiology ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/metabolism ; Entorhinal Cortex/diagnostic imaging ; Female ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Positron-Emission Tomography ; Repetition Priming ; Tauopathies/diagnostic imaging ; Tauopathies/psychology ; Temporal Lobe/metabolism ; Temporal Lobe/physiology ; Young Adult ; tau Proteins/genetics ; tau Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; MAPT protein, human ; tau Proteins
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2504-20.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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