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  1. Article ; Online: Patient-Level and Center-Level Factors Associated with Required Predonation Weight Loss among Obese Living Kidney Donors.

    Perry, Jackson / McLeod, M Chandler / Reed, Rhiannon D / Baker, Gavin A / Stanford, Luke A / Allen, Joshua / Jones, Bernarez / Robinson, Tayana / MacLennan, Paul A / Kumar, Vineeta / Locke, Jayme E

    Kidney360

    2024  Volume 5, Issue 3, Page(s) 437–444

    MeSH term(s) Humans ; Kidney Transplantation ; Obesity/complications ; Kidney ; Weight Loss
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diabetes-free survival among living kidney donors and non-donors with obesity: A longitudinal cohort study.

    Killian, A Cozette / Reed, Rhiannon D / McLeod, M Chandler / MacLennan, Paul A / Kumar, Vineeta / Pittman, Sydney E / Maynor, Andrew G / Stanford, Luke A / Baker, Gavin A / Schinstock, Carrie A / Silkensen, John R / Roll, Garrett R / Segev, Dorry L / Orandi, Babak J / Lewis, Cora E / Locke, Jayme E

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0276882

    Abstract: Background: Approval of living kidney donors (LKD) with end-stage kidney disease (ESKD) risk factors, such as obesity, has increased. While lifetime ESKD development data are lacking, the study of intermediate outcomes such as diabetes is critical for ... ...

    Abstract Background: Approval of living kidney donors (LKD) with end-stage kidney disease (ESKD) risk factors, such as obesity, has increased. While lifetime ESKD development data are lacking, the study of intermediate outcomes such as diabetes is critical for LKD safety. Donation-attributable diabetes risk among persons with obesity remains unknown. The purpose of this study was to evaluate 10-year diabetes-free survival among LKDs and non-donors with obesity.
    Methods: This longitudinal cohort study identified adult, LKDs (1976-2020) from 42 US transplant centers and non-donors from the Coronary Artery Risk Development in Young Adults (1985-1986) and the Atherosclerosis Risk in Communities (1987-1989) studies with body mass index ≥30 kg/m2. LKDs were matched to non-donors on baseline characteristics (age, sex, race, body mass index, systolic and diastolic blood pressure) plus diabetes-specific risk factors (family history of diabetes, impaired fasting glucose, smoking history). Accelerated failure time models were utilized to evaluate 10-year diabetes-free survival.
    Findings: Among 3464 participants, 1119 (32%) were LKDs and 2345 (68%) were non-donors. After matching on baseline characteristics plus diabetes-specific risk factors, 4% (7/165) LKDs and 9% (15/165) non-donors developed diabetes (median follow-up time 8.5 (IQR: 5.6-10.0) and 9.1 (IQR: 5.9-10.0) years, respectively). While not significant, LKDs were estimated to live diabetes-free 2 times longer than non-donors (estimate 1.91; 95% CI: 0.79-4.64, p = 0.15).
    Conclusions: LKDs with obesity trended toward living longer diabetes-free than non-donors with obesity, suggesting within the decade following donation there was no increased diabetes risk among LKDs. Further work is needed to evaluate donation-attributable diabetes risk long-term.
    MeSH term(s) Humans ; Young Adult ; Kidney Transplantation/adverse effects ; Longitudinal Studies ; Living Donors ; Cohort Studies ; Obesity/complications ; Obesity/epidemiology ; Kidney Failure, Chronic ; Diabetes Mellitus/etiology
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0276882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Change in Body Mass Index and Attributable Risk of New-Onset Hypertension Among Obese Living Kidney Donors.

    Reed, Rhiannon D / McLeod, M Chandler / MacLennan, Paul A / Kumar, Vineeta / Pittman, Sydney E / Maynor, Andrew G / Stanford, Luke A / Baker, Gavin A / Schinstock, Carrie A / Silkensen, John R / Roll, Garrett R / Segev, Dorry L / Orandi, Babak J / Lewis, Cora E / Locke, Jayme E

    Annals of surgery

    2022  Volume 278, Issue 1, Page(s) e115–e122

    Abstract: Objective: To examine whether body mass index (BMI) changes modify the association between kidney donation and incident hypertension.: Background: Obesity increases hypertension risk in both general and living kidney donor (LKD) populations. Donation- ...

    Abstract Objective: To examine whether body mass index (BMI) changes modify the association between kidney donation and incident hypertension.
    Background: Obesity increases hypertension risk in both general and living kidney donor (LKD) populations. Donation-attributable risk in the context of obesity, and whether weight change modifies that risk, is unknown.
    Methods: Nested case-control study among 1558 adult LKDs (1976-2020) with obesity (median follow-up: 3.6 years; interquartile range: 2.0-9.4) and 3783 adults with obesity in the Coronary Artery Risk Development in Young Adults (CARDIA) and Atherosclerosis Risk in Communities (ARIC) studies (9.2 y; interquartile range: 5.3-15.8). Hypertension incidence was compared by donor status using conditional logistic regression, with BMI change investigated for effect modification.
    Results: Overall, LKDs and nondonors had similar hypertension incidence [incidence rate ratio (IRR): 1.16, 95% confidence interval (95% CI): 0.94-1.43, P =0.16], even after adjusting for BMI change (IRR: 1.25, 95% CI: 0.99-1.58, P =0.05). Although LKDs and nondonors who lost >5% BMI had comparable hypertension incidence (IRR: 0.78, 95% CI: 0.46-1.34, P =0.36), there was a significant interaction between donor and >5% BMI gain (multiplicative interaction IRR: 1.62, 95% CI: 1.15-2.29, P =0.006; relative excess risk due to interaction: 0.90, 95% CI: 0.24-1.56, P =0.007), such that LKDs who gained weight had higher hypertension incidence than similar nondonors (IRR: 1.83, 95% CI: 1.32-2.53, P <0.001).
    Conclusions: Overall, LKDs and nondonors with obesity had similar hypertension incidence. Weight stability and loss were associated with similar hypertension incidence by donor status. However, LKDs who gained >5% saw increased hypertension incidence versus similar nondonors, providing support for counseling potential LKDs with obesity on weight management postdonation.
    MeSH term(s) Young Adult ; Humans ; Body Mass Index ; Kidney Transplantation/adverse effects ; Case-Control Studies ; Nephrectomy ; Risk Factors ; Obesity/complications ; Obesity/epidemiology ; Hypertension/epidemiology ; Hypertension/etiology ; Living Donors
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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