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Book ; Online: Nutritional Management and Outcomes in Malnourished Medical Inpatients

Stanga, Zeno / Schuetz, Philipp

2020

Keywords	Research & information: general ; Biology, life sciences ; Food & society ; type 1 diabetes mellitus ; bioelectrical impedance analysis ; phase angle ; children ; adolescents ; protein ; malnutrition ; critical care ; mortality ; outcomes ; hospital readmission ; ICU Survivors ; inflammation ; nutritional assessment ; biomarkers ; albumin ; prealbumin ; IGF-1 ; elderly ; prognostic marker ; Pediatric Intensive Care Unit ; enteral nutrition ; early parenteral nutrition ; critical illness ; iron ; copper ; selenium ; zinc ; thiamine ; vitamin B12 ; obesity ; glucose control ; hyperglycemia ; parenteral nutrition ; nutritional support ; insulin ; Geriatric patients ; older persons ; therapy ; interventions ; chronic critical illness ; Nutrition Risk Screening (NRS-2002) ; age ; nutrition ; vasopressors ; shock ; glucose ; diabetes ; underfeeding ; economic challenges ; nutritional management ; mid-arm muscle circumference ; dual-energy X-ray absorptiometry ; computed tomography ; fat-free mass ; appendicular skeletal muscle mass ; lean soft tissue ; skeletal muscle index ; chronic disease ; old ; anorexia nervosa ; refeeding syndrome ; weight gain ; length of stay ; nutritional risk screening ; monitoring ; micronutrient deficiency ; oral nutritional supplements ; artificial nutrition ; gastroparesis ; dumping syndrome ; pathophysiology ; clinical presentation ; treatment ; nutritional therapy ; cancer ; cachexia ; sarcopenia ; survival ; nutritional support team ; efficacy ; metabolic syndrome ; insulin resistance ; dietary pattern ; carbohydrates ; fat ; indirect calorimetry ; indirect calorimeter ; resting energy expenditure ; nutrition therapy ; medical nutrition therapy ; intensive care unit ; intermediate care unit ; critically ill patients ; nutritional counselling ; nursing ; e-counselling ; dehydration ; dysphagia ; fluid intake ; water ; cirrhosis ; ascites ; sarcopenic obesity ; vitamins ; micronutrients ; all-in-one parenteral admixture ; compatibility ; stability ; pharmaceutical expertise ; drug admixing ; drug administration ; hospital ; nutrition care ; continuity of care ; process indicators ; benchmarking ; disease related malnutrition ; diagnosis ; management ; hypophosphatemia ; n/a
Size	1 electronic resource (428 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044385
ISBN	9783039364923 ; 3039364928
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Trends of physical fitness related to weight status: An analysis including over 412,000 Swiss young male conscripts from 2007 to 2022.

Gubelmann, Cédric / Stanga, Zeno / Staub, Kaspar / Marques-Vidal, Pedro

Preventive medicine reports

2024 Volume 38, Page(s) 102591

Abstract: Objective: The high prevalence of obesity among young adults in the civilian population pose challenges in recruiting physically fit soldiers. We assessed the trend of physical fitness related to weight status among Swiss male conscripts.: Methods: ... ...

Abstract	Objective: The high prevalence of obesity among young adults in the civilian population pose challenges in recruiting physically fit soldiers. We assessed the trend of physical fitness related to weight status among Swiss male conscripts. Methods: Cross-sectional data of medical examination data during mandatory conscription for the Swiss Armed Forces, 2007-2022 (N = 412,186). The conscription physical test (CPT) assessed five aspects of physical fitness, each aspect scoring 0-25, one component being an endurance test (ET). CPT and ET categories were defined as per military guidelines: "Insufficient", "Sufficient", "Good", "Very Good" and "Excellent". Weight status was based on body mass index (BMI). Results: Conscripts with obesity (BMI ≥ 30 kg/m Conclusion: Male Swiss conscripts with overweight and obesity have lower physical fitness than normal weight conscripts, and this condition tends to worsen over the conscription years.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2024.102591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The influence of patients' nutritional risk, nutritional status, and energy density in MEDPass versus conventional administration of oral nutritional supplements - A secondary analysis of a randomized controlled trial.

Schläppi, Karin / Reber, Emilie / Schönenberger, Katja A / Stanga, Zeno / Kurmann, Silvia

The journal of nutrition, health & aging

2024 Volume 28, Issue 3, Page(s) 100170

Abstract: Objectives: The clinical influence of nutritional risk, nutritional status, and energy density of oral nutritional supplements (ONS) in MEDPass versus conventional administration of ONS is currently unknown. The aim of this analysis was to examine ... ...

Abstract	Objectives: The clinical influence of nutritional risk, nutritional status, and energy density of oral nutritional supplements (ONS) in MEDPass versus conventional administration of ONS is currently unknown. The aim of this analysis was to examine whether these variables have an impact on clinical outcomes. Methods: Secondary analysis of the intention to treat dataset of the randomized controlled MEDPass Trial in geriatric and medical inpatients. Patients in the intervention group received 4 × 50 ml ONS during the medication rounds (MEDPass mode), while those in the control group received ONS in a non-standardized manner. The examined endpoints included energy and protein coverage, ONS intake, handgrip strength (HGS), weight, appetite nausea and 30-day mortality. Three subgroup analyses for NRS 2002 total score (3, 4 or 5-7 points), NRS 2002 impaired nutritional status score (0, 1, 2 or 3 points) and energy density of the ONS (1.5 kcal/mL or 2 kcal/mL) were performed using linear and logistic regression with interaction and mixed effect models. Results: The data of 202 patients (103 women and 99 men) at nutritional risk (NRS total 2002 score ≥3), mean (SD) age 82.2 (6.5) years were included. There was no significant difference between the groups in the primary endpoint energy coverage in all three subgroup analyses. There were also no significant differences between the groups in the secondary endpoints of protein coverage, ONS intake, HGS, weight, appetite, nausea, and 30-day mortality. Conclusion: The MEDPass mode of ONS administration was not superior to the conventional mode of administration in this study. ONS with high energy density (≥2 kcal/mL) should be offered since current evidence shows a tendency towards improved appetite, increased ONS and increased energy intake.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Nutritional Status ; Malnutrition ; Hand Strength ; Energy Intake ; Nausea ; Dietary Supplements ; Administration, Oral
Language	English
Publishing date	2024-02-02
Publishing country	France
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1016/j.jnha.2024.100170
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Should handgrip strength be considered when choosing the administration mode of oral nutritional supplements in geriatric patients? A secondary analysis of the MEDPass Trial.

Uhlmann, Katja / Reber, Emilie / Schonenberger, Katja A / Stanga, Zeno / Kurmann, Silvia

Nutrition (Burbank, Los Angeles County, Calif.)

2024 Volume 124, Page(s) 112429

Abstract: Objective: It is important to individualize nutrition therapy and to identify whether certain patient groups benefit from a specific intervention such as oral nutritional supplements (ONS). This study investigated whether patients with weak handgrip ... ...

Abstract	Objective: It is important to individualize nutrition therapy and to identify whether certain patient groups benefit from a specific intervention such as oral nutritional supplements (ONS). This study investigated whether patients with weak handgrip strength (HGS) benefit better from ONS administration in the Medication Pass Nutritional Supplement Program (MEDPass) mode regarding the individual coverage of energy and protein requirements throughout their hospitalization. Methods: A secondary analysis of the intention-to-treat data set of the randomized controlled MEDPass trial was conducted. Weak HGS was defined as <27 kg for men and <16 kg for women. Linear mixed-effect models adjusted for the stratification factors energy density of ONS and nutritional risk screening 2002 score were used to address the aim of the study. Results: We included 188 participants. Energy and protein coverage did not differ between the patients with weak or normal HGS depending on ONS administration mode (P = 0.084, P = 0.108). Patients with weak HGS and MEDPass administration mode tended to have the lowest energy and protein coverage (estimated mean, 77.2%; 95% confidence interval [CI], 69.3%-85% and estimated mean, 95.1%; 95% CI, 85.3%-105%, respectively). Patients with weak HGS and conventional ONS administration had the highest energy and protein coverage (estimated mean, 90%; 95% CI, 82.8%-97.2% and estimated mean, 110.2%; 95% CI, 101.3%-119%, respectively). Conclusion: No clear recommendations regarding the mode of ONS administration depending on HGS can be made. In clinical practice, appetite and satiety in patients with weak HGS should be monitored, and the ONS administration mode should be adjusted accordingly.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2024.112429
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Distribution of oral nutritional supplements with medication: Is there a benefit? A systematic review

Krebs, Fabian / Uhlmann, Katja / Stanga, Zeno / Kurmann, Silvia

Nutrition. 2022 Apr., v. 96

2022

Abstract: Disease-related malnutrition remains a major burden for patients and health care systems. The Medication Pass Nutritional Supplement Program (MEDPass) involves providing patients with oral nutritional supplements (ONS) in unusually small amounts three to ...

Abstract	Disease-related malnutrition remains a major burden for patients and health care systems. The Medication Pass Nutritional Supplement Program (MEDPass) involves providing patients with oral nutritional supplements (ONS) in unusually small amounts three to four times per day during medication rounds. This systematic review aims to evaluate the impact of MEDPass ONS administration on compliance, total energy and protein intake, food intake, body weight and handgrip strength in hospitalized adults and nursing-home residents.We conducted a systematic literature search in the databases MEDLINE, Embase, ScienceDirect, and the Cochrane Library and included randomized controlled trials (RCTs), non-RCTs, and before–after studies. Validated tools specific to the study design were used to assess the included studies.Ten studies were identified, including two RCTs, three non-RCTs, and five before–after trials. Compliance increased by 23.4% to 66% with MEDPass administration, resulting in compliance rates of 72.7% to 96%. With MEDPass administration, body weight increased by 1% to 6.8% or remained stable. The assessed evidence on total energy intake is ambiguous for protein, with a trend toward an increased intake. Trials on energy intake from food show mixed results as well. One study suggested a slight increase in handgrip strength. The included studies predominantly raise concerns for bias.We conclude that MEDPass ONS administration increases compliance in hospitalized adults and nursing-home residents. For all other outcomes, robust and well-powered trials are necessary.
Keywords	body weight ; compliance ; drug therapy ; energy intake ; experimental design ; food intake ; hand strength ; health services ; malnutrition ; protein intake ; systematic review
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2021.111569
Database	NAL-Catalogue (AGRICOLA)

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Article: [No title information]

Strahm, Rachel / Stanga, Zeno

Revue medicale suisse

2020 Volume 16, Issue 679, Page(s) 169–171

Title translation	Erkennen, klassifizieren und behandeln der Unterernährung.
MeSH term(s)	Humans ; Malnutrition/classification ; Malnutrition/diagnosis ; Malnutrition/therapy
Language	German
Publishing date	2020-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5998: Show issues

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Article ; Online: Determinants of Treatment Toxicity in Patients with Soft Tissue Sarcomas

Schönenberger, Katja A. / Reber, Emilie / Schläppi, Karin / Baumgartner, Annic / Stanga, Zeno / Kollár, Attila

Nutrition and Cancer. 2023 Sept. 14, v. 75, no. 8 p.1638-1645

2023

Abstract: Soft tissue sarcomas are rare malignant tumors. Traditionally, treatment is guided by patient and tumor characteristics. Data on the influence of patient characteristics, particularly nutritional status, on clinical outcomes are scarce. Body composition ... ...

Abstract	Soft tissue sarcomas are rare malignant tumors. Traditionally, treatment is guided by patient and tumor characteristics. Data on the influence of patient characteristics, particularly nutritional status, on clinical outcomes are scarce. Body composition and its changes during treatment play an essential role in predicting toxicity, clinical outcomes, and mortality. This analysis aimed to investigate the relationship between treatment toxicity and body composition. Patients diagnosed with sarcoma who underwent first-line palliative chemotherapy between October 2017 and January 2020 were included. Baseline and follow-up computed tomographic scans at the third lumbar vertebra, available from diagnostic purposes, were analyzed using SliceOmatic software. Treatment toxicity was defined as a composite score of the Common Terminology Criteria for Adverse Events. Nutritional Risk Screening (NRS) 2002 score, psoas muscle thickness to height ratio, and comorbidity showed a significant association with overall toxicity, while skeletal muscle index and age showed a strong trend. In summary, the NRS 2002 tool must be routinely implemented in inpatient and outpatient settings for cancer patients, and nutritional therapy needs to become a fixed component of multimodal cancer treatment. Furthermore, validated standardized procedures for the quantification of muscle mass are needed to individualize and optimize cancer treatment.
Keywords	body composition ; cancer therapy ; comorbidity ; computer software ; diet therapy ; drug therapy ; mortality ; muscles ; nutrition risk assessment ; nutritional status ; patients ; sarcoma ; skeletal muscle ; terminology ; tomography ; toxicity ; vertebrae
Language	English
Dates of publication	2023-0914
Size	p. 1638-1645.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2023.2227405
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Role of Dietary Fibre in Enteral Nutrition in Sepsis Prevention and Therapy: A Narrative Review.

Huwiler, Valentina V / Scalise, Melanie / Schönenberger, Katja A / Mühlebach, Stefan / Stanga, Zeno / Balmer, Maria L

Nutrients

2023 Volume 15, Issue 11

Abstract: Objective: This narrative review summarises the current evidence on the role of dietary fibre in enteral nutrition in the prevention and therapy of sepsis, with a focus on critically ill patients. The aim is to discuss the implications for clinical ... ...

Abstract	Objective: This narrative review summarises the current evidence on the role of dietary fibre in enteral nutrition in the prevention and therapy of sepsis, with a focus on critically ill patients. The aim is to discuss the implications for clinical practice and identify future directions for policy and research. Resources: We searched MEDLINE and Google Scholar for records on sepsis, critically ill, enteral nutrition, and dietary fibre. We included all types of articles such as meta-analyses, reviews, clinical trials, preclinical studies, and in vitro studies. Data were evaluated for significance and clinical relevance. Synopsis of Review: Despite the ongoing debate, enteral nutrition containing dietary fibres showed great potential in attenuating sepsis-related outcomes and preventing the incidence of sepsis in critically ill patients on enteral nutrition. Dietary fibres target different underlying mechanisms such as microbiota, mucosal barrier integrity, local cellular immune response, and systemic inflammation. We discuss the clinical potential and concerns that currently exist with the standard implementation of dietary fibre in enterally fed intensive care patients. Additionally, we identified research gaps that should be addressed to determine effectiveness and the role of dietary fibres in sepsis itself and its associated outcomes.
MeSH term(s)	Humans ; Enteral Nutrition ; Critical Illness/therapy ; Critical Care ; Dietary Fiber ; Sepsis/prevention & control
Chemical Substances	Dietary Fiber
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15112489
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Effect of a Modified Mindfulness-Based Stress Reduction (MBSR) Program on Symptoms of Stress and Depression and on Saliva Cortisol and Serum Creatine Kinase among Male Wrestlers.

Mousavi, Elham / Sadeghi-Bahmani, Dena / Khazaie, Habibolah / Brühl, Annette Beatrix / Stanga, Zeno / Brand, Serge

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 11

Abstract: Objectives: The aims of the present study were two-fold: to investigate whether, compared to an active control condition, a modified mindfulness-based stress reduction (MBSR) program could (1) reduce symptoms of stress and depression, and (2) regulate ... ...

Abstract	Objectives: The aims of the present study were two-fold: to investigate whether, compared to an active control condition, a modified mindfulness-based stress reduction (MBSR) program could (1) reduce symptoms of stress and depression, and (2) regulate salivary cortisol and serum creatine kinase (CK) concentrations, two physiological stress markers. Methods: Thirty male wrestlers ( Results: Over time, symptoms of stress and depression decreased; the level of decrease was more prominent in the MBSR condition than the active control condition (significant p values and large effect sizes of interaction). Further, cortisol and creatine kinase concentrations also decreased more in the MBSR condition compared to the active control condition (large effect sizes of interaction). Conclusions: The present study's findings suggest that among male wrestlers, a modified MBSR intervention have the potential to reduce both psychological (stress and depression) and physiological (cortisol and creatine kinase) indices as compared to an active control condition.
Language	English
Publishing date	2023-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11111643
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Article: Nutritional Management and Outcomes in Malnourished Medical Inpatients in 2020: The Evidence Is Growing!

Schuetz, Philipp / Stanga, Zeno

Journal of clinical medicine

2019 Volume 9, Issue 1

Abstract: Access to adequate food is a fundamental human right [ ... ]. ...

Abstract	Access to adequate food is a fundamental human right [...].
Language	English
Publishing date	2019-12-20
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9010027
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