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  1. Book ; Online ; E-Book: Autoimmunerkrankungen in der Neurologie

    Stangel, Martin / Mäurer, Mathias

    Diagnostik und Therapie

    2018  

    Author's details Martin Stangel, Mathias Mäurer (Hrsg.)
    Keywords Medicine ; Immunology ; Rheumatology ; Neurology
    Language German
    Size 1 Online-Ressource (X, 326 Seiten), 34 Illustrationen
    Edition 2., aktualisierte und erweiterte Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019755490
    ISBN 978-3-662-55530-9 ; 9783662555293 ; 3-662-55530-1 ; 3662555298
    DOI 10.1007/978-3-662-55530-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Thesis: Auswirkung von Dimethylfumarat und Monomethylfumarat auf die Expression von Zytokinen, Wachstumsfaktoren und neurotrophen Faktoren in aktivierten Ratten-Astrozyten

    Gingele, Marina / Stangel, Martin

    2021  

    Institution Medizinische Hochschule Hannover
    Klinik für Neurologie
    Author's details vorgelegt von Marina Gingele ; aus der Klinik für Neurologie der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof. Dr. med. Martin Stangel
    Language German ; English
    Size 1 ungezähltes Blatt, 16 Blätter, 13 Blätter, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    Note Text auf Deutsch, Sonderabdruck auf Englisch ; Enthält 1 Zeitschriftenaufsatz aus „Brain Sciences", Jg. 9 (2019)
    HBZ-ID HT021713642
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 192 order for loan Magazin

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  3. Book ; Online ; E-Book: Neuroinfektiologie

    Meyding-Lamadé, Uta / Stangel, Martin / Weber, Jörg

    2021  

    Author's details Uta Meyding-Lamadé, Martin Stangel, Jörg Weber (Hrsg.)
    Keywords Infektionserkrankungen ; Herpes simplex ; Tropenkrankheiten ; Infektionen ; Neuroborreliose ; H1N1 ; Reisemedizin ; HIV ; Tropenmedizin ; Borreliose ; Meningitis
    Subject code 610
    Language German
    Size 1 Online-Ressource (XIV, 501 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020897391
    ISBN 978-3-662-61669-7 ; 9783662616680 ; 3-662-61669-6 ; 3662616688
    DOI 10.1007/978-3-662-61669-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book: Autoimmunerkrankungen in der Neurologie

    Stangel, Martin / Mäurer, Mathias

    Diagnostik und Therapie

    2012  

    Author's details Martin Stangel ; Mathias Mäurer
    Keywords Neuroimmunologie
    Subject Immunoneurologie
    Language German
    Size XIV, 277 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017069152
    ISBN 978-3-642-20476-0 ; 3-642-20476-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 5434 order for loan Magazin

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  5. Article: Neuroinfektiologie. Neue Erreger in der Neuroinflammation

    Stangel, Martin

    Neuro aktuell

    2018  Volume 9, Issue 8, Page(s) 31

    Language German
    Document type Article
    ZDB-ID 2263121-5
    ISSN 1869-6597 ; 0932-4607
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Emerging myelin repair agents in preclinical and early clinical development for the treatment of multiple sclerosis.

    Gingele, Stefan / Stangel, Martin

    Expert opinion on investigational drugs

    2020  Volume 29, Issue 6, Page(s) 583–594

    Abstract: Introduction: Remyelination is a highly effective regenerative process that can restore axon function, prevent axonal loss, and reverse clinical deficits after demyelination. Hence, the promotion of remyelination is a logical goal in patients with ... ...

    Abstract Introduction: Remyelination is a highly effective regenerative process that can restore axon function, prevent axonal loss, and reverse clinical deficits after demyelination. Hence, the promotion of remyelination is a logical goal in patients with multiple sclerosis (MS) in which remyelination is often insufficient. However, despite great progress regarding the development of immunomodulatory therapies for MS and an abundance of promising evidence from preclinical experiments so far, no therapy has convincingly demonstrated clinically significant remyelination properties. Therefore, enhancing myelin repair is an urgent and unmet need in MS.
    Areas covered: We searched clinicaltrials.gov and pubmed.ncbi.nlm.nih.gov and focused on therapeutic agents in development from the preclinical stage to clinical phase II. We selected agents for which data are available from
    Expert opinion: The evidence to promote remyelination is very promising for several agents, some of which possess anti-muscarinergic properties. Since remyelination is a complex process that involves various coordinated steps, a combination of different therapeutic approaches addressing different aspects of this regenerative mechanism may be reasonable. Furthermore, suitable surrogate markers of remyelination are necessary for proof-of-concept clinical trials.
    MeSH term(s) Animals ; Disease Models, Animal ; Drug Development ; Humans ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/physiopathology ; Muscarinic Antagonists/pharmacology ; Myelin Sheath/drug effects ; Myelin Sheath/pathology ; Remyelination/drug effects
    Chemical Substances Muscarinic Antagonists
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2020.1762567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online ; Thesis: Targeted metabolomic profiling of cerebrospinal fluid from patients with progressive multifocal leukoencephalopathy

    Luo, Yi [Verfasser] / Stangel, Martin [Akademischer Betreuer]

    2023  

    Author's details Yi Luo ; Akademischer Betreuer: Martin Stangel ; Klinik für Neurologie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  8. Book ; Thesis: Bestimmung der Signalsequenz für die Endozytose des humanen Transferrinrezeptors

    Stangel, Martin

    = Determination of the signal sequence for endocytosis of the human transferrin receptor

    1990  

    Title variant Determination of the signal sequence for endocytosis of the human transferrin receptor
    Author's details vorgelegt von Martin Stangel
    Size 1 Mikrofiche
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Göttingen, Univ., Diss., 1992
    Note [2], 69 Bl.: Ill., graph. Darst.
    HBZ-ID HT004536833
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 MB 772 order for loan Magazin

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  9. Article ; Online: Neurodegeneration and neuroprotection in multiple sclerosis.

    Stangel, Martin

    Current pharmaceutical design

    2012  Volume 18, Issue 29, Page(s) 4471–4474

    Abstract: The damage of axons and neurons in multiple sclerosis (MS) is well recognised and correlates with neurological disability. The reasons leading to axonal and neuronal injury are diverse and possibly change from an inflammatory mediated mechanism to a ... ...

    Abstract The damage of axons and neurons in multiple sclerosis (MS) is well recognised and correlates with neurological disability. The reasons leading to axonal and neuronal injury are diverse and possibly change from an inflammatory mediated mechanism to a neurodegenerative mechanism over the course of the disease. Acute axonal injury is associated with inflammation in the CNS and thus immunomodulatory treatments may also protect neurons from further damage. However, more effective immune treatments also bear the risk for severe side effects. Thus, neuroprotection will become more important to be combined with safe immunomodulation. Although several targets for neuroprotection have been identified experimentally, the translation into clinical treatments proves very difficult. Only few and small trials have investigated substances that may be neuroprotective, however, none had proven to have a substantial effect in MS patients. Clinical trials of remyelination, considered as a natural way of neuroprotection, were likewise not able to achieve clinical benefit. Thus, the development of a neuroprtective treatment in MS will be a major challenge in the decades to come.
    MeSH term(s) Animals ; Axons/pathology ; Clinical Trials as Topic ; Drug Design ; Humans ; Immunologic Factors/adverse effects ; Immunologic Factors/pharmacology ; Inflammation/drug therapy ; Inflammation/pathology ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Multiple Sclerosis/physiopathology ; Nerve Degeneration/drug therapy ; Nerve Degeneration/pathology ; Neuroprotective Agents/adverse effects ; Neuroprotective Agents/pharmacology
    Chemical Substances Immunologic Factors ; Neuroprotective Agents
    Language English
    Publishing date 2012-05-18
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161212802502189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book ; Online ; Thesis: De- und Remyelinisierung bei gealterten C57BL/6J Mäusen im Cuprizone-Modell

    Henkel, Florian [Verfasser] / Stangel, Martin [Akademischer Betreuer]

    2022  

    Author's details Florian Henkel ; Akademischer Betreuer: Martin Stangel ; Klinik für Neurologie
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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