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  1. Article ; Online: Young-Onset Colorectal Cancer in Serbia: Tertiary Cancer Center Experience.

    Nikolic, Neda / Spasic, Jelena / Stanic, Nemanja / Nikolic, Vladimir / Radosavljevic, Davorin

    Journal of adolescent and young adult oncology

    2022  Volume 12, Issue 2, Page(s) 207–214

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Young Adult ; Adolescent ; Humans ; Adult ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/surgery ; Serbia/epidemiology ; Retrospective Studies ; Neoplasm Staging ; Disease-Free Survival ; Prognosis
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2607978-1
    ISSN 2156-535X ; 2156-5333
    ISSN (online) 2156-535X
    ISSN 2156-5333
    DOI 10.1089/jayao.2021.0230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Low-Cost Genetic and Clinical Predictors of Response and Toxicity of Platinum-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer.

    Spasic, Jelena / Cavic, Milena / Stanic, Nemanja / Zaric, Bojan / Kovacevic, Tomi / Radosavljevic, Davorin / Nagorni-Obradovic, Ljudmila

    Dose-response : a publication of International Hormesis Society

    2022  Volume 20, Issue 2, Page(s) 15593258221111666

    Abstract: Background: This study aimed to evaluate for the first time whether certain genetic and clinical factors could serve as minimally invasive predictors of survival and toxicity to platinum-based chemotherapy in advanced lung adenocarcinoma.: Methods: ... ...

    Abstract Background: This study aimed to evaluate for the first time whether certain genetic and clinical factors could serve as minimally invasive predictors of survival and toxicity to platinum-based chemotherapy in advanced lung adenocarcinoma.
    Methods: The study included 121 advanced lung adenocarcinoma patients treated with platinum-based dublets until progression or unacceptable toxicity. Response was evaluated using standard radiological methods and toxicity graded according to the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Genotyping was performed using PCR-RFLP. Statistical significance was set at P < .05.
    Results: No significant influence of the examined polymorphisms on the occurrence of high-grade toxicity was detected. However, TP53 72Pro allele carriers were more prone to nausea (P = .037) and thrombocytopenia (P = .051). Anemia and neuropathy occurred more frequently in XRCC1 399Arg allele carriers (Pearson χ2 test, P = .025 and P = .004 respectively). RAD51 135CC carriers were significantly more prone to neutropenia (P = .027).
    Conclusions: A set of easily determined genetic and clinical predictors of survival and specific toxicity profiles of platinum-based chemotherapy in advanced lung adenocarcinoma were determined in this study, which might be useful for the construction of population-specific, time- and cost-efficient prognostic and predictive algorithms.
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2440820-7
    ISSN 1559-3258
    ISSN 1559-3258
    DOI 10.1177/15593258221111666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hematological parameters in EGFR-mutated advanced NSCLC patients treated with TKIs: predicting survival and toxicity.

    Jokic, Vera / Savic-Vujovic, Katarina / Spasic, Jelena / Stanic, Nemanja / Marinkovic, Mladen / Radosavljevic, Davorin / Cavic, Milena

    Expert review of anticancer therapy

    2021  Volume 21, Issue 6, Page(s) 673–679

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Protein Kinase Inhibitors/adverse effects ; Retrospective Studies
    Chemical Substances Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2021.1893694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients.

    Nikolic, Neda / Radosavljevic, Davorin / Gavrilovic, Dusica / Nikolic, Vladimir / Stanic, Nemanja / Spasic, Jelena / Cacev, Tamara / Castellvi-Bel, Sergi / Cavic, Milena / Jankovic, Goran

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 10

    Abstract: Background and ... ...

    Abstract Background and objectives
    MeSH term(s) Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/surgery ; Aged ; Colorectal Neoplasms/pathology ; Humans ; Male ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57101108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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