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  1. Article ; Online: Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods: response to comments from Dr. Luis-Lima.

    Staples, Amy / Wong, Craig / Schwartz, George J

    Pediatric nephrology (Berlin, Germany)

    2019  Volume 34, Issue 9, Page(s) 1631

    MeSH term(s) Adolescent ; Child ; Creatinine ; Glomerular Filtration Rate ; Humans ; Iohexol ; Pilot Projects ; Renal Insufficiency, Chronic
    Chemical Substances Iohexol (4419T9MX03) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2019-06-16
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-019-04286-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods.

    Staples, Amy / Wong, Craig / Schwartz, George J

    Pediatric nephrology (Berlin, Germany)

    2018  Volume 34, Issue 3, Page(s) 459–464

    Abstract: Background: Measurement of glomerular filtration rate by iohexol disappearance (iGFR) has become a gold standard in the pediatric chronic kidney disease (CKD) population. The need for serial phlebotomy can be difficult and minimizing venipunctures would ...

    Abstract Background: Measurement of glomerular filtration rate by iohexol disappearance (iGFR) has become a gold standard in the pediatric chronic kidney disease (CKD) population. The need for serial phlebotomy can be difficult and minimizing venipunctures would be beneficial. Furthermore, finger stick collection for dried blood spot (DBS) may be more tolerable in the pediatric population, and equivalence between these two methods may further simplify the process.
    Methods: This was a cross-sectional study in children and adolescents 1 to 21 years with stages I-IV CKD. Iohexol was infused and blood drawn 10, 30, 120, and 300 min later. Blood spots on filter paper were collected by finger stick after each of the latter two blood draws. The rate of iohexol plasma disappearance was used to calculate GFR. Pearson's correlation coefficient and bias, Students t test, and Bland-Altman graphical representations were used to compare methods.
    Results: Forty-one patients were recruited. The mean creatinine was 1.13 mg/dL (SD 0.45), the mean 4-point iGFR was 73.2 ml/min/1.73m
    Conclusions: The 2-point iGFR was highly correlated and agreed well with the 4-point iGFR. The same was true for the DBS method and the 2-point venous method. DBS sampling by finger stick sampling at 2 time points after iohexol infusion gave an acceptably accurate measurement of GFR.
    MeSH term(s) Adolescent ; Age Factors ; Blood Specimen Collection/adverse effects ; Blood Specimen Collection/methods ; Child ; Contrast Media/administration & dosage ; Contrast Media/analysis ; Contrast Media/metabolism ; Creatinine/blood ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Humans ; Injections, Intravenous ; Iohexol/administration & dosage ; Iohexol/analysis ; Iohexol/metabolism ; Male ; Metabolic Clearance Rate ; Pilot Projects ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology
    Chemical Substances Contrast Media ; Iohexol (4419T9MX03) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2018-10-12
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-018-4110-4
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  3. Article ; Online: Risk factors for progression of chronic kidney disease.

    Staples, Amy / Wong, Craig

    Current opinion in pediatrics

    2010  Volume 22, Issue 2, Page(s) 161–169

    Abstract: Purpose of review: The present review provides an overview of the identified risk factors for chronic kidney disease (CKD) progression emphasizing the pediatric population.: Recent findings: Over the past 10 years, there have been significant changes ...

    Abstract Purpose of review: The present review provides an overview of the identified risk factors for chronic kidney disease (CKD) progression emphasizing the pediatric population.
    Recent findings: Over the past 10 years, there have been significant changes to our understanding and study of preterminal kidney failure. Recent refinements in the measurement of glomerular filtration rate and glomerular filtration rate estimating equations are important tools for identification and association of risk factors for CKD progression in children. In pediatric CKD, lower level of kidney function at presentation, higher levels of proteinuria, and hypertension are known markers for a more rapid decline in glomerular filtration rate. Anemia and other reported risk factors from the pregenomic era require further study and validation. Genome-wide association studies have identified genetic loci that have provided novel genetic risk factors for CKD progression.
    Summary: With cohort studies of children with CKD becoming mature, they have started to yield important refinements to the assessment of CKD progression. Although many of the traditional risk factors for renal progression will certainly be assessed, such cohorts will be important for evaluating novel risk factors identified by genome-wide studies.
    MeSH term(s) Child ; Disease Progression ; Glomerular Filtration Rate ; Humans ; Kidney Failure, Chronic/physiopathology ; Risk Factors
    Language English
    Publishing date 2010-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0b013e328336ebb0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Outcomes of shared institutional review board compared with multiple individual site institutional review board models in a multisite clinical trial.

    Martin, Samantha L / Allman, Phillip H / Dugoff, Lorraine / Sibai, Baha / Lynch, Stephanie / Ferrara, Jennifer / Aagaard, Kjersti / Zornes, Christina / Wilson, Jennifer L / Gibson, Marie / Adams, Molly / Longo, Sherri A / Staples, Amy / Saade, George / Beche, Imene / Carter, Ebony B / Owens, Michelle Y / Simhan, Hyagriv / Frey, Heather A /
    Khan, Shama / Palatnik, Anna / August, Phyllis / Irby, Les'Shon / Lee, Tiffany / Lee, Christine / Schum, Paula / Chan-Akeley, Rosalyn / Duhon, Catera / Rincon, Monica / Gibson, Kelly / Wiegand, Samantha / Eastham, Donna / Oparil, Suzanne / Szychowski, Jeff M / Tita, Alan

    American journal of obstetrics & gynecology MFM

    2023  Volume 5, Issue 6, Page(s) 100861

    Abstract: Background: Institutional review boards play a crucial role in initiating clinical trials. Although many multicenter clinical trials use an individual institutional review board model, where each institution uses their local institutional review board, ... ...

    Abstract Background: Institutional review boards play a crucial role in initiating clinical trials. Although many multicenter clinical trials use an individual institutional review board model, where each institution uses their local institutional review board, it is unknown if a shared (single institutional review board) model would reduce the time required to approve a standard institutional review board protocol.
    Objective: This study aimed to compare processing times and other processing characteristics between sites using a single institutional review board model and those using their individual site institutional review board model in a multicenter clinical trial.
    Study design: This was a retrospective study of sites in an open-label, multicenter randomized control trial from 2014 to 2021. Participating sites in the multicenter Chronic Hypertension and Pregnancy trial were asked to complete a survey collecting data describing their institutional review board approval process.
    Results: A total of 45 sites participated in the survey (7 used a shared institutional review board model and 38 used their individual institutional review board model). Most sites (86%) using the shared institutional review board model did not require a full-board institutional review board meeting before protocol approval, compared with 1 site (3%) using the individual institutional review board model (P<.001). Median total approval times (41 vs 56 days; P=.42), numbers of submission rounds (1 vs 2; P=.09), and numbers of institutional review board stipulations (1 vs 4; P=.12) were lower for the group using the shared institutional review board model than those using the individual site institutional review board model; however, these differences were not statistically significant.
    Conclusion: The findings supported the hypothesis that the shared institutional review board model for multicenter studies may be more efficient in terms of cumulative time and effort required to obtain approval of an institutional review board protocol than the individual institutional review board model. Given that these data have important implications for multicenter clinical trials, future research should evaluate these findings using larger or multiple multicenter trials.
    MeSH term(s) Female ; Pregnancy ; Humans ; Ethics Committees, Research ; Retrospective Studies ; Surveys and Questionnaires
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.100861
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  5. Book: The birth of development

    Staples, Amy L. S

    how the World Bank, Food and Agriculture Organization, and World Health Organization changed the world, 1945-1965

    (New studies in U.S. foreign relations ; 1)

    2006  

    Institution World Bank
    Food and Agriculture Organization of the United Nations
    World Health Organization
    Author's details Amy L.S. Staples
    Series title New studies in U.S. foreign relations ; 1
    Keywords Economic assistance/History ; Food supply/International cooperation/History ; Agricultural assistance/History ; Medical assistance/History
    Language English
    Size xvi, 349 p. ;, 25 cm.
    Publisher Kent State University Press
    Publishing place Kent, Ohio
    Document type Book
    ISBN 0873388496 ; 9780873388498
    Database NAL-Catalogue (AGRICOLA)

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  6. Book: The birth of development

    Staples, Amy L. S

    how the World Bank, Food and Agriculture Organization, and World Health Organization changed the world, 1945 - 1965

    (New studies in U. S. foreign relations ; 1)

    2006  

    Institution Food and Agriculture Organization of the United Nations
    World Bank
    World Health Organization
    International Bank for Reconstruction and Development
    FAO
    Weltgesundheitsorganisation
    Author's details Amy L. S. Staples
    Series title New studies in U. S. foreign relations ; 1
    MeSH term(s) History, 20th Century ; International Agencies/history ; International Cooperation/history
    Keywords Agricultural assistance/History ; Economic assistance/History ; Food supply/International cooperation/History ; Medical assistance/History ; Internationale Wirtschaftsbeziehungen ; Entwicklungsländer ; Welt ; Entwicklung ; Entwicklungsfinanzierung ; Entwicklungshilfe ; Nahrungsmittelhilfe ; Landwirtschaftliche Entwicklung ; Gesundheitsversorgung ; Geschichte ; Entwicklungsorganisation ; Internationale Beziehungen
    Language English
    Size XVI, 349 S., 25 cm
    Publisher Kent State Univ. Press
    Publishing place Kent, Ohio
    Document type Book
    Note Includes bibliographical references (p. 195-337) and index ; The birth of development -- Constructing an international economic worldview -- The World Bank and development, 1945-1963 -- The international economic diplomacy of the World Bank -- Food and agriculture in the international realm -- The limits of internationalism : the Food and Agriculture Organization, 1946-1957 -- Redefining an international role for the Food and Agriculture Organization -- The growth of international cooperation in medicine -- Constructing international authority in the World Health Organization -- Exercising international authority : the malaria eradication program -- Conclusion
    ISBN 0873388496 ; 9780873388498
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book: The birth of development

    Staples, Amy L. S

    how the World Bank, Food and Agriculture Organization, and World Health Organization changed the world, 1945 - 1965

    (New studies in U. S. foreign relations ; 1)

    2006  

    Institution Food and Agriculture Organization of the United Nations
    World Bank
    World Health Organization
    Weltbank
    FAO
    Weltgesundheitsorganisation
    Author's details Amy L. S. Staples
    Series title New studies in U. S. foreign relations ; 1
    MeSH term(s) History, 20th Century ; International Agencies/history ; International Cooperation/history
    Keywords Agricultural assistance/History ; Economic assistance/History ; Food supply/International cooperation/History ; Medical assistance/History ; Internationale Wirtschaftsbeziehungen ; Entwicklungsländer ; Welt ; Entwicklung ; Entwicklungsfinanzierung ; Entwicklungshilfe ; Nahrungsmittelhilfe ; Landwirtschaftliche Entwicklung ; Gesundheitsversorgung ; Geschichte ; Entwicklungsorganisation ; Internationale Beziehungen
    Language English
    Size XVI, 349 S., 25 cm
    Document type Book
    Note Includes bibliographical references (p. 195-337) and index ; The birth of development -- Constructing an international economic worldview -- The World Bank and development, 1945-1963 -- The international economic diplomacy of the World Bank -- Food and agriculture in the international realm -- The limits of internationalism : the Food and Agriculture Organization, 1946-1957 -- Redefining an international role for the Food and Agriculture Organization -- The growth of international cooperation in medicine -- Constructing international authority in the World Health Organization -- Exercising international authority : the malaria eradication program -- Conclusion
    ISBN 0873388496 ; 9780873388498
    Database ECONomics Information System

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  8. Article ; Online: The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group.

    Selewski, David T / Gist, Katja M / Nathan, Amy T / Goldstein, Stuart L / Boohaker, Louis J / Akcan-Arikan, Ayse / Bonachea, Elizabeth M / Hanna, Mina / Joseph, Catherine / Mahan, John D / Mammen, Cherry / Nada, Arwa / Reidy, Kimberly / Staples, Amy / Wintermark, Pia / Griffin, Russell / Askenazi, David J / Guillet, Ronnie

    Pediatric research

    2019  Volume 87, Issue 3, Page(s) 550–557

    Abstract: Background: We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study.: Methods: Retrospective analysis of infants <36 weeks' ... ...

    Abstract Background: We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study.
    Methods: Retrospective analysis of infants <36 weeks' gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight.
    Outcome: Mechanical ventilation (MV) at postnatal day 7.
    Results: One hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: -2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10-1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07-1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06-1.13) were independently associated with MV on postnatal day 7. In a similar analysis, a negative FB at postnatal day 7 protected against the need for MV at postnatal day 7 (aOR 0.21, 95% CI 0.12-0.35).
    Conclusions: Positive peak FB during the first postnatal week and more positive FB on postnatal day 7 were independently associated with MV at postnatal day 7. Those with a negative FB at postnatal day 7 were less likely to require MV.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Birth Weight ; Canada/epidemiology ; Female ; Fluid Shifts ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Prognosis ; Respiration, Artificial ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; United States/epidemiology ; Water-Electrolyte Balance ; Water-Electrolyte Imbalance/diagnosis ; Water-Electrolyte Imbalance/epidemiology ; Water-Electrolyte Imbalance/physiopathology ; Water-Electrolyte Imbalance/therapy
    Keywords covid19
    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-019-0579-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  9. Article: Norris E. Dodd and the connections between domestic and international agricultural policy

    Staples, Amy L. S

    Agricultural history : a publication of the Agricultural History Society Vol. 74, No. 2 , p. 393-403

    2000  Volume 74, Issue 2, Page(s) 393–403

    Author's details Amy L. S. Staples
    Keywords Agrarpolitik ; International ; USA
    Language English
    Publisher Univ. of California Pr.
    Publishing place Berkeley, Calif.
    Document type Article
    ZDB-ID 430278-3
    Database ECONomics Information System

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  10. Article ; Online: The impact of fluid balance on outcomes in critically ill near-term/term neonates: a report from the AWAKEN study group.

    Selewski, David T / Akcan-Arikan, Ayse / Bonachea, Elizabeth M / Gist, Katja M / Goldstein, Stuart L / Hanna, Mina / Joseph, Catherine / Mahan, John D / Nada, Arwa / Nathan, Amy T / Reidy, Kimberly / Staples, Amy / Wintermark, Pia / Boohaker, Louis J / Griffin, Russell / Askenazi, David J / Guillet, Ronnie

    Pediatric research

    2018  Volume 85, Issue 1, Page(s) 79–85

    Abstract: Background: In sick neonates admitted to the NICU, improper fluid balance can lead to fluid overload. We report the impact of fluid balance in the first postnatal week on outcomes in critically ill near-term/term neonates.: Methods: This analysis ... ...

    Abstract Background: In sick neonates admitted to the NICU, improper fluid balance can lead to fluid overload. We report the impact of fluid balance in the first postnatal week on outcomes in critically ill near-term/term neonates.
    Methods: This analysis includes infants ≥36 weeks gestational age from the Assessment of Worldwide Acute Kidney injury Epidemiology in Neonates (AWAKEN) study (N = 645). Fluid balance: percent weight change from birthweight.
    Primary outcome: mechanical ventilation (MV) on postnatal day 7.
    Results: The median peak fluid balance was 1.0% (IQR: -0.5, 4.6) and occurred on postnatal day 3 (IQR: 1, 5). Nine percent required MV at postnatal day 7. Multivariable models showed the peak fluid balance (aOR 1.12, 95%CI 1.08-1.17), lowest fluid balance in 1st postnatal week (aOR 1.14, 95%CI 1.07-1.22), fluid balance on postnatal day 7 (aOR 1.12, 95%CI 1.07-1.17), and negative fluid balance at postnatal day 7 (aOR 0.3, 95%CI 0.16-0.67) were independently associated with MV on postnatal day 7.
    Conclusions: We describe the impact of fluid balance in critically ill near-term/term neonates over the first postnatal week. Higher peak fluid balance during the first postnatal week and higher fluid balance on postnatal day 7 were independently associated with MV at postnatal day 7.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/mortality ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Adult ; Birth Weight ; Critical Illness ; Female ; Gestational Age ; Hospital Mortality ; Humans ; India ; Infant, Newborn ; Infant, Premature ; Intensive Care Units, Neonatal ; Male ; North America ; Premature Birth ; Respiration, Artificial ; Retrospective Studies ; Risk Factors ; Term Birth ; Time Factors ; Treatment Outcome ; Water-Electrolyte Balance ; Water-Electrolyte Imbalance/diagnosis ; Water-Electrolyte Imbalance/mortality ; Water-Electrolyte Imbalance/physiopathology ; Water-Electrolyte Imbalance/therapy ; Weight Gain ; Young Adult
    Language English
    Publishing date 2018-09-20
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-018-0183-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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