Article ; Online: Joint effect of cognitive function and C-reactive protein on all-cause mortality risk: 1999-2002 NHANES.
2022 Volume 74, Page(s) 111–117
Abstract: Purpose: Examine the joint effect of cognitive function and C-reactive protein (CRP) on all-cause mortality risk in older U.S. adults.: Methods: Sample included 1335 older adult (≥60 years of age) participants in the 1999-2002 National Health and ... ...
Abstract | Purpose: Examine the joint effect of cognitive function and C-reactive protein (CRP) on all-cause mortality risk in older U.S. adults. Methods: Sample included 1335 older adult (≥60 years of age) participants in the 1999-2002 National Health and Nutrition Examination Survey. A four-level variable was created using cognitive function and CRP concentration. Mortality was assessed using National Center for Health Statistics linked death records from the National Death Index. Results: Increased risk of all-cause mortality was revealed in adults with high CRP and low cognitive function and in those with low to average CRP and low cognitive function (P < .0001 for both). Sex-stratified analyses revealed increased all-cause mortality risk in males with low cognitive function, independent of CRP concentration. However, in females, a significant increase in all-cause mortality risk was only observed in those with low to average CRP and low cognitive function. Conclusions: Low cognitive function was associated with increased all-cause mortality risk independent of CRP concentration. However, the joint effect of cognitive function and CRP on all-cause mortality risk differed according to sex. |
---|---|
MeSH term(s) | Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; Cognition/physiology ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/mortality ; Female ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Risk Factors |
Chemical Substances | Biomarkers ; C-Reactive Protein (9007-41-4) |
Language | English |
Publishing date | 2022-07-20 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1074355-8 |
ISSN | 1873-2585 ; 1047-2797 |
ISSN (online) | 1873-2585 |
ISSN | 1047-2797 |
DOI | 10.1016/j.annepidem.2022.07.003 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 3225: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.