Article: Rhabdomyolysis and renal failure associated with gemfibrozil monotherapy.
2004 Volume 38, Issue 2, Page(s) 232–234
Abstract: Objective: To report a case of rhabdomyolysis and acute renal failure associated with gemfibrozil monotherapy of hyperlipidemia.: Case summary: A 30-year-old white man with hypertension, type 1 diabetes mellitus, and hyperlipidemia was hospitalized ... ...
| Abstract | Objective: To report a case of rhabdomyolysis and acute renal failure associated with gemfibrozil monotherapy of hyperlipidemia. Case summary: A 30-year-old white man with hypertension, type 1 diabetes mellitus, and hyperlipidemia was hospitalized due to myalgias, nausea, and vomiting that began after he started working as a jackhammer operator 4 days previously. His medications were lisinopril, aspirin, insulin, and gemfibrozil. Creatine kinase and creatinine, which previously had been mildly elevated and normal, respectively, were markedly elevated, consistent with rhabdomyolysis with acute renal failure. Discussion: As of December 8, 2003, this is the only report of a patient with normal baseline creatinine level who developed rhabdomyolysis with acute renal failure associated with gemfibrozil monotherapy. Strenuous exertion, hypovolemia, and lisinopril use may have contributed to the severity of illness. An objective causality assessment revealed that an adverse drug reaction to gemfibrozil was possible. Conclusions: Gemfibrozil monotherapy of hyperlipidemia may predispose to rhabdomyolysis with acute renal failure. Patients using gemfibrozil should be cautioned regarding strenuous exertion, dehydration, and the need for prompt evaluation of myalgias. |
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| MeSH term(s) | Acute Kidney Injury/chemically induced ; Adult ; Creatinine/blood ; Diabetes Mellitus, Type 1/complications ; Gemfibrozil/adverse effects ; Humans ; Hyperlipidemias/complications ; Hyperlipidemias/drug therapy ; Hypertension/complications ; Hypolipidemic Agents/adverse effects ; Male ; Physical Exertion ; Rhabdomyolysis/chemically induced ; Rhabdomyolysis/physiopathology | |||||
| Chemical Substances | Hypolipidemic Agents ; Creatinine (AYI8EX34EU) ; Gemfibrozil (Q8X02027X3) | |||||
| Language | English | |||||
| Publishing date | 2004-02 | |||||
| Publishing country | United States | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 1101370-9 | |||||
| ISSN | 1542-6270 ; 1060-0280 | |||||
| ISSN (online) | 1542-6270 | |||||
| ISSN | 1060-0280 | |||||
| DOI | 10.1345/aph.1D282 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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