LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Cancer: A suppression switch.

    Starobinets, Hanna / Debnath, Jayanta

    Nature

    2013  Volume 504, Issue 7479, Page(s) 225–226

    MeSH term(s) Animals ; Autophagy ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Genes, p53/genetics ; Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Tumor Suppressor Protein p53
    Language English
    Publishing date 2013-12-04
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature12841
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.

    Rudnick, Jenny A / Monkkonen, Teresa / Mar, Florie A / Barnes, James M / Starobinets, Hanna / Goldsmith, Juliet / Roy, Srirupa / Bustamante Eguiguren, Sofía / Weaver, Valerie M / Debnath, Jayanta

    Genes & development

    2021  Volume 35, Issue 13-14, Page(s) 963–975

    Abstract: Autophagy inhibitors are currently being evaluated in clinical trials for the treatment of diverse cancers, largely due to their ability to impede tumor cell survival and metabolic adaptation. More recently, there is growing interest in whether and how ... ...

    Abstract Autophagy inhibitors are currently being evaluated in clinical trials for the treatment of diverse cancers, largely due to their ability to impede tumor cell survival and metabolic adaptation. More recently, there is growing interest in whether and how modulating autophagy in the host stroma influences tumorigenesis. Fibroblasts play prominent roles in cancer initiation and progression, including depositing type 1 collagen and other extracellular matrix (ECM) components, thereby stiffening the surrounding tissue to enhance tumor cell proliferation and survival, as well as secreting cytokines that modulate angiogenesis and the immune microenvironment. This constellation of phenotypes, pathologically termed desmoplasia, heralds poor prognosis and reduces patient survival. Using mouse mammary cancer models and syngeneic transplantation assays, we demonstrate that genetic ablation of stromal fibroblast autophagy significantly impedes fundamental elements of the stromal desmoplastic response, including collagen and proinflammatory cytokine secretion, extracellular matrix stiffening, and neoangiogenesis. As a result, autophagy in stromal fibroblasts is required for mammary tumor growth in vivo, even when the cancer cells themselves remain autophagy-competent . We propose the efficacy of autophagy inhibition is shaped by this ability of host stromal fibroblast autophagy to support tumor desmoplasia.
    MeSH term(s) Animals ; Autophagy/genetics ; Cell Line, Tumor ; Cell Transformation, Neoplastic/pathology ; Fibroblasts/metabolism ; Humans ; Mice ; Stromal Cells ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.345629.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 54: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.

    Starobinets, Hanna / Ye, Jordan / Broz, Miranda / Barry, Kevin / Goldsmith, Juliet / Marsh, Timothy / Rostker, Fanya / Krummel, Matthew / Debnath, Jayanta

    The Journal of clinical investigation

    2016  Volume 126, Issue 12, Page(s) 4417–4429

    Abstract: The rising success of cancer immunotherapy has produced immense interest in defining the clinical contexts that may benefit from this therapeutic approach. To this end, there is a need to ascertain how the therapeutic modulation of intrinsic cancer cell ... ...

    Abstract The rising success of cancer immunotherapy has produced immense interest in defining the clinical contexts that may benefit from this therapeutic approach. To this end, there is a need to ascertain how the therapeutic modulation of intrinsic cancer cell programs influences the anticancer immune response. For example, the role of autophagy as a tumor cell survival and metabolic fitness pathway is being therapeutically targeted in ongoing clinical trials that combine cancer therapies with antimalarial drugs for the treatment of a broad spectrum of cancers, many of which will likely benefit from immunotherapy. However, our current understanding of the interplay between autophagy and the immune response remains incomplete. Here, we have evaluated how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer. We observed equivalent levels of T cell infiltration and function within autophagy-competent and -deficient tumors, even upon treatment with the anthracycline chemotherapeutic doxorubicin. Similarly, we found equivalent T cell responses upon systemic treatment of tumor-bearing mice with antimalarial drugs. Our findings demonstrate that antitumor adaptive immunity is not adversely impaired by autophagy inhibition in these models, allowing for the future possibility of combining autophagy inhibitors with immunotherapy in certain clinical contexts.
    MeSH term(s) Animals ; Antimalarials/pharmacology ; Autophagy/drug effects ; Autophagy/immunology ; Cell Line, Tumor ; Female ; Immunity, Cellular/drug effects ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/immunology ; Mammary Neoplasms, Experimental/pathology ; Melanoma/drug therapy ; Melanoma/immunology ; Melanoma/pathology ; Mice ; Mice, Transgenic ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
    Chemical Substances Antimalarials
    Language English
    Publishing date 2016-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI85705
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: An Empirical Antigen Selection Method Identifies Neoantigens That Either Elicit Broad Antitumor T-cell Responses or Drive Tumor Growth.

    Lam, Hubert / McNeil, Lisa K / Starobinets, Hanna / DeVault, Victoria L / Cohen, Roger B / Twardowski, Przemyslaw / Johnson, Melissa L / Gillison, Maura L / Stein, Mark N / Vaishampayan, Ulka N / DeCillis, Arthur P / Foti, James J / Vemulapalli, Vijetha / Tjon, Emily / Ferber, Kyle / DeOliveira, Daniel B / Broom, Wendy / Agnihotri, Parul / Jaffee, Elizabeth M /
    Wong, Kwok-Kin / Drake, Charles G / Carroll, Pamela M / Davis, Thomas A / Flechtner, Jessica Baker

    Cancer discovery

    2021  Volume 11, Issue 3, Page(s) 696–713

    Abstract: Neoantigens are critical targets of antitumor T-cell responses. The ATLAS bioassay was developed to identify neoantigens empirically by expressing each unique patient-specific tumor mutation individually ... ...

    Abstract Neoantigens are critical targets of antitumor T-cell responses. The ATLAS bioassay was developed to identify neoantigens empirically by expressing each unique patient-specific tumor mutation individually in
    MeSH term(s) Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Cancer Vaccines/administration & dosage ; Cancer Vaccines/immunology ; Cell Line, Tumor ; Clinical Trials as Topic ; DNA Mutational Analysis ; Disease Models, Animal ; Disease Progression ; Genomics/methods ; Humans ; Immunity, Cellular ; Immunogenicity, Vaccine ; Melanoma, Experimental ; Mice ; Mutation ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Treatment Outcome ; Vaccination
    Chemical Substances Antigens, Neoplasm ; Biomarkers, Tumor ; Cancer Vaccines
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-20-0377
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top